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| 1 | Patients with early recurrence of hepatocellular carcinoma have poor prognosis显示文摘BACKGROUND: Early recurrence(ER) after hepatic resection(HR) is a poor prognostic factor for patients with hepatocellular carcinoma(HCC). This study aimed to identify the clinicopathological features, outcomes, and risk factors for ER after HR for small HCC in order to clarify the reasons why ER is a worse recurrence pattern.METHODS: We retrospectively examined 130 patients who underwent HR for small HCC(≤30 mm). Recurrence was classified into ER(<2 years) and late recurrence(LR)(≥2 years). The clinicopathological features, outcomes, and risk factors for ER were analyzed by multivariate analysis.RESULTS: ER was observed in 39 patients(30.0%). The survival rate of the ER group was significantly lower than that of the LR group(P<0.005), and ER was an independent prognostic factor for poor survival(P=0.0001). The ER group had a significantly higher frequency(P=0.0039) and shorter interval(P=0.027) of development to carcinoma beyond the Milan criteria(DBMC) compared with the LR group, and ER was an independent risk factor for DBMC(P<0.0001). Multi-nodularity, non-simple nodular type, and microvascular invasion were independent predictors for ER(P=0.012, 0.010, and 0.019, respectively).CONCLUSIONS: ER was a highly malignant recurrence pattern associated with DBMC and subsequent poor survival after HR for small HCC. Multi-nodularity, non-simple nodular type, and microvascular invasion predict ER, and taking these factors into consideration may be useful for the decision of the treatment strategy for small HCC after HR. | Tomoki Kobayashi Hiroshi Aikata Tsuyoshi Kobayashi Hideki Ohdan Koji Arihiro Kazuaki Chayama | 2017 | Hepatobiliary & Pancreatic Diseases International2017，16，3： | 15 |
| 2 | Clinical significance of type V_I pit pattern subclassification in determining the depth of invasion of colorectal neoplasms显示文摘AIM: To clarify whether subclassification of the type VI pit pattern on the basis of magnifying colonoscopy findings is useful in determining the type and depth of invasion of colorectal neoplasms.METHODS: We retrospectively analyzed 272 colorectal neoplasms (117 dysplasias and 155 submucosal invasive carcinomas; 228 patients) with a type V pit pattern [type VI, n = 202; type VN, n = 70 (Kudo and Tsuruta classification system)]. We divided lesions with a type VI pit pattern into two subclasses, mildly irregular lesions and severely irregular lesions, according to the prominent and detailed magnifying colonoscopy findings. We examined the relation between these two subclasses and histology/invasion depth.RESULTS: One hundred and four lesions (51.5%) were judged to be mildly irregular, and 98 lesions (48.5%) were judged to be severely irregular. Ninety-seven (93.3%) mildly irregular lesions showed dysplasias or submucosal invasion of less than 1000 μm (SM < 1000 μm). Fifty-five (56.1%) severely irregular lesions showed submucosal invasion equal to or deeper than 1000 μm (SM ≥ 1000 μm). Mild irregularity was found significantly more often in dysplasias or lesions with SM < 1000 μm than in lesions with SM ≥ 1000 μm (P < 0.01).CONCLUSION: Subclassification of the type VI pit pattern is useful for identifying dysplasias or lesions with SM < 1000 μm. | Hiroyuki Kanao Shinji Tanaka Shiro Oka Iwao Kaneko Shigeto Yoshida Koji Arihiro Masaharu Yoshihara Kazuaki Chayama | 2008 | World Journal of Gastroenterology2008，14，2： | 15 |
| 3 | Immunohistochemical molecular markers as predictors of curability of endoscopically resected submucosal colorectal cancer显示文摘AIM: To clarify the usefulness of immunohistochemical molecular markers in predicting lymph node metastasis of submucosal colorectal cancer. METHODS: We examined microvessel density, lymphatic vessel density, the Ki-67 labeling index, expression of MUC1 and Matrix metalloproteinase-7 (MMP-7) in tumor cells, and expression of cathepsin D in stromal cells at the invasive front by immunostaining of samples resected from 214 patients with submucosal colorectal cancer. Pathologic features were assessed on hematoxylin-eosin- stained samples. We evaluated the relations between clinicopathologic/immunohistochemical features and lymph node metastasis. RESULTS: Lesions of the superficial type, with an unfavorable histologic grade, budding, lymphatic involvement, high microvessel density (≥ 40), high lymphatic vessel density (≥ 9), high Ki-67 labeling index (≥ 42), and positivity of MUC1, cathepsin D, and