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| 1 | Inhibition of the PIN1-NRF2/GPX4 axis imparts sensitivity to cisplatin in cervical cancer cells显示文摘The incidence of cervical cancer(cC)ranks the fourth in female malignant tumors globally.Chemoresistance is one of the main causes of treatment failure in advanced recurrent CC.Prolyl isomerase 1(PIN1)is overexpressed in a variety of tumors,and is closely associated with the malignant potential of tumor cells,such as transformation,proliferation,invasion and metastasis.In the present study,we demonstrate that cell death induced by suppression of PIN1 could be inhibited by ferrostatin-1(Fer-1)and ferroptosis biomarkers including lactate dehydrogenase(LDH)release,lipid peroxidation and malondialdehyde(MDA)are upregulated by downregulating PIN1.We then discover that abrogation of PIN1 greatly decreases the level of glutathione peroxidase 4(GPX4)and the level of PIN1 is positively correlated with the level of GPX4.Furthermore,the knockdown of PIN1 promotes ferroptosis induced by RSL3.The mechanism involves PIN1 silencing which downregulates GPX4 by decreasing the level of nuclear factor E2-related factor 2(NRF2).Furthermore,overexpression of NRF2 inhibits RSL3-mediated ferroptosis of CC cells when PIN1 is silenced.In addition,our results indicate that cisplatin(DDP)induces ferroptosis,which is restrained by overexpression of PIN1.The PIN1 inhibitor,KPT-6566,promotes the cytotoxic effect of DDP.The present study reveals that PIN1 affects ferroptosis and sensitivity to DDP in CC cells via the NRF2/GPX4 axis,thereby identifying PIN1 as a potential therapeutic target for Cc. | Zheng Zhang Qiangsheng Hu Shuang Ye Libing Xiang 无 | 2022 | Acta Biochimica et Biophysica Sinica2022，54，9： | 4 |
| 2 | Key nodes of the trust transitivity in social Internet of things显示文摘The trustee and the trustor may have no previous interaction. So,intermediate nodes trusted by both the trustor and the trustee are selected to transit trust between them. But only a few intermediate nodes are key nodes which can significantly affect the transitivity of trust. To the best of our knowledge,there are no algorithms for finding key nodes of the trust transitivity. To solve this problem,the concept of trust is presented,and a comprehensive model of the transitivity of trust is provided. Then,the key nodes search( KNS) algorithm is proposed to find out the key nodes of the trust transitivity. The KNS algorithm is verified with three real social network datasets and the results show that the algorithm can find out all the key nodes for each node in directed,weighted,and non-fully connected social Internet of things( SIoT) networks. | Li Wenna Lin Zhiting Sun Libing Xiang Yaqin Wang Pengfei | 2018 | The Journal of China Universities of Posts and Telecommunications2018，25，4： | 0 |
| 3 | Draft Genome of White-blotched River Stingray Provides Novel Clues for Niche Adaptation and Skeleton Formation显示文摘The white-blotched river stingray(Potamotrygon leopoldi)is a cartilaginous fish native to the Xingu River,a tributary of the Amazon River system.As a rare freshwater-dwelling cartilaginous fish in the Potamotrygonidae family in which no member has the genome sequencing information available,P.leopoldi provides the evolutionary details in fish phylogeny,niche adaptation,and skeleton formation.In this study,we present its draft genome of 4.11 Gb comprising 16,227 contigs and 13,238 scaffolds,with contig N50 of 3937 kb and scaffold N50 of 5675 kb in size.Our analysis shows that P.leopoldi is a slow-evolving fish that diverged from elephant sharks about 96 million years ago.Moreover,two gene families related to the immune system(immunoglobulin heavy constant delta genes and T-cell receptor alpha/delta variable genes)exhibit expansion in P.leopoldi only.We also identified the Hox gene clusters in P.leopoldi and discovered that seven Hox genes shared by five representative fish species are missing in P.leopoldi.The RNA sequencing data from P.leopoldi and other three fish species demonstrate that fishes have a more diversified tissue expression spectrum when compared to mammals.Our functional studies suggest that lack of the gc gene encoding vitamin D-binding protein in cartilaginous fishes(both P.leopoldi and Callorhinchus milii)could partly explain the absence of hard bone in their endoskeleton.Overall,this genome resource provides new insights into the niche adaptation,body plan,and skeleton formation of P.leopoldi,as well as the genome evolution in cartilaginous fishes. | Jingqi Zhou Ake Liu Funan He Yunbin Zhang Libing Shen Jun Yu Xiang Zhang | 2023 | Genomics, Proteomics & Bioinformatics2023，21，3： | 0 |
| 4 | Monte Carlo performance study of virtual high performance computing cluster over cloud显示文摘Objective:As a high computation cost discipline,nuclear science and engineering still relies heavily on traditional high performance computing(HPC)clusters.However,the usage of traditional HPC for nuclear science and engineering has been limited due to the poor flexibility,the software compatibility and the poor user interfaces.Virtualized/virtual HPC(vHPC)can mimic an HPC by using a cloud computing platform.In this work,we designed and developed a vHPC system for employment in nuclear engineering.Methods:The system is tested using the computation of the numberπby Monte Carlo and an X-ray digital imaging system simulation.The performance of the vHPC system is compared with that of the traditional HPCs.Results:As the number of the simulated particles increases,the virtual cluster computing time grows propor-tionally.The time used for the simulation of the X-ray imaging was about 21.1 h over a 12 kernels virtual server.Experimental results show that the performance of virtual cluster computing and the actual physical machine is almost the same.Conclusions:From these tests,it is concluded that vHPC is a good alternative for employing in nuclear engineering.The proposed vHPC in this paper will make HPC flexible and easy to deploy. | Libing Zhu Ze Xi Peng Cong Gongyi Yu Yuan Liu Xincheng Xiang Wei Xu Xiangang Wang | 2022 | Radiation Medicine and Protection2022，3，3： | 0 |
| 5 | High-performance fiber strain sensor of carbon nanotube/thermoplastic polyurethane@styrene butadiene styrene with a double percolated structure显示文摘In this work,a high-performance fiber strain sensor is fabricated by constructing a double percolated structure,consisting of carbon nanotube(CNT)/thermoplastic polyurethane(TPU)continuous phase and styrene butadiene styrene(SBS)phase,incompatible with TPU(CNT/TPU@SBS).Compared with other similar fiber strain sensor systems without double percolated structure,the CNT/TPU@SBS sensor achieves a lower percolation threshold(0.38 wt.%)and higher electrical conductivity.The conductivity of 1%-CNT/TPU@SBS(4.12×10^(-3) S·m^(-1))is two orders of magnitude higher than that of 1%-CNT/TPU(3.17×10^(-5) S·m^(-1))at the same CNT loading of 1 wt.%.Due to double percolated structure,the 1%-CNT/TPU@SBS sensor exhibits a wide strain detection range(0.2%-100%)and an ultra-high sensitivity(maximum gauge factor(GF)is 32411 at 100%strain).Besides,the 1%-CNT/TPU@SBS sensor shows a high linearity(R^(2)=0.97)at 0%-20%strain,relatively fast response time(214 ms),and stability(500 loading/unloading cycles).The designed sensor can efficiently monitor physiological signals and movements and identify load distribution after being woven into a sensor array,showing broad application prospects in wearable electronics. | Dong XIANG Libing LIU Xiaoyu CHEN Yuanpeng WU Menghan WANG Jie ZHANG Chunxia ZHAO Hui LI Zhenyu LI Ping WANG Yuntao LI | 2022 | Frontiers of Materials Science2022，16，1： | 0 |
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