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| 1 | Hypofractionated stereotactic rad iotherapy alone without whole-brain irradiation for patien ts with solitary and oligo brain metastasis using noninvasive fixation of the skull显示文摘To evaluate the efficacy and toxicity of hypofractionated stereotactic radiotherapy(HSRT)using noninvasive fixation of the sk ull on solitary or oligo brain metastatic p atients as an alternative to stereotactic radiosurgery(SRS)using invasive fixation.The subjects were 87patients who had 4or fewer brain meta stases(50solitary,37oligometastases).Treatment was conducted on 159meta stases by using a linac-based stereotactic system.T he median isocentric dose was 35Gy in4fractions.Whole-brain irradiati on was not applied as an initial treatment.For the salvage treatmen t of metachronous brain metastases,repeat HSRT or whole-brain irradiation was applied.The actuarial1-year local tumor control rate was 81%.Treatment-related complicatio ns were observed in 4patients in the e arly period(<3months)and in 2patients in the late period.T he median survival period was 8.7mon ths.Metachronous brain metastases occurred in 30patients,and none of the 18patients who were eligible for salvage HSRT refused to re ceive it again.Hypofractionated stereotactic radiotherapy achieved tumor control and survival equivalent to those of SRS reported i n the literature.The results suggested that HSRT could be an alternative for solitary or oligo br ain metastatic patients with less to xicity and less invasiveness compared to | Aoyama H Shirato H Onimaru R Kagei K Ikeda J Ishii N Sawamura Y Miyasaka K | 2003 | 癌症2003，22，7： | 12 |
| 2 | 脑缺血后N-myc下游调控基因2保护血脑屏障完整性显示文摘脑缺血后血脑屏障(BBB)的破坏与外周细胞向脑内浸润、病孔损形成与进展、以及临床病程恶化密切相关。目前BBB完整性的调控机制,尤其是在永久性缺血后的调控机制尚未明确。本研究使用小鼠永久性脑缺血模型进行相关研究,结果显示,星形胶质细胞N-myc下游调控基因2(NDRG2)可能是缺血性脑卒中后BBB通透性的调控分子,该分子与分化和应激相关。免疫组化显示,在永久性大脑中动脉闭塞(MCAO)后,NDRG2在星形胶质细胞中的表达显著增加。敲除NDRG2基因,脑梗死体积增加,免疫细胞在缺血同侧大脑半球积聚增加。MCAO后,NDRG2基因敲除小鼠缺血侧皮质的缺血灶内及灶周血管周围区域内的血清蛋白(包括纤维蛋白原和免疫球蛋白)的外渗增强此之,MCAO后NDRG2基因敲除小鼠体内基质金属蛋白酶(MMPs)的表达也显著增加。在细胞培养中,NDRG2-/-星形胶质细胞中MMP-3的表达和分泌增加,这种增加可被腺病毒介导的NDRG2再表达所逆转。综上所述,脑缺血后,星形胶质细胞内的NDRG2可能通过调节MMP的表达,而在BBB通透性的调节和免疫细胞浸润中起到重要作用。 | Takarada-Iemata M Yoshikawa A Ta HM Okitani N Nishiuchi T Aida Y Kamide T Hattori T Ishii H Tamatani T Le TM Roboon J Kitao Y Matsuyama T Nakada M Hori O 聂昊 | 2018 | 神经损伤与功能重建2018，13，4： | 4 |
| 3 | A high power ultrasonic linear motor using a longitudinal and bending hybrid bolt-clamped langevin type transducer显示文摘 | YUN C H ISHII Takaaki NAKAMURA Kentaro | 2001 | Jpn J Appl Phys2001，40，： | 2 |
| 4 | 卒中介入治疗培训指南:国际多学会共识文件显示文摘1背景
缺血性卒中是全球人口死亡和残疾的首要原因。很多急性大血管闭塞(emergent large vesselocclusion,ELVO)患者都会遗留长期残疾。事实上,这些颅内大动脉闭塞经常会导致大面积脑损伤,进而造成患者死亡或严重致残。 | Lavine SD Cockroft K Hoh B Bambakidis N Khalessi AA Woo H Riina H Siddiqui A Hirsch JA Chong W Rice H Wenderoth J Mitchell P Coulthard A Signh TJ Phatorous C Khangure M Klurfan P ter Brugge K Iancu D Gunnarsson T Pongpech S Rodesch G Soderman M Taylor A Krings T Orbach D Picard L Suh DC Zheng HQ Jansen O Muto M Szikora I Pierot L Brouwer P Gralla J Renowden S Andersson T Fiehler J Turjman F White P Januel AC Spelle L Kulcsar Z Chapot R Biondi A Dima S Taschner C Szajner M Krajina A Sakai N Matsumaru Y Yoshknura S Ezura M Fujinaka T Iihara K Ishii A Higashi T Hirohata M Hyodo A Ito Y Kawanishi M Kiyosue H Kobayashi E Kobayashi S Kuwayama N Matsumoto Y Miyachi S Murayama Y Nagata I Nakahara I Nemoto S Niimi Y Oishi H Satomi J Satow T Sugiu K Tanaka M Terada T Yamagami H Diaz O Lylyk P Jayaraman MV Patsalides A Gandhi CD Lee SK Abruzzo T Albani B Ansari SA Arthur AS Baxter BW Bulsara KR Chen M Almandoz JE Fraser JF Heck DV Hetts SW Hussain MS Klucznik RP Leslie-Mawzi TM Mack WJ McTaggart RA Meyers PM Mocco J Prestigiacomo CA Pride GL Rasmussen PA Starke RM Sunenshine PJ Tarr RW Frei DF Pabo M Nogueira RG Zaidat OO Jovin T Linfante I Yavagal D Liebeskind D Novakovic R Pongpech S 许岩 孙瑞 郭芮兵 | 2017 | 国际脑血管病杂志2017，25，5： | 2 |
