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| 1 | 乳腺癌的分子分类及其临床应用显示文摘乳腺癌是一组异质性很高的肿瘤。当前在乳腺癌的诊断和治疗上已取得了重要进展,包括乳腺摄片筛查、化疗方案以及针对ER和HER2的内分泌治疗和靶向治疗,已开始降低了乳腺癌的病死率。然而在确定哪些患者对哪种治疗最有效,以及哪些患者最易复发等方面取得的成效很小。目前临床医师面临的主要挑战是怎样最好地评估和预测肿瘤的临床过程和患者的临床结局。 | 唐平 魏兵 David G. Hicks Kristin Skinner 步宏 | 2009 | 中华病理学杂志2009，38，1： | 24 |
| 2 | ^(18)F-FDG PET/CT显像在鼻咽癌分期与疗效监测中的临床应用价值显示文摘背景与目的:18F-脱氧葡萄糖(fluorine-18 fluorodeoxyglucose,18F-FDG)PET/CT显像可明显提高肺癌、食管癌等多种肿瘤的诊断、分期与疗效监测的准确性,有助于更准确地制定治疗方案。本研究探讨全身18F-FDG PET/CT显像在鼻咽癌首次分期、再分期及疗效监测中的临床应用价值。方法:回顾性分析澳大利亚Peter MacCallum肿瘤中心2002年2月至2005年12月43例鼻咽癌患者的18F-FDG PET/CT全身扫描报告,根据临床资料、病理结果及临床随访结果,计算18F-FDG PET/CT与传统影像学检查CT、MRI的准确性、特异性、灵敏度、阳性预测值与阴性预测值,并对结果进行比较和分析。结果:18F-FDG PET/CT诊断鼻咽癌总的准确率、敏感性、特异性、阳性预测值与阴性预测值分别为95.3%、100.0%、85.7%、93.8%、100.0%,传统影像学检查CT、MRI分别为65.5%、79.4%、64.7%、81.8%、57.9%。18F-FDGPET/CT诊断结果使2例首次分期、7例再分期患者治疗方案得到改变,并影响1例首次分期和3例再分期患者治疗方案的制定;在疗效监测组中,指导医生修改治疗方案共11例(其中5例为原则性的修改)。18F-FDG PET/CT检测到2例第二原发肿瘤,1例是甲状腺癌,1例是低度恶性胃癌。结论:18F-FDG PET/CT全身显像对鼻咽癌N、M分期与疗效监测的临床作用可能优于CT、MR检查。 | 王国慧 Eddie W. F. Lau Ramdave Shakher David S. Binns Annette Hogg Elizabeth Drummond Rodney J. Hicks | 2007 | 癌症2007，26，6： | 19 |
| 3 | 亚洲土壤对酸化的敏感性:现状与展望显示文摘一直以来,研究者发现在中国南方及东南亚地区存在土壤酸化超出标准稳定状态的临界载荷的现象,但尚无证据能够说明土壤酸化在中国境外的影响。本研究介绍了一种在硫(S)、氮(N)和钙(Ca)的未来潜在排放情景下,亚洲土壤敏感性对酸沉降的时间效应的计算方法。这种方法通过对亚洲可用性数据的匹配,制作了区域尺度图,估算了在相应的酸沉降条件下,土壤盐基饱和度需要多少时间(年)能达到20%的临界上限。研究结果表明,南亚、东南亚和东亚的土壤类型敏感地区,包括中国南部部分地区,以及缅甸、海南、老挝、泰国、越南和印度西高止山脉等,达到显著酸化的程度可能需要0~50年(尺度),这主要取决于当地的管理水平、生物和非生物的因素等。为了更明确地评估风险,需要贯穿亚洲代表不同植被和土壤类型及管理制度的典型区域的定点观测数据,如土壤化学、沉降(尤其是相应的阳离子沉降)、土壤和生态系统中硫、氮含量、可收获的生物量及风化速率等。本文介绍的国家和区域评估土壤的简单方法,可以对土壤酸化相关的影响时间尺度进行正确评价,有助于下一步研究,通过相关措施可降低酸化的风险。 | W. Kevin Hicks Johan C. I. Kuylenstierna Anne Owen Frank Dentener Hans-Martin Seip Henning Rodhe 马泽清(译) 哈艳梅(译) | 2008 | AMBIO-人类环境杂志2008，37，4： | 8 |
| 4 | A 3D morphometric perspective for facial gender analysis and classification using geodesic path curvature features显示文摘The relationship between the shape and gender of a face, with particular application to automatic gender classification, has been the subject of significant research in recent years. Determining the gender of a face, especially when dealing with unseen examples, presents a major challenge. This is especially true for certain age groups, such as teenagers, due to their rapid development at this phase of life. This study proposes a new set of facial morphological descriptors,based on 3D geodesic path curvatures, and uses them for gender analysis. Their goal is to discern key facial areas related to gender, specifically suited to the task of gender classification. These new curvature-based features are extracted along the geodesic path between two biological landmarks located in key facial areas.Classification performance based on the new features is compared with that achieved using the Euclidean and geodesic distance measures traditionally used in gender analysis and classification. Five different experiments were conducted on a large teenage face database(4745 faces from the Avon Longitudinal Study of Parents and Children) to investigate and justify the use of the proposed curvature features. Our experiments show that the combination of the new features with geodesic distances provides a classification accuracy of 89%. They also show that nose-related traits provide the most discriminative facial feature for gender classification, with the most discriminative features lying along the 3D face profile curve. | Hawraa Abbas Yulia Hicks David Marshall Alexei I.Zhurov StephenRichmond | 2018 | Computational Visual Media2018，4，1： | 5 |
