|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Mutual interaction between oxidative stress and endoplasmic reticulum stress in the pathogenesis of diseases specifically focusing on non-alcoholic fatty liver disease显示文摘Reactive oxygen species(ROS) are produced during normal physiologic processes with the consumption of oxygen. While ROS play signaling roles, when they are produced in excess beyond normal antioxidative capacity this can cause pathogenic damage to cells. The majority of such oxidation occurs in polyunsaturated fatty acids and sulfhydryl group in proteins, resulting in lipid peroxidation and protein misfolding, respectively. The accumulation of misfolded proteins in the endoplasmic reticulum(ER) is enhanced under conditions of oxidative stress and results in ER stress, which, together, leads to the malfunction of cellular homeostasis. Multiple types of defensive machinery are activated in unfolded protein response under ER stress to resolve this unfavorable situation. ER stress triggers the malfunction of protein secretion and is associated with a variety of pathogenic conditions including defective insulin secretion from pancreatic β-cells and accelerated lipid droplet formation in hepatocytes. Herein we use nonalcoholic fatty liver disease(NAFLD) as an illustration of such pathological liver conditions that result from ER stress in association with oxidative stress. Protecting the ER by eliminating excessive ROS viathe administration of antioxidants or by enhancing lipidmetabolizing capacity via the activation of peroxisome proliferator-activated receptors represent promising therapeutics for NAFLD. | Junichi Fujii Takujiro Homma Sho Kobayashi Han Geuk Seo | 2018 | World Journal of Biological Chemistry2018，9，1： | 17 |
| 2 | Immunotherapy for colorectal cancer显示文摘The incidence of colorectal cancer(CRC)is on the rise,and the prognosis for patients with recurrent or metastatic disease is extremely poor.Although chemotherapy and radiation therapy can improve survival rates,it is imperative to integrate alternative strategies such as immunotherapy to improve outcomes for patients with advanced CRC.In this review,we will discuss the effect of immunotherapy for inducing cytotoxic T lymphocytes and the major immunotherapeutic approaches for CRC that are currently in clinical trials,including peptide vaccines,dendritic cell-based cancer vaccines,whole tumor cell vaccines,viral vector-based cancer vaccines,adoptive cell transfer therapy,antibody-based cancer immunotherapy,and cytokine therapy.The possibility of combination therapies will also be discussed along with the challenges presented by tumor escape mechanisms. | Shigeo Koido Toshifumi Ohkusa Sadamu Homma Yoshihisa Namiki Kazuki Takakura Keisuke Saito Zensho Ito Hiroko Kobayashi Mikio Kajihara Kan Uchiyama Seiji Arihiro Hiroshi Arakawa Masato Okamoto Jianlin Gong Hisao Tajiri | 2013 | World Journal of Gastroenterology2013，19，46： | 11 |
| 3 | 日本土传病害防治现状(下)显示文摘3.土传病害的防治现状 (1)抗病品种和抗病砧根的应用 抗病品种的使用可降低土传病害的暴发,在蔬菜栽培中可用抗病砧木来防治土传病害。在大田作物栽培中,抗小麦土传病毒病、立枯病、条斑病和伏革茵效枯病的品种己经使用。另外,对赤豆褐茎腐病、晚疫病、大豆茎枯病,对马铃薯晚疫病也在病菌生理小种和抗病品种方面正在继续研究。 | Yoshihisa Homma 夏正俊 | 1993 | 世界农业1993，，6： | 9 |
| 4 | X射线荧光分析法测定铁矿石中全铁显示文摘铁矿石中全铁的含量范围通常较宽,因此需要高的分析精确度。尽管熔融制样法已经被普遍用于铁矿石的X射线荧光光谱分析,但作为样品制备的另一种方法,压片法由于简便、快捷的特点,其应用需求同样较大。康普顿散射比法已经被普遍用于岩石等样品中的重金属元素测定,其中荧光X射线与X射线管线发射的康普顿散射X射线的强度比被用作校正。不过,这种方法不能为矿石和精矿中高含量重金属元素的测定提供足够的准确度。本研究建立了一种新的方法,在元素间校正项中,将基本参数法获取的理论α系数用于康普顿散射比校正。本方法可以将铁矿石中全铁含量的测定准确度提高到0.14%(质量分数)。 | KATAOKA Y HOMMA H KOHNO H | 2011 | 冶金分析2011，31，7： | 8 |
| 5 | 日本土传病害防治现状及有关问题显示文摘土传细菌、放线菌和真菌病害,发生的主要原因是连作,其次为线虫传播.在合理轮作和品种布局的基础上,栽培抗病品种是其防治根本,并可针对不同病害采取施用有机物,清除病残体、生物防治、调节土壤理化性质,化学防治等措施来控制土传病病害的发生. | Yoshihisa Homma 夏正俊 | 1992 | 国外农学(植物保护)1992，5，2： | 7 |
