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| 1 | Comparison of cytokine and phosphoprotein profiles in idiopathic and Crohn’s disease-related perianal fistula显示文摘BACKGROUND Perianal fistulae are either primary(idiopathic)or secondary[commonly associated with Crohn’s disease,(CD)].It is assumed,although not proven,that the pathophysiology differs.AIM To systematically compare the clinical phenotypes,cytokine and phosphoprotein profiles of idiopathic and CD-related perianal fistulae.METHODS Sixty-one patients undergoing surgery for perianal fistula were prospectively recruited(48 idiopathic,13 CD)into a cohort study.Clinical data,including the Perineal Disease Activity Index(PDAI)and EQ-5D-5L were collected.Biopsies of the fistula tract,granulation tissue,internal opening mucosa and rectal mucosa were obtained at surgery.Concentrations of 30 cytokines and 39 phosphoproteins were measured in each biopsy using a magnetic bead multiplexing instrument and a chemiluminescent antibody array respectively.Over 12000 clinical and 23500 laboratory measurements were made.RESULTS The PDAI was significantly higher(indicating more active disease)in the CD group with a mean difference of 2.40(95%CI:0.52-4.28,P=0.01).Complex pathoanatomy was more prevalent in the CD group,namely more multiple fistulae,supralevator extensions,collections and rectal thickening.The IL-12p70 concentration at the internal opening specimen site was significantly higher(median difference 19.7 pg/mL,99%CI:0.2-40.4,P=0.008)and the IL-1RA/IL-1βratio was significantly lower in the CD group at the internal opening specimen site(median difference 15.0,99%CI=0.4-50.5,P=0.008).However in the remaining 27 cytokines and all 39 of the phosphoproteins across the four biopsy sites,no significant differences were found between the groups.CONCLUSION CD-related perianal fistulae are more clinically severe and anatomically complex than idiopathic perianal fistulae.However,overall there are no major differences in cytokine and phosphoprotein profiles. | James B Haddow Omar Musbahi Thomas T MacDonald Charles H Knowles | 2019 | World Journal of Gastrointestinal Pathophysiology2019，10，4： | 2 |
| 2 | Thomashow components of the Arabidopsis C repeat/dehydration responsive element bindingfactor cold-response pathway are conserved in Brassica napus and other plant species显示文摘 | KIRSTEN R J SUSANNE K KEENAN L A XIN Z VOLKER H JAMES Z Z THOMAS D MICHAEL F | 2001 | Plant Plzysiology2001，127，3： | 1 |
| 3 | The New Industrial Engineering:Information Technology and Business Process Redesign 显示文摘 | Thomas H Davenport James E Sbort | 1990 | Sloan Management Review1990，31，4： | 1 |
| 4 | Long acting delivery systems for narcotic antagonists II: release rates of naltrexone from poly(lactic acid) composites 显示文摘 | Seymour Yolles Thomas D Leafe James H R Woodland | 1975 | Journal of Pharmaceutical Sciences1975，64，2： | 1 |
| 5 | 隐蔽性高血压与左心室重构和运动性高血压反应的关系显示文摘运动性高血压反应[hypertensive response to exercise,HRE;定义为诊室血压正常但运动时收缩压≥210(男性),≥190mmHg(女性),或舒张压≥105mmHg]可以独立地预测死亡率。该研究评估HRE患者中隐蔽性高血压的患病率及其与心血管危险因素(包括左心室质量指数)的相关性。方法:入选(54±9)岁未治疗的HRE患者72例(60%男性,经运动负荷超声心动图检查无冠状动脉性疾病)进行全面的临床和超声心动图(包括中心动脉压和脉搏波传导速度)检查及24h动态血压监测。 | James E Sharman James L Hare Scott Thomas Justin E Davies Rodel Leano Carly Jenkins Thomas H Marwick | 2011 | 中华高血压杂志2011，19，12： | 1 |
| 6 | Contribution of abnormal central blood pressure to left ventricular filling pressure during exercise in patients with heart failure and preserved ejection fraction显示文摘 | David J Holland Julian W Sacre Rodel L Leano Thomas H Marwick James E Sharman | 2011 | Journal of Hypertension2011，，： | 1 |
| 7 | Release behavior for powder injection molding in stereo lithography molds 显示文摘 | James G H Thomas L S David W R | 2001 | Rapid Prototyping Journai2001，7，2： | 1 |
| 8 | Localized corrosion of friction stir spot welds in magnesium AZ31 alloy 显示文摘 | James A North Thomas H Thorpe Steven J | 2012 | ECS Trans2012，41，25： | 1 |
| 9 | Chemical approaches to artificial photosynthesis显示文摘 | James H A A Brennaman M K Thomas J M | 2005 | Inorg Chem2005，44，20： | 1 |
| 10 | Reductive Dechlorination of Hight Concentrations of Tetrachloroethene to Ethene by an Anaerobic Enrichment Culture in the Absence of Methanogenesis显示文摘 | James M Gossett Stephen H Zinder | 1991 | Applied and Environmental Microbiology1991，57，8： | 1 |
| 11 | Construction and Economic Development:The Case of Hong Kong显示文摘 | James M W Wong Y H Chiang Thomas S N G | 2008 | Construction Management and Economics2008，26，8： | 1 |
| 12 | Synthe- sis and characterization of hydroxyapatite-silk com- posite scaffold for bone tissue engineering 显示文摘 | LIN Y-C THOMAS K H T JAMES C H G | 2011 | Current Nanoseienee2011，7，6： | 1 |
| 13 | A Quality-Based Review of Randomized Controlled Trials of Cognitive-Behavioral Therapy for Depression: An Assessment and Metaregression显示文摘 | Thoma Nathan C McKay Dean Gerber Andrew J Milrod Barbara L Edwards Anna R Kocsis James H | 2012 | The American Journal of Psychiatry2012，，1： | 1 |
| 14 | Heat transfer from tubes in crossflow显示文摘 | Zukauskas A James P H Thomas F | | 0，，： | 1 |
| 15 | A New Dietary Inflammatory Index Predicts Interval Changes in Serum High-Sensitivity C-Reactive Protein1-3显示文摘 | Cavicchia Philip P Steck Susan E Hurley Thomas G Hussey James R Ma Yunsheng Ockene Ira S Hébert James R | 2009 | The Journal of Nutrition2009，，12： | 1 |
| 16 | Soot in coal combustion systems 显示文摘 | Fletcher Thomas H Ma Jinliang Rigby James R | 1997 | Prog Energy Combust Sci1997，23，： | 1 |
| 17 | Epiploic appetldagitis显示文摘 | JAMES H THOMAS | 1974 | S G O1974，133，1： | 1 |
| 18 | Post buckling analysis of a wind turbine blade substrueture显示文摘 | Thomas M H Dharmaraj M James E L | 2005 | Journal of Solar Energy Engineering2005，127，4： | 1 |
| 19 | Stock, Efficient Tests for an Autoregressive Unit Root显示文摘 | Elliott Graham Thomas J Rothenberg James H | 1996 | Econometrica1996，64，： | 1 |
| 20 | The new industrial engineering: Information technology and business process re-design 显示文摘 | Thomas H Davenport and James E Short | 1990 | Sloan Management Review1990，31，4： | 1 |
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