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| 1 | Combination of inflammation-related cytokines promotes long-term muscle stem cell expansion显示文摘 | Xin Fu Jun Xiao Yuning Wei Sheng Li Yan Liu Jie Yin Kun Sun Hao Sun Huating Wang Zongkang Zhang Bao-Ting Zhang Chun Sheng Hongyan Wang Ping Hu | 2015 | Cell Research2015，25，6： | 16 |
| 2 | Kinetics of the accumulation of group 2 innate lymphoid cells in IL-33-induced and IL-25-induced murine models of asthma:a potential role for the chemokine CXCL16显示文摘ILC2s are implicated in asthma pathogenesis, but little is known about the mechanisms underlying their accumulation in airways.We investigated the time course of ILC2 accumulation in different tissues in murine models of asthma induced by a serial per-nasalchallenge with ovalbumin (OVA), house dust mice (HDM), IL-25 and IL-33 and explored the potential roles of ILC2-attractingchemokines in this phenomenon. Flow cytometry was used to enumerate ILC2s at various time points. The effects of cytokines andchemokines on ILC2 migration were measured in vitro using a chemotaxis assay and in vivo using small animal imaging. Comparedwith saline and OVA challenge, both IL-25 and IL-33 challenge alone induced significant accumulation of ILC2s in the mediastinallymph nodes, lung tissue and bronchoalveolar lavage fluid of challenged animals, but with a distinct potency and kinetics. In vitro,IL-33 and CXCL16, but not IL-25 or CCL25, directly induced ILC2 migration. Small animal in vivo imaging further confirmed that asingle intranasal provocation with IL-33 or CXCL16 was sufficient to induce the accumulation of ILC2s in the lungs followinginjection via the tail vein. Moreover, IL-33-induced ILC2 migration involved the activation of ERK1/2, p38, Akt, JNK and NF-κB, whileCXCL16-induced ILC2 migration involved the activation of ERK1/2, p38 and Akt. These data support the hypothesis that epitheliumderived IL-25 and IL-33 induce lung accumulation of ILC2s, while IL-33 exerts a direct chemotactic effect in this process. AlthoughILC2s express the chemokine receptors CXCR6 and CCR9, only CXCL16, the ligand of CXCR6, exhibits a direct chemoattractanteffect. | Yan Li Shihao Chen Yafei Chi Yiran Yang Xiwen Chen Huating Wang Zhe Lv Jingjing Wang Linjie Yuan Ping Huang Kewu Huang Chris JCorrigan Wei Wang Sun Ying | 2019 | Cellular & Molecular Immunology2019，16，1： | 13 |
| 3 | Increasing yield potential through manipulating of an ARE1 ortholog related to nitrogen use efficiency in wheat by CRISPR/Cas9显示文摘Wheat(Triticum aestivum L.)is a staple food crop consumed by more than 30%of world population.Nitrogen(N)fertilizer has been applied broadly in agriculture practice to improve wheat yield to meet the growing demands for food production.However,undue N fertilizer application and the low N use efficiency(NUE)of modern wheat varieties are aggravating environmental pollution and ecological deterioration.Under nitrogen-limiting conditions,the rice(Oryza sativa)abnormal cytokinin response1 repressor1(are1)mutant exhibits increased NUE,delayed senescence and consequently,increased grain yield.However,the function of ARE1 ortholog in wheat remains unknown.Here,we isolated and characterized three TaARE1 homoeologs from the elite Chinese winter wheat cultivar ZhengMai 7698.We then used CRISPR/Cas9-mediated targeted mutagenesis to generate a series of transgene-free mutant lines either with partial or triple-null taare1 alleles.All transgene-free mutant lines showed enhanced tolerance to N starvation,and showed delayed senescence and increased grain yield in field conditions.In particular,the AABBdd and aabbDD mutant lines exhibited delayed senescence and significantly increased grain yield without growth defects compared to the wild-type control.Together,our results underscore the potential to manipulate ARE1 orthologs through gene editing for breeding of high-yield wheat as well as other cereal crops with improved NUE. | Jiahui Zhang Huating Zhang Shaoya Li Jingying Li Lei Yan Lanqin Xia | 2021 | Journal of Integrative Plant Biology2021，63，9： | 13 |
