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| 1 | Long non-coding RNAs in cancer显示文摘Long non-coding RNAs (lncRNAs) are a group of RNA transcripts that exceed 200 nt in length, yet lack significant open reading frames (ORFs) [1–4]. In contrast | GONG ZhaoJian ZHANG ShanShan ZHANG WenLing HUANG HongBin LI Qiao DENG Hao MA Jian ZHOU Ming XIANG Juan Juan WU MingHua LI XiaYu XIONG Wei LI XiaoLing LI Yong ZENG ZhaoYang LI GuiYuan | 2012 | Science China(Life Sciences)2012，55，12： | 22 |
| 2 | Nasopharyngeal carcinoma:Advances in genomics and molecular genetics显示文摘Nasopharyngeal carcinoma (NPC) is a squamous-cell carcinoma that arises in the epithelial lining of the nasopharynx [1]. This neoplasm has a notable ethnic and geographic distribution,being of high prevalence in southern China but rare in other parts of the world [2]. | ZENG ZhaoYang HUANG HongBin ZHANG WenLing XIANC Bo ZHOU Ming ZHOU YanHong MA Jian YI Mei LI XiaYu LI XiaoLing XIONG Wei LI GuiYuan | 2011 | Science China(Life Sciences)2011，54，10： | 13 |
| 3 | Overexpressed miR-9 promotes tumor metastasis via targeting E-cadherin in serous ovarian cancer显示文摘MicroRNAs (miRNAs ) 玩在在各种各样的癌症的发展和前进的关键角色。不正常的 miR-9 表示仍然保持模糊,并且卵巢的癌症的变形前进上的一致都没被到达。在这研究,从生物信息学分析的结果证明 E-cadherin mRNA 的 3-UTR 被 miR-9 直接调整。酶记者试金结果证实 miR-9 能直接指向这 3-UTR。在卵巢的癌症织物的 miR-9 和 E-cadherin 表示被 qRT-PCR 确定。移植和侵略被在 SKOV3 和 A2780 愈合弯屈和 Transwell 系统试金检测。qRT-PCR 和西方的污点被执行检测上皮 ? 间充质的联系转变的 mRNA 和蛋白质。Immunofluorescence 技术被用来分析表示和 E-cadherin, N-cadherin,和 vimentin 的 subcellular 本地化。结果证明 miR-9 经常与配对的主要的相比是在变形浆液的卵巢的癌症织物的 upregulated。miR-9 的 Upregulation 能 downregulate E-cadherin 的表示但是 upregulate 间充质的标记(N-cadherin 和 vimentin ) 的表示。miR-9 的 Overexpression 能在卵巢的癌症支持房间移植和侵略,并且这些进程能有效地经由 miR-9 禁止者被禁止。因此,我们的学习证明 miR-9 可以经由指向 E-cadherin 和一条新奇潜在的治疗学的途径控制卵巢的癌症的转移支持卵巢的癌症转移。 | Bo Zhou Hongbin Xu Meng Xia Chaoyang Sun Na Li Ensong Guo Lili Guo Wanying Shan Hao Lu Yifan Wu Yuan Li Degui Yang Danhui Weng Li Meng Junbo Hu Ding Ma Gang Chen Kezhen Li | 2017 | Frontiers of Medicine2017，11，2： | 10 |
| 4 | Tectonics and Petroleum Potential of the East China Sea Shelf Rift Basin显示文摘There are two Cenozoic sedimentary basins in the East China Sea. They are the East China Sea shelf basin and the Okinawa Trough basin. The former can be divided into a western and an eastern rift region. The development of the shelf basin underwent continental-margin fault depression, post-rift and then tectonic inversion stages. Available exploration results show that the distribution of source rocks is controlled by the basin architecture and its tectonic evolution. In the Xihu depression, mudstones and coals are the main source rocks. The eastern rift region has good geological conditions for the formation of large oil and gas fields. | LI Peilian HOU Hongbin MA Huifu | 2000 | Acta Geologica Sinica(English Edition)2000，74，3： | 9 |
| 5 | Green fluorescent protein (GFP) transgenic pig produced by somatic cell nuclear transfer显示文摘Transgenic somatic cell nuclear transfer is a very promising route for producing transgenic farm ani-mals. Research on GFP transgenic pigs can provide useful information for breeding transgenic pigs, human disease models and human organ xenotransplantation. In this study, a liposomal transfection system was screened and transgenic embryos were reconstructed by nuclear transfer of GFP positive cells into enucleated in vitro matured oocytes. The development of reconstructed embryos both in vitro and in vivo was observed, and GFP expression was determined. The results showed that porcine fe-tal-derived fibroblast cells cultured with 4.0 μL/mL liposome and 1.6 μg/mL plasmid DNA for 6 h re-sulted in the highest transfection rate (3.6%). The percentage of GFP reconstructed embryos that de-veloped in vitro to the blastocyst stage was 10%. Of those the GFP positive percentage was 48%. Re-constructed transgenic embryos were transferred to 10 recipients. 