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| 1 | Hepatocellular carcinoma redirects to ketolysis for progression under nutrition deprivation stress显示文摘癌症房间以他们的能力著名给新陈代谢的小径换新电线在各种各样的压力条件下面支持幸存和增长。尽管在肝生产了,酉同类身体没在正常的成年的肝房间被消费。我们这里发现酉同类分解代谢或 ketolysis 在 hepatocellular 被重新激活在营养剥夺条件下面的癌(HCC ) 房间。机械学地, 3-oxoacid CoA-transferase 1 (OXCT1 ) ,其表情在正常的成年的肝纸巾被压制的限制率的 ketolytic 酶,被浆液重新导致被触发饥饿的 mTORC2-AKT-SP1 在 HCC 房间发信号。而且,我们观察到在 HCC 的那提高的 ketolysis 为 AMPK 激活的压抑是批评的并且保护 HCC 房间免受过多的 autophagy 的伤害,从而提高肿瘤生长。重要地,临床的 HCC 样品的分析表明那增加的 OXCT1 表情预言更高耐心的死亡。一起拿,我们这里揭开剥夺营养的 HCC 房间为精力由采用酉同类身体的新奇新陈代谢的改编供应和癌症前进。 | De Huang Tingting Li Lin Wang Long Zhang Ronghui Yan Kui Li Songge Xing Gongwei Wu Lan Hu Weidong Jia Sheng-Cai Lin Chi V Dang Libing Song Ping Gao Huafeng Zhang | 2016 | Cell Research2016，26，10： | 27 |
| 2 | miR-486 sustains NF-KB activity by disrupting multiple NF-KB-negative feedback loops显示文摘 | Libing Song Chuyong Lin Hul Gong Chanjuan Wang Liping Liu Jueheng Wu Sha Tao Bo Hu Shi-Yuan Cheng Mengfeng Li Jun Li | 2013 | Cell Research2013，23，2： | 6 |
| 3 | Inhibition of the PIN1-NRF2/GPX4 axis imparts sensitivity to cisplatin in cervical cancer cells显示文摘The incidence of cervical cancer(cC)ranks the fourth in female malignant tumors globally.Chemoresistance is one of the main causes of treatment failure in advanced recurrent CC.Prolyl isomerase 1(PIN1)is overexpressed in a variety of tumors,and is closely associated with the malignant potential of tumor cells,such as transformation,proliferation,invasion and metastasis.In the present study,we demonstrate that cell death induced by suppression of PIN1 could be inhibited by ferrostatin-1(Fer-1)and ferroptosis biomarkers including lactate dehydrogenase(LDH)release,lipid peroxidation and malondialdehyde(MDA)are upregulated by downregulating PIN1.We then discover that abrogation of PIN1 greatly decreases the level of glutathione peroxidase 4(GPX4)and the level of PIN1 is positively correlated with the level of GPX4.Furthermore,the knockdown of PIN1 promotes ferroptosis induced by RSL3.The mechanism involves PIN1 silencing which downregulates GPX4 by decreasing the level of nuclear factor E2-related factor 2(NRF2).Furthermore,overexpression of NRF2 inhibits RSL3-mediated ferroptosis of CC cells when PIN1 is silenced.In addition,our results indicate that cisplatin(DDP)induces ferroptosis,which is restrained by overexpression of PIN1.The PIN1 inhibitor,KPT-6566,promotes the cytotoxic effect of DDP.The present study reveals that PIN1 affects ferroptosis and sensitivity to DDP in CC cells via the NRF2/GPX4 axis,thereby identifying PIN1 as a potential therapeutic target for Cc. | Zheng Zhang Qiangsheng Hu Shuang Ye Libing Xiang 无 | 2022 | Acta Biochimica et Biophysica Sinica2022，54，9： | 4 |
| 4 | Improved oxygen reduction reaction via a partially oxidized Co-CoO catalyst on N-doped carbon synthesized by a facile sand-bath method显示文摘High active and durable non-noble metal electrocatalysts are urgently developed to satisfy the high performance oxygen reduction reaction(ORR). We successfully synthesized Co-CoOx anchored on nitrogen-doped carbon via a facile sand-bath method(SBM), i.e., Co-CoOx/N-C(SBM). The as-obtained Co-CoOx/N-C(SBM) exhibited overwhelming superiorities to Co-CoO/N-C prepared by conventional heat treatment(CHT), particularly in electrochemical performance of ORR. Although Co-CoOx/N-C(SBM)showed smaller specific surface area of 276.8 m^2/g than that of 939.5 m^2/g from Co-CoO/N-C(CHT), the Co-CoOx/N-C(SBM) performed larger pore diameter and more Co_3O_4 active component resulting in better ORR performance in 0.1 mol/L KOH solution. The Co-CoO_x/N-C(SBM) delivered onset potential of 0.91 V vs. RHE, mid-wave potential of 0.85 V vs. RHE and limited current density of 5.46 mA/cm^2 much better than those of the Co-CoO/N-C(CHT). Furthermore, Co-CoOx/N-C(SBM) showed greater stability and better methanol tolerance superior to the commercial 20 wt% Pt/C. | Libing Hu Feng Yu Huifang Yuan Gang Wang Mincong Liu Lina Wang Xueyan Xue Banghua Peng Zhiqun Tian Bin Dai | 2019 | Chinese Chemical Letters2019，30，3： | 4 |
