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| 1 | Experimental obstructive jaundice alters claudin-4 expression in intestinal mucosa: Effect of bombesin and neurotensin显示文摘瞄准:调查试验性的妨碍的黄疸和外长的 bombesin 和 neurotensin (NT )(BBS ) 的影响紧密的连接(TJ ) 的表示上的管理在老鼠的肠上皮的蛋白质 claudin-4。方法:四十只男 Wistar 老鼠随机被划分成五个组:我 = 控制, II = 假冒操作, III = 胆汁管结扎(BDL ) , IV = BDL+BBS (30 microg/kg 每 d ) , V = BDL+NT (300 microg/kg 每 d ) 。在 d 的实验的结束 10,内毒素在门和大动脉的血被测量。终端回肠的织物节组织学地被检验并且免疫组织化学地为在肠上皮的 claudin-4 表示的评估。结果:妨碍的黄疸导致了重要的门和大动脉的 endotoxemia 表明的肠的障碍失败。Claudin-4 表示显著地被增加在上面在 jaundiced 老鼠的第三根绒毛并且一起来它的侧面的分发的规定被注意。BBS 或 NT 的管理恢复了 claudin-4 表示到控制状态并且显著地减少了门和大动脉的 endotoxemia。结论:在肠上皮的试验性的妨碍的黄疸增加 claudin-4 表示,它可以是贡献粘膜障碍的混乱的一个关键因素。毁坏规章的肽 BBS, NT 能阻止这扇改变和还原剂门和全身的 endotoxemia。 | Stelios F Assimakopoulos Constantine E Vagianos Aristides S Charonis Ilias H Alexandris Iris Spiliopoulou Konstantinos C Thomopoulos Vassiliki N Nikolopoulou Chrisoula D Scopa | 2006 | World Journal of Gastroenterology2006，12，21： | 21 |
| 2 | Metastatic pattern in esophageal and gastric cancer:Influenced by site and histology显示文摘BACKGROUND Detailed information on metastatic patterns in of patients with esophageal and gastric cancer is limited.Early recognition of metastases is important to avoid futile locoregional treatments.Furthermore,knowledge on metastatic patterns is necessary for further development of personalized treatment modalities.AIM To gain insight into the metastatic pattern of gastroesophageal cancer.METHODS A nationwide retrospective autopsy study of 3876 patients with adenocarcinoma(AC)or squamous cell carcinoma(SCC)of the esophagus or stomach between 1990 and 2017 was performed.Only patient with metastases were included for analysis.The metastatic pattern was analyzed according to the primary tumor location and histological subtype.RESULTS Metastatic disease was found in 268 esophageal and 331 gastric cancer patients.In esophageal cancer,the most common metastatic locations were liver(56%),distant lymph nodes(53%)and lung(50%).Esophageal AC showed more frequently metastases to the peritoneum and bone compared with esophageal SCC.In gastric cancer,the most common metastatic locations were distant lymph nodes(56%),liver(53%)and peritoneum(51%).Intestinal-type AC of the stomach showed metastases to the liver more frequently,whereas metastases to the bone,female reproductive organs and colorectum were observed more frequently in diffuse-type gastric AC.CONCLUSION This study showed differences in metastatic patterns of patients with esophageal and gastric cancer according to the primary tumor location and histological subtype. | Moniek HP Verstegen Mitchell Harker Carlijn van de Water Jolanda van Dieren Niek Hugen Iris D Nagtegaal Camiel Rosman Rachel S van der Post | 2020 | World Journal of Gastroenterology2020，26，39： | 9 |
| 3 | 根据血压等级确定脑卒中和冠状动脉粥样硬化性心脏病死亡的终生风险:日本EPOCH(观察队列的心血管预防证据)研究显示文摘在亚洲人群中.很少研究关注根据血压分类确定脑卒中和冠状动脉粥样硬化性心脏病(coronary heartdisease,CHD)的终生风险。该研究旨在用一个包含个体参与者数据的荟萃分析大数据库来评估它。该荟萃分析纳入来源于13个队列的107 737名日本人(男性占42.4%,平均年龄55.1岁)。在平均(15.2±5.3)年(1 559 136人年)的随访期.1922人死于脑卒中,913人死于CHDO研究者在调整其他死亡危险因素后估计风险。 | 陈嘉睿(译) 练桂丽(审校) Satoh M Ohkubo T Asayama K Murakami Y Sugiyama D Yamada M Saitoh S Sakata K Irie F Sairenchi T Ishikawa S Kiyama M Ohnishi H Miura K Imai Y Ueshima H Okamura T EPOCH-JAPAN research group | 2019 | 中华高血压杂志2019，27，4： | 9 |
| 4 | The second European evidence-based Consensus on the diagnosis and management of Crohn’s disease: Special situations显示文摘 | Gert Van Assche Axel Dignass Walter Reinisch C. Janneke van der Woude Andreas Sturm Martine De Vos Mario Guslandi Bas Oldenburg Iris Dotan Philippe Marteau Alessandro Ardizzone Daniel C. Baumgart Geert D’Haens Paolo Gionchetti Francisco Portela Boris Vuce | 2009 | Journal of Crohn’s and Colitis2009，，1： | 3 |