5 of them were pregnant, and 3 de-livered 6 cloned piglets in which 4 piglets were transgenic for the GFP as verified by both GFP protein expression and GFP DNA sequence analysis. The percentage of reconstructed embryos that resulted in cloned piglets was 1.0%; while the percentage of piglets that were transgenic was 0.7%. This is the first group of transgenic cloned pigs born in China, marking a great progress in Chinese transgenic cloned pig research. | LIU ZhongHua SONG Jun WANG ZhenKun TIAN JiangTian KONG QingRan ZHENG Zhong YIN Zhi GAO Li MA HaiKun SUN Shuang LI YuTian WANG HongBin R S PRATHER | 2008 | Chinese Science Bulletin2008，53，7： | 8 |
| 6 | Cooling mechanism of embankment with block stone interlayer in Qinghai-Tibet railway显示文摘In order to study the cooling mechanism of embankment with block stone interlayer under open and closed conditions,an experimental railway section was built and data within one freeze-thaw cycle were collected. The results explain well the cooling mechanism of embankment with block stone interlayer. Under the open condition in cold seasons,the enforced convection effect occurs within block stone interlayer when the wind speed is large;however,the weak air convection occurs within the block stone interlayer near the bottom of the embankment when the wind speed is slow. Under the open condition in warm seasons,heat conduc-tion occurs within block stone interlayer due to the change in wind speed and di-rection. Under the closed condition,however,the enforced convection within block stone interlayer is so weak that heat conduction is dominant in the whole year be-cause wind is blocked. Therefore,the cooling effect of embankment with a block stone interlayer to the soil beneath it is produced by enforced convection and weak free air convection;both its process and the cooling intensity are controlled by the local wind speed and direction. Because of the difference in the cooling effects,the soil temperature beneath the embankment has a temperature difference of 2℃―4℃ between the open and closed conditions. | WU QingBai CHENG HongBin JIANG GuanLi MA Wei LIU YongZhi | 2007 | Science China(Technological Sciences)2007，50，3： | 8 |
| 7 | Novel MWCNT-Support for Co-Mo Sulfide Catalyst in HDS of Thiophene and HDN of Pyrrole显示文摘与自制的多围的碳 nanotubes (MWCNT,在以后的文本作为 CNT 简化了) 作为支持,支持 CNT 的 Co-Mo-S 催化剂,作为 x%( 集体百分比) 表示了 MoiCoj/CNTs,被准备。他们为 thiophene hydrodesulfurization (HDS ) 和吡咯 hydrodenitrification (HDN ) 的催化表演反应被学习,并且由交流与参比系统相比支持了。在以 1.5 MPa , 613 K , C4H4S/H2=3.7/96.3 (摩尔比率)和 GHSV 的反应状况的 7.24%Mo3Co1/CNTs 催化剂上?? 8000 mlSTp/( g-cat.h ), thiophene 的特定的 HDS 活动到达了 3.29 mmolc4H4s/( s-molMo ),它1.32倍高于那( 2.49 mmolc4H4s/( s-molMo ))基于交流的对应物,并且2.47倍高于那( 1.33 mmolc4H4s/( s-molMo ))交流与各自的最佳的 装载Mo3Co1 支持的催化剂总计, 16.90%Mo3Co1/AC 。类似的反应化学药品行为也在吡咯 HDN 的情况中被观察。当催化剂载体为 thiophene HDS 或吡咯 HDN 反应在明显的激活精力引起了小变化,它试验性地代替交流用 CNT 被发现那,但是在催化联盟者的集中导致了重要增加在工作催化剂的表面的活跃瞬间种类(瞬间(4+))。在另一方面, H2-TPD 大小表明支持 CNT 的催化剂能 reversibly 在从室温到大约 673 K 的温度在气压下面吸附氢的更大的数量。这个唯一的特征将帮助在工作催化剂的表面与活跃 hydrogen-adspecies 的更高静止状态的集中产生微型环境。上面提及的两个因素对增加 thiophene HDS 和吡咯 HDN 反应的率有利。给词调音:多围的碳 nanotube;Mo-Co-S/CNTs 催化剂;thiophene hydrodesulphurization;吡咯 | Kunming Dong Xiaoming Ma Hongbin Zhang Guodong Lin | 2006 | Journal of Natural Gas Chemistry2006，15，1： | 6 |