| 5 | Dimericbiscognienynes B and C: New diisoprenyl-cyclohexene-type meroterpenoid dimers from Biscogniauxia sp.显示文摘Dimericbiscognienynes B and C(1 and 2), two new diisoprenyl-cyclohexene-type meroterpenoid dimers,were isolated from Biscogniauxia sp. 71-10-1-1. Their structures, including the absolute configurations,were determined by spectroscopic analyses and ECD experiments. Meroterpenoids are special natural products that originate from mixed terpenoid-nonterpenoid pathway. As a member of meroterpenoid family, diisoprenyl-cyclohexene/ane-type meroterpenoids composed of two isoprenyl chains(C5 unit)and a cyclohexene/ane moiety(C6 unit), featuring diverse skeleton structures with wide range of bioactivities. In these reported diisoprenyl-cyclohexene/ane-type meroterpenoids, only three dimers were identified. The discovery of the two new dimers added members of this rare class of meroterpenoids. | Huan Zhao Meizhi Wang Guodong Chen Dan Hu Enqing Li Yibo Qu Libing Zhou Liangdong Guo Xinsheng Yao Hao Gao | 2019 | Chinese Chemical Letters2019，30，1： | 3 |
| 6 | Defective ZnS nanoparticles anchored in situ on N-doped carbon as a superior oxygen reduction reaction catalyst显示文摘Defect engineering has been used to develop low-cost and effective catalysts to boost oxygen reduction reactions.However,the development of catalysts that use metal cation vacancies as the active sites for oxygen reduction reaction is lacking.In this study,ZnS nanoparticles on N-doped carbon serve as an oxygen reduction reaction catalyst.These catalysts were prepared via a one-step method at 900℃.Amazingly,the high-resolution transmission electron microscope image revealed obvious defects in the ZnS nanoparticles.These facilitated the catalyst synthesis,and the product displayed good electrocatalytic performance for the oxygen reduction reaction in an alkaline medium,including a lower onset potential,lower mid-wave potential,four electron transfer process,and better durability compared with 20 wt%Pt/C.More importantly,the density functional theory results indicated that using the Zn vacancies in the prepared catalyst as active sites required a lower reaction energy to produce OOH*from*OO toward oxygen reduction reaction.Therefore,the proposed catalyst with Zn vacancies can be used as a potential electrocatalyst and may be substitutes for Pt-based catalysts in fuel cells,given the novel catalyst’s resulting performance. | Libing Hu Zengxi Wei Feng Yu Huifang Yuan Mincong Liu Gang Wang Bangfiua Peng Bin Dai Jianmin Ma | 2019 | Journal of Energy Chemistry2019，28，12： | 3 |
| 7 | Overwhelming electrochemical oxygen reduction reaction of zinc-nitrogen-carbon from biomass resource chitosan via a facile carbon bath method显示文摘Developing high efficiency and low cost electrocatalysts is critical for the enhancement of oxygen reduction reaction(ORR),which is the fundamental for the development and commercialization of renewable energy conversion technology.Herein,zinc-nitrogen-carbon(Zn-N-C)was prepared by using biomass resource chitosan via a facile carbon bath method.The obtained Zn-N-C delivered a high specific surface area(794.7 cm^2/g)together with pore volume(0.49 cm^3/g).During the electrochemical evaluation of oxygen reduction reaction(ORR),Zn-N-C displayed high activity for ORR with an onset pote ntial E0=0.96 VRHE and a half wave potential E1/2=0.86 VRHE,which were more positive than those of the comme rcial 20 wt%Pt/C benchmark catalyst(E0=0.96 VRHE and E1/2=0.81 VRHE).In addition,the ZnN-C catalyst also had a better stability and methanol tolerance than those of the Pt/C catalyst. | Libing Hu Feng Yu Fu Wang Shengchao Yang Banghua Peng Long Chen Gang Wang Juan Hou Bin Dai Zhi-Qun Tian | 2020 | Chinese Chemical Letters2020，31，5： | 2 |
