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| 1 | reatment of allergic inflammation and hyperresponsiveness by a simple compound, Bavachinin, isolated from Chinese herbs显示文摘气喘的发炎被一种类型调停 2 助手 T 房间(Th2 ) cytokine 反应,和堵住的 Th2 cytokine 生产被证明有一个有势力治疗学对气喘的发炎的效果。用 IL-4-green 荧光灯蛋白质(GFP ) 记者老鼠,我们表明了那 Bavachinin,从中国植物孤立的单个混合物,显著地禁止的 Th2 cytokine 生产包括 IL-4, IL-5 和 IL-13。尤其是,在 ovalbumin (卵) 的这复合几乎完全堵住的发炎敏化动物气喘模型。而且,我们证明这化学药品有选择地影响 GATA-3 的水平,由影响 GATA-3 mRNA 的稳定性最可能。第一次,我们的结果证明这单个混合物的潜在的治疗学的价值源于中国植物。 | Xi Chen Ti Wen Jun Wei Zhenzhou Wu Puyue Wang Zhangyong Hong Liqing Zhao Bin Wang Richard Flavell Shumei Gao Min Wang Zhinan Yin | 2013 | Cellular & Molecular Immunology2013，10，6： | 9 |
| 2 | Taxonomic Distinctness of Macrofauna as an Ecological Indicator in Laizhou Bay and Adjacent Waters显示文摘In this paper, we assessed the ecological and biodiversity status in the Bohai Sea through a quantitative survey on mac-rofaunal community at 25 stations in Laizhou Bay and adjacent waters in the autumn of 2006.We tested the robustness and effectiveness of taxonomic distinctness as an ecological indictor by analyzing its correlation with species richness and natural environmental variables and by analyzing other ecological indicators (Shannon-Wiener H' and W statistics from Abundance Biomass Comparison curve).Results so obtained indicated that the benthic environment of the study waters in general is not under major impact of anthropogenic disturbance, but some stations in Laizhou Bay and along the coast of the Shandong Peninsula and even in the central Bohai Sea might be moderately disturbed and showed signs of ecological degradation.The taxonomic distinctness measures △+ and Λ+ were independent of sampling effort and natural environment factors and were compliant to other ecological indicators.Further application of the taxonomic distinctness indicator to assess marine biodiversity and ecosystem health on a larger regional scale with historical data seems promising. | ZHOU Hong HUA Er ZHANG Zhinan | 2010 | Journal of Ocean University of China2010，9，4： | 9 |
| 3 | Meiofauna Distribution in Intertidal Sandy Beaches Along China Shoreline(18?–40?N)显示文摘In this study,the distribution pattern of meiofauna from nine sandy beaches at six latitudinal gradients along Chinese coast between 18 and 40?N was studied on their meiofauna abundance to examine the effect of latitudinal gradients.In general,meiofauna abundance was lower in four subtropical beaches in Xiamen(24?N) and Zhoushan(29?N) than that in other beaches.Meiofauna abundance differed little between tropical and temperate beaches.The taxonomic structure of meiofauna showed a dominance of nematode in colder area.The relative composition of turbellarians and polychaetes increased in warmer area.In addition to latitudinal gradient,salinity,oxygenation,sediment grain size affect also the meiofauna latitudinal distribution.As for horizontal distribution,the highest meiofauna abundance was found in low tidal zone at tropical beaches,and in middle tidal zone at temperate beaches.The horizontal distribution of meiofauna was controlled by both physical and biotic factors including feeding and anthropogenic activities.Although meiofauna abundance exhibited a horizontal difference,the composition of meiofaunal main taxa was unanimous horizontally at all beaches at the same sampling latitude. | HUA Er ZHANG Zhinan ZHOU Hong MU Fanghong LI Jia ZHANG Ting CONG Bingqing LIU Xiaoshou | 2016 | Journal of Ocean University of China2016，15，1： | 7 |
| 4 | Enoplus taipingensis,a new species of marine nematode from the rocky intertidal seaweeds in the Taiping Bay,Qingdao显示文摘One new species of free-living marine nematodes Enoplus taipingensis sp.nov.from the rocky intertidal seaweeds in the Taiping Bay,Qingdao is described and illustrated with scanning electron microscopy observation and 18S rRNA gene sequence analysis.Enoplus taipingensis is characterized by special arrangement of lateral setae on the tail,three cervical setae,distal structure on the supplement,and much longer body length with bigger De Man ratio 'a'.Type specimens are deposited in the College of Marine Life Science,Ocean University of China. | ZHANG Zhinan ZHOU Hong | 2012 | Acta Oceanologica Sinica2012，31，2： | 2 |
