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| 1 | Helicobacter pylori infection and liver diseases: Epidemiology and insights into pathogenesis显示文摘Both Helicobacter pylori(H. pylori) infection and liver diseases, including nonalcoholic fatty liver disease(NAFLD), viral hepatitis, and hepatocellular carcinoma(HCC), have high prevalences worldwide, and the relationship between H. pylori infection and liver disease has been discussed for many years. Although positive correlations between H. pylori and NAFLD have been identified in some clinical and experimental studies, nega-tive correlations have also been obtained in high-quality clinical studies. Associations between H. pylori and the pathogenesis of chronic viral hepatitis, mainly disease progression with fibrosis, have also been suggested in some clinical studies. Concerning HCC, a possible role for H. pylori in hepatocarcinogenesis has been identified since H. pylori genes have frequently been detected in resected HCC specimens. However, no study hasrevealed the direct involvement of H. pylori in promoting the development of HCC. Although findings regarding the correlations between H. pylori and liver disease pathogenesis have been accumulating, the existing data do not completely lead to an unequivocal conclusion. Further high-quality clinical and experimental analyses are necessary to evaluate the efficacy of H. pylori eradication in ameliorating the histopathological changes observed in each liver disease. | Kazuya Okushin Takeya Tsutsumi Kazuhiko Ikeuchi Akira Kado Kenichiro Enooku Hidetaka Fujinaga Kyoji Moriya Hiroshi Yotsuyanagi Kazuhiko Koike | 2018 | World Journal of Gastroenterology2018，24，32： | 15 |
| 2 | Groundwater monitoring of an open-pit limestone quarry:Water-rock interaction and mixing estimation within the rock layers by geochemical and statistical analyses显示文摘Water-rock interaction and groundwater mixing are important phenomena in understanding hydrogeological systems and the stability of rock slopes especially those consisting largely of moderately watersoluble minerals like calcite. In this study, the hydrogeological and geochemical evolutions of groundwater in a limestone quarry composed of three strata: limestone layer(covering), interbedded layer under the covering layer, and slaty greenstone layer(basement) were investigated. Water-rock interaction in the open-pit limestone quarry was evaluated using PHREEQC, while hierarchical cluster analysis(HCA)and principal component analysis(PCA) were used to classify and identify water sources responsible for possible groundwater mixing within rock layers. In addition, Geochemist's Workbench was applied to estimate the mixing fractions to clarify sensitive zones that may affect rock slope stability. The results showed that the changes in Ca2+and HCO3àconcentrations of several groundwater samples along the interbedded layer could be attributed to mixing groundwater from the limestone layer and that from slaty greenstone layer. Based on the HCA and PCA results, groundwaters were classified into several types depending on their origin:(1) groundwater from the limestone layer(LO),(2) mixed groundwater flowing along the interbedded layer(e.g., groundwater samples L-7, L-11, S-3 and S-4), and(3) groundwater originating from the slaty greenstone layer(SO). The mixing fractions of 41% LO: 59% SO, 64% LO: 36% SO, 43%LO: 57% SOand 25% LO: 75% SOon the normal days corresponded to groundwaters L-7, L-11, S-3 and S-4,respectively, while the mixing fractions of groundwaters L-7 and L-11(61% LO: 39% SOand 93% LO: 7% SO,respectively) on rainy days became the majority of groundwater originating from the limestone layer.These indicate that groundwater along the interbedded layer significantly affected the stability of rock slopes by enlarging multi-breaking zones in the layer through calcite dissolution and inducing high water pressure, tension cracks and potential sliding plane along this layer particularly during intense rainfall episodes. | Khy Eam Eang Toshifumi Igarashi Megumi Kondo Tsurugi Nakatani Carlito Baltazar Tabelin Ryota Fujinaga | 2018 | International Journal of Mining Science and Technology2018，28，6： | 6 |