| 8 | Design of antibacterial peptide-like conjugated molecule with broad spectrum antimicrobial ability显示文摘Increasing multidrug-resistant(MDR) superbugs emerge worldwide causing a public health crisis. Consequently, it is urgent to find new antibiotics with efficient broad-spectrum antimicrobial activity. By virtue of versatility in molecular design, a new peptide-like cell membrane-broken molecule, oligo-(7,7′-bifluoren-benzo[c][1,2,5]thiadiazole)(OFBT) possessing a conjugated backbone and eight pendant guanidyl moieties was designed and synthesized. OFBT exhibits favorable broad-spectrum of antimicrobial activity to pathogens including Gram-negative and Gram-positive bacteria, and fungi with the minimum inhibitory concentration(MIC)below 3.0 μM. Moreover, OFBT exhibits high selectivity for pathogens over human cells to make it a promising broad spectrum antimicrobial agent. | Hui Chen Meng Li Zhang Liu Rong Hu Shengliang Li Yuan Guo Fengting Lv Libing Liu Yilin Wang Yuanping Yi Shu Wang | 2018 | Science China Chemistry2018，61，1： | 1 |
| 9 | HvWRKY2 acts as an immunity suppressor and targets HvCEBiP to regulate powdery mildew resistance in barley显示文摘Plants use a sophisticated immune system to perceive pathogen infection and activate immune responses in a tightly controlled manner.In barley,Hv WRKY2 acts as a repressor in barley disease resistance to the powdery mildew fungus,Blumeria graminis f.sp.hordei(Bgh).However,the molecular features of Hv WRKY2 in its DNA-binding and repressor functions,as well as its target genes,are uncharacterized.We show that the W-box binding of Hv WRKY2 requires an intact WRKY domain and an upstream sequence of~75 amino acids,and the Hv WRKY2 W-box binding activity is linked to its repressor function in disease resistance.Chromatin immunoprecipitation(ChIP)-seq analysis identified HvCEBiP,a putative chitin receptor gene,as a target gene of Hv WRKY2 in overexpressing transgenic barley plants.ChIP-qPCR and Electrophoretic Mobility Shift Assay(EMSA)verified the direct binding of Hv WRKY2 to a W-boxcontaining sequence in the HvCEBiP promoter.Hv CEBiP positively regulates resistance against Bgh in barley.Our findings suggest that Hv WRKY2 represses barley basal immunity by directly targeting pathogen-associated molecular pattern(PAMP)recognition receptor genes,suggesting that Hv CEBiP and likely chitin signaling function in barley PAMP-triggered immune responses to Bgh infection. | Deshui Yu Renchun Fan Ling Zhang Pengya Xue Libing Liao Meizhen Hu Yanjun Cheng Jine Li Ting Qi Shaojuan Jing Qiuyun Wang Arvind Bhatt Qian-Hua Shen | 2023 | The Crop Journal2023，11，1： | 1 |
| 10 | A Joint Power and Bandwidth Allocation Method Based on Deep Reinforcement Learning for V2V Communications in 5G显示文摘Vehicular communications have recently attracted great interest due to their potential to improve the intelligence of the transportation system.When maintaining the high reliability and low latency in the vehicle-to-vehicle(V2V)links as well as large capacity in the vehicle-to-infrastructure(V2I)links,it is essential to flexibility allocate the radio resource to satisfy the different requirements in the V2V communication.This paper proposes a new radio resources allocation system for V2V communications based on the proximal strategy optimization method.In this radio resources allocation framework,a vehicle or V2V link that is designed as an agent.And through interacting with the environment,it can learn the optimal policy based on the strategy gradient and make the decision to select the optimal sub-band and the transmitted power level.Because the proposed method can output continuous actions and multi-dimensional actions,it greatly reduces the implementation complexity of large-scale communication scenarios.The simulation results indicate that the allocation method proposed in this paper can meet the latency constraints and the requested capacity of V2V links under the premise of minimizing the interference to vehicle-to-infrastructure communications. | Xin Hu Sujie Xu Libing Wang Yin Wang Zhijun Liu Lexi Xu You Li Weidong Wang | 2021 | China Communications2021，18，7： | 1 |
