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| 1 | Tumor-secreted miR-214 induces regulatory T cells: a major link between immune evasion and tumor growth显示文摘 | Yuan Yin Xing Cai Xi Chen Hongwei Liang Yujing Zhang Jing Li Zuoyun Wang Xiulan Chen Wen Zhang Seiji Yokoyama Cheng Wang Liang Li Limin Li Dongxia Hou Lei Dong Tao Xu Takachika Hiroi Fuquan Yang Hongbin Ji Junfeng Zhang Ke Zen Chen-Yu Zhang | 2014 | Cell Research2014，24，10： | 33 |
| 2 | Types,Characteristics and Significances of Migrating Pathways of Gas-bearing Fluids in the Shenhu Area,Northern Continental Slope of the South China Sea显示文摘The first marine gas hydrate expedition in China has been conducted by Guangzhou Marine Geological Survey in the Shenhu Area, northern continental slope of the South China Sea. Previous study has analyzed the P-T conditions, geophysical anomalies and saturation calculations of these gas hydrates, but has not documented in detail the migration of gas-bearing fluids in the study area. Based on the interpretations of 2D/3D seismic data, this work identified two types of migration pathways for gas-bearing fluids in the Shenhu area, i.e., vertical and lateral pathways. The vertical pathways(largescale faults, gas chimneys and mud diapirs) presented as steep seismic reflection anomalies, which could be traced downward to the Eocene source rocks and may penetrate into the Late Miocene strata. The deeper gases/fluids might be allowed migrating into the shallower strata through these vertical conduits. However, the distributions showed distinct differences between these pathways. Large-scale faults developed only in the north and northeast of the Shenhu area, while in the drilling area gas chimneys were the sole vertical migration pathways. Since the Pliocene, normal faults, detachment faults and favorable sediments have constituted the lateral pathways in the Shenhu gas hydrate drilling area. Although these lateral pathways were connected with gas chimneys, they exerted different effects on hydrate formation and accumulation. Gas-bearing fluids migrated upward along gas chimneys might further migrate laterally because of the normal faults, thereby enlarging the range of the chimneys. Linking gas chimneys with the seafloor, the detachment faults might act as conduits for escaping gases/fluids. Re-deposited sediments developed at the early stage of the Quaternary were located within the gas hydrate stability zone, so hydrates would be enriched in these favorable sediments. Compared with the migration pathways(large-scale faults and mud diapirs) in the LW3-1 deep-sea oil/gas field, the migration efficiency of the vertical pathways(composed of gas chimneys) in the gas hydrate drilling area might be relatively low. Description and qualitative discrimination of migration pathways in the Shenhu gas hydrate drilling area are helpful to further understand the relationship between good-quality deep source rocks and shallow, mainly biogenicallyproduced, hydrates. As the main source rocks of the Baiyun sag, lacustrine mudstones in the Wenchang and Enping Formations may provide thermogenic methane. Gas chimneys with relatively low migration efficiency created the vertical pathways. Caused by the Dongsha tectonic movement, the release of overpressured fluids might reduce the vertical migration rates of the thermogenic methane. The thick bathyal/abyssal fine-grained sediments since the Late Miocene provided migration media with low permeability. These preconditions may cause carbon isotopic fractionation ofthermogenic methane during long-distance vertical migrations. Therefore, although geochemical analyses indicate that the methane forming gas hydrate in the Shenhu area was mainly produced biogenically, or was mixed methane primarily of microbial origin, thermogenic methane still contribute significantly. | SU Ming SHA Zhibin ZHANG Cuimei WANG Hongbin WU Nengyou YANG Rui LIANG Jinqiang QIAO Shaohua CONG Xiaorong LIU Jie | 2017 | Acta Geologica Sinica(English Edition)2017，91，1： | 16 |