| 8 | Effects of Er on the microstructure and properties of AZ31 magnesium alloy prepared via the EMS process显示文摘The effects of small amounts of the rare-earth element erbium on the microstructure and the mechanical properties of AZ31 magnesium alloy via the electromagnetic stirring(EMS) process have been studied.It has been shown that AZ31-Er alloys are mainly composed of α-Mg solid solution and β-Mg17Al12 phases.When the Er content reaches 0.12 wt.%,the characteristic peaks of Al2Er can be observed.The micro-structure is obviously refined and the tensile strength of the AZ31-based alloy at ambient temperature is significantly improved by contents of 0.03 wt.% Er,especially the elongation(δ=19%).More addition of Er obviously decreases the tensile strength and elongation of the AZ31-based alloy because of the grain coarsening and the reduction of β-Mg17Al12 phases. | MA Yutao,ZHANG Xingguo,LIU Hongbin,and MENG Linggang School of Materials Science and Engineering,Dalian University of Technology,Dalian 116023,China | 2010 | Rare Metals2010，29，4： | 6 |
| 9 | 20 Years Advances in Preparation of Potassium Salts from Potassic Rocks:A Review显示文摘Long-term research on key techniques of clean utilization of potassic rocks from over twenty localities has been performed to settle the shortage of soluble potassium resources in China. The results show that K-feldspar as the principal mineral enriched in potassium could be decomposed in the media of Ca(OH)_2, NaOH, KOH-H_2O solution via hydrothermal treatment, into tobermorite, hydroxylcancrinite, and kalsilite respectively. By further processing, these compounds are feasible for being as slow-release carrier of potassium nitrate, extracting alumina, and preparing farm-oriented fertilizers of potassium sulphate and nitrate. Correspondingly, the filtrate is KOH,(Na, K)_2SiO_3, and K_2SiO_3 solution, from which potassium carbonate, sulphate, nitrate, and phosphate could be easily fabricated. As NaO H and KOH are recycled in the processing chains by causticizing sodium and/or potassium metasilicate solutions, the hydrothermal alkaline techniques as developed in this research have several advantages as lower consumption of disposable mineral resources and energy, maximized utilization of potassic mineral resources, as well as clean productions etc. Based on the approaches presented in this paper, the technical system of efficiently utilizing insoluble potassium resources has been established. The hydrothermal alkaline methods are feasible to be industrialized on a large scale, thus resulting in decreasing imports of potash fertilizers, improving the pattern of potassium fertilizer consumption, and enhancing the supplying guarantee of potassium resource in China. | MA Hongwen YANG Jing SU Shuangqing LIU Meitang ZHENG Hong WANG Yingbin QI Hongbin ZHANG Pan YAO Wengui | 2015 | Acta Geologica Sinica(English Edition)2015，89，6： | 5 |
| 10 | Comparison of Two Air Pollution Episodes over Northeast China in Winter 2016/17 Using Ground-Based Lidar显示文摘This study analyzes and compares aerosol properties and meteorological conditions during two air pollution episodes in 19–22(E1) and 25–26(E2) December 2016 in Northeast China. The visibility, particulate matter(PM) mass concentration, and surface meteorological observations were examined, together with the planetary boundary layer(PBL) properties and vertical profiles of aerosol extinction coefficient and volume depolarization ratio that were measured by a ground-based lidar in Shenyang of Liaoning Province, China during December 2016–January 2017.Results suggest that the low PBL