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| 1 | Long-term follow-up of distal intestinal obstruction syndrome in cystic fibrosis显示文摘AIM: To investigate the long-term follow-up of distal intestinal obstruction syndrome(DIOS) in Israeli cystic fibrosis(CF) patients.METHODS: This is a multi-center,comparative,retrospective study in which we reviewed the medical records of all CF patients from three major CF centers in Israel who were treated in the period from 1980 to 2012.Patients diagnosed with DIOS were defined as the study group.The patients were diagnosed with DIOS based on their clinical presentation and typical findings on either abdominal X-ray or computerized tomography scan.For the control group,CF patients with no DIOS were matched to the patients in the study group for age,sex,and cystic fibrosis transmembrane conductance regulator(CFTR) mutations.For both groups,the collected data included age,sex,CFTR genotype,weight,height,and body mass index.Clinical data included respiratory function tests in the last five years prior to the study,respiratory function test immediately before and after the DIOS event,number of hospitalizations,sputum culture results,and CFrelated conditions diagnosed according to the CF clinical practice guidelines.In the study group,data on the DIOS treatment and tendency for DIOS recurrence were also analyzed.RESULTS: The medical charts for a total of 350 CF patients were reviewed.Of the 350 CF patients,26(7.4%) were diagnosed with DIOS.The control group included 31 CF patients with no DIOS diagnosis.The mean follow-up period was 21.6 ± 8.2 years.The total of DIOS episodes in the follow-up period was 60.The distribution of DIOS episodes was as follows: 6/26(23.1%) study patients had one episode of DIOS intheir lifetime,7/26(26.9%) had two episodes,7/26(26.9%) had three episodes,and 6/26(23.1%) had four or more episodes.Compared to the control group,DIOS patients had a significantly higher incidence of meconium ileus in the past(65.4% vs 0%,respectively,P < 0.02),more Aspergillus spp.colonization(34.6% vs 3.2%,respectively,P < 0.02),and a higher number of hospitalizations due to respiratory exacerbations(8.6 vs 6.2 mean total hospitalizations per follow-up period,respectively,P < 0.02).No other significant differences were found between the control and study groups.The conservative treatment of DIOS,which mainly includes hydration and stool softeners,was successful in 82% of the episodes.The survival rate was similar for both groups.CONCLUSION: CF patients with DIOS suffer from recurrent hospitalizations and airway pathogen acquisition.Although recurrence of DIOS is common,conservative treatment is successful in most patients. | Moran Lavie Tzipora Manovitz Daphna Vilozni Sarina Levy-Mendelovich Ifat Sarouk Ilana Weintraubv David Shoseyov Malena Cohen-Cymberknoh Joseph Rivlin Ori Efrati | 2015 | World Journal of Gastroenterology2015，21，1： | 10 |
| 2 | Constitutive expression of feedback-insensitive cystathionine γ-synthase increases methionine levels in soybean leaves and seeds显示文摘Soybean(Glycine max(L.) Merr.) is a major crop that provides plant-origin protein and oil for humans and livestock.Although the soybean vegetative tissues and seeds provide a major source of high-quality protein,they suffer from low concentration of an essential sulfur-containing amino acid,methionine,which significantly limits their nutritional quality.The level of methionine is mainly controlled by the first unique enzyme of methionine synthesis,cystathione γ-synthase(CGS).Aiming to elevate methionine level in vegetative tissues and seeds,we constitutively over-expressed a feedback-insensitive Arabidopsis CGS(At D-CGS) in soybean cultivars,Zigongdongdou(ZD) and Jilinxiaoli 1(JX).The levels of soluble methionine increased remarkably in leaves of transgenic soybeans compared to wild-type plants(6.6-and 7.3-fold in two transgenic ZD lines,and 3.7-fold in one transgenic JX line).Furthermore,the total methionine contents were significantly increased in seeds of the transgenic ZD lines(1.5-to 4.8-fold increase) and the transgenic JX lines(1.3-to 2.3-fold increase) than in the wild type.The protein contents of the transgenic soybean seeds were significantly elevated compared to the wild type,suggesting that the scarcity of methionine in soybeans may limit protein accumulation in soybean seeds.The increased protein content did not alter the profile of major storage proteins in the seeds.Generally,this study provides a promising strategy to increase the levels of methionine and protein in soybean through the breeding programs. | YU Yang HOU Wen-sheng Yael Hacham SUN Shi WU Cun-xiang Ifat Matityahu SONG Shi-kui Rachel Amir HAN Tian-fu | 2018 | Journal of Integrative Agriculture2018，17，1： | 4 |
| 3 | Isolation, identification and quantitation of hydroxycirmamic acid conjugates, potential platform chemicals, in the leaves and stems of Miscanthus giganteus using LC-ESI-MSn显示文摘 | Ifat P Michael DT Barbara H | 2011 | Phytochemistry2011，72，18： | 1 |
