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| 1 | The microsatellite polymorphism of heme oxygenase-1 is associated with baseline plasma IL-6 level but not with restenosis after coronary in-stenting显示文摘Background Vascular smooth muscle cells (VSMCs) can express heme-oxygenase (HO), a rate-limiting enzyme in the degradation of heme to bilirubin, ferritin and carbon monoxide (CO). VSMC-derived CO can suppress VSMC proliferation and may serve as an antiproliferation factor. The promoter region of HO-1 shows a polymorphism with different (GT)_n repeats that has been reported to differently induce gene expression. The objective of this study was to examine the effect of this variation on the occurrence of restenosis after in-stent treatment in patients with coronary artery disease. Methods Candidates who underwent coronary stent implantation were genotyped for the HO-1 promoter polymorphism using polymerase chain reaction (PCR) and automated DNA capillary sequencer. Serum levels of IL-6 and C-reactive protein (CRP) were obtained at baseline, 24 hours and 48 hours after stenting. The primary end point for the study was angiographic evidence of in-stent restenosis at 6 months. All parameters for evaluation of restenosis were analysed by quantitatve computer-assisted angiographic analysis (QCA). Results One hundred and eighty-seven patients who underwent coronary stent implantation were studied of whom 27.8% showed ≥50% restenosis after 6 months. The distribution of (GT)_n repeats of all patients in the promoter region of HO-1 genotype ranged from 22 to 42, with (GT)_ 25 and (GT)_ 32 being the two most common alleles. The allelic repeats were divided into the short class (S) with 29 (GT)_n, the middle class (M) with 30-37 (GT)_n and the long class (L) with 38 (GT)_n. There was no significant difference in the restenosis between the genotype groups or between post operation levels of inflammation markers, but carriers of the S allele (n=120) had 33.3% lower baseline IL-6 compared with non-S carriers (n=67, P=0.0008). Conclusions Although no association was observed between the HO-1 promoter polymorphism aod coronary in-stent restenosis following the stent procedure, the association with plasma IL-6 levels suggests that HO-1 S allele might protect from the atherosclerotic inflammatory process. | LI Ping Mohamed A. Elrayess Abuzeid H. Gomma Jutta Palmen Emma Hawe Kim M. Fox Steve E. Humphries | 2005 | Chinese Medical Journal2005，，18： | 6 |
| 2 | Cytokine and cytokine receptor gene polymorphisms and their functionality显示文摘 | Andrew J.P. Smith Steve E. Humphries | 2008 | Cytokine and Growth Factor Reviews2008，，1： | 3 |
| 3 | Barrett’s metaplasia glands are clonal, contain multiple stem cells and share a common squamous progenitor显示文摘 | Anna M Nicholson Trevor A Graham Ashley Simpson Adam Humphries Nicola Burch Manuel Rodriguez-Justo Marco Novelli Rebecca Harrison Nicholas A Wright Stuart A C McDonald Janusz A Jankowski | 2012 | Gut2012，，10： | 3 |
| 4 | 心脏病及非心脏病患者降低舒张压的效果:收缩压干预试验结果分析显示文摘收缩压和舒张压低于何种阈值时心血管事件增多仍然不明确。应用收缩压干预试验(systolic blood pressure intervention trial,SPRINT)的数据,研究者评估了1519例心血管病患者和7574位非心血管病者的收缩压和舒张压与心血管事件之间的关系。 | 刘青 叶鹏 Khan NA Rabkin SW Zhao Y McAlister FA Park JE Guan M Chan S Humphries KH | 2018 | 中华高血压杂志2018，26，6： | 3 |
| 5 | MicroRNA-214 protects the mouse heart from ischemic injury by controlling Ca^sup 2+^ overload and cell death显示文摘 | Aurora Arin B Mahmoud Ahmed I Luo Xiang Johnson Brett A van Rooij Eva Matsuzaki Satoshi Humphries Kenneth M Hill Joseph A Bassel-Duby Rhonda Sadek Hesham A Olson Eric N | 2012 | EN2012，，4： | 2 |
| 6 | Photoinhibition of Photosynthesis in Nature显示文摘 | S P Long S Humphries P G Falkowski | 1994 | Annual Review of Plant Physiology and Plant Molecular Biology1994，，： | 2 |
| 7 | Progression to chronic atrial fibrillation after the initial diagnosis of paroxysmal atrial fibrillation: Results from the Canadian Registry of Atrial Fibrillation显示文摘 | Charles R. Kerr Karin H. Humphries Mario Talajic George J. Klein Stuart J. Connolly Martin Green John Boone Robert Sheldon Paul Dorian David Newman | 2005 | American Heart Journal2005，，3： | 2 |
