|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Rhubarb extract partially improves mucosal integrity in chemotherapy-induced intestinal mucositis显示文摘AIM To investigate the effects of orally gavaged aqueous rhubarb extract(RE) on 5-fluorouracil(5-FU)-induced intestinal mucositis in rats. METHODS Female Dark Agouti rats(n = 8/group) were gavaged daily(1 mL) with water, high-dose RE(HDR; 200 mg/kg) or low-dose RE(LDR; 20mg/kg) for eight days. Intestinal mucositis was induced(day 5) with 5-FU(150 mg/kg) via intraperitoneal injection. Intestinal tissue samples were collected for myeloperoxidase(MPO) activity and histological examination. Xenopus oocytes expressing aquaporin 4 water channels were prepared to examine the effect of aqueous RE on cell volume, indicating a potential mechanism responsible for modulating net fluid absorption and secretion in the gastrointestinal tract. Statistical significance was assumed at P < 0.05 by one-way ANOVA. RESULTS B o d y w e i g h t w a s s i g n i f i c a n t l y r e d u c e d i n r a t s administered 5-FU compared to healthy controls(P < 0.01). Rats administered 5-FU significantly increased intestinal MPO levels(≥ 307%; P < 0.001), compared to healthy controls. However, LDR attenuated this effect in 5-FU treated rats, significantly decreasing ileal MPO activity(by 45%; P < 0.05), as compared to 5-FU controls. 5-FU significantly reduced intestinal mucosal thickness(by ≥ 29% P < 0.001) as compared to healthy controls. LDR significantly increased ileal mucosal thickness in 5-FU treated rats(19%; P < 0.05) relative to 5-FU controls. In xenopus oocytes expressing AQP4 water channels, RE selectively blocked water influx into the cell, induced by a decrease in external osmotic pressure. As water efflux was unaltered by the presence of extracellular RE, the directional flow of water across the epithelial barrier, in the presence of extracellular RE, indicated that RE may alleviate water loss across the epithelial barrier and promote intestinal health in chemotherapy-induced intestinal mucositis.CONCLUSION In summary, low dose RE improves selected parameters of mucosal integrity and reduces ileal inflammation, manifesting from 5-FU-induced intestinal mucositis. | Juliana E Bajic Georgina L Eden Lorrinne S Lampton Ker Y Cheah Kerry A Lymn Jinxin V Pei Andrea J Yool Gordon S Howarth | 2016 | World Journal of Gastroenterology2016，22，37： | 3 |
| 2 | An investigation into thermal comfort in the summer season of Ghadames, Libya 显示文摘 | Ealiwa M A Takia A H Howarth A T | 2001 | Building and Environment2001，36，2： | 1 |
| 3 | Effects on male rats of di-(2-ethylhexyl) phthalate and di-n-hexylphthalate administered alone or in combination显示文摘 | Howarth J A Price S C Dobrota M | 2001 | Toxicol Lett2001，121，1： | 1 |
| 4 | Manufactur- ing energy use in eight OECD countries 显示文摘 | HOWARTH R B SCHIPPER L DUERR P A | 1991 | Energy Economics1991，13，2： | 1 |
| 5 | Methane and the greenhouse-gas footprint of natural gas from shale formations显示文摘 | Howarth R W Santoro R Ingraffea A | 2011 | Climatic Change2011，106，4： | 1 |
| 6 | Discours^based valuation ofecosystem services: Establishing fair outcomes through groupdeliberation显示文摘 | WILSON M A HOWARTH R | 2002 | Ecological Economics2002，41，： | 1 |
| 7 | Performance ofhelical computed tomography in unselected outpatients withsuspected pulmonary embolism 显示文摘 | Perrier A Howarth N Didier D | 2001 | Ann Int Med2001，335，2： | 1 |
| 8 | Venting and leaking of methane from shale gas development: Response to Cathles et al显示文摘 | Howarth R W Santoro R Ingraffea A | 2012 | Climatic Change2012，113，2： | 1 |
| 9 | Catalytic raeemisation of alcohols:applications to enzymatic resolution reactions 显示文摘 | Dinh P M Howarth J A Williams J M J | 1996 | Tetrahedron Letters1996，37，42： | 1 |
| 10 | Human alterations of the global nitrogen cycle: Causes and eonsequences显示文摘 | Vitousek P M Aber J A Howarth R W | 1997 | Ecol Appl1997，，7： | 1 |
| 11 | Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2)显示文摘 | Bentley SD Chater KF Cerdeno-Tarraga AM Challis GL Thomson NR James KD Harris DE Quail MA Kieser H Harper D Bateman A Brown S Chandra G Chen CW Collins M Cronin A Fraser A Goble A Hidalgo J Hornsby T Howarth S Huang CH Kieser T Larke L Murphy L Oliver K O | | 0，，： | 1 |
| 12 | Vitamin E ameliorates the de- cremental effect of paraquat on cardiomyocyte contractility in rats 显示文摘 | Fahim MA Howarth FC Nemmar A | 2013 | PLoS One2013，8，57： | 1 |
| 13 | Effects of epidermal growth factor administration on repair of acetic acid-induced colonic ulcerations in rats显示文摘 | Ribbons K A Howarth G S Ford W D | 1997 | Growth Factors1997，14，23： | 1 |
| 14 | Methane and the greenhouse-gas footprint of natural gas from shale formations 显示文摘 | Howarth R W Santoro R Ingraffea A | 2011 | Climatic Change2011，106，4： | 1 |
| 15 | A radio-sensitive primary osteosarcoma in the lung显示文摘 | Wajstaub S Bezjak A Howarth D | 2011 | Int J Clin Oncol2011，16，1： | 1 |
| 16 | Methane and the Greenhouse-gas Footprint of Natural Gas from Shale Formations显示文摘 | Howarth R W Santoro R Ingrffea A | 2011 | Climatic Change2011，106，4： | 1 |
| 17 | Vitamin E ameliorates the decremental effect of paraquat on cardiomyocyte contractility in rats 显示文摘 | Fahim MA Howarth FC Nemmar A | 2013 | PLoS One2013，8，57： | 1 |
| 18 | Airway Wall Remodelling in Asthma显示文摘 | Redington A E Howarth P H | 1997 | Throax1997，52，4： | 1 |
| 19 | Hydrogen production from hazelnut shell by applying air-blown downdraft gasification technique显示文摘 | Midilli A Dogru M Howarth C R | 2001 | Intemational Journal of Hydrogen Energy2001，26，1： | 1 |
| 20 | Catalytic racemisation of alcohols: applications to enzymatic resolution reactions显示文摘 | DINH P M HOWARTH J A HUDNOTT A R | 1996 | TelrahedronLetters1996，37，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员