MMP-7 showed a significantly high incidence of lymph node metastasis. Multivariate analysis revealed that high microvessel density, unfavorable histologic grade, cathepsin D positivity, high lymphatic vessel density, superficial type, budding, and MUC1 positivity were independent risk factors for lymph node metastasis.A combined examination with four independent immunohistochemical markers (microvessel density, cathepsin D, lymphatic vessel density, and MUC1) revealed that all lesions that were negative for all markers or positive for only one marker were negative for lymph node metastasis. CONCLUSION: Analysis of a combination of immuno- histochemical molecular markers in endoscopically resected specimens of submucosal colorectal cancer allows prediction of curability regardless of the pathologic features visible of hematoxylin-eosin-stained sections. | Iwao Kaneko Shinji Tanaka Shiro Oka Shigeto Yoshida Toru Hiyama Koji Arihiro Fumio Shimamoto Kazuaki Chayama | 2007 | World Journal of Gastroenterology2007，13，28： | 12 |
| 4 | Insights from advances in research of chemically induced experimental models of human inflammatory bowel disease显示文摘Inflammatory bowel disease(IBD),the most important being Crohn's disease and ulcerative colitis,results from chronic dysregulation of the mucosal immune system in the gastrointestinal tract.Although the pathogenesis of IBD remains unclear,it is widely accepted that genetic,environmental,and immunological factors are involved.Recent studies suggest that intestinal epithelial defenses are important to prevent inflammation by protecting against microbial pathogens and oxidative stresses.To investigate the etiology of IBD,animal models of experimental colitis have been developed and are frequently used to evaluate new anti-inflammatory treatments for IBD.Several models of experimental colitis that demonstrate various pathophysiological aspects of the human disease have been described.In this manuscript,we review the characteristic features of IBD through a discussion of the various chemically induced experimental models of colitis(e.g.dextran sodium sulfate-,2,4,6-trinitrobenzene sulfonic acid-,oxazolone-,acetic acid-,and indomethacin-induced models).We also summarize some regulatory and pathogenic factors demonstrated by these models that can,hopefully,be exploited to develop future therapeutic strategies against IBD. | Mayumi Kawada Atsuko Arihiro Emiko Mizoguchi | 2007 | World Journal of Gastroenterology2007，13，42： | 12 |
| 5 | Immunotherapy for colorectal cancer显示文摘The incidence of colorectal cancer(CRC)is on the rise,and the prognosis for patients with recurrent or metastatic disease is extremely poor.Although chemotherapy and radiation therapy can improve survival rates,it is imperative to integrate alternative strategies such as immunotherapy to improve outcomes for patients with advanced CRC.In this review,we will discuss the effect of immunotherapy for inducing cytotoxic T lymphocytes and the major immunotherapeutic approaches for CRC that are currently in clinical trials,including peptide vaccines,dendritic cell-based cancer vaccines,whole tumor cell vaccines,viral vector-based cancer vaccines,adoptive cell transfer therapy,antibody-based cancer immunotherapy,and cytokine therapy.The possibility of combination therapies will also be discussed along with the challenges presented by tumor escape mechanisms. | Shigeo Koido Toshifumi Ohkusa Sadamu Homma Yoshihisa Namiki Kazuki Takakura Keisuke Saito Zensho Ito Hiroko Kobayashi Mikio Kajihara Kan Uchiyama Seiji Arihiro Hiroshi Arakawa Masato Okamoto Jianlin Gong Hisao Tajiri | 2013 | World Journal of Gastroenterology2013，19，46： | 11 |
| 6 | Hepatocellular 癌和在一个肝糖存储疾病病人的肝的焦点的榴状的增生显示文摘 Glycogen storage disease type Ia (GSD-Ia; also called von Gierke disease) is an autosomal recessive disorder of carbohydrate metabolism caused by glucose-6-phosphatase deficiency. There have been many reports describing hepatic tumors in GSD patients; however, most of these reports were of hepatocellular adenomas, whereas there are only few reports describing focal nodular hyperplasia (FNH) or hepatocellular carcinoma (HCC). We report a case with GSD-Ia who had undergone a partial resection of the liver for FNH at 18 years of age and in whom moderately differentiated HCC had developed. Preoperative imaging studies, including ultrasonography, dynamic computer tomography (CT) and magnetic resonance imaging, revealed benign and malignant features. In particular, fluorodeoxyglucose-positron emission tomography (FDG-PET)/CT