| 5 | Effects of Organic Enrichment on Sandy Beach Meiofauna:A Laboratory Microcosm Experiment显示文摘Meiofauna samples from intertidal sediments of Qingdao No.2 Bathing Beach, China, were collected for field study, and subjected to organic enrichment in a laboratory microcosm experiment for 21 d. There were three different treatments including non-organic addition as the control, low-organic enrichment (2 g DW green algae per 150 mL) and high-organic enrichment (10 g DW green algae per 150 mL). After 21 d, the meiofauna richness decreased in both organic enrichment treatments. Among the three treatments, total meiofauna abundance was significantly different, and the control groups had higher abundance than the other two treatment groups. However, the responses of the meiofauna abundance in the two organic enrichment treatments were non-significantly different. The relationship of meiofaunal abundance and nematode/copepod ratios to organic matter and oxygen level in the microcosm experiments were discussed. | WANG Jianing ZHOU Hong ZHANG Zhinan CONG Bingqing XU Shuhui | 2011 | Journal of Ocean University of China2011，10，3： | 2 |
| 6 | Therapeutic effects of a novel tylophorine analog, NK‐007, on collagen‐induced arthritis through suppressing tumor necrosis factor α production and Th17 cell differentiation显示文摘 | Ti Wen Yangguang Li Meng Wu Xiaolin Sun Xiucong Bao Yuquan Lin Jianlei Hao Lin Han Guangchao Cao Ziwen Wang Yuxiu Liu Zhenzhou Wu Zhangyong Hong Puyue Wang Liqing Zhao Zhanguo Li Qingmin Wang Zhinan Yin | 2012 | Arthritis & Rheumatism2012，，9： | 2 |
| 7 | Changes in the shelf macrobenthic community over large temporal and spatial scales in the Bohai Sea, China 显示文摘 | ZHOU Hong ZHANG Zhinan LIU Xiaoshou | 2007 | Journal of Marine Systems2007，67，34： | 1 |
| 8 | Phytal meiofauna of a rocky shore at the cape d'Aguilar marine reserve,Hong Kong显示文摘 | Zhang Zhinan Zhou Hong | 1997 | The Marine Flora and Fauna of Hong Kong and Southern China1997，，： | 1 |
| 9 | Phytal meiofauna of a rocky shore at the cape d' A_guilar marine reserve, Hong Kong 显示文摘 | Zhang Zhinan Zhou Hong | 1997 | The Marine Flora and Fauna of Hong Kong and Southern China1997，，： | 1 |
| 10 | Estimates of Autumntime Benthic Secondary Production in Laizhou Bay and Adjacent Bohai Sea Waters显示文摘The whole metazoan community inhabiting Laizhou Bay and adjacent Bohai Sea waters were sampled in late autumn,2006.Secondary production estimates for macrofauna and meiofauna were made separately.Total benthic secondary production was as high as 8.38 ± 4.08 g ash-free dry weight(AFDW) m-2 a-1,which represented the autumn production level.In general,macrofaunal secondary production in Laizhou Bay was much lower than that in adjacent Bohai Sea areas.In contrast,meiofaunal secondary production in Laizhou Bay was higher than that in adjacent Bohai Sea areas.Macrofauna contributed 61% to benthic secondary production(5.09 ± 3.26 g AFDW m-2 a-1),lower than the value in previous studies in Bohai Sea.Sediment granulometric characteristics and bottom-water salinity could explain the substantial variability in the macrofauna biomass and production.Meiofaunal production was an important component of benthic production and exceeded macrofauna production under exceptional conditions,e.g.in Laizhou Bay,where macrofauna was restricted.Chlorophyll pigments(Chl-a) concentrations in sediment explained the general meiofaunal biomass and production distribution here. | HUA Er ZHOU Hong ZHANG Zhinan YU Zishan | 2010 | Journal of Ocean University of China2010，9，3： | 0 |