| 4 | The incremental impact of residual SYNTAX score on long - term clin- ical outcomes in patients with multivessel coronary artery disease treated by percutaneous coronary interventions显示文摘 | Guy Witberg MD Ifat Lavi PhD Abid Assali MD | 2015 | Catheterization and Cardiovascular Interventions2015，86，1： | 1 |
| 5 | Overlapping decompositions and expansions of Petri nets显示文摘 | Aybar A Ifat A | 2002 | IEEE Transactions on Automatic Control2002，47，3： | 1 |
| 6 | Feeding jejunostomy: Does the benefit overweight the risk (a retrospective study from a single centre)显示文摘 | Mohd Lateef Wani Abdul Gani Ahangar Gh Nabi Lone Shyam Singh Ab Majeed Dar Mohd Akbar Bhat Reyaz Ahmad Lone Ifat Irshad | 2010 | International Journal of Surgery2010，，5： | 1 |
| 7 | Transplantation of human bone marrow mesenchymal stem cells as a thin subretinal layer ameliorates retinal degeneration in a rat model of retinal dystrophy显示文摘 | Adi Tzameret Ifat Sher Michael Belkin Avraham J. Treves Amilia Meir Arnon Nagler Hani Levkovitch-Verbin Iris Barshack Mordechai Rosner Ygal Rotenstreich | 2014 | Experimental Eye Research2014，，： | 1 |
| 8 | Soluble methionine enhances accumulation of a 15 kDa zein, a methionine- rich storage protein, in transgenic alfalfa but not in transgenic tobacco plants 显示文摘 | Amira G Ifat M Tal A Hana B Shmuel Rachel A | 2005 | Journal of Experimental Botany2005，56，419： | 1 |
| 9 | Modeling of drug release from erodible tablets 显示文摘 | Ifat K Amnom H Assaf G | 1997 | J Pharm Sci1997，86，1： | 1 |
| 10 | Soluhle methionine enhances aeeunaulation of a 15 ku zein, a methionine-rieh storage protein, in transgenieealfalfa but not in transgenie tobacco plants 显示文摘 | Golan Amira btatityahu Ifat Avraham Tal | 2005 | Journal of Experimental Botany2005，56，419： | 1 |
| 11 | In Situ TEM Measurements of the Mechanical Properties and Behavior of WS_(2)Nanotubes显示文摘The mechanical properties of individual WS2 nanotubes were investigated and directly related to their atomic structure details by in situ transmission electron microscope measurements.A brittle mode deformation was observed in bending tests of short(ca.1μm in length)multilayer nanotubes.This mode can be related to the atomic structure of their shells.In addition,longer nanotubes(67μm in length)were deformed in situ scanning electron microscope,but no plastic deformation was detected.A“sword-in-sheath”fracture mechanism was revealed in tensile loading of a nanotube,and the sliding of inner shells inside the outermost shell was imaged“on-line”.Furthermore,bending modulus of 217 GPa was obtained from measurements of the electric-fi eld-induced resonance of these nanotubes. | Ming Sheng Wang Ifat Kaplan-Ashiri Xian Long Wei Rita Rosentsveig Hanoch Daniel Wagner Reshef Tenne Lian Mao Peng | 2008 | Nano Research2008，1，1： | 1 |
| 12 | Maxillary sinus augmentation in the presence of antral pseudocyst: a clinical approach显示文摘 | Ofer Mardinger Ifat Manor Eitan Mijiritsky Abraham Hirshberg | 2007 | Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology2007，，2： | 1 |
| 13 | Soluble methionine enhanced the accumulation of 15 kDa zein, a methionine rich storage protein, in BY2 cells and in alfalfa transgenic plants but not in transgenic tobacco plants显示文摘 | Amira G Ifat M Tal A | 2005 | Journal of Experimental Botany2005，56，419： | 1 |
| 14 | Dosoretz Influence of seasonal and op- erating conditions on the rejection of pharmaceutical ac- tive compounds by RO and NF membranes显示文摘 | Shirra Gurreznik Ifat Korenmenashe Lilly Heller- grossman | 2011 | Desalina- tion2011，277，： | 1 |
| 15 | The efficacy and safety of argon plasma coagulation therapy in Barrett’s esophagus显示文摘 | Andrew J. Grade Ifat A. Shah Susan M. Medlin Francisco C. Ramirez | 1999 | Gastrointestinal Endoscopy1999，，1： | 1 |
| 16 | Malignant mesothelioma presenting as colonic tumor显示文摘 | Ifat A. Shah Amporn Somsin Sheila X. Wong Osama S. Gani | 1998 | Human Pathology1998，，： | 1 |
| 17 | Intersubject synchronization of cortical activity during natural vision 显示文摘 | Hasson U Nir Y Levy Ifat | 2004 | Science2004，303，： | 1 |
| 18 | Soluble methionine enhanced the accumulation of 15 ku zein, a methionine rich storage protein, in BY2 cells and in alfalfa transgenic plants but not in transgenic tobacco plants显示文摘 | Amira G Ifat M Tal M | 2005 | J Exp Bot2005，56，419： | 1 |
| 19 | Changes in chemical constituents during the maturation and ripening of two commercially important pomegranate accessions显示文摘 | Elinor Shwartz Ira Glazer Irit Bar-Ya’akov Ifat Matityahu Igal Bar-Ilan Doron Holland Rachel Amir | 2009 | Food Chemistry2009，，3： | 1 |
| 20 | Soluble methionine enhances accumulation of a15kDa zein,a methionine-rich storage pro-tein,in transgenic alfalfa but not in transgenic tobacco plants显示文摘 | Amira G Ifat M Tal A | 2005 | Journal of Experimental Botany2005，419，： | 1 |
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