| 11 | Reduced levels of 5a-reductase 2 in adult prostate tissue and impli- cations for BPH Therapy显示文摘 | Niu Yinong Ge Rongbin Hu Libing | 2011 | The Prostate2011，71，： | 1 |
| 12 | High efficient oxygen reduction performance of Fe/Fe3C nanoparticles in situ encapsulated in nitrogen-doped carbon via a novel microwave-assisted carbon bath method显示文摘Fe-based carbon materials are widely considered promising to replace Pt/C as next-generation electrocatalysts towards oxygen reduction reaction (ORR). However, the preparation of Fe-based carbon materials is still carried out by conventional heating method (CHM). Herein, a novel microwave-assisted carbon bath method (MW-CBM) was proposed, which only took 35 min to synthesize Fe/Fe3C nanoparticles encapsulated in N-doped carbon layers derived from Prussian blue (PB). The catalyst contained large specific surface area and mesoporous structure, abundant Fe-Nx and C–N active sites, unique core-shell structure. Due to the synergistic effects of these features, the as-prepared Fe/Fe3C@NC-2 displayed outstanding ORR activity with onset potential of 0.98 VRHE and halfwave potential of 0.87 VRHE, which were more positive than 20 wt.% Pt/C (0.93 VRHE and 0.82 VRHE). Besides, Fe/Fe3C@NC-2 gave a better stability and methanol tolerance than Pt/C towards ORR in alkaline media, too. | Mincong Liu Xue Yin Xuhong Guo Libing Hu Huifang Yuan Gang Wang Fu Wang Long Chen Lili Zhang Feng Yu | 2019 | Nano Materials Science2019，1，2： | 1 |
| 13 | Detection and Analysis of Number of Ralstonia solanacearum in Soil before Winter Tillage in Fuzhou Tobacco-growing Area, Jiangxi Province显示文摘[Objective]The paper was to optimize the tobacco planting area in Fuzhou City and to prevent the outbreak of tobacco bacterial wilt in large area.[Method]At the end of 2017,soil samples were collected from plots planned to be planted with tobacco in the following year in Yihuang,Guangchang,Lichuan and Le’an counties.[Result]Among 352 plots,116 plots were infected by Ralstonia solanacearum,while 236 plots were free of the pathogen,and the infected plots accounted for 32.95% of total plots.Among them,75 plots exceeded the order of magnitudes of 103,accounting for 21.31% of total plots and 64.66% of infected plots.It is suggested that the plots with an order of magnitude above 103 should be pretreated with quicklime or purple soil,or conducted crop rotation,or seeds must be directly abandoned;the dosage of biocontrol agents should be increased in planting.The plots with an order of magnitude below 103 should be pretreated with quicklime or purple soil,and the dosage of biocontrol agents should be increased in planting.[Conclusion]The results provide reliable theoretical basis and data support for soil improvement and bacterial wilt control. | Zhang Zhigao Hu Liwei Feng Xiaohu Mou Wenjun Wang Libing Zhang Rui | 2019 | Plant Diseases and Pests2019，10，5： | 1 |
| 14 | Author Correction: miR-486 sustains NF-κB activity by disrupting multiple NF-κB-negative feedback loops显示文摘Correction to:Cell Research http://gffzzd3cc09b8251d45dfswvb0p5u9vkbn6nn5.ffgz.tsg.suse.edu.cn/10.1038/cr.2012.174,published online 18 December 2012 With this letter we the authors of article1 published in Cell Research request for correction to the paper.In the article above referred,it has come to our attention that the representative tube formation images of negative control(NC)was mistakenly used in the Fig.7G during figure assembly. | Libing Song Chuyong Lin Hui Gong Chanjuan Wang Liping Liu Jueheng Wu Sha Tao Bo Hu Shi-Yuan Cheng Mengfeng Li Jun Li | 2021 | Cell Research2021，31，10： | 0 |
