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| 1 | Comparison of visual acuity outcomes between ranibizumab and bevacizumab treatment in neovascular age-related macular degeneration显示文摘AIM:To compare visual acuity(VA) outcomes between intravitreal injection of bevacizumab and ranibizumab in the treatment of neovascular age-related macular degeneration(AMD).· METHODS:We conducted a consecutive,retrospective case series study in patients with newly diagnosed all type choroidal neovascularization(CNV) secondary to AMD who received an intravitreal injection of bevacizumab(1.25mg) or ranibizumab(0.3mg) at Lions Eye Institute,Western Australia from Mar.2006 to May 2008.All patients received injection at baseline with additional monthly injections given at the discretion of the treating physician.Main outcome measures were changes in VA.· RESULTS:There were 371 consecutive patients received injection at least in one eye with at least 6 months of follow up(median of 12.0 months).Bevacizumab treatment prevented 221 out of 278(79.5%) patients from losing <15 letters in VA compared with 79 out of 93(84.9%) of ranibizumab treated patients(P=0.25).While 68(24.5%) of bevacizumab treated patients gained ≥15 letters of VA compared with 24(25.8%) of ranibizumab treated patients(P=0.79).75.3% and 66.2% patients benefited from ranibizumab and bevacizumab respectively with final VA better than 6/60(P=0.10).Multivariate analysis showed that pre-treatment VA was negatively associated with benefit outcome.Assignment of injection was not associated with VA outcome of benefit after adjusting the covariate(P=0.857).CONCLUSION:There are no difference in treatment efficacy in terms of VA between bevacizumab and ranibizumab in routine clinical condition. | Ian J Constable Ian L McAllister Timothy Isaacs | 2011 | International Journal of Ophthalmology(English edition)2011，4，1： | 3 |
| 2 | Diabetes mellitus, revascularization and outcomes in elderly patients with myocardial infarction-related cardiogenic shock显示文摘Background The prognostic role of diabetes mellitus(DM)in elderly patients with myocardial infarction-related cardiogenic shock(MI-CS)remains controversial.Little information exists about the impact of intensive cardiac care unit(ICCU)and revascularization on outcomes of elderly patients with MI-CS.We aimed to assess the prognostic impact of DM according to age in patients with MI-CS,and to analyze the impact ICCU management and revascularization on in-hospital mortality in MI-CS patients at older ages.Methods Discharge episodes with diagnosis of CS associated with MI were selected from the Spanish National Health System’s Basic Data Set.Centers were classified according to their availability of ICCU.Main outcome measured was in-hospital mortality.Results A total of 23,590 episodes of MI-CS were identified,of whom 12,447(52.8%)were in patients aged≥75 years.The impact of DM on in-hospital mortality was different among age subgroups.While in younger patients,DM was associated to a higher mortality risk(0.52 vs.0.47,OR=1.12,95%CI:1.06–1.18,χ^2<0.001),this association became non-significant in older patients(0.76 vs.0.81,χ^2=0.09).Adjusted mortality rate of MI-CS aged≥75 years was lower in patients admitted to hospitals with ICCU(adjusted mortality rate:74.2%vs.77.7%,P<0.001)and in patients undergoing revascularization(74.9%vs.77.3%,P<0.001).Conclusions Prognostic impact of DM in patients with MI-CS was different according to age,with a significantly lower impact at older ages.The availability of ICCU and revascularization were associated with better outcomes in these complex patients. | Miquel Gual Albert Ariza-Solé María García Márquez Cristina Fernández JoséL Bernal Francesc Formiga María-Isabel Barrionuevo JoséC Sánchez-Salado Victòria Lorente Júlia Pascual Isaac Llaó Oriol Alegre Angel Cequier Javier Elola | 2020 | Journal of Geriatric Cardiology2020，17，10： | 2 |