height led to poor pollution dilution in E1, while the high PBL accompanied by low visibility in E2 might have been due to cross-regional and vertical air transmission. The PM mass concentration decreased as the PBL height increased in E1 while these two variables were positively correlated in E2. The enhanced winds in E2 diffused the pollutants and contributed largely to the aerosol transport. Strong temperature inversion in E1 resulted in increased PM2.5 and PM10 concentrations, and the winds in E2 favoured the southwesterly transport of aerosols from the North China Plain into the region surrounding Shenyang. The large extinction coefficient was partially attributed to the local pollution under the low PBL with high ground-surface PM mass concentrations in E1,whereas the cross-regional transport of aerosols within a high PBL and the low PM mass concentration near the ground in E2 were associated with severe aerosol extinction at high altitudes. These results may facilitate better understanding of the vertical distribution of aerosol properties during winter pollution events in Northeast China. | Yanjun MA Hujia ZHAO Yunsheng DONG Huizheng CHE Xiaoxiao LI Ye HONG Xiaolan LI Hongbin YANG Yuche LIU Yangfeng WANG Ningwei LIU Cuiyan SUN | 2018 | Journal of Meteorological Research2018，32，2： | 5 |
| 11 | SARS-CoV-2 ORF10 suppresses the antiviral innate immune response by degrading MAVS through mitophagy显示文摘The global coronavirus disease 2019(COVID-19)pandemic caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has caused severe morbidity and mortality in humans.It is urgent to understand the function of viral genes.However,the function of open reading frame 10(ORF10),which is uniquely expressed by SARS-CoV-2,remains unclear.In this study,we showed that overexpression of ORF10 markedly suppressed the expression of type I interferon(IFN-I)genes and IFN-stimulated genes.Then,mitochondrial antiviral signaling protein(MAVS)was identified as the target via which ORF10 suppresses the IFN-I signaling pathway,and MAVS was found to be degraded through the ORF10-induced autophagy pathway.Furthermore,overexpression of ORF10 promoted the accumulation of LC3 in mitochondria and induced mitophagy.Mechanistically,ORF10 was translocated to mitochondria by interacting with the mitophagy receptor Nip3-like protein X(NIX)and induced mitophagy through its interaction with both NIX and LC3B.Moreover,knockdown of NIX expression blocked mitophagy activation,MAVS degradation,and IFN-I signaling pathway inhibition by ORF10.Consistent with our observations,in the context of SARS-CoV-2 infection,ORF10 inhibited MAVS expression and facilitated viral replication.In brief,our results reveal a novel mechanism by which SARS-CoV-2 inhibits the innate immune response;that is,ORF10 induces mitophagy-mediated MAVS degradation by binding to NIX. | Xingyu Li Peili Hou Wenqing Ma Xuefeng Wang Hongmei Wang Zhangping Yu Huasong Chang Tiecheng Wang Song Jin Xue Wang Wenqi Wang Yudong Zhao Yong Zhao Chunqing Xu Xiaomei Ma Yuwei Gao Hongbin He | 2022 | Cellular & Molecular Immunology2022，19，1： | 4 |