| 6 | Oxidative stress as a potential causal factor for autoimmune hemolytic anemia and systemic lupus erythematosus显示文摘The kidneys and the blood system mutually exert influence in maintaining homeostasis in the body. Because the kidneys control erythropoiesis by producing erythropoietin and by supporting hematopoiesis, anemia is associated with kidney diseases. Anemia is the most prevalent genetic disorder, and it is caused by a deficiency of glucose 6-phosphate dehydrogenase(G6PD), for which sulfhydryl oxidation due to an insufficient supply of NADPH is a likely direct cause. Elevated reactive oxygen species(ROS) result in the sulfhydryl oxidation and hence are another potential cause for anemia. ROS are elevated in red blood cells(RBCs) under superoxide dismutase(SOD1) deficiency in C57BL/6 mice. SOD1 deficient mice exhibit characteristics similar to autoimmune hemolytic anemia(AIHA) and systemic lupus erythematosus(SLE) at the gerontic stage. An examination of AIHA-prone New Zealand Black(NZB) mice, which have normal SOD1 and G6 PD genes, indicated that ROS levels in RBCs are originally high and further elevated during aging. Transgenic overexpression of human SOD1 in erythroid cells effectively suppresses ROS elevation and ameliorates AIHA symptoms such as elevated anti-RBC antibodies and premature death in NZB mice. These results support the hypothesis that names oxidative stress as a risk factor for AIHA and other autoimmune diseases such as SLE. Herein we discuss the association between oxidative stress and SLE pathogenesis based mainly on the genetic and phenotypic characteristics of NZB and New Zealand white mice and provide insight into the mechanism of SLE pathogenesis. | Junichi Fujii Toshihiro Kurahashi Tasuku Konno Takujiro Homma Yoshihito Iuchi | 2015 | World Journal of Nephrology2015，4，2： | 7 |
| 7 | Single-Walled Carbon Nanotube Growth with Non-Iron- Group “Catalysts” by Chemical Vapor Deposition显示文摘Various materials have been found to“catalyze”carbon nanotube growth in chemical vapor deposition(CVD)when they become nano-sized particles.These involve not only metals,such as Pd,Pt,Au,Ag,and Cu,but also semiconductors,such as Si,Ge,and SiC.Alumina and diamond nanoparticles also produce carbon nanotubes.These“catalysts”,which are better called“seeds”,can be categorized into two types:one type forms a eutectic liquid or highly-mobile alloy with carbon,and carbon atoms precipitate from the eutectic alloy;the other type remains as a solid phase and form a carbon surface layer during CVD growth.In this paper,we review recent studies of SWCNT growth with these non-iron-group materials and highlight the mechanisms involved. | Yoshikazu Homma Huaping Liu Daisuke Takagi Yoshihiro Kobayashi | 2009 | Nano Research2009，2，10： | 6 |
| 8 | Erect panicle super rice varieties enhance yield by harvest index advantages in high nitrogen and density conditions显示文摘The erect panicle(Ep) type is an important characteristic for japonica super rice in Northeast China and plays a significant role in enhancing yield. The Ep type is considered to be a genetic ideotype resource to the japonica super rice group by virtue of its agronomic advantages such as grain number per panicle and biomass. This study addresses the effects of nitrogen and planting density conditions on yielding performance regarding panicle type(PT) using the recombinant inbred line(RIL) population derived from the cross between an Ep variety Liaogeng 5 and non-Ep variety Wanlun 422. The genetics underlying the Ep type proved to be robust not only for panicle-type optimization but also plant height, panicle length, flag leaf length and seed density. We also found that regardless of nitrogen and density, correlation between harvest index(HI) and plant height was not significant in Ep type whatever the nitrogen and density. The application of Ep type provides a potential strategy for yield improvement by increasing biomass through HI maintainable in rice. | TANG Liang GAO Hong Hirooka Yoshihiro Homma Koki Nakazaki Tetsuya LIU Tian-sheng Shiraiwa Tatsuhiko XU Zheng-jin | 2017 | Journal of Integrative Agriculture2017，16，7： | 4 |