| 4 | Myofiber necroptosis promotes muscle stem cell proliferation via releasing Tenascin-C during regeneration显示文摘Necroptosis,a form of programmed cell death,is characterized by the loss of membrane integrity and release of intracellular contents,the execution of which depends on the membrane-disrupting activity of the Mixed Lineage Kinase Domain-Like protein(MLKL)upon its phosphorylation.Here we found myofibers committed MLKL-dependent necroptosis after muscle injury.Either pharmacological inhibition of the necroptosis upstream kinase Receptor Interacting Protein Kinases 1(RIPK1)or genetic ablation of MLKL expression in myofibers led to significant muscle regeneration defects.By releasing factors into the muscle stem cell(MuSC)microenvironment,necroptotic myofibers facilitated muscle regeneration.Tenascin-C(TNC),released by necroptotic myofibers,was found to be critical for MuSC proliferation.The temporary expression of TNC in myofibers is tightly controlled by necroptosis;the extracellular release of TNC depends on necroptotic membrane rupture.TNC directly activated EGF receptor(EGFR)signaling pathway in MuSCs through its N-terminus assembly domain together with the EGF-like domain.These findings indicate that necroptosis plays a key role in promoting MuSC proliferation to facilitate muscle regeneration. | Shen'ao Zhou Wei Zhang Gaihong Cai Yingzhe Ding Caixia Wei Sheng Li Yu Yang Jie Qin Dan Liu Hao Zhang Xiexiang Shao Jianhua Wang Hongye Wang Wenjun Yang Huating Wang She Chen Ping Hu Liming Sun | 2020 | Cell Research2020，30，12： | 4 |
| 5 | Genetically encoded X-ray cellular imaging for nanoscale protein localization显示文摘Spatial resolution defines the physical limit of microscopes for probing biomolecular localization and interactions in cells.Whereas synchrotron-based X-ray microscopy(XRM)represents a unique approach for imaging a whole cell with nanoscale resolution due to its intrinsic nanoscale resolution and great penetration ability,existing approaches to label biomolecules rely on the use of exogenous tags that are multi-step and error-prone.Here,we repurpose engineered peroxidases as genetically encoded X-ray-sensitive tags(GXET)for site-specific labeling of protein-of-interest in mammalian cells.We find that 3,3-diaminobenzidine(DAB)polymers that are in-situ catalytically formed by fusion-expressed peroxidases are visible under XRM.Using this new tag,we imaged the protein location associated with the alteration of a DNA-methylation pathway with an ultra-high resolution of 30 nanometers.Importantly,the excellent energy resolution of XRM enables multicolor imaging using different peroxidase tags.The development of GXET enlightens the way to nanoscopic imaging for biological studies. | Huating Kong Jichao Zhang Jiang Li Jian Wang Hyun-Joon Shin Renzhong Tai Qinglong Yan Kai Xia Jun Hu Lihua Wang Ying Zhu Chunhai Fan | 2020 | National Science Review2020，7，7： | 3 |
| 6 | Fibroblast growth factor 21:a novel metabolic regulator from pharmacology to physiology显示文摘Fibroblast growth factor 21(FGF21)is a member of the fibroblast growth factor family.It actually functions as endocrine hormones but does not regulate cell growth and differentiation.It is demonstrated that FGF21 acts on multiple tissue to coordinate carbohydrate and lipid metabolism,including enhancing insulin sensitivity,decreasing triglyceride concentrations,causing weight loss,ameliorating obesity-associated hyperglycemia and hyperlipidemia.Moreover,FGF21 also plays important roles in some physiological processes,such as fasting and feeding,growth hormone axis and thermogenic function of brown adipose tissue.Clinical relevance of FGF21 in humans is still unclear,and the basis and consequences of increased FGF21 in metabolic disease remain to be determined.Both the pharmacological actions and physiological roles make FGF21 attractive drug candidates for treating metabolic disease,but some questions remain to be answered.This article concentrates on recent advances in our understanding of FGF21. | Huating Li Jing Zhang Weiping Jia | 2013 | Frontiers of Medicine2013，7，1： | 2 |
| 7 | Serum osteo-calcin concentrations in relation to glucose and lipid metabolism in Chinese individuals显示文摘 | Mi Zhou Xiaojing Ma Huating Li | 2009 | European Journal of Endocrinology2009，161，5： | 1 |
| 8 | Optimization of nobiletin extraction assisted by microwave from orange byproduct using response surface methodology显示文摘 | ZHANG Yu LI Hongjun DOU Huating | 2013 | Food Science and Biotechnology2013，22，： | 1 |