| 5 | D-MELD risk capping improves post-transplant and overall mortality under markov microsimulation显示文摘AIM: To hypothesize that the product of calculated Model for End-Stage Liver Disease score excluding exception points and donor age(D-MELD) risk capping ± Rule 14 could improve post liver transplant and overall survival after listing.METHODS: Probabilities derived from the United Network for Organ Sharing database between 2002 and 2004 were used to simulate potential outcomes for all patients listed for transplantation. The Markov simula-tion was then modified by screening matches using a 1200 or 1600 D-MELD risk cap ± allowing transplants for Model for End-Stage Liver Disease(MELD) ≤ 14(Rule 14). The differential impact of the rule changes was assessed.RESULTS: The Markov simulation accurately reproduced overall and post transplant survival. A 1200 D-MELD risk cap improved post-transplant survival. Both the 1200 and 1600 risk caps improved overall survival for waitlisted patients. The addition of Rule 14 further improved post transplant and overall survival by redistribution of donor livers to recipients in higher MELD subgroups. The mechanism for improved overall and post-transplant survival after listing was due to shifting a larger percentage of transplants to the moderate MELD score subgroup(MELD 15-29) while also ensuring that high MELD recipients have livers of high quality to achieve excellent post transplant survival.CONCLUSION: A 1200 D-MELD risk cap + Rule 14 provided the greatest overall benefit primarily by focusing liver transplantation towards the moderate MELD recipient. | Jeffrey B Halldorson Robert L Carithers Jr Renuka Bhattacharya Ramasamy Bakthavatsalam Iris W Liou Andre A Dick Jorge D Reyes James D Perkins | 2014 | World Journal of Transplantation2014，4，3： | 2 |
| 6 | Lipopolysaccharide induces a stromal-epithelial signaling axis in a rat model of chronic periodontitis显示文摘 | Firth JD Ekuni D Irie K | 2013 | J Clin Periodontol2013，40，1： | 1 |
| 7 | Reusing semi-specified behavior models in systems analysis and design显示文摘 | Iris R B Dori D Shmuel K | 2009 | Software and Systems Modeling2009，8，2： | 1 |
| 8 | Suppressing effect of CaCO3 on the dioxins emission from poly (vinyl chloride) (PVC)incineration显示文摘 | Sun R D Irie H Nishikawa T | 2003 | Polymer Degradation and Stability2003，79，2： | 1 |
| 9 | Uncertain analgetic efficacy of intraurethral instillation of anesthetic jelly in rigid cystoseopy for men显示文摘 | Matsuda D Irie A Shimura S | 2005 | Nippon Hinyokika Gakkai Zasshi2005，96，6： | 1 |
| 10 | Modeling design patterns for semi-automatic reuse in system design显示文摘 | Galia S Iris R B Dori D | 2010 | J of Database Management2010，21，1： | 1 |
| 11 | Brain lesions on MRI and endogenous sex hormones in elderly men显示文摘 | Irie F Strozyk D Peila R | 2006 | Neurobiol Aging2006，27，8： | 1 |
| 12 | HER2 diagnostics in gastric cancer—guideline validation and development of standardized immunohistochemical testing显示文摘 | Josef Rüschoff Manfred Dietel Gustavo Baretton Susanne Arbogast Axel Walch Geneviéve Monges Marie-Pierre Chenard Frédérique Penault-Llorca Iris Nagelmeier Werner Schlake H. H?fler H. H. Kreipe | 2010 | Virchows Archiv2010，，3： | 1 |
| 13 | Region growing with pulse-coupled neural networks: an alternative to seeded region growing 显示文摘 | Stewart Robert D Fermin Iris Opper Manfred | 2002 | IEEE Trans Neural Networks2002，13，6： | 1 |
| 14 | Lack of Association Between the MEF2A Gene and Myocardial Infarction显示文摘 | Wolfgang Lieb Bj?rn Mayer Inke R. K?nig Iris Borwitzky Anika G?tz Silke Kain Christian Hengstenberg Patrick Linsel-Nitschke Marcus Fischer Angela D?ring H -Erich Wichmann Thomas Meitinger Reinhold Kreutz Andreas Ziegler Heribert Schunkert Jeanette Erdmann | 2008 | Circulation2008，，2： | 1 |
| 15 | Eugenol and its structural analogs inhibit monoamine oxidase A and exhibit antidepressant-like activity显示文摘 | Irie Y Li D J | 2005 | Bioorg Med Chem2005，13，15： | 1 |
| 16 | WorkPlan: constraint-based database for work pacakage scheduling 显示文摘 | Hyun Jeong Choo Iris D Tommelein Glenn Ballard etc | 1999 | Journal of Construction Engineering and Management1999，125，3： | 1 |
| 17 | Adolescent suicide attempts:risks and protectors显示文摘 | Iris W B Marjorie I Michael D | 2001 | Pediatrics2001，107，： | 1 |
| 18 | HER2 diagnostics in gastric cancer—guideline validation and development of standardized immunohistochemical testing显示文摘 | Josef Rüschoff Manfred Dietel Gustavo Baretton Susanne Arbogast Axel Walch Geneviéve Monges Marie-Pierre Chenard Frédérique Penault-Llorca Iris Nagelmeier Werner Schlake H. H?fler H. H. Kreipe | 2010 | Virchows Archiv2010，，3： | 1 |
| 19 | Effects of infertility and infertility duration on femalesexual functions显示文摘 | Iris A Aydogan Kirmizi D Taner CE | 2013 | Arch Gynecol Obstet2013，287，4： | 1 |
| 20 | Preparation of 2,2-bis(p-fluorophenyl)-1,1,1-trichloroethane and proof of the position of the fluorine in the compound显示文摘 | Colorado Iris R Mendizabal G D | 1947 | Rev Inst Salubr Enferm Trop (Mex)1947，8，： | 1 |
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