| 9 | Clinical impacts of mesothelin expression in gastrointestinal carcinomas显示文摘Mesothelin,C-ERC/mesothelin is a 40-kD a cell surface glycoprotein that is normally present on normal mesothelial cells lining the pleura,peritoneum,and pericardium.Moreover,mesothelin has been shown to be overexpressed in several human cancers,including virtually all mesothelioma and pancreatic cancer approximately 70% of ovarian cancer and extra bile duc cancer,and 50% of lung adenocarcinomas and gastric cancer.The full-length human mesothelin gene encodes the primary product,a 71-k Da precursor protein.The71-kD a mesothelin precursor is cleaved into two products40-k Da C-terminal fragment that remains membranebound via glycosylphosphatidylinositol anchor,and a31-kD a N-terminal fragment,megakaryocyte potentiating factor,which is secreted into the blood.The biologica functions of mesothelin remain largely unknown However,results of recent studies have suggested tha the mesothelin may play a role of cell proliferation and migration.In pancreatic cancer,mesothelin expression was immunohistochemically observed in all cases,bu absent in normal pancreas and in chronic pancreatitis Furthermore,the expression of mesothelin was correlated with an poorer patient outcome in severa human cancers.The limited mesothelin expression in normal tissues and high expression in many cancers makes it an attractive candidate for cancer therapy.The present review discusses the expression and function o mesothelin in cancer cells and the utility of mesothelin as a target of cancer therapy. | Takahiro Einama Futoshi Kawamata Hirofumi Kamachi Hiroshi Nishihara Shigenori Homma Fumihiko Matsuzawa Tatsuzo Mizukami Yuji Konishi Munenori Tahara Toshiya Kamiyama Okio Hino Akinobu Taketomi Satoru Todo | 2016 | World Journal of Gastrointestinal Pathophysiology2016，7，2： | 4 |
| 10 | PERSISTENT HIF-1α ACTIVATION IN GUT ISCHEMIA/REPERFUSION INJURY: POTENTIAL ROLE OF BACTERIA AND LIPOPOLYSACCHARIDE显示文摘 | Jadd Koury Edwin A Deitch Hiroshi Homma Billy Abungu Pranoti Gangurde Michael R Condon Qi Lu Da-Zhong Xu Rena Feinman | 2004 | Shock2004，，3： | 3 |
| 11 | Fusions between dendritic cells and whole tumor cells as anticancer vaccines显示文摘 | Shigeo Koido Sadamu Homma Masato Okamoto Yoshihisa Namiki Kazuki Takakura Kan Uchiyama Mikio Kajihara Seiji Arihiro Hiroo Imazu Hiroshi Arakawa Shin Kan Hideo Komita Masaki Ito Toshifumi Ohkusa Jianlin Gong Hisao Tajiri | 2013 | OncoImmunology2013，，： | 3 |
| 12 | Chronic kidney disease and erectile dysfunction显示文摘Erectile dysfunction(ED) is a common condition among male chronic kidney disease(CKD) patients.Its prevalence is estimated to be approximately 80% among these patients.It has been well established that the production of nitric oxide from the cavernous nerve and vascular endothelium and the subsequent production of cyclic GMP are critically important in initiating and maintaining erection.Factors affecting these pathways can induce ED.The etiology of ED in CKD patients is multifactorial.Factors including abnormalities in gonadal-pituitary system,disturbance in autonomic nervous system,endothelial dysfunction,anemia(and erythropoietin deficiency),secondary