| 5 | SNL fibroblast feeder layers support derivation and maintenance of human induced pluripotent stem cells显示文摘Induced pluripotent stem(iPS) cells can be derived from human somatic cells by cellular reprogramming.This technology provides a potential source of non-controversial therapeutic cells for tissue repair,drug discovery,and opportunities for studying the molecular basis of human disease.Normally,mouse embryonic fibroblasts(MEFs) are used as feeder layers in the initial derivation of iPS lines.The purpose of this study was to determine whether SNL fibroblasts can be used to support the growth of human iPS cells reprogrammed from somatic cells using lentiviral expressed reprogramming factors.In our study,iPS cells expressed common pluripotency markers,displayed human embryonic stem cells(hESCs) morphology and unmethylated promoters of NANOG and OCT4.These data demonstrate that SNL feeder cells can support the derivation and maintenance of human iPS cells. | Chuanying Pan Amy Hicks Xuan Guan Hong Chen Colin E. Bishop | 2010 | Journal of Genetics and Genomics2010，37，4： | 5 |
| 6 | Isolation and proteomic analysis of the SYP61 compartment reveal its role in exocytic trafficking in Arabidopsis显示文摘endomembrane 系统是建筑群和动态细胞内部的 trafficking 网络。它很正在质问在实时追踪单个泡和他们的货物;然而,亲密关系纯化允许泡处于他们的自然状态被孤立以便他们的成分蛋白质能被识别。在植物开创这条途径,我们孤立 SYP61 trans-Golgi 网络分隔空间并且与从另外的细胞器的仅仅最小的干扰执行了它的内容的全面 proteomic 分析。SYP61 的 proteome 揭示了以前没被归功于到这分隔空间的未知功能的蛋白质的协会。我们识别了完全的 SYP61 圈套建筑群,包括规章的蛋白质并且由显示出在 planta 与 SYP61 联系的几这些蛋白质验证了 proteome 数据。我们进一步识别了 SYP121 复杂并且纤维素 synthases,建议那 SYP61 在 exocytic trafficking 和房间墙部件的运输起一个作用到血浆膜。在包括针鼹鼠的 SYP61 proteome 的未知功能的蛋白质的存在提供机会识别新奇 trafficking 部件和货物。处于他们的自然状态的植物泡的亲密关系纯化为复杂 endomembrane 网络的进一步的分析和解剖提供一个基础。途径是广泛地适用的并且能在植物负担得起几张泡人口的学习,它能与 SYP61 泡 proteome 相比。 | Georgia Drakakaki Wilhelmina van de Ven Songqin Pan Yansong Miao Junqi Wang Nana F Keinath Brent Weatherly Liwen Jiang Karin Schumacher Glenn Hicks Natasha Raikhel | 2012 | Cell Research2012，22，2： | 4 |
| 7 | Hepatitis B Virus Screening Before Chemotherapy for Lymphoma: A Cost-Effectiveness Analysis显示文摘 | Urszula Zurawska Lisa K. Hicks Gloria Woo Chaim M. Bell Murray Krahn Kelvin K. Chan Jordan J. Feld | 2012 | Journal of Clinical Oncology2012，，26： | 3 |
| 8 | A plant molecular DNA minipreparation version 显示文摘 | Dellaporta S L Wood J Hicks J B | 1983 | Plant Mol Biol Rep1983，1，： | 2 |
| 9 | Complications of Pedicle Screw Fixation in Scoliosis Surgery: A Systematic Review显示文摘 | John M. Hicks Amit Singla Francis H. Shen Vincent Arlet | 2010 | Spine2010，，11： | 2 |
| 10 | Parametrically constrained geometry relaxations for high-throughput materials science显示文摘Reducing parameter spaces via exploiting symmetries has greatly accelerated and increased the quality of electronic-structure calculations.Unfortunately,many of the traditional methods fail when the global crystal symmetry is broken,even when the distortion is only a slight perturbation(e.g.,Jahn-Teller like distortions).Here we introduce a flexible and generalizable parametric relaxation scheme and implement it in the all-electron code FHI-aims.This approach utilizes parametric constraints to maintain symmetry at any level.After demonstrating the method’s ability to relax metastable structures,we highlight its adaptability and performance over a test set of 359 materials,across 13 lattice prototypes.Finally we show how these constraints can reduce the number of steps needed to relax local lattice distortions by an order of magnitude.The flexibility of these constraints enables a significant acceleration of high-throughput searches for novel materials for numerous applications. | Maja-Olivia Lenz Thomas A.R.Purcell David Hicks Stefano Curtarolo Matthias Scheffler Christian Carbogno | 2019 | npj Computational Materials2019，，1： | 2 |
