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| 1 | Endoscopic diagnosis of extrahepatic bile duct carcinoma:Advances and current limitations显示文摘The accurate diagnosis of extrahepatic bile duct carcinoma is difficult,even now.When ultrasonography(US)shows dilatation of the bile duct,magnetic resonance cholangiopancreatography followed by endoscopic US(EUS)is the next step.When US or EUS shows localized bile duct wall thickening,endoscopic retrograde cholangiopancreatography should be conducted with intraductal US(IDUS)and forceps biopsy.Fluorescence in situ hybridization increases the sensitivity of brush cytology with similar specificity.In patients with papillary type bile duct carcinoma,three biopsies are sufficient.In patients with nodular or infiltrating-type bile duct carcinoma,multiple biopsies are warranted,and IDUS can compensate for the limitations of biopsies.In preoperative staging,the combination of dynamic multidetector low computed tomography(MDCT)and IDUS is useful for evaluating vascular invasion and cancer depth infiltration.However,assessment of lymph nodes metastases is difficult.In resectable cases,assessment of longitudinal cancer spread is important.The combination of IDUS and MDCT is useful for revealing submucosal cancer extension,which is common in hilar cholangiocarcinoma.To estimate the mucosal extenextension,which is common in extrahepatic bile duct carcinoma,the combination of IDUS and cholangioscopy is required.The utility of current peroral cholangioscopy is limited by the maneuverability of the“baby scope”.A new baby scope(10 Fr),called“SpyGlass”has potential,if the image quality can be improved.Since extrahepatic bile duct carcinoma is common in the Far East,many researchers in Japan and Korea contributed these studies,especially,in the evaluation of longitudinal cancer extension. | Kiichi Tamada Jun Ushio Kentaro Sugano | 2011 | World Journal of Clinical Oncology2011，2，5： | 26 |
| 2 | Diagnostic and therapeutic single-operator cholangiopancreatoscopy in biliopancreatic diseases:Prospective multicenter study in Japan显示文摘AIM: To assess the utility and safety of single-operator cholangiopancreatoscopy(SOCPS) using the Spy Glass system in widespread clinical application for biliary and pancreatic diseases.METHODS: This study was a prospective case series conducted in 20 referral centers in Japan. There were 148 patients who underwent SOCPS; 124 for biliary diseases and 24 for pancreatic diseases. The attempted interventions were SOCPS examination, SOCPS-directed tissue sampling, and therapy for stone removal, among others. The main outcomes were related to the procedure success rate in terms of visualizing the target lesions, SOCPS-directed adequate tissue sampling, and complete stone removal. RESULTS: A total of 148 patients were enrolled for the diagnosis of indeterminate biliary and pancreatic lesions or treatment of biliary and pancreatic disease. The overall procedure success rate of visualizing the target lesions was 91.2%(135/148). The overall procedural success rates of visualizing the target lesions of diagnostic SOCPS in the bile duct and pancreatic duct were 95.5%(84/89) and 88.2%(15/17), respectively. Diagnosis: the overall adequate tissue for histologic examination was secured in 81.4% of the 86 patients who underwent biopsy under SOCPS(bile duct, 60/75, 80.0%; pancreatic duct, 10/11, 90.9%). The accuracy of histologic diagnosis using SOCPS-directed biopsies in indeterminate bile duct lesions was 70.7%(53/75). In the pancreatic duct, the accuracy of SOCPS visual impression of intraductal papillary mucinous neoplasm was 87.5%(14/16). Stone therapy: complete biliary and pancreatic stone clearance combined with SOCPS-directed stone therapy using electrohydraulic lithotripsy or laser lithotripsy was achieved in 74.2%(23/31) and 42.9%(3/7) of the patients, respectively. Others: SOCPS using the Spy Glass system was used in cannulation of the cystic duct in two patients and for passing across the obstructed self-expandable metallic stent for