| 12 | Luminescence tuning of Ce^3+,Pr^3+activated(Y,Gd)AGG system by band gap engineering and energy transfer显示文摘Tuning of phosphor luminescence properties,including the emission energy/intensity and thermal stability,is an important way to develop superior luminescent materials for diverse applications.In this work,we discuss the effect of band gap engineering and energy transfer on the luminescence properties of Ce^3+or Pr^3+doped(Y,Gd)AGG systems,and analyze the underlying reasons for their different phenomena.By using VUV-UV excitation spectra and constructing VRBE schemes,the changes of host band structure,5 d excited level energies and emission thermal stability of Ce^3+and Pr^3+with the incorporation of Gd^3+ions were studied.In addition,the energy transfer dynamics was also investigated in terms of the luminescence decay curves.This work demonstrates a way to tune phosphor luminescence properties by combining band gap engineering and energy transfer tailoring and provides an inspiring discussion on the different results of Ce^3+doping on the Ce^3+and Pr^3+emissions. | Yiyi Ou Weijie Zhou Fengkai Ma Chunmeng Liu Rongfu Zhou Fang Su Yan Huang Pieter Dorenbos Hongbin Liang | 2020 | Journal of Rare Earths2020，38，5： | 3 |
| 13 | Influence of nano-diamond content on the microstructure,mechanical and thermal properties of the ZK60 composites显示文摘The effect of nano diamond(ND)content on the microstructure,mechanical properties,and thermal conductivity of ZK60+x(x=0,0.05,0.1,0.15,0.2 wt.%)ND composites were investigated.The microstructures of ND/ZK60 composites were observed,which indicated that the nanoscale MgZn_(2) and ND particles distributed evenly in theα-Mg matrix.The tensile yield strength(TYS)and compressive yield strength(CYS)of the composites first increased remarkably and then decreased with further increasing the ND content.Due to the surface area of the matrix-diamond interface increased and the grains sizes of composites decreased with the amount of ND increase,which cause the coefficient of thermal expansion(CTE)of the composites reduced significantly.Meanwhile,the thermal conductivity of the composite material decreases from 129 W·m^(−1)·K^(−1) to 116 W·m^(−1)·K^(−1) with the content of ND increasing from 0.05%to 2.0%.The thermal conductivity of the composites increases to the maximum and then decrease with the increase of temperature(in temperature range of 273-573 K).The ZK60+0.05 ND showed superior mechanical and thermal conductivity property,TYS of 343.97 MPa,CYS of 341.74 MPa,elongation of 15.71%,CTE of 7.3×10^(−6)K^(−1),and thermal conductivity of 129 W·m^(−1)·K^(−1) at room temperature.It is demonstrated that the ND content has an obvious influence on the microstructure,mechanical properties,and thermal conductivity of ND/ZK60 composites. | Hongbin Ma Jinhui Wang Hongyu Wang Ningning Dong Junwei Zhang Peipeng Jin Yong Peng | 2022 | Journal of Magnesium and Alloys2022，10，2： | 3 |
| 14 | Modeling plants with sensor data显示文摘Sensor data, typically images and laser data, are essential to modeling real plants. However, due to the complex geometry of the plants, the measurement data are generally limited, thereby bringing great difficulties in classifying and constructing plant organs, comprising leaves and branches. The paper presents an approach to modeling plants with the sensor data by detecting reliable sharp features, i.e. the leaf apexes of the plants with leaves and the branch tips of the plants without leaves, on volumes recovered from the raw data. The extracted features provide good estimations of correct positions of the organs. Thereafter, the leaves are reconstructed separately by simply fitting and optimizing a generic leaf model. One advantage of the method is that it involves limited manual intervention. For plants without leaves, we develop an efficient strategy for decomposition-based skeletonization by using the tip features to reconstruct the 3D models from noisy laser data. Experiments show that the sharp feature detection algorithm is effective, and the proposed plant modeling approach is competent in constructing realistic models with sensor data. | MA Wei XIANG Bo ZHA HongBin LIU Jia ZHANG XiaoPeng | 2009 | Science in China(Series F)2009，52，3： | 3 |
