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| 1 | Gastric cancer arising from the remnant stomach after distal gastrectomy:A review显示文摘Gastric stump carcinoma was initially reported by Balfore in 1922,and many reports of this disease have since been published. We herein review previous reports of gastric stump carcinoma with respect to epidemiology,carcinogenesis,Helicobacter pylori(H. pylori) infection,Epstein-Barr virus infection,clinicopathologic characteristics and endoscopic treatment. In particular,it is noteworthy that no prognostic differences are observed between gastric stump carcinoma and primary upper third gastric cancer. In addition,endoscopic submucosal dissection has recently been used to treat gastric stump carcinoma in the early stage. In contrast,many issues concerning gastric stump carcinoma remain to be clarified,including molecular biological characteristics and the carcinogenesis of H.pylori infection.We herein review the previous pertinent literature and summarize the characteristics of gastric stump carcinoma reported to date. | Shinsuke Takeno Tatsuya Hashimoto Kenji Maki Ryosuke Shibata Hironari Shiwaku Ippei Yamana Risako Yamashita Yuichi Yamashita | 2014 | World Journal of Gastroenterology2014，20，38： | 13 |
| 2 | 多重稳固的胰腺的 hamartomas : 一份案例报告和文学的评论显示文摘 Non-neoplastic tumor-like lesions in the pancreas are uncommon.Here,we present a case of multiple solid pancreatic hamartomas in a 78-year-old Japanese woman.Her computed tomography revealed a pancreatic mass,measuring 1.8 cm in maximum diameter.However,no symptoms were found.She was not an alcoholic and had no history of pancreatitis.The patient underwent a pancreatoduodenectomy,and three well-demarcated solid nodules measuring 1.7 cm,0.4 cm,and 0.3 cm in diameter were found in the pancreatic head.Microscopically,the lesions were composed of non-neoplastic,disarranged acinar cells and ducts embedded in a sclerotic stroma with elongated spindle cells that lacked discrete islets.The stromal spindle cells were immunoreactive for CD34 and CD117.The histological diagnosis was multiple solid hamartomas of the pancreas.There has been no recurrence 30 mo after surgery.So far,18 cases of pancreatic hamartoma have been reported in the English literature,including our case.Six out of these 18 cases seemed to fit the criteria of solid pancreatic hamartoma.Although the number of cases was limited,solid pancreatic hamartomas seem to be benign tumor-like lesions,which are found incidentally in healthy middle-aged adults,but occasionally involve the whole pancreas,resulting in a poor prognosis.Solid pancreatic hamartoma was sometimes associated with minor pancreatic abnormality,and multiple small lesions other than the main tumors were detected in a small number of cases.From these findings,one may speculate that solid pancreatic hamartoma could be the result of a malformation during the development of the pancreas. | Fumi Kawakami Michio Shimizu Hiroshi Yamaguchi Shigeo Hara Ippei Matsumoto Yonson Ku Tomoo Itoh | 2012 | World Journal of Gastrointestinal Oncology2012，4，9： | 5 |