| 3 | Controlling factors for gas hydrate occurrence in Shenhu area on the northern slope of the South China Sea显示文摘Temperature and pressure on seafloor of the northern slope in the South China Sea are suitable for gas hydrate formation, but bottom simulation reflector (BSR), an indication of gas hydrate occurrence, only occurred in limited areas of the slope. Drillings in the BSR-distributed area (the District S) on the northern slope of the South China Sea suggested that gas hydrate only occurred at Sites SH2, SH3, and SH7 with high saturation (up to 20%-40%), and there is no hydrate at Sites SH1 and SH5 although the distance between SH1 to SH3 is only 500m. In this paper, we investigated seafloor gradient, fault development, temperature, and pressure in the District S on the northern slope of the South China Sea to understand the possible factors con- trolling BSR distribution and gas hydrate occurrence. The District S is a structurally fractured continental slope zone and its seafloor gradient varied greatly. The BSR-occurred areas have an average gradient of 19.89×10 2 whereas the BSR-free zone has the average gradient of 10.57×10 2 . The calculated relative structural intensities from fault densities and displacements show that the BSR-distributed areas tend to occur in the areas with a moderately high structural intensity, where faults frequently developed close to the seafloor that are possibly favored for lateral migration of gases. On the basis of temperatures and pressures at drilling sites, hydrate-occurred Sites SH2, SH3, and SH7 are located within the thermodynamically stable area for methane hydrate, and hydrate-absent Sites SH1 and SH5 are out of the thermodynamically stable area for methane hydrate formation, suggesting that both BSR and the thermodynamic stability are necessary for hydrate occurrence in the subsurface. | WANG HongBin YANG ShengXiong WU NengYou ZHANG GuangXue LIANG JinQiang CHEN DuoFu | 2013 | Science China Earth Sciences2013，56，4： | 10 |
| 4 | Biological mechanism of controlling cotton aphid (Homoptera: aphididae) by the marginal alfalfa zone surrounding cotton field显示文摘At the beginning stage of cotton aphids (Aphis gossypii Glover) invading the cotton field, large numbers of insects have accumulated in the marginal alfalfa (Medicago sativa L.) zone surrounding it. They are 6.94 times (excluded natural enemies) as many as the aphids in cotton field. Most of these insects are Therioaphid maculata (Buckton), and occur in fields 10-15 d earlier than cotton aphids. Consequently, abundant natural enemies have bred in alfalfa zone when cotton aphids increase rapidly in cotton fields in the middle of June in Xinhe County, Xinjiang Autonomous Region. The total number of the major natural enemies, including Coccinellids, Chrysopids and Syphid flies in alfalfa zone, is 13.65 times that in cotton field within the same acreage of fields. At this period, it is very effective to force the natural enemies from the alfalfa zone into the nearby cotton field to control the rapid increase of cotton aphid population by cutting the alfalfa stands. | ZHANG Runzhi LIANG Hongbin TIAN Changyan ZHANG Guangxue | 2000 | Chinese Science Bulletin2000，45，4： | 9 |
| 5 | PI3K/Akt/mTOR signaling orchestrates the phenotypic transition and chemo-resistance of small cell lung cancer显示文摘Small cell lung cancer(SCLC)is a phenotypically heterogeneous disease with an extremely poor prognosis,which is mainly attributed to the rapid development of resistance to chemotherapy.However,the relation between the growth phenotypes and chemo-resistance of SCLC remains largely unclear.Through comprehensive bioinformatic analyses,we found that the heterogeneity of SCLC phenotype was significantly associated with different sensitivity to chemotherapy.Adherent or semiadherent SCLC cells were enriched with activation of the PI3K/Akt/mTOR pathway and were highly chemoresistant.Mechanistically,activation