| 5 | Cytokine-induced neutrophil chemoattractant in a rat model of lipopolysaccharide-induced acute lung injury显示文摘 | Yamasawa H Ishii Y Kitamura S | 1999 | Inflammation1999，23，3： | 2 |
| 6 | Some bounds on approximation algorithms for n|m|I|Lmax and n|2 |F|Lmax scheduling problems 显示文摘 | Masuda T Ishii H Nishzda I | 1983 | Opns Res Soc Japan1983，26，： | 2 |
| 7 | Aasymptotic Stability and Blowing Upof Solutions of Some Nonlinear Equations显示文摘 | Ishii H | 1977 | J Diff Equs1977，26，2： | 1 |
| 8 | Effect of vesicular-arbuscular mycorrhizal fungi on the growth, photosynthsis, transpiration and the distribution of photosynathates of bearing satsumam and arintrees显示文摘 | Shrestha Y H Ishii T | 1995 | Jounlal of Japanese Society of Horticultural Science1995，65，： | 1 |
| 9 | Role of ghrelin in streptozotocininduced diabetic hyperphagia 显示文摘 | Ishii S Kamegai J Tamura H | 2002 | Endocrinology2002，143，49： | 1 |
| 10 | High serum levels of thrombospondin-1 in patients with idiopathic interstitial pneumonia 显示文摘 | Ide M Ishii H Mukae H | 2008 | Respir Med2008，102，11： | 1 |
| 11 | Token+constraint systems for tangible interaction with digital information 显示文摘 | Ullmer B Ishii H Jacob R J K | 2005 | A CM Transactions on Computer Human Interaction2005，12，1： | 1 |
| 12 | Structures and proper-ties of seven isoforms of the NMDA receptor generated by al-ternative splicing显示文摘 | Sugihara H Moriyoshi K Ishii T | 1992 | Biochem Biophys Res Commun1992，185，： | 1 |
| 13 | Pre-treatment of cucumber plants with acibenzolar-S-methyl systemically primes a phenylalanine ammonia lyase gene (PAL1) for enhanced expression upon attack with a pathogenic fungus显示文摘 | Cools H J Ishii H | 2002 | Physiological and Molecular Plant Pathology2002，61，5： | 1 |
| 14 | Elevated SCF levels in theserum of patients with chronic renal failure显示文摘 | Kitoh T Ishikawa H Ishii T | 1998 | Br J Haemesatol1998，102，5： | 1 |
| 15 | Apoptosis and cell proliferation in the development of gastric carcinomas:associations with cmyc and p53 protein expression显示文摘 | Ishii H H Gobe G C Pan W | 2002 | J Gastroenterol Hepatol2002，17，： | 1 |
| 16 | FHIT is up-regulated by inflammatory stimuli and inhibits prostaglandin E2-mediated cancer progression显示文摘 | Mimori K Ishii H Nagahara H | 2006 | Cancer Res2006，66，5： | 1 |
| 17 | Physiological role of peroxisomal beta-oxidation in liver of fasted rats显示文摘 | Ishii H Horie S Suga T | 1980 | J Biochem1980，87，： | 1 |
| 18 | Elevated SCF levels in the serum of patients with chronic renal failure 显示文摘 | Kitoh T Ishikawa H Ishii T | 1998 | Br J Haematol1998，102，5： | 1 |
| 19 | Synthesis of a novel poly( binaphthylene ether) with a low dielectric constant 显示文摘 | Tsuchiya K Ishii H Shibasaki Y | 2004 | Macromolecules2004，37，13： | 1 |
| 20 | Sequential follow-up results of catheter intervention for coronary artery lesions after Kawasaki disease:quantitative comary artery angiography and intravascular ultrasound imaging study 显示文摘 | Ishii M Ueno T Ikeda H | 2002 | Circulation2002，105，25： | 1 |
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