| 3 | Osteocalcin as a hormone regulating glucose metabolism显示文摘The number of patients with osteoporosis and diabetes is rapidly increasing all over the world. Bone is recently recognized as an endocrine organ. Accumulating evidence has shown that osteocalcin, which is specifically expressed in osteoblasts and secreted into the circulation, regulates glucose homeostasis by stimulating insulin expression in pancreas and adiponectin expression in adipocytes, resulting in improving glucose intolerance. On the other hand, insulin and adiponectin stimulate osteocalcin expression in osteoblasts, suggesting that positive feedforward loops exist among bone, pancreas, and adipose tissue. In addition, recent studies have shown that osteocalcin enhances insulin sensitivity and the differentiation in muscle, while secreted factors from muscle, myokines, regulate bone metabolism. These findings suggest that bone metabolism and glucose metabolism are associated with each other through the action of osteocalcin. In this review, I describe the role of osteocalcin in the interaction among bone, pancreas, brain, adipose tissue, and muscle. | Ippei Kanazawa | 2015 | World Journal of Diabetes2015，6，18： | 5 |
| 4 | Hemorrhagic shock due to submucosal esophageal hematoma along with mallory-weiss syndrome:A case report显示文摘BACKGROUND Esophageal submucosal hematoma is a rare condition.Although the exact etiology remains uncertain,vessel fragility with external factors is believed to have led to submucosal bleeding and hematoma formation;the vessel was ruptured by a sudden increase in pressure due to nausea,and the hematoma was enlarged by antiplatelet or anticoagulant therapy.Serious conditions are rare,with a better prognosis.We present the first known case of submucosal esophageal hematoma-subsequent hemorrhagic shock due to Mallory-Weiss syndrome.CASE SUMMARY A 73-year-old female underwent endovascular treatment for an unruptured cerebral aneurysm.The patient received aspirin and clopidogrel before surgery and heparin during surgery,and was well during the surgery.Several hours after returning to the ICU,she complained of chest discomfort,vomited 500 m L of fresh blood,and entered hemorrhagic shock.Esophageal submucosal hematoma with Mallory-Weiss syndrome was diagnosed through an endoscopic examination and computed tomography.In addition to a massive fluid and erythrocyte transfusion,we performed a temporary compression for hemostasis with a Sengstaken-Blakemore(S-B)tube.Afterwards,she became hemodynamically stable.On postoperative day 1,we performed an upper gastrointestinal endoscopy and confirmed no expansion of the hematoma nor any recurring bleeding;therefore,we removed the S-B tube and clipped the gastric mucosal laceration at the esophagogastric junction.We started oral intake on postoperative day 10.The patient made steady progress,and was discharged on postoperative day 33.CONCLUSION We present the first known case of submucosal esophageal hematoma subsequent hemorrhagic shock due to Mallory-Weiss syndrome. | Jiro Oba Daisuke Usuda Shiho Tsuge Riki Sakurai Kenji Kawai Shun Matsubara Risa Tanaka Makoto Suzuki Hayabusa Takano Shintaro Shimozawa Yuta Hotchi Kenki Usami Shungo Tokunaga Ippei Osugi Risa Katou Sakurako Ito Kentaro Mishima Akihiko Kondo Keiko Mizuno Hiroki Takami Takayuki Komatsu Tomohisa Nomura Manabu Sugita | 2022 | World Journal of Clinical Cases2022，10，27： | 3 |
| 5 | Wind-Tunnel Investigation of the Aerodynamic Performance of Surface-Modification Cables显示文摘学界对包括风雨激振(RWIV)和干索驰振(DG)在内的斜拉桥拉索的风致振动等的研究已经有相当长的时间。一般来说,我们会应用机械阻尼器或表面处理来抑制振动。特别是已开发出几种表面处理拉索,包括压痕、纵向平行突起、螺旋角和U形开槽。最近又开发了一种带螺旋突起的新型空气动力学稳定拉索,这种拉索已被证明具有与锯齿状拉索相似的低阻力系数,并且可以防止拉索表面形成水线。在本研究中,应用风洞实验对这种拉索在各种来流角度和突起尺寸下的RWIV稳定性进行了研究。发现对于所有测试风角,螺旋突起拉索对于RWIV和DG在空气动力学基础上都能保持稳定,突起尺寸的影响也得到了确认。 | Hiroshi Katsuchi Hitoshi Yamada Ippei Sakaki Eiichi Okado | 2017 | Engineering2017，3，6： | 2 |