a malignant biliary stricture in two patients. All procedures were successful in both SOCPS-guided therapies. The incidence of procedure-related adverse events was 5.4%(8/148). CONCLUSION: SOCPS with direct visualization and biopsy for diagnosis and SOCPS-directed therapy for biliary and pancreatic diseases can be safely performed with a high success rate. | Toshio Kurihara Ichiro Yasuda Hiroyuki Isayama Toshio Tsuyuguchi Taketo Yamaguchi Ken Kawabe Yoshinobu Okabe Keiji Hanada Tsuyoshi Hayashi Takao Ohtsuka Syuhei Oana Hiroshi Kawakami Yoshinori Igarashi Kazuya Matsumoto Kiichi Tamada Shomei Ryozawa Hiroki Kawashima Yutaka Okamoto Iruru Maetani Hiroyuki Inoue Takao Itoi | 2016 | World Journal of Gastroenterology2016，22，5： | 20 |
| 3 | Multicenter study of endoscopic preoperative biliary drainage for malignant distal biliary obstruction显示文摘AIM: To determine the optimal method of endoscopic preoperative biliary drainage for malignant distal biliary obstruction.METHODS: Multicenter retrospective study was conducted in patients who underwent plastic stent(PS) or nasobiliary catheter(NBC) placement for resectable malignant distal biliary obstruction followed by surgery between January 2010 and March 2012. Procedurerelated adverse events, stent/catheter dysfunction(occlusion or migration of PS/NBC, developmentof cholangitis, or other conditions that required repeat endoscopic biliary intervention), and jaundice resolution(bilirubin level < 3.0 mg/d L) were evaluated. Cumulative incidence of jaundice resolution and dysfunction of PS/NBC were estimated using competing risk analysis. Patient characteristics and preoperative biliary drainage were also evaluated for association with the time to jaundice resolution and PS/NBC dysfunction using competing risk regression analysis.RESULTS: In total, 419 patients were included in the study(PS, 253 and NBC, 166). Primary cancers included pancreatic cancer in 194 patients(46%), bile duct cancer in 172(41%), gallbladder cancer in three(1%), and ampullary cancer in 50(12%). The median serum total bilirubin was 7.8 mg/d L and 324 patients(77%) had ≥ 3.0 mg/d L. During the median time to surgery of 29 d [interquartile range(IQR), 30-39 d]. PS/NBC dysfunction rate was 35% for PS and 18% for NBC [Subdistribution hazard ratio(SHR) = 4.76; 95%CI: 2.44-10.0, P < 0.001]; the pig-tailed tip was a risk factor for PS dysfunction. Jaundice resolution was achieved in 85% of patients and did not depend on the drainage method(PS or NBC).CONCLUSION: PS has insufficient patency for preoperative biliary drainage. Given the drawbacks of external drainage via NBC, an alternative method of internal drainage should be explored. | Naoki Sasahira Tsuyoshi Hamada Osamu Togawa Ryuichi Yamamoto Tomohisa Iwai Kiichi Tamada Yoshiaki Kawaguchi Kenji Shimura Takero Koike Yu Yoshida Kazuya Sugimori Shomei Ryozawa Toshiharu Kakimoto Ko Nishikawa Katsuya Kitamura Tsunao Imamura Masafumi Mizuide Nobuo Toda Iruru Maetani Yuji Sakai Takao Itoi Masatsugu Nagahama Yousuke Nakai Hiroyuki Isayama | 2016 | World Journal of Gastroenterology2016，22，14： | 18 |
| 4 | Activation of hypoxia-inducible factor 1 attenuates periapical inflammation and bone loss显示文摘Hypoxia(low oxygen level) is an important feature during infections and affects the host defence mechanisms. The host has evolved specific responses to address hypoxia, which are strongly dependent on the activation of hypoxia-inducible factor 1(HIF-1).Hypoxia interferes degradation of HIF-1 alpha subunit(HIF-1α), leading to stabilisation of HIF-1α, heterodimerization with HIF-1 beta subunit(HIF-1β) and subsequent activation of HIF-1 pathway. Apical periodontitis(periapical lesion) is a consequence of endodontic infection and ultimately results in destruction of tooth-supporting tissue, including alveolar bone. Thus far, the role of HIF-1 in periapical lesions has not been systematically examined. In the present study, we determined the role of HIF-1 in a wellcharacterised mouse periapical lesion model using two HIF-1α-activating