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| 1 | Analysis of the phosphatidylinosit ol 3'-kinase signaling pathway in glioblastoma patients in vivo显示文摘Deregulated signaling through the p hosphatidylinositol 3-kinase(PI3K)pathway is common in many types of can cer,including glioblastoma.Dissecting the molecular events associated with activation of this pathway in glioblastoma p atients in vivo presents an important challenge that has implic ations for the development and clini cal testing of PI3K pathway inhibito rs.Using an immunohistochemical analysis appl ied to a tissue microarray,we performed hierarchical clustering and mul tidimensional scaling,as well as univariate and multivariate analyses,to dissect the PI3K pathway in v ivo.We demonstrate that loss of the t umor suppressor protein PTEN,which antagonizes PI3K pathwa y activation,is highly correlated w ith activation of the main PI3K effec tor Akt in vivo.We also show that Akt activation is signific antly correlated with phosphorylation of mammalian target of rapamycin(mTOR),the family of forkhead transcription factors(FOXO1,FOXO3a,and FOXO4),and S6,which are thought to promote its effects.Expression of the mutan t epidermal growth factor receptor vIII is also tightly correlated with phosphorylation of these effectors,d emonstrating an additional route to PI3K pathway activation in glioblastomas in vivo.These results provide the first dissection of the PI3K path way in glioblastoma in vivo and suggest an approach to stratifying patients for targeted kinase inhi bitor | Choe G Horvath S Cloughesy TF Crosby K Seligson D Palotie A Inge L Smith BL Sawyers CL Mischel PS | 2003 | 癌症2003，22，7： | 41 |
| 2 | Hypertonicity:Clinical entities,manifestations and treatment显示文摘Hypertonicity causes severe clinical manifestations and is associated with mortality and severe short-term and longterm neurological sequelae. The main clinical syndromes of hypertonicity are hypernatremia and hyperglycemia.Hypernatremia results from relative excess of body sodium over body water. Loss of water in excess of intake,gain of sodium salts in excess of losses or a combination of the two are the main mechanisms of hypernatremia.Hypernatremia can be hypervolemic,euvolemic or hypovolemic. The management of hypernatremia addresses both a quantitative replacement of water and,if present,sodium deficit,and correction of the underlying pathophysiologic process that led to hypernatremia.Hypertonicity in hyperglycemia has two components,solute gain secondary to glucose accumulation in the extracellular compartment and water loss through hyperglycemic osmotic diuresis in excess of the losses of sodium and potassium. Differentiating between these two components of hypertonicity has major therapeutic implications because the first component will be reversed simply by normalization of serum glucose concentration while the second component will require hypotonic fluid replacement. An estimate of the magnitude of the relative water deficit secondary to osmotic diuresis is obtained by the corrected sodium concentration,which represents a calculated value of the serum sodium concentration that would result from reduction of the serum glucose concentration to a normal level. | Helbert Rondon-Berrios Christos Argyropoulos Todd S Ing Dominic S Raj Deepak Malhotra Emmanuel I Agaba Mark Rohrscheib Zeid J Khitan Glen H Murata Joseph I Shapiro Antonios H Tzamaloukas | 2017 | World Journal of Nephrology2017，6，1： | 2 |
| 3 | TLR3 and TLR4 expression in healthy and diseased human endometrium显示文摘 | Allhorn S B(o)ing C Koch A A | 2008 | Reprod Biol Endocrinol2008，6，： | 1 |
| 4 | Functional expression of the multimodal extracellular calcium-sensing receptor in pulmonary neuro- endocrine cells显示文摘 | Robrecht LB Inge B Kathy S | 2013 | J Cell Sci2013，126，19： | 1 |
| 5 | First-use reactions during hemodialysis:a definition of subtypes显示文摘 | Daugirdas J J Ing T S | 1998 | Kidney Int1998，24，4： | 1 |
| 6 | Beta-catenin regulates vascular endothelial growth factor expression in colon cancer显示文摘 | Easwaran V Lee S H Inge L | 2003 | Cancer Res2003，63，12： | 1 |
| 7 | Suscepti-bilily to UV-A and UV-B provocation doesnot correlate with disease severity of jtolv-morphic light eruption 显示文摘 | Janssens AS Pavel S I ing T | 2007 | Arch Dermatol2007，143，5： | 1 |
| 8 | Space laser altimeter pointing bias calibra- tion from range residual analysis 显示文摘 | LUTHCKE S B ROWLANDS D D STONEK- ING E | 2000 | Journal of spacecraft and rockets2000，，： | 1 |
| 9 | On the security of a visual cryptography scheme for color images显示文摘 | iNG F Y WONG D S | 2009 | Pattern Recognition2009，42，5： | 1 |
| 10 | Salt tectonics driven by dif- ferential sediment loading:stability analysis and finite-element experi- ments显示文摘 | Gemmer L Ings S J Medvedev S | 2004 | Basin Research2004，16，： | 1 |
| 11 | How social and human capital influence opportunity recognition and resource mobilization in India's handloom industry 显示文摘 | Bhawavatula S Elfi'ing T Tilbu A | 2010 | Journal of Business Venturing2010，25，3： | 1 |
| 12 | Detection and characterization of long pulse low velocity impact damage in plastic bonded explosives显示文摘 | Chen P W Huang F L Dai K D I)ing Y S | 2005 | International Journal of Impact Engineering2005，31，49： | 1 |
| 13 | Dynamic modelling of passive margin salt tectonics:effects of water loading, sediment properties andsedimentation patterns显示文摘 | Gemmer L Beaumont C Ings S J | 2005 | Basin Research2005，17，： | 1 |
| 14 | beta-Catenin regulates vascular endothelial growth factorexpression in colon cancer 显示文摘 | Easwaran V Lee S H Inge L Guo L Goldbeck C Garrett E etal | 2003 | Cancer Res2003，63，： | 1 |
| 15 | Direct Reprogramming of Fibroblasts into Neural Stem Cells by Defined Factors显示文摘 | Dong Wook Han Natalia Tapia Andreas Hermann Kathrin Hemmer Susanne H?ing Marcos J. Araúzo-Bravo Holm Zaehres Guangming Wu Stefan Frank S?ren Moritz Boris Greber Ji Hun Yang Hoon Taek Lee Jens C. Schwamborn Alexander Storch Hans R. Sch?ler | 2012 | Cell Stem Cell2012，，4： | 1 |
| 16 | The nature of the normal form map for soft impacting systems显示文摘 | Ma Y Ing J Banerjee S | 2008 | International Journal of Non-Linear Mechanics2008，43，6： | 1 |
| 17 | beta-Catenin regulates vascular endothelial growth factor expression in colon cancer显示文摘 | Easwaran V Lee S H Inge L | 2003 | Cancer Res2003，63，12： | 1 |
| 18 | Mechanical properties of smal fragment screws显示文摘 | Col inge CA Stern S Cordes S | | 0，，373： | 1 |
| 19 | Applying support vector machines to predict building energy consumption in tropical region显示文摘 | ING Bing CAO Cheng LEE S E | 2005 | Energy and Buildings2005，37，5： | 1 |
| 20 | Blind and robust audio watermarking scheme based on SVD-DCT显示文摘 | BAI Yinglei ING Y S and ZHEN Li | 2011 | Signal Processing2011，91，8： | 1 |
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