| 6 | Study of Unsteady Flow Simulation of Backward Impeller with Non-uniform Casing显示文摘The flow characteristics of the centrifugal fans with different blade outlet angles are basically discussed on steady and unsteady simulations for a rectangular casing fan. The blade outlet angles of the impellers are 35° and 25° respectively. The unsteady flow behavior in the passage of the impeller 35° is quite different from that in the steady flow behavior. The large flow separation occurs in the steady flow field and unsteady flow field of the impeller 35°, the flow distribution in the circumferential direction varies remarkably and the flow separation on the blade occurs only at the back region of the fan; but the steady flow behavior in the impeller 25° is almost consistent with the unsteady flow behavior, the flow distribution of the circumferential direction doesn't vary much and the flow separation on the blade hardly occurs. When the circumferential variation of the flow in the impeller is large, the steady flow simulation is not coincident to the unsteady flow simulation. | War War Min Swe Hiroya MORIMATSU Hidechito HAYASHI Tetsuya OKUMURA Ippei ODA | 2017 | Journal of Thermal Science2017，26，3： | 2 |
| 7 | Angiotensin receptor blocker neprilysin inhibitors显示文摘Heart failure(HF)is a clinical syndrome that results from a structural or functional cardiac disorder that reduces the ability of the ventricle of the heart to fill with,or eject,blood.It is a multifaceted clinical condition that affects up to 2%of the population in the developed world,and is linked to significant morbidity and mortality;it is therefore considered a major concern for public health.Regarding the mechanism of HF,three neurohumoral factors-the reninangiotensin-aldosterone system,the sympathetic nervous system,and natriuretic peptides—are related to the pathology of chronic HF(CHF),and the targets of treatment.Angiotensin receptor blocker and neprilysin inhibitor(angiotensinreceptor neprilysin inhibitor),namely sacubitril/valsartan(SAC/VAL),has been introduced as a treatment for CHF.SAC/VAL is an efficacious,safe,and costeffective therapy that improves quality of life and longevity in patients with HF with reduced ejection fraction(HFrEF),and reduces hospital admissions.An inhospital initiation strategy offers a potential new avenue to improve the clinical uptake of SAC/VAL.In the last five years,SAC/VAL has been established as a cornerstone component of comprehensive disease-modifying medical therapy in the management of chronic HFrEF.On the other hand,further work,with carefully designed and controlled preclinical studies,is necessary for understanding the molecular mechanisms,effects,and confirmation of issues such as long-term safety in both human and animal models. | Daisuke Usuda Toshihiro Higashikawa Yuta Hotchi Kenki Usami Shintaro Shimozawa Shungo Tokunaga Ippei Osugi Risa Katou Sakurako Ito Toshihiko Yoshizawa Suguru Asako Kentaro Mishima Akihiko Kondo Keiko Mizuno Hiroki Takami Takayuki Komatsu Jiro Oba Tomohisa Nomura Manabu Sugita | 2021 | World Journal of Cardiology2021，13，8： | 2 |
| 8 | Clinical characteristics of 12 cases of appendiceal diverticulitis: a comparison with 378 cases of acute appendicitis显示文摘 | Ippei Yamana Shunji Kawamoto Kazuo Inada Shuji Nagao Takahisa Yoshida Yuichi Yamashita | 2012 | Surgery Today2012，，4： | 2 |
| 9 | Presenilin-2 in the cynomolgus monkey brain: investigation of age-related changes显示文摘 | Nobuyuki Kimura Shin’ ichiro Nakamura Fumiko Ono Ippei Sakakibara Yoshiyuki Ishii Shigeru Kyuwa Yasuhiro Yoshikawa | 2004 | Primates2004，，3： | 1 |
| 10 | Enhanced thermal stability of poly(lactide)s in the melt by enantiomeric polymer blending显示文摘 | Hideto Tsuji Ippei Fukui | 2003 | Polymer2003，，10： | 1 |