| 9 | High serum level of fibroblast growth factor 21 is an independent predictor of non-alcoholic fatty liver disease: A 3-year prospective study in China显示文摘 | Huating Li Kun Dong Qichen Fang Xuhong Hou Mi Zhou Yuqian Bao Kunsan Xiang Aimin Xu Weiping Jia | 2012 | Journal of Hepatology2012，，： | 1 |
| 10 | The citrus flavonoid nobiletin inhibits proliferation and induces apoptosis in human pancreatic cancer cells in vitro显示文摘 | ZHANG Yu DOU Huating LI Hongjun | 2014 | Food Science and Biotechnology2014，23，： | 1 |
| 11 | Glycated haemoglobi- nAlc for diagnosing diabetes in Chinese population: cross section- al epidemiological survey显示文摘 | Yuqian Bao Xiaojing Ma Huating Li | 2010 | BMJ2010，340，： | 1 |
| 12 | Optimization of nobiletin extraction assisted by microwave from orange byproduct using response surface methodology显示文摘 | Yu Zhang Hongjun Li Huating Dou Zhifei He Houjiu Wu Zhigao Sun Hua Wang Xuegen Huang Yaqin Ma | 2013 | Food Science and Biotechnology2013，，1： | 1 |
| 13 | Fibroblast growth factor 21 levels are increased in nonalcoholic fatty liver disease patients and are correlated with hepatic triglyceride显示文摘 | Huating Li Qichen Fang Fei Gao Jia Fan Jian Zhou Xiaoying Wang Huizhen Zhang Xiaoping Pan Yuqian Bao Kunsan Xiang Aimin Xu Weiping Jia | 2010 | Journal of Hepatology2010，，5： | 1 |
| 14 | Glycated haemoglobin A1C for diagnosing diabetes in Chinese population:cross sectional epidemiological survey显示文摘 | BAO YUQIAN MA XIAOJING LI HUATING | 2010 | BMJ2010，340，： | 1 |
| 15 | Preparation and properties of graphene nanosheets–polystyrene nanocomposites via in situ emulsion polymerization显示文摘 | Huating Hu Xianbao Wang Jingchao Wang Li Wan Fangming Liu Han Zheng Rong Chen Chunhui Xu | 2009 | Chemical Physics Letters2009，，4： | 1 |
| 16 | Preparation and properties of graphene nanosheets–polystyrene nanocomposites via in situ emulsion polymerization显示文摘 | Huating Hu Xianbao Wang Jingchao Wang Li Wan Fangming Liu Han Zheng Rong Chen Chunhui Xu | 2009 | Chemical Physics Letters2009，，4： | 1 |
| 17 | Glycated haemoglobin A1c for diagnosing diabetes in Chinese population:cross sectional epidemiological survey显示文摘 | Yuqian Bao Xiaojing Ma Huating Li etal | 2010 | BMJ2010，，340： | 1 |
| 18 | Primary amine-functionalized mesoporous phenolic resin as an effective and stable solid base catalyst for Knoevenagel reactions in water显示文摘A primary amine functionalized ordered mesoporous phenolic resin(NH2-MPR)was obtained by an evaporationinduced self-assembly method.The as-prepared NH2-MPR material possessed large surface area and ordered twodimensional hexagonal mesoporous structure.Also,the amine groups were well-dispersed in the mesoporous channels.It can act as an efficient solid base to promote Knoevenagel condensation of various aldehydes with ethyl cyanoacetate in water with high conversion and selectivity.This excellent performance was attributed ordered mesopores and hydrophobic pore surface,which resulted in the decreased the interference of water solvent and the increased active sites accessibility.Noted that it was comparable with homogenous base catalysts in the water-medium Knoevenagel condensation reaction,and it can be reused for at least five times without significant reduction in the catalytic efficiency. | Kaixuan Wang Huating Jiang Min Tong Yao Xiao Hexing Li Fang Zhang | 2020 | Green Synthesis and Catalysis2020，1，1： | 0 |
| 19 | Flourishing Ancient Huaiyang显示文摘FlourishingAncientHuaiyangINTHEEASTERNPARTofHenanProvince,sitsHuaiyangCounty,knownasWanqiuinThreeEmperors"(Fuxi,NuwaandShenno... | LI HUATING LI JUNFA | 1996 | China Today1996，45，2： | 0 |
| 20 | Study of Water Treatment Residue Used as a Profile Control Agent显示文摘从水处理过程的大量残余逐渐地在 waterflood 油矿积累了并且因此引起了严肃的环境污染。水处理残余是灰暂停,与 1.08 g/cm3 的密度,并且主要包含超过 65% 轻 CaCO3, MgCO3, CaSO4, Fe2S3 和 Ca (哦) 2。这份报纸在油矿在核心渗透和它的申请上查明水处理残余的效果。实验室的 Coreflooding 测试在二个人工的核心和一个自然核心被进行。核心变化被演员组模型图象分析,水银注射方法和扫描电子显微镜学(SEM ) 评估。新鲜的水被注入另一个自然核心,它与水处理残余被插,到决定有效 life.The 结果显示水处理残余有一个强烈插的能力,到侵蚀的一个电阻和长有效的生活,并且因此,它能为侧面 control.In 被用作便宜原料过去的 8 年,水处理残余的 60,164 m3 的一个总数被用于 151 个井处理的侧面控制,与98%的成功比率和 effecti 在地测试,侧面控制代理人增加了注射者的开始的压力和注射压力,并且减少明显的水 injectivity 系数,显著地改善的吸入侧面和变长的一般水准满足注射者的生活。28,381 大量另外的油从这些相应油井被恢复,与 3,069.55 潨敬 ? 湩匠 ? 挠湡映捡汩瑩瑡 ? 敤票牤瑡潩的经济好处吗? | Hou Tianjiang Zhao Huating Li Zongtian Zhao Puchun Xiao Liping | 2005 | Petroleum Science2005，2，4： | 0 |
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