hyperparathyroidism,drugs,zinc deficiency,and psychological problems are implicated in the occurrence of ED.An improvement of general conditions is the first step of treatment.Sufficient dialysis and adequate nutritional intake are necessary.In addition,control of anemia and secondary hyperparathyroidism is required.Changes of drugs that potentially affect erectile function may be necessary.Further,zinc supplementation may be necessary whenzinc deficiency is suspected.Phosphodiesterase type 5 inhibitors(PDE5Is) are commonly used for treating ED in CKD patients,and their efficacy was confirmed by many studies.Testosterone replacement therapy in addition to PDE5 Is may be useful,particularly for CKD patients with hypogonadism.Renal transplantation may restore erectile function.ED is an early marker of cardiovascular disease(CVD),which it frequently precedes; therefore,it is crucial to examine the presence of ED in CKD patients not only for the improvement of the quality of life but also for the prevention of CVD attack. | Etsu Suzuki Hiroaki Nishimatsu Shigeyoshi Oba Masao Takahashi Yukio Homma | 2014 | World Journal of Nephrology2014，3，4： | 3 |
| 13 | Current Immunotherapeutic Approaches in Pancreatic Cancer显示文摘 | Shigeo Koido Sadamu Homma Akitaka Takahara Yoshihisa Namiki Shintaro Tsukinaga Jimi Mitobe Shunichi Odahara Toyokazu Yukawa Hiroshi Matsudaira Keisuke Nagatsuma Kan Uchiyama Kenichi Satoh Masaki Ito Hideo Komita Hiroshi Arakawa Toshifumi Ohkusa Jianlin Go | 2011 | Clinical and Developmental Immunology2011，，： | 3 |
| 14 | Dendritic cell-based vaccine for pancreatic cancer in Japan显示文摘'Vaccell' is a dendritic cell(DC)-based cancer vaccine which has been established in Japan. The DCs play central roles in deciding the direction of host immune reactions as well as antigen presentation. We have demonstrated that DCs treated with a streptococcal immune adjuvant OK-432, produce interleukin-12, induce Th1-dominant state, and elicit anti-tumor effects, more powerful than those treated with the known DCmaturating factors. We therefore decided to mature DCs by the OK-432 for making an effective DC vaccine, Vaccell. The 255 patients with inoperable pancreatic cancer who received standard chemotherapy combined with DC vaccines, were analyzed retrospectively. Survival time of the patients with positive delayed type hypersensitivity(DTH) skin reaction was significantly prolonged as compared with that of the patients with negative DTH. The findings strongly suggest that there may be 'Responders' for the DC vaccine in advanced pancreatic cancer patients. We next conducted a smallscale prospective clinical study. In this trial, we pulsed HLA class Ⅱ-restricted WT1 peptide(WT1-Ⅱ) in addition to HLA class Ⅰ-restricted peptide(WT1-Ⅰ) into the DCs. Survival of the patients received WT1-Ⅰ and-Ⅱ pulsed DC vaccine was significantly extended as compared to that of the patients received DCs pulsed with WT1-Ⅰ or WT1-Ⅱ alone. Furthermore, WT1-specific DTH positive patients showed significantly improved the overall survival as well as progressionfree survival as compared to the DTH negative patients. The activation of antigen-specific immune responses by DC vaccine in combination with standard chemotherapy may be associated with a good clinical outcome in advanced pancreatic cancer. We are now planning a pivotal study of the Vaccell in appropriate protocols in Japan. | Masato Okamoto Masanori Kobayashi Yoshikazu Yonemitsu Shigeo Koido Sadamu Homma | 2016 | World Journal of Gastrointestinal Pharmacology and Therapeutics2016，7，1： | 2 |