| 3 | Mitochondrial reactive oxygen species generation triggers inflammatory response and tissue injury associated with hepatic ischemia–reperfusion: Therapeutic potential of mitochondrially targeted antioxidants显示文摘 | Partha Mukhopadhyay B?la Horváth Zsuzsanna Zsengell?r Sándor Bátkai Zongxian Cao Malek Kechrid Eileen Holovac Katalin Erd?lyi Galin Tanchian Lucas Liaudet Isaac E. Stillman Joy Joseph Balaraman Kalyanaraman Pál Pacher | 2012 | Free Radical Biology and Medicine2012，，5： | 2 |
| 4 | Quality of reporting and ev- idence in American Academy of Pediatrics guidelines 显示文摘 | Isaac A Saginur M Hartling L | 2013 | Pediat- rics2013，131，4： | 1 |
| 5 | The eggshell lech- nique for prevention of cement leakage during kyphoplasty 显示文摘 | Greene D L Isaac R Neuwirth M | 2007 | Spinal Disord Tech2007，20，3： | 1 |
| 6 | Absolute and Relative Rewards for Individuals in Team Production 显示文摘 | Dickinson David L Isaac Mark R | 1998 | Manageri- al and Decision Economics1998，19，45： | 1 |
| 7 | Microplate fluorescence assay for the quantification of double stranded DNA using SYBR Green I dye显示文摘 | Leggate J Allain R Isaac L | 2006 | Biotechnol Lett2006，28，： | 1 |
| 8 | In search of predatory pricing 显示文摘 | Isaac R Mark and Vernon L Smith | 1985 | Journal of Political Economy1985，93，： | 1 |
| 9 | Kandek The Meaning of a Liberal Education 显示文摘 | Isaac L | 1939 | reachers College Record1939，41，2： | 1 |
| 10 | Kandet, The Challenge to Democracy 显示文摘 | Isaac L | 1936 | NASSP Bulletin:National Association of Secondary School Princi- ples1936，20，61： | 1 |
| 11 | Accuracy of the Xpert MTB/RIF test for the diagnosis of pulmonary tuberculosis in chil- dren admitted to hospital in Cape Town, South Africa: a descrip- tive study显示文摘 | Nicol MP Workman L Isaacs W | 2011 | Lancet Infect Dis2011，11，11： | 1 |
| 12 | Blocks and subgroups显示文摘 | Isaacs I M Scott L | 1972 | J Algebra1972，20，： | 1 |
| 13 | Heat shock protein 90 as a molecular target for cancer therapeutics显示文摘 | Isaacs JS Xu W Neckers L | 2003 | Cancer Cell2003，3，3： | 1 |
| 14 | Transcatheter aortic valve implantation in very elderly patients: immediate results and medium term follow-up显示文摘ObjectiveTo 评估立即的 transcatheter 在有严重、征兆的大动脉的狭窄的很老的病人的大动脉的阀门培植(TAVI ) 结果和中期的后续(作为).MethodsThis multicenter,观察、未来的学习在三所医院里被执行。我们包括了连续很老(>85 年) 病人与作为严重由 TAVI 对待。主要端点是在包括的二 years.ResultsThe 研究从任何原因评估死亡率有一个平均数的 160 个连续病人 87 ± 变老;2.1 年(从 85 ~ 94 年的范围) 和 18.8%± 的吝啬的逻辑 EuroSCORE;11.2% 与 57 (35.6%) 病人得分 ≥20% 。程序的成功率是 97.5% ,与 25 (15.6%) 与主要流血经历尖锐复杂并发症的病人(最经常) 。全球死亡率在住院期间是 8.8%(n = 14 ) 并且 30 天的死亡率是 10%(n = 16 ) 。中部在时期上面列在后面是 252.24 ±232.17 天。在后续时期期间, 28 (17.5%) 病人们死了(他们中的 17 个由于心脏的原因) 。估计的二年全面、心脏的幸存率使用 Kaplan-Meier 方法分别地是 71% 和 86.4% 。比例的危险回归给看了的考克斯可变 EuroSCORE ≥20 是与全面 mortality.ConclusionsTAVI 联系的唯一的变量在很老的病人的一张选择人口安全、有效。我们的调查结果支持在病人的这个复杂的组的这个新过程的采纳。 | Isaac Pascual Antonio J Mu oz-García Diego López-Otero Pablo Avanzas Manuel F Jimenez-Navarro Belén Cid-Alvarez Raquel del Valle Juan H Alonso-Briales Raimundo Ocaranza-Sanchez José M Hemández Ramiro Trillo-Nouche César Morís | 2015 | Journal of Geriatric Cardiology2015，12，4： | 1 |
| 15 | Percutaneous disk decompression using nucleoplasty 显示文摘 | Sharps L Isaacs Z | 2002 | Pain Physician2002，5，： | 1 |
| 16 | Light, temperature, and anthocyanin production 显示文摘 | ISAAC R ALBERTO L M | 1986 | Plant Physiology1986，81，： | 1 |
| 17 | Heat shock protein 90 as a molecular target for cancer therapeutics 显示文摘 | Isaacs J S Xu W Neckers L | 2003 | Cancer Cell2003，3，3： | 1 |
| 18 | Tacrolimus for the treatment of fistulas in patients with crohn’s disease: a randomized, placebo-controlled trial显示文摘 | William J Sandborn Daniel H Present Kim L Isaacs Douglas C Wolf Eugene Greenberg Stephen B Hanauer Brian G Feagan Lloyd Mayer Therese Johnson Joseph Galanko Christopher Martin Robert S Sandler | 2003 | Gastroenterology2003，，2： | 1 |
| 19 | Transplantation of neonatal porcine islets and sertoli cel s into nonimmunosuppressed nonhuman primate s显示文摘 | Isaac JR Skinner S E l iot R | | 0，，01： | 1 |
| 20 | Kandel, The Profession of Teaching显示文摘 | Isaac L | 1940 | School and Society1940，，52： | 1 |
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