| 15 | Synthesis of Fan-Shaped C3 Molecule with Three Glycyrrhetinic Acid Units and Self-Assembly Properties显示文摘有三个 glycyrrhetinic 酸单位的一个新奇扇形的 C3 分子在高产量经由“按化学”被综合并且自己组装特征在不同混合溶剂被学习。 | Hu, Jun Yu, Libing Zhang, Meng Ju, Yong | 2011 | Chinese Journal of Chemistry2011，29，6： | 0 |
| 16 | Effects of Microbial Fertilizers in Improving Acidic Tobacco-planting Soil and Tobacco Leaf Quality显示文摘[Objectives]This study was conducted to improve acidic soil and enhance the quality of tobacco leaves.[Methods]The effects of different microbial fertilizers on improving acidic tobacco-planting soil and tobacco leaf quality were investigated through plot experiments.[Results]The application of microbial fertilizers could improve the pH value of acidic soil,and composite microbial agent A showed the best application effect.The application of bio-organic fertilizer was beneficial to improving the contents of available phosphorus and available boron in acidic soil.The application of composite microbial agent A was beneficial to improving the contents of available phosphorus and available potassium in acidic soil,and could promote the growth of tobacco plants and improve the economic traits of flue-cured tobacco and the coordination of chemical components in tobacco leaves.The application of composite microbial agent B led to a downward trend in the content of available boron in acidic soil.The application of composite microbial agent B could promote the absorption of nutrients by tobacco plants,and improve their disease resistance and the quality of tobacco leaves.Due to the differences in functional microorganisms contained,the application effects of different microbial fertilizers in improving acidic tobacco-planting soil and improving tobacco leaf quality varied.Overall,the application of microbial fertilizers could increase soil pH,activate soil nutrients,promote tobacco growth,enhance disease resistance,increase tobacco output value,and improve tobacco quality.Microbial fertilizers have good application prospects in improving acidic soil and improving tobacco quality.[Conclusions]The application of microbial fertilizers to improve acidic tobacco-planting soil can ensure the normal growth and development of tobacco plants and the improvement of tobacco leaf quality,achieving high-quality and sustainable development of Zhaotong tobacco. | Xia NI Shungang SHEN Xianyi ZENG Dewen LI Yeming FU Min CHEN Chaokai YU Libing QI Ying-guo RUAN Changchong ZI Haohan GONG Guangjun HU Mengsheng ZHANG Xu ZHANG Shu PENG Hongbing LI | 2023 | Agricultural Biotechnology2023，12，2： | 0 |
| 17 | Identification of Germline Mutations in East‑Asian Young Never‑Smokers with Lung Adenocarcinoma by Whole‑Exome Sequencing显示文摘Recently,an increasing number of young never-smokers are diagnosed with lung cancer.The aim of this study is to investigate the genetic predisposition of lung cancer in these patients and discover candidate pathogenic variants for lung adenocarcinoma in young never-smokers.Peripheral blood was collected from 123 never-smoking east-Asian patients diagnosed with lung adenocarcinoma before the age of 40.Whole-exome sequencing(WES)was conducted on genomic DNA extracted from peripheral blood cells.As a result,3,481 single nucleotide variants were identified.By bioinformatical tools and the published gene list associated with genetic predisposition of cancer,pathogenic variants were detected in ten germline genes:ATR,FANCD2,FANCE,GATA2,HFE,MSH2,PDGFRA,PMS2,SDHB,and WAS.Patients with pathogenic variants were more likely to occur in females(9/10,90.0%)and have stage IV lung adenocarcinoma(4/10,40%).Furthermore,germline muta-tions in 17 genes(ASB18,B3GALT5,CLEC4F,COL6A6,CYP4B1,C6orf132,EXO1,GATA4,HCK,KCP,NPHP4,PIGX,PPIL2,PPP1R3G,RRBP1,SALL4,and TTC28),which occurred in at least two