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| 1 | Surgical techniques and postoperative management to prevent postoperative pancreatic fistula after pancreatic surgery显示文摘Postoperative pancreatic fistula (POPF) is one of the most severe complications after pancreatic surgeries. POPF develops as a consequence of pancreatic juice leakage from a surgically exfoliated surface and/or anastomotic stump, which sometimes cause intraperitoneal abscesses and subsequent lethal hemorrhage. In recent years, various surgical and perioperative attempts have been examined to reduce the incidence of POPF. We reviewed several well-designed studies addressing POPF-related factors, such as reconstruction methods, anastomotic techniques, stent usage, prophylactic intra-abdominal drainage, and somatostatin analogs, after pancreaticoduodenectomy and distal pancreatectomy, and we assessed the current status of POPF. In addition, we also discussed the current status of POPF in minimally invasive surgeries, laparoscopic surgeries, and robotic surgeries. | Hiromichi Kawaida Hiroshi Kono Naohiro Hosomura Hidetake Amemiya Jun Itakura Hideki Fujii Daisuke Ichikawa | 2019 | World Journal of Gastroenterology2019，25，28： | 43 |
| 2 | miR-122-5p as a novel biomarker for alpha-fetoproteinproducing gastric cancer显示文摘AIM To investigate the clinical utility of alpha-fetoprotein(AFP)-producing gastric cancer(AFPGC)-specific microRNA(mi RNA)for monitoring and prognostic prediction of patients.METHODS We performed a comprehensive miRNA array-based approach to compare miRNA expression levels between AFP-positive and AFP-negative cells in three patients with primary AFPGC.We next examined the expression levels of the selected miRNAs in five AFPGC and ten non-AFPGC tissue samples by quantitative reverse transcription-polymerase chain reaction to validate their utility.We also investigated the expression levels of the selected miRNA not only in tissue but also in plasma samples.Moreover,we investigated the relationship between plasma AFP levels and plasma selected miRNA expression levels,and also investigated the correlation of the selected miRNA expression levels and malignant potential.RESULTS Among the five miRNAs selected from the miRNA array results,the expression levels of miR-122-5p were significantly higher in the AFPGC patients than in the non-AFPGC patients(P<0.05).In tissue samples,mi R-122-5p expression level tended to be lower in the non-AFPGC tissue than the normal gastric mucosa.Conversely,in the AFPGC tissue,miR-122-5p expression level was significantly higher in the AFPGC tissue than both the normal gastric mucosa and the nonAFPGC tissue samples(P<0.05).Plasma mi R-122-5p expression levels were also significantly higher in the AFPGC patients than the health volunteers and the nonAFPGC patients(P<0.05)and were strongly correlated with plasma AFP levels(r=0.7975,P<0.0001).Moreover,the correlation of miR-122-5p expression in tissue samples with malignant potential was stronger than that of plasma AFP level in the AFPGC patients.In contrast,no correlation was found between mi R-122-5p expression levels and liver metastasis in the non-AFPGC patients.CONCLUSION miR-122-5p might be a useful biomarker for early detection and disease monitoring in AFPGC. | Suguru Maruyama Shinji Furuya Kensuke Shiraishi Hiroki Shimizu Hidenori Akaike Naohiro Hosomura Yoshihiko Kawaguchi Hidetake Amemiya Hiromichi Kawaida Makoto Sudo Shingo Inoue Hiroshi Kono Daisuke Ichikawa | 2018 | World Journal of Gastrointestinal Oncology2018，10，10： | 6 |
| 3 | Improvement of drilling performence by vibration cutting显示文摘 | HIDETAKE KUBOTA | 1999 | The International Journal for Manufacturing Science & Production1999，2，2： | 1 |