of the PI3K/Akt/mTOR pathway promotes the phenotypic transition from suspension to adhesion growth pattern and confers SCLC cells with chemo-resistance.Such chemo-resistance could be largely overcome by combining chemotherapy with PI3K/Akt/mTOR pathway inhibitors.Our findings support that the PI3K/Akt/mTOR pathway plays an important role in SCLC phenotype transition and chemo-resistance,which holds important clinical implications for improving SCLC treatment. | Xuefeng Li Cheng Li Chenchen Guo Qiqi Zhao Jiayu Cao Hsin-Yi Huang Meiting Yue Yun Xue Yujuan Jin Liang Hu Hongbin Ji | 2021 | Journal of Genetics and Genomics2021，48，7： | 5 |
| 6 | Microglia modulation with 1070-nm light attenuates Aβ burden and cognitive impairment in Alzheimer’s disease mouse model显示文摘Photobiomodulation,by utilizing low-power light in the visible and near-infrared spectra to trigger biological responses in cells and tissues,has been considered as a possible therapeutic strategy for Alzheimer’s disease(AD),while its specific mechanisms have remained elusive.Here,we demonstrate that cognitive and memory impairment in an AD mouse model can be ameliorated by 1070-nm light via reducing cerebralβ-amyloid(Aβ)burden,the hallmark of AD.The glial cells,including microglia and astrocytes,play important roles in Aβclearance.Our results show that 1070-nm light pulsed at 10 Hz triggers microglia rather than astrocyte responses in AD mice.The 1070-nm lightinduced microglia responses with alteration in morphology and increased colocalization with Aβare sufficient to reduce Aβload in AD mice.Moreover,1070-nm light pulsed at 10 Hz can reduce perivascular microglia and promote angiogenesis to further enhance Aβclearance.Our study confirms the important roles of microglia and cerebral vessels in the use of 1070-nm light for the treatment of AD mice and provides a framework for developing a novel therapeutic approach for AD. | Lechan Tao Qi Liu Fuli Zhang Yuting Fu Xi Zhu Xiaofu Weng Hongbin Han Yong Huang Yuanzhen Suo Liang Chen Xiaoling Gao Xunbin Wei | 2021 | Light(Science & Applications)2021，10，10： | 4 |
| 7 | Luminescence tuning of Ce^3+,Pr^3+activated(Y,Gd)AGG system by band gap engineering and energy transfer显示文摘Tuning of phosphor luminescence properties,including the emission energy/intensity and thermal stability,is an important way to develop superior luminescent materials for diverse applications.In this work,we discuss the effect of band gap engineering and energy transfer on the luminescence properties of Ce^3+or Pr^3+doped(Y,Gd)AGG systems,and analyze the underlying reasons for their different phenomena.By using VUV-UV excitation spectra and constructing VRBE schemes,the changes of host band structure,5 d excited level energies and emission thermal stability of Ce^3+and Pr^3+with the incorporation of Gd^3+ions were studied.In addition,the energy transfer dynamics was also investigated in terms of the luminescence decay curves.This work demonstrates a way to tune phosphor luminescence properties by combining band gap engineering and energy transfer tailoring and provides an inspiring discussion on the different results of Ce^3+doping on the Ce^3+and Pr^3+emissions. | Yiyi Ou Weijie Zhou Fengkai Ma Chunmeng Liu Rongfu Zhou Fang Su Yan Huang Pieter Dorenbos Hongbin Liang | 2020 | Journal of Rare Earths2020，38，5： | 3 |
| 8 | Epidemiological Investigation of an Inhalational Anthrax Patient Traveling for Medical Treatment in Beijing Municipality,China,August 2021显示文摘Summary What is already known about this topic?Inhalational anthrax,also known as pulmonary anthrax,is an infectious disease caused by Bacillus anthracis.The patients are usually infected by inhaling aerosolized B.anthracis spores from dead animals or animal products.Compared to cutaneous anthrax,inhalational anthrax is rare and deadly and few cases in China were reported.What is added by this report?This report covers all information of clinical features,laboratory testing,and epidemiological