| 11 | miR-126 mitigates the osteogenic differentiation of human bone marrow-derived mesenchymal stem cells by targeting the ERK1/2 and Bcl-2 pathways显示文摘Human bone marrow mesenchymal stem cells(hBMMSCs)are a promising cell source for bone engineering owing to their high potential to differentiate into osteoblasts.The objective of the present study is to assess microRNA-126(miR-126)and examine its effects on the osteogenic differentiation of hBMMSCs.In this study,we investigate the role of miR-126 in the progression of osteogenic differentiation(OD)as well as the apoptosis and inflammation of hBMMSCs during OD induction.OD is induced in hBMMSCs,and matrix mineralization along with other ODassociated markers are evaluated by Alizarin Red S(AR)staining and quantitative PCR(qPCR).Gain-and loss-offunction studies are performed to demonstrate the role of miR-126 in the OD of hBMMSCs.Flow cytometry and qPCR-based cytokine expression studies are performed to investigate the effect of miR-126 on the apoptosis and inflammation of hBMMSCs.The results indicate that miR-126 expression is downregulated during the OD of hBMMSCs.Gain-and loss-of function assays reveal that miR-126 upregulation inhibits the differentiation of hBMMSCs into osteoblasts,whereas the downregulation of miR-126 promotes hBMMSC differentiation,as assessed by the determination of osteogenic genes and alkaline phosphatase activity.Furthermore,the miR-126 level is positively correlated with the production of inflammatory cytokines and apoptotic cell death.Additionally,our results suggest that miR-126 negatively regulates not only B-cell lymphoma 2(Bcl-2)expression but also the phosphorylation of extracellular signal-regulated protein kinase(ERK)1/2.Moreover,restoring ERK1/2 activity and upregulating Bcl-2 expression counteract the miR-126-mediated suppression of OD in hBMMSCs by promoting inflammation and apoptosis,respectively.Overall,our findings suggest a novel molecular mechanism relevant to the differentiation of hBMMSCs into osteoblasts,which can potentially facilitate bone formation by counteracting miR-126-mediated suppression of ERK1/2 activity and Bcl-2 expression. | Ying Zhang Yiping Dong Qiushi Wei Zhikun Zhuang Youwen Liu Qiang Yuan Wei He Zhenhao Jing Jitian Li Peifeng Li Leilei Zhang Zhinan Hong Ning Zhang Haibin Wang Wuyin Li | 2023 | Acta Biochimica et Biophysica Sinica2023，55，3： | 0 |
| 12 | Cathepsin D knockdown regulates biological behaviors of granulosa cells and affects litter size traits in goats显示文摘Cathepsin D(CTSD),the major lysosomal aspartic protease that is widely expressed in different tissues,potentially regulates the biological behaviors of various cells.Follicular granulosa cells are responsive to the increase of ovulation number,hence indirectly influencing litter size.However,the mechanism underlying the effect of CTSD on the behaviors of goat granulosa cells has not been fully elucidated.This study used immunohistochemistry to analyze CTSD localization in goat ovarian tissues.Moreover,western blotting was applied to examine the differential expression of CTSD in the ovarian tissues of monotocous and polytocous goats.Subsequently,the effects of CTSD knockdown on cell proliferation,apoptosis,cell cycle,and the expression of candidate genes of the prolific traits,including bone morphogenetic protein receptor IB(BMPR-IB),follicle-stimulating hormone(FSHR),and inhibinα(INHA),were determined in granulosa cells.Results showed that CTSD was expressed in corpus luteum,follicle,and granulosa cells.Notably,CTSD expression in the monotocous group was significantly higher than that in the polytocous group.In addition,CTSD knockdown could improve granulosa cell proliferation,inhibit cell apoptosis,and significantly elevate the expression of proliferating cell nuclear antigen(PCNA)and B cell lymphoma 2(Bcl-2),but it lowered the expression of Bcl-2-associated X(Bax)and caspase-3.Furthermore,CTSD knockdown significantly reduced the ratios of cells in the G0/G1 and G2/M phases but substantially increased the ratio of cells in the S phase.The expression levels of cyclin D2 and cyclin E were elevated followed by the obvious decline of cyclin A1 expression.However,the expression levels of BMPR-IB,FSHR,and INHA clearly increased as a result of CTSD knockdown.Hence,our findings demonstrate that CTSD is an important factor affecting the litter size trait in goats by regulating the granulosa cell proliferation,apoptosis,cell cycle,and the expression of candidate genes of the prolific trait. | Zhinan ZHOU Xiang CHEN Min ZHU Weiwei WANG Zheng AO Jiafu ZHAO Wen TANG Lei HONG | 2021 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2021，22，11： | 0 |
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