| 3 | Isolation and multilineage differentiation of bovine bone marrow mesenchymal stem cells显示文摘 | Darko Bosnakovski Morimichi Mizuno Gonhyung Kim Satoshi Takagi Masahiro Okumura Toru Fujinaga | 2005 | Cell and Tissue Research2005，，2： | 2 |
| 4 | Structurebased computational database screening, in vitro assay, and NMR assessment of compounds that target TAR RNA显示文摘 | LIND K E DU Z FUJINAGA K | 2002 | Chem Biol2002，9，2： | 1 |
| 5 | Traeheo-innominate artery fistula: two case reports and a clinical review显示文摘 | Komatsu T Sowa T Fujinaga T | 2013 | Ann Thorac Cardiovasc Surg2013，19，1： | 1 |
| 6 | Development of nested PCR based on the viaB sequence to detect Salmonella typhi显示文摘 | HASHIMOTO Y ITHO Y FUJINAGA Y | 1995 | J Clin Mierobiol1995，33，： | 1 |
| 7 | In vivo anatomical analysis of arterial con- tact with lxigemlnal nerve: detection with three-dimensional spoiled grass imagin显示文摘 | Ueda F Suzuki M Fujinaga Y | 1999 | Br J Radiol1999，72，9： | 1 |
| 8 | Dose coronary artery stenting for acute myocardial infarction improve left ventricular overload at the chronic stage?显示文摘 | Nomura M Fujinaga H | 2004 | Japan Heart J2004，45，2： | 1 |
| 9 | Detection of human Papillomavirus deoxyribonucleic acid in penile carcinoma by polymerase chain reaction and in situ hybridization显示文摘 | Kumamoto Y Fujinaga K | 1993 | J Urol1993，149，1： | 1 |
| 10 | Development of nested PCR based on the ViaB sequence to detect Salmonella显示文摘 | Hashimoto Y Itho Y Fujinaga Y | 1995 | J Clin Microbiol1995，33，3： | 1 |
| 11 | Improvement of the oral bioavailability of digitalis glycosides by cyclodextrin complexation显示文摘 | Uekama K Fujinaga T Hirayama F | 1983 | J Pharm Sci1983，72，11： | 1 |
| 12 | Neurobiology of nitrous oxide-induced antinociceptive effects 显示文摘 | FUJINAGA M MAZE M | 2002 | Mol Neurobiol2002，25，2： | 1 |
| 13 | Independent risk factors for chronic cyclosporine induced nephropathy in children with nephrotic syndrome显示文摘 | Fujinaga S Kaneko K Muto T | 2006 | Arch Dis Child2006，91，8： | 1 |
| 14 | High-dose Mizoribine Therapy for Childhood-onset Frequently Relapsing Steroid-dependent Nephrotic Syndrome with Cyclosporin Nephrotoxicity显示文摘 | OHTOMO Y FUJINAGA S TAKADA M | 2005 | Pediatr Nephrol2005，20，12： | 1 |
| 15 | The angiotension type 2(AT2)receptorantagonizes the growth effects of the AT1 receptor:gain of function study using genetransfer显示文摘 | Nakajima M Hutchinson HG Fujinaga M | 1995 | Proc Natl Acad Sci USA1995，92，10： | 1 |
| 16 | Locally applied cilostazol suppresses neointimal hyperplasia by inhibiting tenascin-C synthesis and smooth muscle cell proliferation in free artery grafts显示文摘 | Fujinaga K Onoda K Yamamoto K | 2004 | J Thorac Cardiovasc Surg2004，128，3： | 1 |
| 17 | Cyclosporine versus mycophenolate mofetii for maintenance of remission of steroid-dependent nephrotic syndrome after a single infusion of rituximab显示文摘 | Fujinaga S Someya T Watanabe T Ito A Ohtomo Y Shimizu T | 2013 | Eur J Pediatr2013，172，： | 1 |
| 18 | A follow-up report on a new method of segmental resection for small-sized early lung cancer显示文摘 | Toru Bando Ryo Miyahara Hiroaki Sakai Tsuyoshi Shoji Makoto Sonobe Kiyoshi Sato Takuji Fujinaga Fengshi Chen Kenichi Okubo Toshiki Hirata Hiromi Wada | 2008 | Lung Cancer2008，，1： | 1 |
| 19 | Nephrotoxicity of once-daily cyclosporine A in minimal change nephrotic syndrome显示文摘 | Fujinaga S Hirano D Murakami H | 2012 | Pediatric Nephrology2012，27，4： | 1 |
| 20 | Topical formulations and wound healing applications of chitosan 显示文摘 | UENO H MORI T FUJINAGA T | 2001 | Advanced Drug Delivery Reviews2001，52，2： | 1 |
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