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| 1 | Successful outcome after combined chemotherapeutic and surgical management in a case of esophageal cancer with breast and brain relapse显示文摘Esophageal cancer (EC) is a highly lethal disease. Approximately 50% of patients present with metastatic EC and most patients with localized EC will have local recurrence or develop metastases, despite potentially curative local therapy. The most common sites of distant recurrence are represented by lung, liver and bone while brain and breast metastases are rare. Usually patients with advanced disease are not treated aggressively and their median survival is six months. We report a woman patient who developed breast and brain metastases after curative surgery. We treated her with a highly aggressive chemotherapeutic and surgical combination resulting in a complete remission of the disease even after 11-year follow-up. We think that in super selected patients with more than one metastasis, when functional status is good and metastases are technically resectable, a surgical excision may be considered as a salvage option and chemotherapy should be delivered to allow a systemic control. | Davide Adriano Santeufemia Gianfranca Piredda Giovanni Maria Fadda Paolo Cossu Rocca Salvatore Costantino Giovanni Sanna Maria Giuseppa Sarobba Maria Antonietta Pinna Carlo Putzu Antonio Farris | 2006 | World Journal of Gastroenterology2006，12，34： | 4 |
| 2 | Updates in the pathogenesis, diagnosis and management of ectopic varices显示文摘 | Ahmed Helmy Khalid Al Kahtani Mohamed Al Fadda | 2008 | Hepatology International2008，，3： | 3 |
| 3 | Biofilm Demolition and Antibiotic Treatment to Eradicate Resistant Helicobacter pylori : A Clinical Trial显示文摘 | Giovanni Cammarota Giovanna Branca Fausta Ardito Maurizio Sanguinetti Gianluca Ianiro Rossella Cianci Riccardo Torelli Giovanna Masala Antonio Gasbarrini Giovanni Fadda Raffaele Landolfi Giovanni Gasbarrini | 2010 | Clinical Gastroenterology and Hepatology2010，，9： | 3 |
| 4 | Brain activity of anandamide:a rewarding bliss?显示文摘Anandamide is a lipid mediator that acts as an endogenous ligand of CB1 receptors.These receptors are also the primary molecular target responsible for the pharmacological effects of Δ9-tetrahydrocannabinol,the psychoactive ingredient in Cannabis sativa.Several studies demonstrate that anandamide exerts an overall modulatory effect on the brain reward circuitry.Several reports suggest its involvement in the addiction-producing actions of other abused drugs,and it can also act as a behavioral reinforcer in animal models of drug abuse.Importantly,all these effects of anandamide appear to be potentiated by pharmacological inhibition of its metabolic degradation.Enhanced brain levels of anandamide after treatment with inhibitors of fatty acid amide hydrolase,the main enzyme responsible for its degradation,seem to affect the rewarding and reinforcing actions of many drugs of abuse.In this review,we will provide an overview from a preclinical perspective of the current state of knowledge regarding the behavioral pharmacology of anandamide,with a particular emphasis on its motivational/reinforcing properties.We will also discuss how modulation of anandamide levels through inhibition of enzymatic metabolic pathways could provide a basis for developing new pharmaco-therapeutic tools for the treatment of substance use disorders. | Maria Scherma Paolo Masia Valentina Satta Walter Fratta Paola Fadda Gianluigi Tanda | 2019 | Acta Pharmacologica Sinica2019，40，3： | 2 |
| 5 | Uterine tumors resembling ovarian sex cord tumors: a case report of conservative management in young women显示文摘 | Berretta R Patrelli TS Fadda GM | 2009 | Int J Gyneeol Cancer2009，19，4： | 1 |