| 8 | Inflammatory response to coronary artery bypass surgery: Does the heme-oxygenase-1 gene microsatellite polymorphism play a role?显示文摘Background Heme-oxygenase 1 (HO-1) is a rate-limiting enzyme in the degradation of heme to bilirubin, ferritin and carbon monoxide (CO) and may have significant anti-inflammatory function. The HO-1 gene promoter region shows microsatellite polymorphism with different (GT)n repeats, reported to differently induce gene expression, with the short allele associated with higher gene expression. We measured the acute inflammatory response using coronary artery bypass surgery (CABG) as a well-characterized and uniform stimulus and examined the correlation between levels of IL-6, C-reactive protein (CRP) and fibrinogen and their relationship to HO-1 genotype.Methods Two hundred and seventy-five consecutive patients undergoing CABG were genotyped for the HO-1 promoter polymorphism using PCR and automated DNA capillary sequencer. IL-6, CRP and fibrinogen were measured at baseline and 6, 24, 48, 72, 96 and 120 hours after CABG.Results Complete IL-6,CRP and fibrinogen measures were available in 220 patients. Before surgery IL-6 levels showed a strong correlation with CRP and fibrinogen ( r =0.48, P <0.0001; r =0.41, P <0.0001 respectively), with a significant correlation between CRP and fibrinogen ( r =0.61, P <0.0001). All three acute phase reactants showed a significant increase after CABG. After surgery, peak IL-6 was strongly correlated with peak CRP ( r =0.34, P =0.0009) but not with peak fibrinogen ( r =0.15, P =0.13), while peak CRP and peak fibrinogen were significantly correlated ( r =0.415, P <0.0001). HO-1 allelic repeats ranged from 22-42, with (GT) 25 and (GT) 32 being the two most common alleles, and subsequently divided into three groups according to previous published work: <30(GT)n were designated as S (short), 30-37(GT)n as M (middle) and long repeats with >37(GT)n as L (long); allele frequency 0.35, 0.58 and 0.07 respectively. Baseline CRP differed by genotype: those carrying at least one long allele having higher CRP than those with no long allele (3.76±0.79 vs. 2.07±0.17, P =0.013). Conversely, those carrying at least one short allele had higher fibrinogen levels than those with no short allele (3.83±0.79 vs. 3.51±0.88, P =0.006). Conclusions There is a strong correlation between the measured acute phase reactants both at baseline and after the inflammatory response to CABG in patients with coronary disease. There was an association between the HO-1 microsatellite polymorphism and CRP and fibrinogen levels at baseline but there was no similar association following CABG. This may indicate that HO-1 is associated with chronic atherosclerotic inflammatory processes rather than acute. | LI Ping Jules Sanders Emma Hawe David Brull Hugh Montgomery Steve Humphries | 2005 | Chinese Medical Journal2005，，15： | 2 |
| 9 | Lipoprotein(α) as a predictor of myocardial infarction in middle aged men 显示文摘 | Mary S Ayrs S Humphrie S | 2001 | Am J Med2001，110，1： | 1 |
| 10 | Scaling laws of marine predator search behavior 显示文摘 | Sims D W Southall E J Humphries N E | 2008 | Nature2008，451，： | 1 |
| 11 | Inflammation, obesity, stress and coronary heart disease :is interleukin-6 the link? 显示文摘 | Yudkin JS Kumari M Humphries SE | 2000 | Atherosclerosis2000，148，2： | 1 |
| 12 | Risks and benefits of hormone replacement therapys:the evidence speaks显示文摘 | Humphries K Gill S | 2003 | CMAJ2003，168，： | 1 |
| 13 | In vitro and in vivo expansion of hematopoietic stem cells显示文摘 | Sauvageau G Iscove NN Humphries RK | 2004 | Oncogene2004，23，43： | 1 |
| 14 | Trace element mobility during hydrothermal alteration of oceanic basalts显示文摘 | Humphris S E Thompson G | 1978 | Geochimica et Cosmochimica Acta1978，42，： | 1 |
| 15 | Deducing patterns of fluid flow and mixing within the active TAG mound using mineralogical and geochemical data 显示文摘 | TIVEY M K HUMPHRIS S E THOMPSON G | 1995 | Journal of Geophysical Research1995，100，12： | 1 |
| 16 | The effect of short-term swiss ball training on core stability and running economy显示文摘 | Stanton R Peter R R Humphries B | 2004 | Journal of strength and condi- tioning Association2004，18，3： | 1 |
| 17 | Eutrophication and harmful algal blooms: A scientific consensus显示文摘 | J. Heisler P.M. Glibert J.M. Burkholder D.M. Anderson W. Cochlan W.C. Dennison Q. Dortch C.J. Gobler C.A. Heil E. Humphries A. Lewitus R. Magnien H.G. Marshall K. Sellner D.A. Stockwell D.K. Stoecker M. Suddleson | 2008 | Harmful Algae2008，，1： | 1 |
| 18 | Serolog- ical misdiagnosis of acute liver failure associated with echovi- rus 25 due to immunological similarities to hepatitis A virus and prozone effect显示文摘 | Wollersheim S K Humphries R M Cherry J D | 2015 | J Clin Microbiol2015，53，1： | 1 |
| 19 | Disturbed memory amnesia related to intensive care显示文摘 | JONES C GRIFFITHS R D HUMPHRIS G | 2000 | Memory2000，8，2： | 1 |
| 20 | Lipoprotein lipase gene variation is associated with a paternal history of premature coronary artery disease and fasting and postprandial plasma triglycerides: the European Atherosclerosis Research Study (EARS) 显示文摘 | Humphries SE Nicaud V Margalef J Tiret L Talmud PJ | 1998 | Arterioscler Thromb Vasc Biol1998，18，4： | 1 |
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