revealed the atypical findings that FDG accumulated at high levels in the non-tumorous hepatic parenchyma and low levels in the tumor. Right hemihepatectomy was performed. During the perioperative period, high-dose glucose and sodium bicarbonate were administered to control metabolic acidosis. He had multiple recurrences of HCC at 10 mo after surgery and was followed-up with transcatheter arterial chemoembolization. The tumor was already highly advanced when it was found by chance; therefore, a careful follow-up should be mandatory for GSD-I patients as they are at a high risk for HCC, similar to hepatitis patients. | Yoshihiro Mikuriya Akihiko Oshita Hirotaka Tashiro Hironobu Amano Tsuyoshi Kobayashi Kouji Arihiro Hideki Ohdan | 2012 | World Journal of Hepatology2012，4，6： | 4 |
| 7 | Atorvastatin decreases serum levels of advanced glycation endproducts (AGEs) in nonalcoholic steatohepatitis (NASH) patients with dyslipidemia: clinical usefulness of AGEs as a biomarker for the attenuation of NASH显示文摘 | Yuki Kimura Hideyuki Hyogo Sho-ichi Yamagishi Masayoshi Takeuchi Tomokazu Ishitobi Yoshitaka Nabeshima Koji Arihiro Kazuaki Chayama | 2010 | Journal of Gastroenterology2010，，7： | 3 |
| 8 | Fusions between dendritic cells and whole tumor cells as anticancer vaccines显示文摘 | Shigeo Koido Sadamu Homma Masato Okamoto Yoshihisa Namiki Kazuki Takakura Kan Uchiyama Mikio Kajihara Seiji Arihiro Hiroo Imazu Hiroshi Arakawa Shin Kan Hideo Komita Masaki Ito Toshifumi Ohkusa Jianlin Gong Hisao Tajiri | 2013 | OncoImmunology2013，，： | 3 |
| 9 | Characteristics of Metachronous Gastric Tumors after Endoscopic Submucosal Dissection for Gastric Intraepithelial Neoplasms显示文摘 | Tomoyuki Boda Masanori Ito Shiro Oka Yoko Kitamura Norifumi Numata Yoji Sanomura Taiji Matsuo Shinji Tanaka Masaharu Yoshihara Koji Arihiro Kazuaki Chayama Sergio Morini | 2014 | Gastroenterology Research and Practice2014，，： | 2 |
| 10 | A role for IL-17 in induction of an inflammation at the fetomaternal interface in preterm labour显示文摘 | Mika Ito Akitoshi Nakashima Takao Hidaka Motonori Okabe Nguyen Duy Bac Shihomi Ina Satoshi Yoneda Arihiro Shiozaki Shigeki Sumi Koichi Tsuneyama Toshio Nikaido Shigeru Saito | 2009 | Journal of Reproductive Immunology2009，，1： | 2 |
| 11 | Efficacy of atorvastatin for the treatment of nonalcoholic steatohepatitis with dyslipidemia显示文摘 | Hideyuki Hyogo Susumu Tazuma Koji Arihiro Keiko Iwamoto Yoshitaka Nabeshima Motoki Inoue Tomokazu Ishitobi Michihiro Nonaka Kazuaki Chayama | 2008 | Metabolism2008，，12： | 2 |
| 12 | Loss of CD9 with expression of CD31 and VEGF in breast carcinoma, aspredictive factors of lymph node metastasis显示文摘 | Arihiro K Kaneko M Fujii S | 1998 | Breast Cancer1998，5，2： | 1 |
| 13 | Possible involvement of regulatory T cells in tumor onset and progression in primary breast cancer显示文摘 | Masahiro Ohara Yoshiyuki Yamaguchi Kazuo Matsuura Shigeru Murakami Koji Arihiro Morihito Okada | 2009 | Cancer Immunology Immunotherapy2009，，3： | 1 |
| 14 | FOXP3 expression of micrometastasis-positive sentinel nodes in breastcancer patients显示文摘 | Kazuo Matsuura Yoshiyuki Yamaguchi Akihiko Osaki Masahiro Ohara Riki Okita Akiko Emi Shigeru Murakami Koji Arihiro | 2009 | Oncology Reports2009，，5： | 1 |
| 15 | The usefulness of MDCT in Crohn's disease显示文摘 | Nagamata H Inadama E Arihiro S | 2002 | Nippon Shokakibyo Gakkai Zasshi2002，99，： | 1 |
| 16 | Down-regulationof KAI1 messenger RNA expression is not associated withloss of heterozygosity of the KAI1 gene region in lung adeno-carcinoma 显示文摘 | Tagawa K Arihiro K Takeshima Y | 1999 | Jpn J Cancer Res1999，90，9： | 1 |
| 17 | Mutagenicity of aristolochic acid in the lambda/lacZ transgenic mouse (Muta-Mouse) 显示文摘 | Arihiro K Takayoshi S Masamitsu H | 2002 | Murat Res2002，515，： | 1 |
| 18 | Key role for transketolase activity in erythritol production byTrichosporonoides megachiliensis SN - G42 显示文摘 | Katsuhiko S Arihiro T Takashi Y | 2009 | Journal of Bioscience and Bioengineering2009，108，5： | 1 |
| 19 | Intravenous nicardipine dosing for blood pressure lowering in acute intracerebral hemorrhage: the stroke acute management with urgent risk-factor assessment and improvement-intracerebral hemorrhage study显示文摘 | Koga M Arihiro S Hasegawa Y | 2014 | J Stroke Cerebrovasc Dis2014，23，10： | 1 |
| 20 | Fullerene glycoconjugates:A general synthetic approach via cycloaddition of per-O-acetyl glycosyl azides tofullerene显示文摘 | Arihiro Yashiro Yoshihiro Nishida Masatomi Ohno | 1998 | Tetrahedron Letters1998，39，49： | 1 |
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