| 6 | Increased OPG expression and impaired OPG/TRAIL ratio in the aorta of diabetic rats显示文摘 | Vaccarezza M Bortul R Fadda R | 2007 | Med Chem2007，3，4： | 1 |
| 7 | Polycyclic aromatic hydr-ocarbons and cancer in man显示文摘 | Mastrangelo G Fadda E Marzia V | 1996 | Environ Health Perspect1996，104，11： | 1 |
| 8 | Histological classification of lung cancer 显示文摘 | Maggiore C Mule A Fadda G | 2004 | Rays2004，29，4： | 1 |
| 9 | Hydrolysis of porkmuscle sarcoplasmic protoins by Lactobacillus curvaJus andLactobacillus sakei 显示文摘 | Fadda S Sanz Y Vignolo G | 1999 | Applied and Environmental Mi-crobiology1999，65，2： | 1 |
| 10 | Liquid-based cytology in fine-needle aspiration biopsies of the thyroid gland 显示文摘 | Fadda G Rossi ED | 2011 | Acta Cytol2011，55，5： | 1 |
| 11 | Long-term reduction of brain-derived neurotrophic factor levels and signaling impairment following prenatal treatment with the cannabinoid receptor 1 receptor agonist WIN 55-212-2显示文摘 | Maj PF Collu M Fadda P | 2007 | Eur J Neurosci2007，25，11： | 1 |
| 12 | Epidemiologic evidence of cancer risk in textile industry workers: a review and update显示文摘 | G Mastrangelo U Fedeli E Fadda | 2002 | Toxicology and industrial health2002，18，4： | 1 |
| 13 | Curcumin and curcumin-like molecules: from spice to drugs 显示文摘 | Marchiani A Rozzo C Fadda A | 2014 | Curr Med Chem2014，21，2： | 1 |
| 14 | MicroRNA profiling reveals that miR -21, miR486 and miR-214 are upregulated and involved in cell survival in Sezary syndrome 显示文摘 | Narducci M G Arcelli D Picchio M C Lazzeri C Pagani E Sampogna F Scala E Fadda P Cristofoletti C Facchiano A Frontani M Monopoli A Ferracin M Negrini M Lombardo G A Caprini E Russo G | 2011 | Cell Death Disease2011，2，4： | 1 |
| 15 | Innovative traditional italian durum wheat breads: influence of yeast and gluten on performance of sourdough moddizzosu breads 显示文摘 | Fadda Costantino Mafia Santos Eva Piga Antonio | 2010 | Cereal Chemistry2010，87，3： | 1 |
| 16 | Prevention of venous thromboembolism after major orthopedic surgery:indirect comparison of three new oral anticoagulants显示文摘 | Maratea D Fadda V Trippoli S | | 0，，： | 1 |
| 17 | Antimicrobial resistance among non-fermentative gram-negative bacilli isolated from therespiratory tracts of Italian inpatients:a 3-year surveillance study by the Italian Epidemiological Survey显示文摘 | Fadda G Spanu T Ardito F | 2004 | Int J Antimicrob Agents2004，23，3： | 1 |
| 18 | Anionic liposomes for small interfering ribonucleic acid (siRNA) delivery to primary neuronal cells: Evaluation of alpha-synuclein knockdown efficacy显示文摘Alpha-synuclein (在 Lewy 身体(磅) 的 -syn) 免职是 Parkinsons 疾病(PD ) 的主要 neuropathological 特点之一。磅累积被认为 PD 的一个原因的因素,它建议针对减少 -syn 层次的策略能为它的处理是相关的。在现在的学习,我们开发了对明确地被设计由 RNA 干扰减少 neuronal -syn 的小介入核糖核酸酸(siRNA ) 的全身的交货合适的新奇 nanocarriers。当一个指向的代理人被准备,与为 -syn 基因 silencing 复杂、与狂犬病病毒 glycoprotein (RVG ) 装饰的 siRNA 鱼精朊装载的 Anionic liposomes 导出肽。nanoparticles 为他们装载,保护,并且交付到老鼠的功能的 siRNA 的能力被描绘象他们的效率到一样的主要海马趾、外皮的神经原在这些房间导致基因 silencing。而且, nanocarriers 在浆液为他们的稳定性被评估。装饰 RVG 的 liposomes 在 vivo 应用程序为未来显示了合适的特征并且没有改变房间生存能力,成功地在主要神经原导致了 -syn 基因 silencing。一起,我们的结果显示装饰 RVG 的 liposomes 可以是为针对完成的进一步的研究的一个理想的工具在在 PD 的老鼠模型的 vivo -syn 基因 silencing 有效。 | Michele Schlich Francesca Longhena Gaia Faustini Caitriona M. O'Driscoll Chiara Sinico Anna Maria Fadda Arianna Bellucci Francesco Lai | 2017 | Nano Research2017，10，10： | 1 |
| 19 | Le Fort m advancement with and without ostcogenesis distraction显示文摘 | Iannetti G Fadda T Agrillo A | 2006 | J CraniofacSurg2006，17，： | 1 |
| 20 | Updates in the pathogenesis, diagnosis and management of ectopic varices显示文摘 | Ahmed Helmy Khalid Al Kahtani Mohamed Al Fadda | 2008 | Hepatology International2008，，3： | 1 |
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