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| 1 | 脑缺血后N-myc下游调控基因2保护血脑屏障完整性显示文摘脑缺血后血脑屏障(BBB)的破坏与外周细胞向脑内浸润、病孔损形成与进展、以及临床病程恶化密切相关。目前BBB完整性的调控机制,尤其是在永久性缺血后的调控机制尚未明确。本研究使用小鼠永久性脑缺血模型进行相关研究,结果显示,星形胶质细胞N-myc下游调控基因2(NDRG2)可能是缺血性脑卒中后BBB通透性的调控分子,该分子与分化和应激相关。免疫组化显示,在永久性大脑中动脉闭塞(MCAO)后,NDRG2在星形胶质细胞中的表达显著增加。敲除NDRG2基因,脑梗死体积增加,免疫细胞在缺血同侧大脑半球积聚增加。MCAO后,NDRG2基因敲除小鼠缺血侧皮质的缺血灶内及灶周血管周围区域内的血清蛋白(包括纤维蛋白原和免疫球蛋白)的外渗增强此之,MCAO后NDRG2基因敲除小鼠体内基质金属蛋白酶(MMPs)的表达也显著增加。在细胞培养中,NDRG2-/-星形胶质细胞中MMP-3的表达和分泌增加,这种增加可被腺病毒介导的NDRG2再表达所逆转。综上所述,脑缺血后,星形胶质细胞内的NDRG2可能通过调节MMP的表达,而在BBB通透性的调节和免疫细胞浸润中起到重要作用。 | Takarada-Iemata M Yoshikawa A Ta HM Okitani N Nishiuchi T Aida Y Kamide T Hattori T Ishii H Tamatani T Le TM Roboon J Kitao Y Matsuyama T Nakada M Hori O 聂昊 | 2018 | 神经损伤与功能重建2018，13，4： | 4 |
| 2 | Randomized phase II study of gemcitabine and S-1 combination versus gemcitabine alone in the treatment of unresectable advanced pancreatic cancer (Japan Clinical Cancer Research Organization PC-01 study)显示文摘 | Masato Ozaka Yuji Matsumura Hiroshi Ishii Yasushi Omuro Takao Itoi Hisatsugu Mouri Keiji Hanada Yasutoshi Kimura Iruru Maetani Yoshinobu Okabe Masaji Tani Takaaki Ikeda Susumu Hijioka Ryouhei Watanabe Shinya Ohoka Yuki Hirose Masafumi Suyama Naoto Egawa A | 2012 | Cancer Chemotherapy and Pharmacology2012，，5： | 3 |
| 3 | A 10-miRNA risk score-based prediction model for pathological complete response to neoadjuvant chemotherapy in hormone receptor-positive breast cancer显示文摘Patients with hormone receptor(HR)-positive tumors breast cancer usually experience a relatively low pathological complete response(p CR)to neoadjuvant chemotherapy(NAC).Here,we derived a 10-micro RNA risk score(10-mi RNA RS)-based model with better performance in the prediction of p CR and validated its relation with the disease-free survival(DFS)in 755 HRpositive breast cancer patients(273,265,and 217 in the training,internal,and external validation sets,respectively).This model,presented as a nomogram,included four parameters:the 10-mi RNA RS found in our previous study,progesterone receptor(PR),human epidermal growth factor receptor 2(HER2)status,and volume transfer constant(K).Favorable calibration and discrimination of 10-mi RNA RS-based model with areas under the curve(AUC)of 0.865,0.811,and 0.804 were shown in the training,internal,and external validation sets,respectively.Patients who have higher nomogram score(>92.2)with NAC treatment would have longer DFS(hazard ratio=0.57;95%CI:0.39–0.83;P=0.004).In summary,our data showed the 10-mi RNA RS-based model could precisely identify more patients who can attain p CR to NAC,which may help clinicians formulate the personalized initial treatment strategy and consequently achieves better clinical prognosis for patients with HRpositive breast cancer. | Chang Gong Ziliang Cheng Yaping Yang Jun Shen Yingying Zhu Li Ling Wanyi Lin Zhigang Yu Zhihua Li Weige Tan Chushan Zheng Wenbo Zheng Jiajie Zhong Xiang Zhang Yunjie Zeng Qiang Liu RStephanie Huang Andrzej LKomorowski Eddy SYang François Bertucci Francesco Ricci Armando Orlandi Gianluca Franceschini Kazuaki Takabe Suzanne Klimberg Naohiro Ishii Angela Toss Mona PTan Mathew A Cherian Erwei Song | 2022 | Science China(Life Sciences)2022，65，11： | 3 |
| 4 | 卒中介入治疗培训指南:国际多学会共识文件显示文摘1背景
缺血性卒中是全球人口死亡和残疾的首要原因。很多急性大血管闭塞(emergent large vesselocclusion,ELVO)患者都会遗留长期残疾。事实上,这些颅内大动脉闭塞经常会导致大面积脑损伤,进而造成患者死亡或严重致残。 | Lavine SD Cockroft K Hoh B Bambakidis N Khalessi AA Woo H Riina H Siddiqui A Hirsch JA Chong W Rice H Wenderoth J Mitchell P Coulthard A Signh TJ Phatorous C Khangure M Klurfan P ter Brugge K Iancu D Gunnarsson T Pongpech S Rodesch G Soderman M Taylor A Krings T Orbach D Picard L Suh DC Zheng HQ Jansen O Muto M Szikora I Pierot L Brouwer P Gralla J Renowden S Andersson T Fiehler J Turjman F White P Januel AC Spelle L Kulcsar Z Chapot R Biondi A Dima S Taschner C Szajner M Krajina A Sakai N Matsumaru Y Yoshknura S Ezura M Fujinaka T Iihara K Ishii A Higashi T Hirohata M Hyodo A Ito Y Kawanishi M Kiyosue H Kobayashi E Kobayashi S Kuwayama N Matsumoto Y Miyachi S Murayama Y Nagata I Nakahara I Nemoto S Niimi Y Oishi H Satomi J Satow T Sugiu K Tanaka M Terada T Yamagami H Diaz O Lylyk P Jayaraman MV Patsalides A Gandhi CD Lee SK Abruzzo T Albani B Ansari SA Arthur AS Baxter BW Bulsara KR Chen M Almandoz JE Fraser JF Heck DV Hetts SW Hussain MS Klucznik RP Leslie-Mawzi TM Mack WJ McTaggart RA Meyers PM Mocco J Prestigiacomo CA Pride GL Rasmussen PA Starke RM Sunenshine PJ Tarr RW Frei DF Pabo M Nogueira RG Zaidat OO Jovin T Linfante I Yavagal D Liebeskind D Novakovic R Pongpech S 许岩 孙瑞 郭芮兵 | 2017 | 国际脑血管病杂志2017，25，5： | 2 |
| 5 | Rhamnogalacturonan II: structure and function of a borate cross-linked cell wall pectic pelysaccharide显示文摘 | O'Neill M A Ishii T Albersheim P | 2004 | Armu Rev Plant Biol2004，55，： | 1 |
| 6 | Casein kinase 2 is the major enzyme in brain that phosphorylates Ser129 of human alpha synuelein: Implication for alpha-synueleinopathies显示文摘 | ISHII A NONAKA T TANIGUCHI S SAOTO T ARAI T MANN D IWATSUBO T HISANAQA S GOEDERT M HASEQAWA M | 2007 | FEBS Lett2007，581，24： | 1 |
| 7 | Cooperative R&D between Vertically Related Firms With Spillovers 显示文摘 | Ishii A | 2004 | International Journal of Industrial Organization2004，22，89： | 1 |
| 8 | Cancer prevention and therapy in a preclinical mouse model: impact of FHIT viruses显示文摘 | Ishii H Vecchione A Fong LY | 2004 | Curr Gcnc Thcr2004，4，1： | 1 |
| 9 | Au tomatic image stabilizing system by full-digital sig- nal processing显示文摘 | UOMORI K MORMURA A ISHII H | 1990 | IEEE Transactions on Consumer Electronics1990，36，3： | 1 |
| 10 | Estrogen receptor alpha andbeta are prognostic factoid in non-small cell lung cancer显示文摘 | Kawai H Ishii A Washiya K | 2005 | ClinCancer Res2005，11，14： | 1 |
| 11 | 50 carotenoids, sarcinaxanthin, sar- cinaxanthin monoglucoside, and sarcinaxanthin diglucoside, ob- tained from Mlerococcm yunnanen~la 显示文摘 | Osawa A Ishii Y Sasamura N et aL Characterization and an- tio~ddative activities of rare C | 2010 | J Oleo Sci2010，59，12： | 1 |
| 12 | Clinical potential of intravaseular ultrasound for physiological assessment ofenronary stenosis: relation- ship between quantitative ultrasound tomography and pressure-de- rived fi'actional flow reserve 显示文摘 | Takagi A Tsurumi Y Ishii Y | 1999 | Circulation1999，100，3： | 1 |
| 13 | Primary CD30/ Ki-I positive anaplastic large cell lymphoma of skeletal muscle with r(17)t(1;17)(qll;pll)显示文摘 | Ishii E Honda K Nakagawa A | 2000 | Caneer Genet Cyto- genet2000，122，15： | 1 |
| 14 | Effect of adenoviral transduction of the fragile histidine triad gene into esophageal cancer cells显示文摘 | Ishii H Dumon KR Vecchione A | 2001 | Cancer Res2001，61，4： | 1 |
| 15 | Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior显示文摘 | SAKURAI T AMEMIYA A ISHII M | 1998 | Cell1998，92，4： | 1 |
| 16 | Visual assessment of the mandibular cortex on panoramic radiographs to identify postmenopausal women with low bone mineral densities 显示文摘 | Lee K Taguchi A Ishii K | 2005 | Oral Surg Oral Medi Oral Path Oral Radiol Endod2005，100，2： | 1 |
| 17 | Expression of FRA16D/WWOX and FRA3B/FHIT genes in hematopoietic malignancies显示文摘 | Ishii H Vecchione A Furukawa Y | 2003 | Mol Cancer Res2003，1，13： | 1 |
| 18 | Potential cancer therapy with the fragile histidine triad gene; review of the preclinical studies显示文摘 | Ishii H Dumon KR Vecehione A | 2001 | JAMA2001，286，19： | 1 |
| 19 | Low-loss fibre-pigtailed 256 channel arrayed-waveguide grating multiplexer using cascaded laterally-tapered wavegudes 显示文摘 | Ishii M Takagi A | 2001 | Electronics Letters2001，37，23： | 1 |
| 20 | Validation and casework application of a Y chromosome specific STR multiplex显示文摘 | Prinz M Ishii A Coleman A | 2001 | Forensic Sci Int2001，120，3： | 1 |
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