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| 1 | Predictive value of Ki67 and p53 in locally advanced rectal cancer:Correlation with thymidylate synthase and histopathological tumor regression after neoadjuvant 5-FU-based chemoradiotherapy显示文摘AIM: To investigate the predictive value of Ki67 and p53 and their correlation with thymidylate synthase (TS) gene expression in a rectal cancer patient cohort treated according to a standardized recommended neoadjuvant treatment regimen.METHODS: Formalin fixed, paraffin embedded pre-therapeutical tumor biopsies (n = 22) and post-therapeutical resection specimens (n = 40) from patients with rectal adenocarcinoma (clinical UICC stage Ⅱ/Ⅲ) receiving standardized neoadjuvant 5-fluorouracil (5-FU) based chemoradiotherapy were studied for Ki67 and p53 expression by immunohistochemistry and correlated with TS mRNA expression by quantitative TaqMan real-time PCR after laser microdissection. The results were compared with histopathological tumor regression according to a standardized semiquantitative score grading system.RESULTS: Responders (patients with high tumor regression) showed a significantly lower Ki67 expression than non-responders in the pre-therapeutical tumor biopsies (81.2% vs 16.7%; P < 0.05) as well as in the post-therapeutical resection specimens (75.8% vs 14.3%; P < 0.01). High TS mRNA expression was significantly correlated with a high Ki67 index and low TS mRNA expression was significantly correlated with a low Ki67 index in the pre-therapeutical tumor biopsies (corr. coef. = 0.46; P < 0.01) as well as in the post-therapeutical resection specimens (corr. coef. = 0.40; P < 0.05). No significant association was found between p53 and TS mRNA expression or tumor regression.CONCLUSION: Ki67 has, like TS, predictive value in rectal cancer patients after neoadjuvant 5-FU based chemoradiotherapy. The close correlation between Ki67 and TS indicates that TS is involved in active cell cycle processes. | Christiane Jakob Torsten Liersch Wolfdietrich Meyer Heinz Becker Gustavo B Baretton Daniela E Aust | 2008 | World Journal of Gastroenterology2008，14，7： | 29 |
| 2 | Bcl-2 expression, P53 Accumulation,and Apoptosis in Ovarian Carcinoma显示文摘 | Diebold J Baretton G Felchner M | 1996 | Am J Clin Pathol1996，105，： | 1 |
| 3 | Serrated polyps of the colon and rectum (hyperplastic polyps, sessile serrated adenomas, traditional serrated adenomas, and mixed polyps)—proposal for diagnostic criteria显示文摘 | Daniela E. Aust Gustavo B. Baretton | 2010 | Virchows Archiv2010，，3： | 1 |
| 4 | Apoptosis and immunohistochemical Bcl-2 expression in colorectal adenomas and carcinomas显示文摘 | Baretton GB Diebold J Christoforis G | 1996 | Cancer1996，77，： | 1 |
| 5 | HER2 diagnostics in gastric cancer—guideline validation and development of standardized immunohistochemical testing显示文摘 | Josef Rüschoff Manfred Dietel Gustavo Baretton Susanne Arbogast Axel Walch Geneviéve Monges Marie-Pierre Chenard Frédérique Penault-Llorca Iris Nagelmeier Werner Schlake H. H?fler H. H. Kreipe | 2010 | Virchows Archiv2010，，3： | 1 |
| 6 | Apoptosis and immunohistochemical Bcl - 2 expression in colorectal adenomas and carcinomas显示文摘 | Baretton GB Diebold J Christoforis G | 1996 | Cancer1996，77，2： | 1 |
| 7 | HER2 diagnostics in gastric cancer—guideline validation and development of standardized immunohistochemical testing显示文摘 | Josef Rüschoff Manfred Dietel Gustavo Baretton Susanne Arbogast Axel Walch Geneviéve Monges Marie-Pierre Chenard Frédérique Penault-Llorca Iris Nagelmeier Werner Schlake H. H?fler H. H. Kreipe | 2010 | Virchows Archiv2010，，3： | 1 |
| 8 | Endothelialized biological heart valve prostheses in the non-human primate model显示文摘 | Fischloin T Baretton G | 1997 | Eur J Cardiothorac Surg1997，11，： | 1 |
| 9 | Serrated polyps of the colon and rectum (hyperplastic polyps, sessile serrated adenomas, traditional serrated adenomas, and mixed polyps)-proposal for diagnostic criteria 显示文摘 | Aust D E Baretton G B | 2010 | Virchows Arch2010，457，3： | 1 |
| 10 | Immunohistochemical analysis of drug resistance associated protein in ovarian carcinomas显示文摘 | MAYRD PANNEKAMP U BARETTON GB etal | 2000 | Pathol Res Pract2000，196，7： | 1 |
| 11 | Gene expression analysis of HUVEC in response to TF-binding 显示文摘 | GROSSER M MAGDOLEN V BARETTON G | 2011 | Thromb Res2011，127，3： | 1 |
| 12 | Prognostic factors and long-term results after surgery for gallbladder carcinoma:a retrospective study of 127patients显示文摘 | Schauer RJ Meyer G Baretton G | 2001 | Langenbecks Arch Surg2001，386，2： | 1 |
| 13 | Apoptosis and immunohistochemical bel-2 expression in colorectal adenomas and carcinomas显示文摘 | Baretton G B Diebold J Christoforis G | 1996 | Cancer1996，77，： | 1 |
| 14 | Interphase cytogenetic analysis of prostatic carcinomas by use of nonisotopic in situ hybridization 显示文摘 | Baretton GB Valina C Vogt T | 1994 | Cancer Res1994，54，16： | 1 |
| 15 | Prognostic significance of apoptosis and associated factors in oral squamous cell carcinoma显示文摘 | Stoll C Baretton G Ahrens C | 2000 | Virchows Arch2000，436，2： | 1 |
| 16 | HER2 diagnostics in gastric cancer-guideline validation and development of standardized immuno- histoehemieal testing显示文摘 | Ruschoff J Diete M Baretton G | 2010 | Virchows Arch2010，457，3： | 1 |
| 17 | Cellular apoptosis susceptibility gene expression in endometrial carcinoma: correlation with Bcl-2, Bax,and caspasse-3 expression and outcome 显示文摘 | Peiro G Diebold J Baretton GB | 2001 | Int J Gynecol Pathol2001，20，4： | 1 |
| 18 | HER2 diagnostics in gastric cancer guideline validation and development of standardized immunohistochemical testing 显示文摘 | Rtischoff J Dietel M Baretton G | 2010 | Virchows Arch2010，457，3： | 1 |
| 19 | Serrated polyps of the colon and rectum (hyperplastic polyps, sessile serrated adenomas, traditional serrated adenomas, and mixed polyps)—proposal for diagnostic criteria显示文摘 | Daniela E. Aust Gustavo B. Baretton | 2010 | Virchows Archiv2010，，3： | 1 |
| 20 | Apoptosis and immunohistochemical Bcl-2 expression in colorctal adenomas and carcinomas显示文摘 | Baretton GB Diebold J Christoforis G | 1996 | Cancer1996，77，： | 1 |
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