characteristics as well as exposure history of a recent primary inhalational anthrax patient who was seeking medical treatment in Beijing Municipality in August 2021.New laboratory techniques,including second-generation sequencing,polymerase chain reaction,and rapid test for serum antibody,played an important role in the process.What are the implications for public health practice?The information provided in this report,including the correct sample type,epidemiological investigation details,and application of the new diagnostic criteria of anthrax,could assist public health professionals in dealing with anthrax epidemics. | Changying Lin Xiangfeng Dou Daitao Zhang Yinqi Sun Huiqiang Han Chunzhi Chen Xiaojun Zhang Shuang Li Yanwei Chen Hongbin Zhang Bin Wang Zhichao Liang Xin Zhang Feng Wei Jiangli Wang Feng Liu Quanyi Wang Jian Shi Peng Yang | 2022 | China CDC weekly2022，4，1： | 3 |
| 9 | Proportional distribution method for estimating actual grain flow under combine harvester dynamics显示文摘The yield monitors use a constant delay time to match the grain flow with location.Therefore,mixing and smoothing effects on the grain flow are neglected.Although constant time delay compensates for time mismatch,actual grain flow at a combine harvester head is not equal to the grain flow measured by a sensor due to the dynamics effects.In order to eliminate the dynamics effects,a new method for estimating actual grain flow,called proportional distribution(PD),is proposed.This method assumes that actual grain flow is directly proportional to the feedrate.Based on this assumption,the actual grain flow results from redistributing accumulated grain mass over a certain time according to the profile of the feedrate.The PD can avoid the dynamics effects because the feedrate is measured at a combine harvester’s head.Compared with constant time delay,the proposed method can effectively estimate actual grain flow and be applied to improve the accuracy of yield maps. | Wang He Bai Xiaoping Liang Hongbin | 2017 | International Journal of Agricultural and Biological Engineering2017，10，4： | 2 |
| 10 | Self-lubricate and anisotropic wear behavior of AZ91D magnesium alloy reinforced with ternary Ti_2AlC MAX phases显示文摘The dry sliding wear behavior of Ti_2AlC reinforced AZ91 magnesium composites was investigated at sliding velocity of 0.5 m/s under loads of 10, 20, 40 and 80 N using pin-on-disk configuration against a Cr15 steel disc. Wear rates and friction coefficients were registered during wear tests. Worn tracks and wear debris were examined by scanning electron microscopy, energy dispersive X-ray spectrometry and transmission electron microscopy in order to obtain the wear mechanisms of the studied materials. The main mechanisms were characterized as the magnesium matrix oxidation and self-lubrication of Ti_2AlC MAX phase. In all conditions, the composites exhibit superior wear resistance and self-lubricated ability than the AZ91 Mg alloy. In addition, the anisotropic mechanisms in tribological properties of textured Ti_2AlC-Mg composites were confirmed and discussed. | Wenbo Yu Deqiang Chen Liang Tian Hongbin Zhao Xiaojun Wang | 2019 | Journal of Materials Science & Technology2019，35，3： | 2 |
| 11 | Recent progress in advanced core-shell metal-based catalysts for electrochemical carbon dioxide reduction显示文摘Electrochemical carbon dioxide reduction(CO_(2)RR)plays an important role in solving the problem of high concentration of CO_(2)in the atmosphere and realizing carbon cycle.Core-shell structure has many unique features including tandem catalysis,lattice strain effect,defect engineering,which exhibit great potential in electrocatalysis.In this review,we focus on the advanced core-shell metal-based catalysts(CMCs)for electrochemical CO_(2)RR.The recent progress of CMCs in electrocatalytic CO_(2)RR is described as the follow-ing aspects:(1)The mechanism of electrochemical CO_(2)RR and evaluation parameters of electrocatalyst performance,(2)preparation methods of core-shell metal catalysts and core-shell structural advantages and(3)advanced CMCs towards electrochemical CO_(2)RR.Finally,we make a brief conclusion and propose the opportunities and challenges in the field of electrochemical CO_(2)RR. | Fengqi Wang Wenlong Zhang Hongbin Wan Chenxi Li Wankai An Xia Sheng Xiaoyu Liang Xiaopeng Wang Yunlai Ren Xin Zheng Dongcan Lv Yuchen Qin | 2022 | Chinese Chemical Letters2022，33，5： | 2 |