| 15 | Effect of Thermal Cycles on the Thermal Expansion Behavior of T700 Carbon Fiber Bundles显示文摘 | GENG Guohang MA Xiaofei GENG Hongbin WU Yiyong | 2018 | Chemical Research in Chinese Universities2018，34，3： | 3 |
| 16 | Adaptive Control of Discrete-time Nonlinear Systems Using ITF-ORVFL显示文摘Random vector functional ink(RVFL)networks belong to a class of single hidden layer neural networks in which some parameters are randomly selected.Their network structure in which contains the direct links between inputs and outputs is unique,and stability analysis and real-time performance are two difficulties of the control systems based on neural networks.In this paper,combining the advantages of RVFL and the ideas of online sequential extreme learning machine(OS-ELM)and initial-training-free online extreme learning machine(ITFOELM),a novel online learning algorithm which is named as initial-training-free online random vector functional link algo rithm(ITF-ORVFL)is investigated for training RVFL.The link vector of RVFL network can be analytically determined based on sequentially arriving data by ITF-ORVFL with a high learning speed,and the stability for nonlinear systems based on this learning algorithm is analyzed.The experiment results indicate that the proposed ITF-ORVFL is effective in coping with nonparametric uncertainty. | Xiaofei Zhang Hongbin Ma Wenchao Zuo Man Luo | 2022 | IEEE/CAA Journal of Automatica Sinica2022，9，3： | 3 |
| 17 | Abnormally High Expression of BAFF on T Lymphocytes from Lung Cancer- associated Pleural Effusions and Its Potent Anti-tumor Effect显示文摘在现在的学习,激活从恶意的肋膜的流出( MPE )在 T 淋巴细胞上属于肿瘤坏死因素家庭( BAFF )和它的受体( BAFF-R 和 TACI )的因素的 B 房间的表情被排序的激活荧光的房间( FACS )检验分析,并且与那些相比在从非恶意的肋膜的流出( NMPE )和健康控制的 T 淋巴细胞上。它被发现那 CD3 积极 T 淋巴细胞(包括 CD25 和 CD69 积极房间的 CD4 , CD8 ,和部分)在肺的 MPE ,癌症高度并且一致地表示了 BAFF 分子,当 BAFF 的高表情能仅仅在植物凝集素(公众房产管理局)或白介素被发现时,( IL-2 ) 2 从 NMPE 或健康控制导致了 T 淋巴细胞。这些结果与从由即时 PCR 的 BAFF mRNA 察觉的结果一致。另外,当 TACI 的表达式在 CD4^+ T 房间上被增加,但是减少时,从 MPE 的 T 淋巴细胞显著地从 NMPE 或健康控制比那些表示了更多的 BAFF-R,在 CD8^+ T 房间上什么时候与控制相比。Annexin/PI 试金建议 recombinant 人 BAFF (rhBAFF ) 能从 MPE 支持 T 淋巴细胞的幸存率,当圈套受体 TACI-Fc 熔化蛋白质能支持 T 淋巴细胞的 apoptosis 率时。在 ELISA 试金检测的上层清液的 Cytokines 显示出那 rhBAFF 能显著地起来在像的 TACI-Fc-treated 组在 vitro,和 IFN-gamma 水平调整 IFN-gamma 的分泌物控制组的。所有这些结果显示从 MPE 的 T 淋巴细胞上的 BAFF 的反常地高的表示可以起反肿瘤效果的一个作用。 | Haiyan XU Xiaozhou HE Yibei ZHU Tiangzan YAN Hongbin MA Xueguang ZHANG | 2007 | Acta Biochimica et Biophysica Sinica2007，39，12： | 3 |
| 18 | IAP's Solar-Powered Unmanned Surface Vehicle Actively Passes through the Center of typhoon Sinlaku(2020)显示文摘The solar-powered marine unmanned surface vehicle(USV) developed by the USV team of the Institute of Atmospheric Physics is a rugged, long-duration, and autonomous navigation vessel designed for the collection of longrange, continuous, real-time, meteorological and oceanographic measurements, especially under extreme sea conditions(sea state 6–7). These solar-powered USVs completed a long-term continuous navigation observation test over 26 days.During this time, they coordinated double-USV observations and actively navigated into the path of Typhoon Sinlaku(2020) before collecting data very close to its center during the 2020 USV South China Sea Typhoon Observation Experiment. Detailed high temporal resolution(1 min) real-time observations collected by the USV on the typhoon were used for operational typhoon forecasting and warning for the first time. As a mobile meteorological and oceanographic observation station capable of reliable, automated deployment, data collection, and transmission, such solar-powered USVs can replace traditional observation platforms to provide valuable real-time data for research, forecasting, and early warnings for potential marine meteorological disasters. | Hongbin CHEN Jun LI Wenying HE Shuqing MA Yingzhi WEI Jidong PAN Yu ZHAO Xuefen ZHANG Shuzhen HU | 2021 | Advances in Atmospheric Sciences2021，38，4： | 2 |