strategies, dimethyloxalylglycine(DMOG) and adenovirusinduced constitutively active HIF-1α(CA-HIF1 A). Both DMOG and CA-HIF1 A attenuated periapical inflammation and tissue destruction. The attenuation in vivo was associated with downregulation of nuclear factor-κappa B(NF-κB) and osteoclastic gene expressions. These two agents also suppressed NF-κB activation and subsequent production of proinflammatory cytokines by macrophages. Furthermore, activation of HIF-1α by DMOG specifically suppressed lipopolysaccharide-stimulated macrophage differentiation into M1 cells, increasing the ratio of M2 macrophages against M1 cells. Taken together, our data indicated that activation of HIF-1 plays a protective role in the development of apical periodontitis via downregulation of NF-κB, proinflammatory cytokines, M1 macrophages and osteoclastogenesis. | Kimito Hirai Hisako Furusho Kiichi Hirota Hajime Sasaki | 2018 | International Journal of Oral Science2018，10，2： | 16 |
| 5 | 早胃的癌症用的程度的诊断灵活光谱成像颜色改进显示文摘 The demarcation line between the cancerous lesion and the surrounding area could be easily recognized with flexible spectral imaging color enhancement (FICE) system compared with conventional white light images. The characteristic f inding of depressed-type early gastric cancer (EGC) in most cases was revealed as reddish lesions distinct from the surrounding yellowish non-cancerous area without magnification. Conventional endoscopic images provide little information regarding depressed lesions located in the tangential line, but FICE produces higher color contrast of such cancers. Histological f indings in depressed area with reddish col- or changes show a high density of glandular structure and an apparently irregular microvessel in intervening parts between crypts, resulting in the higher color con- trast of FICE image between cancer and surrounding area. Some depressed cancers are shown as whitish lesion by conventional endoscopy. FICE also can pro- duce higher color contrast between whitish cancerous lesions and surrounding atrophic mucosa. For nearly flat cancer, FICE can produce an irregular structuralpattern of cancer distinct from that of the surrounding mucosa, leading to a clear demarcation. Most elevated-type EGCs are detected easily as yellowish lesions with clearly contrasting demarcation. In some cases, a partially reddish change is accompanied on the tumor surface similar to depressed type cancer. In addition, the FICE system is quite useful for the detection of minute gastric cancer, even without magnif ication. These new contrasting images with the FICE system may have the potential to increase the rate of detection of gastric cancers and screen for them more effectively as well as to determine the extent of EGC. | Hiroyuki Osawa Hironori Yamamoto Yoshimasa Miura Mitsuyo Yoshizawa Keijiro Sunada Kiichi Satoh Kentaro Sugano | 2012 | World Journal of Gastrointestinal Endoscopy2012，4，8： | 11 |
| 6 | Endoscopic tissue shielding method with polyglycolic acid sheets and fibrin glue to prevent delayed perforation after duodenal endoscopic submucosal dissection显示文摘 | Kengo Takimoto Yoshihito Imai Kiichi Matsuyama | 2014 | Digestive Endoscopy2014，，： | 5 |
| 7 | Influence Analysis of Emotional Behaviors and User Relationships Based on Twitter Data显示文摘One of the main purposes for which people use Twitter is to share emotions with others.Users can easily post a message as a short text when they experience emotions such as pleasure or sadness.Such tweet serves to acquire empathy from followers,and can possibly influence others' emotions.In this study,we analyze the influence of emotional behaviors to user relationships based on Twitter data using two dictionaries of emotional words.Emotion scores are calculated via keyword matching.Moreover,we design three experiments with different settings: calculate the average emotion score of a user with random sampling,calculate the average emotion score using all emotional tweets,and calculate the average emotion score using emotional tweets,excluding users of few emotional tweets.We evaluate the influence of emotional behaviors to user relationships through the Brunner–Munzel test.The result shows that a positive user is more active than a negative user in constructing user relationships in a specific condition. | Kiichi Tago Qun Jin | 2018 | Tsinghua Science and Technology2018，23，1： | 5 |
