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| 1 | Spatial metabolomics for evaluating response to neoadjuvant therapy in non-small cell lung cancer patients显示文摘Background:The response to neoadjuvant chemotherapy(NAC)differs substantially among individual patients with non-small cell lung cancer(NSCLC).Major pathological response(MPR)is a histomorphological read-out used to assess treatment response and prognosis in patientsNSCLC afterNAC.Although spatial metabolomics is a promising tool for evaluating metabolic phenotypes,it has not yet been utilized to assess therapy responses in patients with NSCLC.We evaluated the potential application of spatial metabolomics in cancer tissues to assess the response to NAC,using a metabolic classifier that utilizes mass spectrometry imaging combined with machine learning.Methods:Resected NSCLC tissue specimens obtained after NAC(n=88)were subjected to high-resolution mass spectrometry,and these data were used to develop an approach for assessing the response to NAC in patients with NSCLC.The specificities of the generated tumor cell and stroma classifiers were validated by applying this approach to a cohort of biologically matched chemotherapy-naive patients with NSCLC(n=85).Results:The developed tumor cell metabolic classifier stratified patients into different prognostic groups with 81.6%accuracy,whereas the stroma metabolic classifier displayed 78.4%accuracy.By contrast,the accuracies of MPR and TNM staging for stratification were 62.5%and 54.1%,respectively.The combination of metabolic and MPR classifiers showed slightly lower accuracy than either individual metabolic classifier.In multivariate analysis,metabolic classifiers were the only independent prognostic factors identified(tumor:P=0.001,hazards ratio[HR]=3.823,95%confidence interval[CI]=1.716-8.514;stroma:P=0.049,HR=2.180,95%CI=1.004-4.737),whereasMPR(P=0.804;HR=0.913;95%CI=0.445-1.874)and TNM staging(P=0.078;HR=1.223;95%CI=0.977-1.550)were not independent prognostic factors.Using Kaplan-Meier survival analyses,both tumor and stroma metabolic classifiers were able to further stratify patients as NAC responders(P<0.001)and non-responders(P<0.001).Conclusions:Our findings indicate that the metabolic constitutions of both tumor cells and the stroma are valuable additions to the classical histomorphology-based assessment of tumor response. | Jian Shen Na Sun Philipp Zens Thomas Kunzke Achim Buck Verena M.Prade Jun Wang Qian Wang Ronggui Hu Annette Feuchtinger Sabina Berezowska Axel Walch | 2022 | Cancer Communications2022，42，6： | 3 |
| 2 | Decline of semen quality during IVF is not associated with subjective male stress显示文摘如果精液质量衰退在期间,现在的学习的目的是估计在 vitro 授精(IVF ) 并且这现象是否被长期的男应力触发。以便测试这个假设,我们首先调查了 155 个男 IVF 病人(严峻的队) 的一个回顾的队。随后,我们在经历他们的第一 IVF 的人开始了未来的队研究并且用一个验证工具估计了精液质量和主观男长期的应力,即富饶问题库存(FPI ) 问询表。在应力和精子质量衰落之间的协会在 IVF (T1 ) 的开始前是 4-6 星期,在卵母细胞的日子,检索(T2 ) 是主要结果。实时出生率,第一三个月流产和差的应答者的率是第二等的结果。在严峻的队,吝啬的进步活动性,然而并非吝啬的精子密度显著地衰退了。有 78/154 (51%) 人和在进步活动性显示出衰落的 50/154 (32%) 人,在精液密度看了衰落。在确认队,进步活动性衰退了,而,从 T1 增加到 T2 的精子密度。78 个人, 27 个人增加了应力(FPI 分数 >146 ) 。精子密度和进步活动性不在有或没有应力的人是显著地不同的。面对男应力,然而,夫妇们有差的应答者,流产和实时出生的更低的率的更高的率。主观应力没在在 IVF 期间观察的精液质量与衰落被联系,但是可以与不利怀孕结果被联系。 | Kazem Nouri Brigitte Litschauer Michael Sator Denise Tiringer Johannes Ott Katherina Walch Lukas A Hefler Clemens B Tempfer | 2014 | Asian Journal of Andrology2014，16，4： | 3 |
| 3 | Tuberosity malposition and migration: Reasons for poor outcomes after hemiarthroplasty for displaced fractures of the proximal humerus显示文摘 | P Boileau S.G Krishnan L Tinsi G Walch J.S Coste D Molé | 2002 | Journal of Shoulder and Elbow Surgery2002，，5： | 2 |