| 4 | Pathogenesis of lipid metabolism disorder in hepatitis C: Polyunsaturated fatty acids counteract lipid alterations induced by the core protein显示文摘 | Hideyuki Miyoshi Kyoji Moriya Takeya Tsutsumi Seiko Shinzawa Hajime Fujie Yoshizumi Shintani Hidetake Fujinaga Koji Goto Toru Todoroki Tetsuro Suzuki Tatsuo Miyamura Yoshiharu Matsuura Hiroshi Yotsuyanagi Kazuhiko Koike | 2010 | Journal of Hepatology2010，，3： | 1 |
| 5 | Boron isotope fractionation accompanying boron mineral formation from aqueous boric acid-sodium hydroxide solutions at 25℃显示文摘 | Takao Oi J unpei Kato Tomoko Ossaka Hidetake Kakihana | 1991 | Geochemical Journal1991，25，： | 1 |
| 6 | Effect of car- diac function on aortic peak time and peak enhancement during coro- nary CT angiography显示文摘 | Shuji Sakai Hidetake Yabuuchi Akiko Chishaki et 01 | 2010 | European Journal of Radiology2010，75，2： | 1 |
| 7 | Development of Wearable Medical Device for Bio-MEMS,BioMEMS and Nanotechnology II显示文摘 | Naoyuki NAKANISHI1 Hidetake YAMAMOTO Kazuyoshi TSUCHIYA | | Edited by0，，： | 1 |
| 8 | Structural studies of 30Na20-5SiO2-65 glasses by nuclear magnetic resonance, raman and infrared spectroscopy 显示文摘 | Hiroshi Y Keishi N Hidetake Y | 1999 | Journal of Non-Crystalline Solids1999，248，： | 1 |
| 9 | Internal fixateon with the low profile plate system compared with kirscher wire fixation : Clinical results of treatment for metacarpal and phalangeal fractures 显示文摘 | Hidetake Takigami Hiroaki Sakano | 2010 | Hand Surgery2010，15，1： | 1 |
| 10 | Incidence of hypertrophic pul- monary osteoarthropathy associated with primary lung cancer 显示文摘 | Miiru I Koichi T Hidetake Y | 2010 | Respirology2010，15，5： | 1 |
| 11 | Glucose 1-phosphate increases active transport of calcium in intestine显示文摘 | Hidetake F Junji N Hisataka K | 2007 | Archives of Biochemistry and Biophysics2007，460，2： | 1 |
| 12 | Application of titanium and its future technology 显示文摘 | Hidetake Kusamichi | 1986 | Journal of The Iron and Steel Institute of Japan1986，6，： | 1 |
| 13 | Pluripotent stem cells as source of dendritic cells for immune therapy显示文摘 | Satoru Senju Shinya Hirata Yutaka Motomura Daiki Fukuma Yusuke Matsunaga Satoshi Fukushima Hidetake Matsuyoshi Yasuharu Nishimura | 2010 | International Journal of Hematology2010，，3： | 1 |
| 14 | Adsorption of cholesterol using amineappended beta-cyclodextrin cross-linked polymers 显示文摘 | HIDETAKE S YOSUKE K | 2006 | Kobunshi Ronbunshu2006，63，6： | 1 |
| 15 | Effect of glycyrrhizin, an active component of licorice roots, on HIV replication in cultures of peripheral blood mononuclear cells from HIV Seropositive patients显示文摘 | Hidetaks S Miva T Makiko K | 2002 | Pathobiology2002，70，： | 1 |
| 16 | Pulmonary Complications after Hepatic Artery Chemoembolization or Infusion via the Inferior Phrenic Artery for Primary Liver Cancer显示文摘 | Tsuyoshi Tajima Hiroshi Honda Toshirou Kuroiwa Hidetake Yabuuchi Takashi Okafuji Kengo Yosimitsu Hiroyuki Irie Hitoshi Aibe Kouji Masuda | 2002 | Journal of Vascular and Interventional Radiology2002，，9： | 1 |
| 17 | Application of titanium and its future technology 显示文摘 | Hidetake Kusam ichi | 1986 | Journal of the Iron and Steel Institute of Japan1986，，6： | 1 |
| 18 | Disruption of Microtubules As an Early Sign of Irreversible Ischemic Injury Immunohistochemical Study of In Situ Canine Hearts显示文摘 | Kunimitsu Iwai Masatsugu Hori Akira Kitabatake Hidetake Kurihara Kiyohisa Uchida Michitoshi Inoue Takenobu Kamada | 1990 | Circulation Research1990，，3： | 1 |
| 19 | An evahmtion of cutting edge and machine ability of inclined planetary motion milling for diffieuh-to-cut materials显示文摘 | HIDETAKE T MITSURU K TAKAFUMI S | 2015 | Proeedia CIRP2015，35，： | 1 |
| 20 | Experimental study on tilted planetary motion drilling for CFRP显示文摘 | HIDETAKE'F KAZUKI O RYO T | 2012 | Procedia C1RP2012，1，： | 1 |
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