| 12 | Inconsistent creep between dendrite core and interdendritic region under different degrees of elemental inhomogeneity in nickel-based single crystal superalloys显示文摘The creep inconsistency between dendrite core and interdendritic region is investigated in a nickel-based single crystal superalloy under 1373 K and 137 MPa.Two specimens with higher and lower degree of elemental inhomogeneity on dendritic structures are compared.For specimen with higher inhomogeneity,stronger segregation of refractory elements reinforces the local strength in dendrite core,but damages the strength in interdendritic region.Creep strain is accumulated faster in interdendritic region giving rise to promoted dislocation shearing inγphase,faster degradation of dislocation networks and facilitated topological inversion of rated structures.Although the segregation of refractory elements produces a high density of topologically close-packed(TCP)phase in dendrite core,faster accumulation of creep strain forms microcracks prior in interdendritic region that gives rise to final rupture of the specimen.In another specimen,increased solid solution time gives rise to overall reduced inhomogeneity.Creep inconsistency is relieved to show more uniform evolution of dislocation substructures and rafting between dendrite core and interdendritic region.The second specimen is ruptured by formation and extension of microcracks along TCP phase although the precipitation of TCP phase is relatively restricted under reduced inhomogeneity.Importantly,the balance of local strength between dendrite core and interdendritic region results in over 40%increase of creep rupture life of the second specimen. | Wanshun Xia Xinbao Zhao Liang Yue Quanzhao Yue Jiangwei Wang Qingqing Ding Hongbin Bei Ze Zhang | 2021 | Journal of Materials Science & Technology2021，，33： | 2 |
| 13 | Effects of ethanol extracts of scorpion on hippocampal apoptosis and caspase-3 expression in lithium chloride-pilocarpine-induced status epilepticus rats显示文摘BACKGROUND: Previous studies have demonstrated that scorpion venom in the scorpion can inhibit epilepsy and apoptosis.However,it remains unclear whether ethanol extracts of scorpion (EES) exhibit similar effects.OBJECTIVE: To investigate the effects of EES on hippocampal apoptosis and caspase-3 expression,and to compare the effects on sodium valproate (positive control drug) in a rat model of status epilepticus induced by lithium chloride-pilocarpine.DESIGN,TIME AND SETTING: This randomized,controlled study was conducted at the Drug Research and Development Center,Kanghong Pharmaceuticals Group,and the Department of Pathology,Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital,China from May 2007 to April 2008.MATERIALS: EES were prepared by Huashen Pharmaceutical,China.Sodium valproate (Hunan Xiangzhong Pharmaceutical,China) and lithium chloride-pilocarpine (Sigma,USA) were also used in the present study.METHODS: From a total of 156 rats,six served as normal controls.The remaining rats were intraperitoneally injected with lithium chloride-pilocarpine to establish status epilepticus models,and then assigned to five groups (n = 30,respectively).Animals in each group were administered drugs at 15 minutes after epileptic seizure by gavage.i.e.in the normal control and model groups,rats were treated with 1 mL/0.1 kg saline.The sodium valproate group was administered 120 mg/kg/d sodium valproate.The low-,moderate-,and high-dose EES groups received treatments of 290,580,and 1 160 mg/kg/d EES.The dispensed concentration