| 19 | Surveillance of emerging infectious diseases for biosecurity显示文摘Emerging infectious diseases, such as COVID-19, continue to pose significant threats to human beings and their surroundings. In addition, biological warfare, bioterrorism, biological accidents, and harmful consequences arising from dual-use biotechnology also pose a challenge for global biosecurity. Improving the early surveillance capabilities is necessary for building a common biosecurity shield for the global community of health for all. Furthermore, surveillance could provide early warning and situational awareness of biosecurity risks. However, current surveillance systems face enormous challenges, including technical shortages, fragmented management, and limited international cooperation. Detecting emerging biological risks caused by unknown or novel pathogens is of particular concern. Surveillance systems must be enhanced to effectively mitigate biosecurity risks. Thus, a global strategy of meaningful cooperation based on efficient integration of surveillance at all levels, including interdisciplinary integration of techniques and interdepartmental integration for effective management, is urgently needed. In this paper, we review the biosecurity risks by analyzing potential factors at all levels globally. In addition to describing biosecurity risks and their impact on global security, we also focus on analyzing the challenges to traditional surveillance and propose suggestions on how to integrate current technologies and resources to conduct effective global surveillance. | Rongzhang Hao Yuqi Liu Wanzhu Shen Rongtao Zhao Bo Jiang Hongbin Song Muyang Yan Hui Ma | 2022 | Science China(Life Sciences)2022，65，8： | 2 |
| 20 | Discovery and identification of EIF2AK2 as a direct key target of berberine for anti-inflammatory effects显示文摘Using chemoproteomic techniques,we first identified EIF2AK2,eEF1A1,PRDX3 and VPS4B as direct targets of berberine(BBR)for its synergistically anti-inflammatory effects.Of them,BBR has the strongest affinity with EIF2AK2 via two ionic bonds,and regulates several key inflammatory pathways through EIF2AK2,indicating the dominant role of EIF2AK2.Also,BBR could subtly inhibit the dimerization of EIF2AK2,rather than its enzyme activity,to selectively modulate its downstream pathways including JNK,NF-κB,AKT and NLRP3,with an advantage of good safety profile.In EIF2AK2 gene knockdown mice,the inhibitory IL-1β,IL-6,IL-18 and TNF-a secretion of BBR was obviously attenuated,confirming an EIF2AK2-dependent anti-inflammatory efficacy.The results highlight the BBR's network mechanism on anti-inflammatory effects in which EIF2AK2 is a key target,and inhibition of EIF2AK2 dimerization has a potential to be a therapeutic strategy against inflammationrelated disorders. | Wei Wei Qingxuan Zeng Yan Wang Xixi Guo Tianyun Fan Yinghong Li Hongbin Deng Liping Zhao Xintong Zhang Yonghua Liu Yulong Shi Jingyang Zhu Xican Ma Yanxiang Wang Jiandong Jiang Danqing Song | 2023 | Acta Pharmaceutica Sinica B2023，13，5： | 2 |
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