| 11 | Bcl-2 and bak may play a pivotal role in sodium butyrate-induced apoptosis in colonic epithelial cells;however overexpression of bcl-2 does not protect against bak-mediated apoptosis 显示文摘 | Hague A Diaz GD Hicks DJ | 1997 | Int J Cancer1997，72，5： | 2 |
| 12 | Population pharmacokinetic model of PI-88, a heparanase inhibitor显示文摘 | Susan F. Hudachek S. Gail Eckhardt Barbara Hicks Daniel L. Gustafson | 2010 | Cancer Chemotherapy and Pharmacology2010，，4： | 2 |
| 13 | Standardized measurement of the future liver remnant prior to extended liver resection: Methodology and clinical associations显示文摘 | Jean-Nicolas Vauthey Amin Chaoui Kim-Anh Do Malcolm M Bilimoria Marc J Fenstermacher Chuslip Charnsangavej Marshall Hicks Guido Alsfasser Gregory Lauwers Irvin F Hawkins James Caridi | 2000 | Surgery2000，，5： | 2 |
| 14 | Tracing knowledge diffusion显示文摘 | Chaomei Chen Diana Hicks | 2004 | Scientometrics2004，，2： | 2 |
| 15 | AFLOW-XtalFinder:a reliable choice to identify crystalline prototypes显示文摘The accelerated growth rate of repository entries in crystallographic databases makes it arduous to identify and classify their prototype structures.The open-source AFLOW-XtalFinder package was developed to solve this problem.It symbolically maps structures into standard designations following the AFLOW Prototype Encyclopedia and calculates the internal degrees of freedom consistent with the International Tables for Crystallography.To ensure uniqueness,structures are analyzed and compared via symmetry,local atomic geometries,and crystal mapping techniques,simultaneously grouping them by similarity.The software(i)distinguishes distinct crystal prototypes and atom decorations,(ii)determines equivalent spin configurations,(iii)reveals compounds with similar properties,and(iv)guides the discovery of unexplored materials.The operations are accessible through a Python module ready for workflows,and through command line syntax.All the 4+million compounds in the AFLOW.org repositories are mapped to their ideal prototype,allowing users to search database entries via symbolic structure-type.Furthermore,15,000 unique structures—sorted by prevalence—are extracted from the AFLOW-ICSD catalog to serve as future prototypes in the Encyclopedia. | David Hicks Cormac Toher Denise CFord Frisco Rose Carlo De Santo Ohad Levy Michael J.Mehl Stefano Curtarolo | 2021 | npj Computational Materials2021，，1： | 2 |
| 16 | Primary lymphoma of bone:correlation of magneitic resonance imaging features with cyto kine production by tumor cells显示文摘 | Hicks DG Gokan T O'Keefe RJ | | 0，，04： | 2 |
| 17 | The POWER2 performance monitor显示文摘 | Welbon E H Chan-Nui C C Shippy D J Hicks D A | 1994 | IBM J Develop1994，38，5： | 2 |
| 18 | 小儿难治性原发性肾病综合征治疗进展显示文摘 | 焦富勇 刘春风 陈亚莉 Tomas Hicks | 2002 | 陕西医学杂志2002，31，3： | 2 |
| 19 | Mild experimental brain injury differentially alters the expression of neurotrophin and neurotrophin receptor mRNAs in the hippocampus 显示文摘 | Hicks R Martin B Zhang L | 1999 | ExpNeurol1999，160，1： | 2 |
| 20 | 全球尺度过量氮元素输入的土壤功能响应显示文摘很少证据显示南半球大陆高度风化、低磷、酸性土壤中氮(N)循环与北美和欧洲有很大的差别。来自南半球的证据表明:不同的土地利用方式中,氮损失的形态和时间模式有相似性;不同大陆林地地表/枯枝落叶层的碳氮比(C:N)对于全球尺度上一系列过程有强烈的预示性;根据北半球增施氮对'受磷制约'的生态系统影响的归纳很可能不适用于南半球生态系统,当地植物结构上和生理上对低磷土壤的适应使得磷制约概念变得可疑;大大地增加了氮的输入和周转的土地利用变化很可能是南半球生态系统的最大威胁;局部氮施入的增加很可能与北半球观测到的效果相似。 | Mark Adams Phil Ineson Dan Binkley Georg Cadisch Naoko Tokuchi Mary Scholes Kevin Hicks 孙会首(译) | 2004 | AMBIO-人类环境杂志2004，33，B12： | 2 |
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