was 1 mL/0.1 kg.Rat seizure behavior was observed.If status epilepticus did not terminated after 1 hour,the rats were intraperitoneally administered atropine (1 mg/kg) and diazepam (10 mg/kg) to terminate seizure.These rats were continuously observed for 6 hours to ensure seizure termination.Then rats were treated with the above-mentioned drugs at 8: 00 am each day until sacrifice,which took place 4 hours after drug administration.MAIN OUTCOME MEASURES: Terminal dUTP nick end labeling (TUNEL)-positive cells and caspase-3 expression were,respectively,determined by TUNEL and immunohistochemistry at 6,24,48,and 72 hours,as well as 7 days,after status epilepticus.Behavioral changes were also measured.RESULTS: A few caspase-3-positive cells were observed.TUNEL-and caspase-3-positive cells were mainly visible in the hippocampal CA1 and CA3 regions 6 hours following status epilepticus in the model and drug intervention groups.The number of TUNEL-positive cells reached a peak at 48 hours following status epilepticus in the sodium valproate group,as well as the moderate-and high-dose EES groups,and number of TUNEL-positive cells reached a peak at 72 hours in the model and low-dose EES groups.The number of caspase-3-positive cells reached a peak at 48 hours in each group.Following treatment of sodium valproate and EES,the number of TUNEL-and caspase-3-positive cells significantly decreased compared with the model group at various time points (P < 0.05).The number of TUNEL-and caspase-3-positive cells was greatest in the low-dose EES group,followed by the moderate-and high-dose EES groups.The number of TUNEL-and caspase-3-positive cells was similar between the sodium valproate and high-dose EES groups.Epileptic seizure was significantly improved in the sodium valproate group,as well as the moderate-and high-dose EES groups,compared with the model group (P < 0.05 or P < 0.01).Treatment with sodium valproate and high-dose EES resulted in the best outcome,although the results were similar (P > 0.05).CONCLUSION: A dose of 1 160 mg/kg/d EES significantly inhibited status epilepticus.This outcome corresponded to a decreased number of apoptotic cells and caspase-3-positive cells,which was similar to sodium valproate.These results suggest that it is not necessary to extract a component from the scorpion for the treatment of epilepsy.The high dose of EES significantly inhibited epilepsy,which correlated with decreased hippocampal caspase-3 expression. | Liang Yu Hongbin Sun Yi Liang Yan Xie Baoming He Fei Xu | 2010 | Neural Regeneration Research2010，5，2： | 2 |
| 14 | Scorpion ethanol extract and valproic acid effects on hippocampal glial fibrillary acidic protein expression in a rat model of chronic-kindling epilepsy induced by lithium chloride-pilocarpine显示文摘The present study analyzed the effects of ethanol extracts of scorpion on epilepsy prevention and hippocampal expression of glial fibrillary acidic protein in a lithium chloride-pilocarpine epileptic rat model. Results were subsequently compared with valproic acid. Results showed gradually- increased hippocampal glial fibrillary acidic protein expression following model establishment; glial fibrillary acidic protein mRNA expression was significantly increased at 3 days, reached a peak at 7 days, and then gradually decreased thereafter. Ethanol extracts of scorpion doses of 580 and 1 160 mg/kg, as well as 120 mg/kg valproic acid, led to a decreased number of glial fibrillary acidic protein-positive cells and glial fibrillary acidic protein mRNA expression, as well as decreased seizure grades and frequency of spontaneously recurrent seizures. The effects of 1 160 mg/kg ethanol extracts of scorpion were equal to those of 120 mg/kg valproic acid. These results suggested that the anti-epileptic effect of ethanol extracts of scorpion were associated with decreased hippocampal glial fibrillary acidic protein expression in a rat model of lithium chloride-pilocarpine induced epilepsy. | Yi Liang Hongbin Sun Liang Yu Baoming He Yan Xie | 2012 | Neural Regeneration Research2012，7，6： | 2 |