| 15 | Production of corticotropin-releasing factor and urocortin from human monocyte-derived dendritic cells is stimulated by commensal bacteria in intestine显示文摘AIM:To examine whether commensal bacteria are a contributing cause of stress-related mucosal inflammation.METHODS:Human peripheral blood monocyte-deriveddendritic cells(MoDCs)were stimulated by commensal bacterial strains,including Escherichia coli,Clostridium clostridioforme,Bacteroides vulgatus(B.vulgatus),Fusobacterium varium(F.varium),and Lactobacillus delbrueckii subsp.bulgaricus.After incubation,corticotropin-releasing factor(CRF)and urocortin 1(UCN1)mRNA in the cells was examined by real-time reverse transcription polymerase chain reaction.Supernatants from the cells were tested for CRF and UCN1 using an enzyme-linked immunosorbent assay.RESULTS:Both CRF and UCN1 were significantly augmented by B.vulgatus and F.varium at both the mRNA and protein levels.In particular,B.vulgatus stimulated human MoDCs,resulting in extremely high levels of CRF and UCN1.CONCLUSION:Stimulation of MoDCs by B.vulgatus and F.varium may be associated with CRF/UCN1-related intestinal disorders,such as irritable bowel syndrome and inflammatory bowel disease. | Shigeo Koido Toshifumi Ohkusa Shin Kan Kazuki Takakura Keisuke Saito Hideo Komita Zensho Ito Hiroko Kobayashi Shinichiro Takami Kan Uchiyama Hiroshi Arakawa Masaki Ito Masato Okamoto Mikio Kajihara Sadamu Homma Hisao Tajiri | 2014 | World Journal of Gastroenterology2014，20，39： | 2 |
| 16 | Diffuse panbronchiolitis in rheumatoid arthritis显示文摘 | Homma S Kawabata M Kishi K t al | 1998 | Eur Respir J1998，2，2： | 2 |
| 17 | Immunotherapy synergizes with chemotherapy targeting pancreatic cancer显示文摘 | Shigeo Koido Sadamu Homma Akitaka Takahara Yoshihisa Namiki Hideo Komita Kan Uchiyama Masaki Ito Jianlin Gong Toshifumi Ohkusa Hisao Tajiri | 2012 | Immunotherapy2012，，1： | 2 |
| 18 | Chemoimmunotherapy targeting Wilms’ tumor 1 (WT1)-specific cytotoxic T lymphocyte and helper T cell responses for patients with pancreatic cancer显示文摘 | Shigeo Koido Sadamu Homma Masato Okamoto Kazuki Takakura Jianlin Gong Haruo Sugiyama Toshifumi Ohkusa Hisao Tajiri | 2014 | OncoImmunology2014，，10： | 2 |
| 19 | Biochar amendment techniques for upland rice production in Northern Laos显示文摘 | Hidetoshi Asai Benjamin K. Samson Haefele M. Stephan Khamdok Songyikhangsuthor Koki Homma Yoshiyuki Kiyono Yoshio Inoue Tatsuhiko Shiraiwa Takeshi Horie | 2008 | Field Crops Research2008，，1： | 2 |
| 20 | Topological pruning enables ultra-low Rayleigh scattering in pressure-quenched silica glass显示文摘Silica glass is the most indispensable material in optical communication applications due to its superior optical properties.The transmission loss of silica glass has been reduced over the past 30 years by continuous efforts toward decreasing density fluctuations by lowering of fictive temperature,e.g.,through improvements in processing or doping.A recent study has shown that shrinkage of structural voids by hot compression is a promising way to further decrease the loss.However,an atomic understanding of the pressure effect is still lacking.Here,using molecular simulations,we connect the void shrinkage to topological pruning of silica network.Two physical models predict that the Rayleigh scattering loss of pressure-quenched silica glass can be reduced by>50%when the glass is quenched at an appropriate pressure(4 GPa in our simulation).Our studies are consistent with available experimental results and demonstrate topologically optimized structure can give desirable properties for optical applications of silica as well as other glasses with similar network structure. | Yongjian Yang Osamu Homma Shingo Urata Madoka Ono John C.Mauro | 2020 | npj Computational Materials2020，，1： | 2 |
您所在的机构暂未开通此部分的功能，请联系管理员