| 1 | Comparison of visual acuity outcomes between ranibizumab and bevacizumab treatment in neovascular age-related macular degeneration显示文摘AIM:To compare visual acuity(VA) outcomes between intravitreal injection of bevacizumab and ranibizumab in the treatment of neovascular age-related macular degeneration(AMD).· METHODS:We conducted a consecutive,retrospective case series study in patients with newly diagnosed all type choroidal neovascularization(CNV) secondary to AMD who received an intravitreal injection of bevacizumab(1.25mg) or ranibizumab(0.3mg) at Lions Eye Institute,Western Australia from Mar.2006 to May 2008.All patients received injection at baseline with additional monthly injections given at the discretion of the treating physician.Main outcome measures were changes in VA.· RESULTS:There were 371 consecutive patients received injection at least in one eye with at least 6 months of follow up(median of 12.0 months).Bevacizumab treatment prevented 221 out of 278(79.5%) patients from losing <15 letters in VA compared with 79 out of 93(84.9%) of ranibizumab treated patients(P=0.25).While 68(24.5%) of bevacizumab treated patients gained ≥15 letters of VA compared with 24(25.8%) of ranibizumab treated patients(P=0.79).75.3% and 66.2% patients benefited from ranibizumab and bevacizumab respectively with final VA better than 6/60(P=0.10).Multivariate analysis showed that pre-treatment VA was negatively associated with benefit outcome.Assignment of injection was not associated with VA outcome of benefit after adjusting the covariate(P=0.857).CONCLUSION:There are no difference in treatment efficacy in terms of VA between bevacizumab and ranibizumab in routine clinical condition. | Ian J Constable Ian L McAllister Timothy Isaacs | 2011 | International Journal of Ophthalmology(English edition)2011，4，1： | 3 |
| 3 | Ethanolic extract of Abrus precatorius leaves protected against mercury chloride-induced hepatocellular damage and cerebral Na+/K+-ATPase dysfunction in wistar rats显示文摘Plants are sources of medicinal compounds,and they play a crucial role in human health maintenance.Abrus precatorius is one of the important medicinal plants that have been alleged for their medicinal properties.This research unraveled the pharmacological effect of ethanolic extract of Abrus precatorius on lipid peroxidation,liver parameters,and Na^(+)/K^(+)-ATPase activity in HgCl_(2) treated wistar rats.Twenty-four(24)albino wistar rats weighing between 150-200 g were distributed into four groups of 6 animals each.Group A(control)received normal saline(0.9% NaCl),group B received 400 mg/kg of the extract only,group C received 4 mg/kg HgCl_(2) only,and group D received 400 mg/kg of extract+4 mg/kg of HgCl_(2).The treatment lasted for two weeks,and the animals were sacrificed on the 15th day.The blood,brains and livers were collected and used for assay of lipid peroxidation,liver function,and sodium pump activity.The results of liver function test revealed an elevated(P<0.05)level of serum aspartate transaminase,alanine transaminase,alkaline phosphatase,and total bilirubin in the group that received HgCl_(2) only(group C)when compared with the normal control(group A)that received normal saline only.However,the administration of extract in group D led to a marked(P<0.05)reduction in the activities of these enzymes and the level of total bilirubin when compared to the negative control(group C).On the contrary,HgCl_(2) caused a significant(P<0.05)reduction in serum total protein and albumin levels,but the extract reversed the effect of HgCl_(2) by elevating their concentrations.Nonetheless,the effect elicited by this extract is comparable to group A which received normal saline.Moreso,the result of lipid peroxidation revealed that HgCl_(2) treatment caused a marked(P<0.05)increase in the formation of lipid peroxidation adducts in both liver and brain homogenates in group C.On the contrary,administration of Abrus precatorius extract profoundly(P<0.05)inhibited HgCl_(2)-induced lipid peroxidation in group D.In addition,HgCl_(2) inhibited the activity of cerebral Na^(+)/K^(+)-ATPase,but the extract restored normalcy by increasing the activity of the enzyme in group D.Consequently,the results obtained justify the traditional use of Abrus precatorius and suggest that Abrus precatorius leaves may be used for management of liver diseases,oxidative stress-linked diseases and some neurodegenerative ailments. | Ebenezer Morayo Ale Steve Osagie Asuelimen Isaac John Umaru Bunmi Olaoluwa Olorundare Victoria Ifeoluwa Ayo Mgbede Joy Timothy Philip Shadrach | 2023 | Toxicology Advances2023，5，2： | 0 |
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