| 15 | Egg-like magnetically immobilized nanospheres: A long- lived catalyst model for the hydrogen transfer reaction in a continuous-flow reactor显示文摘新奇像鸡蛋的 nanosphere 作为长寿催化剂被设计并且被描述为 Fe 3 O 4@nSiO2-NH2-Fe2 O 3 xBi 2 O 3@mSiO2 。催化剂用修改的圣被准备 ? 有没有模板的保护表面的蚀刻的 ber 方法。催化剂粒子由磁性的 Fe 3 是的 O 4 核心蛋黄,忍受活跃 Fe 2 O 3 xBi 2 卵白人,和外部 mesoporous 硅石作为卵轰炸的 O 3 种类。它在一张改正床在 nitro aromatics 的催化减小展出优秀表演到相应苯胺连续流动的反应堆。反应能在学习被做的 80 onal 被执行。题目是怀疑有 TB 感染的病人。在怀疑的区域的整个身体和 SPECT-CT 成像被做 1 和 4 ? 在 370-555 的注射以后的 h ? MBq 99m Tc-ethambu 吗?? | Yongjian Ai Zenan Hu Zixing Shao Li Qi Lei Liu Junjie Zhou Hongbin Sun Qionglin Liang | 2018 | Nano Research2018，11，1： | 2 |
| 16 | Effects of topiramate versus other antiepileptic drugs on the cognitive function of patients with epilepsy显示文摘BACKGROUND: Only very large dose of topiramate has neurotoxicity, indicating that topiramate has low neurotoxicity and high safety. The residual rate of topiramate is affected by many cognitive-related adverse effects. Patients who take topiramate often accompany with thought slowness, difficulty in finding words, dyscalculia, blunt reaction, attention decreasing, memory deterioration, etc. OBJECTIVE: To compare the effects of topiramate with traditional anti-epileptic drugs (including carbamazepine and Valproic acid (VPA) on cognitive function of patients with epilepsy. DESIGN: Observational experiment, self-control and intergroup comparison. SETTING: Sichuan Academy of Medical Science. PARTICIPANTS: Eighty-seven inpatients and outpatients with newly diagnosed epilepsy who received preliminary diagnosis and follow-up in the Department of Neurology, Sichuan People's Hospital between January 2004 and June 2006 were involved in this survey. They were diagnosed according to disease history and electroencephalogram (EEG). The onset type was diagnosed following the definition of epilepsy and epileptic syndrome in 1989 International Anti-epileptic League. The involved patients and their relatives were informed of detection and therapeutic regimen. The patients were assigned into two groups according to table of random digit: traditional antiepileptic drugs group (AEDs group, n =44) and topiramate (TPM) group (n =43). METHODS: ①Among the patients in AEDs group, carbamazepine was the first choice for 21 patients with partial seizures or partial secondarily generalized seizures, and VPA for 23 patients with generalized seizures. The initial dose of carbamazepine was 300 mg/d, and that of VPA was 500 mg/d. Patients in the TPM group took TPM with the initial dose of 25 mg/d, increased by 25 mg/d each week to target dose 150 mg/d within 8 weeks. ② Curative effect was graded into 4 degrees: markedly effective, effective, ineffective and aggravated. Total effective rate was calculated. ③ Cognitive function of patients was tested before and 6 months after administration by using Wechsler Adult Intelligence Scale(WAIS) or Wechsler Intelligence Scale for Children (WISC, Chinese edition), (Higher scores indicated better cognitive function), Stroop color word interference, test of memory of past numbers, test of telling the names of fruits and vegetables within 1 minute (Shorter time for reading word, telling color and memory of past numbers demonstrated better cognitive function. Less errors in reading words, telling colors and memory of past numbers, numbering and telling the names of fruits and vegetables within 1 minute indicated better cognitive function), etc. totally 22 items. ④ t test and paired t test were used for measurement data. MAIN OUTCOME MEASURES: Clinical curative effects and adverse reactions as well as neurological tests. RESULTS: Eighty-four pationts praticipated final analysis and 3 dropped out. ① Inthe AEDS group and TPM group, total effective rate was 86% and 99%, respectively. ② In the AEDs group, there were no significant changes in the scores of each test of WIS before and after