| 11 | Effect of curing temperature and type of cement on early-age shrinkage of high-performance concrete显示文摘 | Pietro L Klaas van B Ippei M | 2001 | Cement and Concrete Research2001，31，12： | 1 |
| 12 | Resection of gallbladder cancer with hepatic metastasis after chemotherapy with gemcitabine显示文摘 | Haruki Morimoto Tetsuo Ajiki Shiro Takase Tsunenori Fujita Taku Matsumoto Yoshiyasu Mita Ippei Matsumoto Yasuhiro Fujino Yasuyuki Suzuki Yoshikazu Kuroda Yonson Ku | 2008 | Journal of Hepato-Biliary-Pancreatic Surgery2008，，6： | 1 |
| 13 | Effects of treatment with risedr- )hate and alfacalcidol on progression of atherosclerosis in postm- ~nopausal women with type 2 diabetes mellitus accompanied with ~steoporosis显示文摘 | Ippei K Toru Y Kumi H | 2010 | Am J Med Sci2010，339，6： | 1 |
| 14 | Visualization of sphingolipids and phospholipids in the fundic gland mucosa of human stomach using imaging mass spectrometry显示文摘AIM:To analyze the lipid distribution in gastric mucosae.METHODS:Imaging mass spectrometry(MS)is a useful tool to survey the distribution of biomolecules in surgical specimens.Here we used the imaging MS apparatus named i MScope to identify the dominant molecules present in the human gastric mucosa near the fundic glands.Five gastric specimens were subjected to iM Scope analysis.These specimens were also analyzed by immunohistochemistry using MUC5 AC,H(+)-K(+)-ATPaseβ Claudin18 antibodies.RESULTS:Three major molecules with m/z 725.5,780.5,and 782.5 detected in the gastric mucosa were identified as sphingomyelin(SM)(d18:1/16:0),phosphatidylcholine(PC)(16:0/18:2),and PC(16:0/18:1),respectively,through MS/MS analyses.Using immunohistological staining,SM(d18:1/16:0)signals were mainly colocalized with the foveolar epithelium marker MUC5 AC.In contrast,PC(16:0/18:2)signals were observed in the region testing positive for the fundic gland marker H(+)-K(+)-ATPaseβ.PC(16:0/18:1)signals were uniformly distributed throughout the mucosa.CONCLUSION:Our basic data will contribute to the studies of lipid species in physical and pathological conditions of the human stomach. | Nobuya Kurabe Hisaki Igarashi Ippei Ohnishi Shogo Tajima Yusuke Inoue Yoshihiko Takahashi Mitsutoshi Setou Haruhiko Sugimura | 2016 | World Journal of Gastrointestinal Pathophysiology2016，7，2： | 1 |
| 15 | Effect curing temperature and type of cement on early-age shrinkage of high-performance concrete显示文摘 | Pietro Lura Klass van Breugel Ippei Maruyama | 2001 | Cement and concrete research2001，31，： | 1 |
| 16 | Proposed new score predicting malignancy of intraductal papillary mucinous neoplasms of the pancreas显示文摘 | Yasuhiro F Ippei M Takashi U | 2007 | Am J Surg2007，194，： | 1 |
| 17 | Synthesis and mechanical properties of carbon nanotube/diamond-like carbon composite films 显示文摘 | KINOSHITA H IPPEI I SAKAI H OHMAE N | 2007 | Diamond and Related Materials2007，16，： | 1 |
| 18 | Influence of electric field on the behavior of Si nanoparticles generated by laser ablation显示文摘 | Junichi M Ippei S Yoshiki N | 1999 | AppliedPhysics Letters1999，75，6： | 1 |
| 19 | Time course analy-sis of gene regulation under cadmium stress in rice显示文摘 | Ippei Ogawa Hiromi Nakanishi Satoshi Mori | 2009 | Plant Soil2009，325，： | 1 |
| 20 | Isoleucine,a potent plasma glucose-lowering amino acid,stimulates glucose uptake in C2C12 myotubes显示文摘 | Masako Doi Ippei Yamaoka | 2003 | Biochemical and Biophysical Research Communications2003，312，： | 1 |
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