| 8 | Can EUS-guided FNA distinguish between gallbladder cancer and xanthogranulomatous cholecystitis?显示文摘 | Susumu Hijioka Mohamed A. Mekky Vikram Bhatia Akira Sawaki Nobumasa Mizuno Kazuo Hara Waki Hosoda Yasuhiro Shimizu Kiichi Tamada Yasumasa Niwa Kenji Yamao | 2010 | Gastrointestinal Endoscopy2010，，3： | 3 |
| 9 | Multi-center randomized controlled study to establish the standard third-line regimen for Helicobacter pylori eradication in Japan显示文摘 | Kazunari Murakami Takahisa Furuta Takashi Ando Takeshi Nakajima Yoshikatsu Inui Tadayuki Oshima Toshihiko Tomita Katsuhiro Mabe Makoto Sasaki Takanori Suganuma Hideyuki Nomura Kiichi Satoh Shinichiro Hori Syuuji Inoue Takeshi Tomokane Mineo Kudo Tomoki In | 2013 | Journal of Gastroenterology2013，，10： | 3 |
| 10 | INTRACELLULAR MANIPULATION BY FEMTOSECOND LASERS:REVIEW显示文摘Multiphoton absorption of femtosecond laser pulses focused through an objective with high numerical aperture(NA)can be used to image and manipulate cellular and intracellular objects.This review highlights recent advances in intracellular manipulation,including nanosurgery and labeling in living cells with femtosecond lasers. | WATARU WATANABE SACHIHIIRO MATSUNAGA KIICHI FUKUI KAZUYOSHI ITOH | 2009 | Journal of Innovative Optical Health Sciences2009，2，1： | 2 |
| 11 | Success rate of curative endoscopic mucosal resection with circumferential mucosal incision assisted by submucosal injection of sodium hyaluronate显示文摘 | Hironori Yamamoto Hiroshi Kawata Keijiro Sunada Kiichi Satoh Yoshinari Kaneko Kenichi Ido Kentaro Sugano | 2002 | Gastrointestinal Endoscopy2002，，4： | 2 |
| 12 | Monitored anes thesia care with dexmedetomidine of a patient with severe pul monary arterial hypertension for inguinal hernioplasty 显示文摘 | HIROMI S KIICHI H MASAMI S | 2010 | Anesth2010，24，： | 1 |
| 13 | Changes in plasma ghrelin levels, gastric ghrelin production, and body weight after Helicobacter pylori cure显示文摘 | Hiroyuki Osawa Hiroto Kita Hirohide Ohnishi Masamitsu Nakazato Yukari Date Christopher L. Bowlus Yumiko Ishino Eiko Watanabe Tomomi Shiiya Hiroaki Ueno Hiroko Hoshino Kiichi Satoh Kentaro Sugano | 2006 | Journal of Gastroenterology2006，，10： | 1 |
| 14 | Repetitive sequences: cause for variation in genome size and chromosome morphology in the genus Oryza显示文摘 | Sakurako Uozu Hiroshi Ikehashi Nobuko Ohmido Hisako Ohtsubo Eiichi Ohtsubo Kiichi Fukui | 1997 | Plant Molecular Biology1997，，6： | 1 |
| 15 | Optimal band imaging system can facilitate detection of changes in depressed-type early gastric cancer显示文摘 | Hiroyuki Osawa Mitsuyo Yoshizawa Hironori Yamamoto Hiroto Kita Kiichi Satoh Hirohide Ohnishi Hidetoshi Nakano Masahiro Wada Masayuki Arashiro Mamiko Tsukui Kenichi Ido Kentaro Sugano | 2008 | Gastrointestinal Endoscopy2008，，2： | 1 |
| 16 | Endothelin-1 causes pulmonary vasodilation in rats 显示文摘 | Kiichi H David M Rodman C | 1990 | Am Physio Soci1990，72，： | 1 |
| 17 | Physical Chemistry of the Groups IVa (Ti, Zr), Va (V, Nb, Ta) and the Rare Earth Elements in Steel显示文摘 | NARITA Kiichi | 1975 | Trans ISIJ1975，15，： | 1 |
| 18 | Neural conversion of Es cells by an inductive activity on human amniotic membrane matrix 显示文摘 | Morio Ueno Michiru Matsumura Kiichi Watanabe | 2006 | PNAS2006，103，25： | 1 |
| 19 | Generation of Rx+/Pax6+ neural retinal precursors from embryonic stem cells显示文摘 | Hanako I Fumitaka O Kiichi W | 2005 | Proc Natl Acad Sci USA2005，102，11： | 1 |
| 20 | Expression of homeobox gene CDX2 precedes that of CDX1 during the progression of intestinal metaplasia显示文摘 | Akashi Eda Hiroyuki Osawa Ichiro Yanaka Kiichi Satoh Hiroyuki Mutoh Ken Kihira Kentaro Sugano | 2002 | Journal of Gastroenterology2002，，2： | 1 |
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