treatment (P > 0.05). In the TPM group, total IQ, word scores, verbal IQ and digit span scores were significantly decreased (t =2.097–4.423,P < 0.05–0.01).Following treatment, the time for reading word and telling color for patients in the AEDs group was prolonged in Stroop color interference test(t =–2.304,–2.454,P < 0.05), and time for reading word and memory of past numbers for patients in the topiramate group was significantly prolonged (t =–3.054, 2.272,P < 0.01,0.05). ③There were no significant differences in scores of WIS before and after treatment in AEDs group and TPM group (P > 0.05). Following treatment, verbal IQ, word scores, total IQ, digit span of patients in the TPM group were significantly lower than those in the AEDs group(t =2.052–3.297,P < 0.05–0.01).There were no significant differences in Stroop color word interference, memory of past numbers and telling the names of fruits and vegetables within 1 minute before and after treatment in AEDsgroup and TPM group (P > 0.05). CONCLUSION: ① Moderate and small doses of both TPM and AEDs may lead to mild cognitive function impairment of patients, mainly presenting delayed reaction and decreased sensitivity. ②TPM mainly influences attention, language comprehension ability and fluency, while AEDs cause delayed reaction easily, but influence executive function mainly. | Fei Xu Qionghua Feng Liang Yu Jie Liu Hongbin Sun | 2007 | Neural Regeneration Research2007，2，2： | 2 |
| 17 | Study on Sensitivity Improving of Fiber Bragg Grating Based pH Sensor显示文摘在基于 FBG 的 pH 传感器中的敏感的关键因素详细被分析。胶化的 multi-thin-layer 结构涂的盖子与一个特殊过程被建议并且实现。有 420 m, 500 m,和 580 m 的涂的厚度的传感器分别地被建立。相应光谱 0.08 nm, 0.13 nm,和 0.22 nm 的移动被检测 pH 传感器是否在 39 的 pH 价值被浸泡。同时,有 580 m 的胶化层厚度的传感器在最佳测量时间时期被测量, pH 价值从 312 变化,在哪个 52 pm/pH 的检测敏感在 612 的 pH 范围被完成。 | Xiongchang Liang Shun’er Chen Hongbin Huang Weiping Liu | 2014 | Photonic Sensors2014，4，1： | 2 |
| 18 | Novel Red Phosphor of Bi^3+ ,Sm^&3+ Co-activated NaEu ( MoO4 ) 2 显示文摘 | Wang Zhengliang Liang Hongbin Gong Menglian | 2007 | Optical Mater2007，29，7： | 1 |
| 19 | A multi-step induced strategy to fabricate core-shell Pt-Ni alloy as symmetric electrocatalysts for overall water splitting显示文摘Devising an electrocatalyst with brilliant efficiency and satisfactory durability for hydrogen production is of considerable demand,especially for large-scale application.Herein,we adopt a multi-step consequential induced strategy to construct a bifunctional electrocatalyst for the overall water splitting.Graphene oxide(GO)was used as a carbon matrix and in situ oxygen source,which was supported by the octahedral PtNi alloy to form the PtxNiy-GO precursor.When calcinating in Ar atmosphere,the oxygen in GO induced the surface segregation of Ni from the PtNi octahedron to form a core-shell structure of Ptx@Niy.Then,the surface-enriched Ni continuously induced the reformation of C in reduced graphene oxide(rGO)to enhance the degree of graphitization.This multi-step induction formed a nanocatalyst Pt_(x)@Ni_(y)-rGO which has very high catalytic efficiency and stability.By optimizing the feeding ratio of PtNi(Pt:Ni=1:2),the electrolytic overall water splitting at 10 mA·cm^(-2) can be driven by an electrolytic voltage of as low as 1.485 V,and hydrogen evolution reaction(HER)only needs an overpotential of 37 mV in 1.0 M KOH aqueous solution.Additionally,the catalyst exhibited consistent existence form in both HER and oxygen evolution reaction(OER),which was verified by switching the anode and cathode of the cell in the electrolysis of water.This work provides a new idea for the synthesis and evaluation of the bifunctional catalysts for water splitting. | Wenjuan Xu Jinfa Chang Yinggang Cheng Hongqi Liu Jifan Li Yongjian Ai Zenan Hu Xinyue Zhang Yiming Wang Qionglin Liang Yang Yang Hongbin Sun | 2022 | Nano Research2022，15，2： | 1 |
| 20 | 显示文摘 | Wang Zhengliang Liang Hongbin Zhou Liya | 2005 | Chemical Physics Letters2005，412，： | 1 |
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