| 4 | Serologic markers of autoimmunity in women with polycystic ovary syndrome显示文摘 | Katrin Hefler-Frischmuth Katharina Walch Wolfgang Huebl Konstantin Baumuehlner Clemens Tempfer Lukas Hefler | 2010 | Fertility and Sterility2010，，7： | 2 |
| 5 | Typical and atypical carcinoid tumors of the lung are characterized by11q deletions as detected by comparative genomic hybridization显示文摘 | Walch AK Zitzelsberger HF Aubele MM | 1998 | Am J Pathol1998，153，： | 1 |
| 6 | A polymorphism in the matrix metalloproteinase - 1 gene promoter is associated with the presence of polyeystie ovary syndrome in Caucasian women 显示文摘 | Walch K Nagele F Zeillinger R | 2005 | Fertil Steril2005，83，5： | 1 |
| 7 | Unreduced posterior luxations and fractures-luxations of the shoulder: a propos of 30 cases 显示文摘 | Walch G Boileau P Martin B etal | 1990 | Rev Chir Orthop Reparatfice Appar Mot1990，76，8： | 1 |
| 8 | Comprehensive Identification of Proteins from MALDI Imaging显示文摘 | Stefan K. Maier Hannes Hahne Amin Moghaddas Gholami Benjamin Balluff Stephan Meding Cédrik Schoene Axel K. Walch Bernhard Kuster | 2013 | Molecular & Cellular Proteomics2013，，10： | 1 |
| 9 | Total serum bilirubin levels during cyclooxygenase inhibitor treatment for patent ductus arteriosus in P reterm infants显示文摘 | Rheinlaender C Helfenstein D walch E | 2009 | Acta Paediatr2009，98，1： | 1 |
| 10 | Experimental studies on the quasi-static axial crushing of steel columns filled with aluminum foam 显示文摘 | Seitzberger M Rammerstorfer F G Gardinger R Degischer H P Blaimschein M Walch C | 2000 | International Journal of Solids and Structures2000，37，： | 1 |
| 11 | Influence of age,gender,body weight and valproate comedication on quetiapine plasma concentra-tions显示文摘 | Aichhorn W Marksteiner J Walch T | 2006 | Int Clin Psychophacol2006，21，2： | 1 |
| 12 | Nitrogen regulation of root branching显示文摘 | Walch -Liu P Ivanov I Filleur S | 2006 | Annals of Botany2006，97，： | 1 |
| 13 | Arthroscopic tenoto-my of the long head of the biceps in the treatment of rotator cuff tears:clinical and radiographic results of 307 cases显示文摘 | Walch G Edward TB Boulahia A | | 0，，03： | 1 |
| 14 | Morphologic study of the glenoid in primary glenohumeral osteoarthritis显示文摘 | Walch G Badet R Boulahia A | 1999 | J Arthroplasty1999，14，6： | 1 |
| 15 | Ammonia induces settlement behavior in oyster larvae显示文摘 | COON S L WALCH M FITT W K | 1990 | Biological Bulletin1990，179，： | 1 |
| 16 | STAT3 mRNA and pro- tein expression in colorectal cancer: effects on STAT3-inducible targets linked to cell survival and proliferation 显示文摘 | Lassmann S Schuster I Walch A | 2007 | J Clin Pathol2007，60，2： | 1 |
| 17 | Long-term results of the Latarjet procedure for anterior instability of the shoulder显示文摘 | Naoko Mizuno Patrick J. Denard Patric Raiss Barbara Melis Gilles Walch | 2014 | Journal of Shoulder and Elbow Surgery2014，，： | 1 |
| 18 | Pro-atherogenic effect of interleukin-4 in endothelial cells: modulation of oxidative stress, nitric oxide and monocyte chemoattractant protein-1 expression 显示文摘 | Walch L Massade L Dufilho M | 2006 | Atherosclerosis2006，187，2： | 1 |
| 19 | HER2 diagnostics in gastric cancer—guideline validation and development of standardized immunohistochemical testing显示文摘 | Josef Rüschoff Manfred Dietel Gustavo Baretton Susanne Arbogast Axel Walch Geneviéve Monges Marie-Pierre Chenard Frédérique Penault-Llorca Iris Nagelmeier Werner Schlake H. H?fler H. H. Kreipe | 2010 | Virchows Archiv2010，，3： | 1 |
| 20 | Alcoholic liver disease显示文摘 | Walch K Alexander G | 2000 | Postgrad Med J2000，76，895： | 1 |
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