patients,displayed potentially pathogenic effects.Gene ontology analysis further showed that these genes with germline mutations were mainly located in nucleo-plasm and associated with DNA repair-related biological processes.The study provides spectrum of pathogenic variants and functional explanation for genetic predisposition of lung adenocarcinoma in young never-smokers,which sheds a light on prevention and early diagnosis of lung cancer. | Fangqiu Fu Xiaoting Tao Zhonglin Jiang Zhendong Gao Yue Zhao Yuan Li Hong Hu Libing Shen Yihua Sun Yang Zhang | 2023 | Phenomics2023，3，2： | 0 |
| 18 | Preparation of Alum-borneol-PVP Drug-loaded Fibers by Electrospinning显示文摘The alum-borneol nanoemulsion(ABN),which combines the mineral medicine alum and the botanical medicine borneol,has been applied for approximately 40 years in the clinical treatment of burns,scalds,radiation dermatitis and shingles,and has a good curative effect.However,the current formula and dosage form of ABN pose problems of low borneol content and ease of precipitation,which greatly affects the efficacy of the drug.In this study,polyvinylpyrrolidone(PVP)was selected as a carrier mixed with different proportions of alum and borneol to produce alum-borneol-PVP fibers(ABPF)by electrospinning.The results showed that the stable system with good drug dispersion was 2:3(alum:borneol).The dissolution content of borneol from the ABPF was about 80%in 4 h,which was much higher than that of the alum-borneol liquid(ABL)and ABN.The ABPF membrane showed a more significant inhibitory effect on Staphylococcus aureus than the ABL and ABN.The composite fiber markedly increased the drug content of borneol,which was 800 times of that in ABN.The fiber had a higher solubility than the nanoemulsion in vitro,which is of great importance for the development of new forms for the clinical application of alum and borneol. | HUANG Libing LIU Yueqi SANG Xinyu SONG Jinghui HU Ping LIU Yong | 2021 | Chemical Research in Chinese Universities2021，37，3： | 0 |
| 19 | Quantitative analysis of the difference of lesion degree between male and female COVID-19 based on digital modeling显示文摘The purpose of this study is to research the difference of lesion volume and its constituent ratio of lung volume of Novel Coronavirus Pneumonia(NCP)between male and female by digital technology.In this study,the CT imaging data and clinical data of 40 NCP patients in Huaihua were collected and divided into two groups:male(n=22)and female(n=18)according to gender. | Yu Huan Liu Guangxing Zhan Meizhi Zhang Zhenwu Sheng Ting Liu Yating Mi Sirong Xie Liang Zhang Feng Hu Luying He Wenyan Rao Libing | 2021 | 解剖学杂志2021，44，S01： | 0 |
| 20 | Study on bone morphology and development of children based on digital three dimensional reconstruction显示文摘This study aims to construct the skeletal system of children at different ages through digital modeling techniques,explore the law of morphological development of childen's skeletal system,so as to provide a reference for the study of children's bone development and digital anatomy.In this study,12 normal boys were selected from 6 age stages(0-6 months,6-12 months,1-3 years old,3-5 years old,5-7 years old,7-10 years old).All patients underwent CT plain scan with a slice thickness of 0.625 mm.The collected CT data was imported into Mimics 19.0 software for three dimensional reconstruction of children's whole body bones.3D printing of children's bone model was used to construct children's bone system.T wo dissected bone specimens were randomly selected and compared with 3D printed models for specific bony landmarks to verify the accuracy of modeling. | Mi Sirong Xie Liang Hu Luying Zhang Feng He Wenyan Liu Guangxing Zhang Zhenwu Yu Huan Zhan Meizhi Liu Yating Sheng Ting Peng Wen Liu Qiangsheng Rao Libing | 2021 | 解剖学杂志2021，44，S01： | 0 |
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