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| 1 | Clinical use of bone-targeting radiopharmaceuticals with focus on alpha-emitters显示文摘Various single or multi-modality therapeutic options are available to treat pain of bone metastasis in patients with prostate cancer.Different radionuclides that emitβ-rays such as 153Samarium and 89Strontium and achieve palliation are commercially available.In contrast toβ-emitters,223Radium as a a-emitter has a short path-length.The advantage of the a-emitter is thus a highly localized biological effect that is caused by radiation induced DNA double-strand breaks and subsequent cell killing and/or limited effectiveness of cellular repair mechanisms.Due to the limited range of the a-particles the bone surface to red bone marrow dose ratio is also lower for 223Radium which is expressed in a lower myelotoxicity.The a emitter 223Radium dichloride is the first radiopharmaceutical that significantly prolongslife in castrate resistant prostate cancer patients with wide-spread bone metastatic disease.In a phaseⅢ,randomized,double-blind,placebo-controlled study 921patients with castration-resistant prostate cancer and bone metastases were randomly assigned.The analysis confirmed the 223Radium survival benefit compared to the placebo(median,14.9 mo vs 11.3 mo;P<0.001).In addition,the treatment results in pain palliation and thus,improved quality of life and a delay of skeletal related events.At the same time the toxicity profile of223Radium was favourable.Since May 2013,223Radium dichloride(Xofigo?)is approved by the US Food and Drug Administration. | Hinrich A Wieder Michael Lassmann Martin S Allen-Auerbach Johannes Czernin Ken Herrmann | 2014 | World Journal of Radiology2014，6，7： | 4 |
| 2 | Modeling slow deformation of polygonal particles using DEM显示文摘We introduce two improvements in the numerical scheme to simulate collision and slow shearing of irregular particles. First, we propose an alternative approach based on simple relations to compute the frictional contact forces. The approach improves efficiency and accuracy of the Discrete Element Method (DEM) when modeling the dynamics of the granular packing. We determine the proper upper limit for the integration step in the standard numerical scheme using a wide range of material parameters. To this end, we study the kinetic energy decay in a stress controlled test between two particles. Second, we show that the usual way of defining the contact plane between two polygonal particles is, in general, not unique which leads to discontinuities in the direction of the contact plane while particles move. To solve this drawback, we introduce an accurate definition for the contact plane based on the shape of the overlap area between touching particles, which evolves continuously in time. | Andrés A. Pea Pedro G. Lind Hans J. Herrmann | 2008 | Particuology2008，6，6： | 2 |
| 3 | 显示文摘 | Martin S T Herrmann H | 1994 | Trans Taraday Soc1994，90，： | 2 |
| 4 | Label-retaining liver cancer cells are relatively resistant to sorafenib显示文摘 | Hong-Wu Xin Chenwi M Ambe Danielle M Hari Gordon W Wiegand Tyler C Miller Jin-Qiu Chen Andrew J Anderson Satyajit Ray John E Mullinax Tomotake Koizumi Russell C Langan Douglas Burka Michelle A Herrmann Paul K Goldsmith Alexander Stojadinovic Udo Rudloff S | 2013 | Gut2013，，12： | 2 |
| 5 | The effect of processing conditions, amount of additives and composition on the microstructures and mechanical properties of α- SiAlON ceramics显示文摘 | KURAMA S HERRMANN M MANDAL H | 2002 | J Eur Ceram Soc2002，22，： | 1 |
| 6 | Dicapryloylglycerol and ammonium ions induce metamorphosis of ascidian larvae显示文摘 | Berking S Herrmann K | 1990 | Roux''s Arch Dev Biol1990，198，： | 1 |
| 7 | The Sunnybrook Stroke Study: A Prospective Study of Depressive Symptoms and Functional Outcome显示文摘 | Herrmann N Black S E Lawrence J | 1998 | Stroke1998，29，3： | 1 |
| 8 | Motivation of software developers in open souree projeets: an intermet-based survey of contributors to the linux kernel 显示文摘 | Hertel G Niedner S and Herrmann S | 2003 | Research Poliey2003，32，7： | 1 |
| 9 | Hepatitis C virus hypervariable region 1modulates receptor interactions,conceals the CD81 binding site,and protects conserved neutralizing epitopes显示文摘 | Bankwitz D Steinmann E Bitzegeio J Ciesek S Friesland M Herrmann E | | 0，，： | 1 |
| 10 | Dominant T cells in idio-pathic nephritic synd rome of childhood 显示文摘 | Frank C Herrmann M Fernandez S | 2000 | Kidney Lnt2000，57，2： | 1 |
| 11 | Functional and neuroanatomic correlations in poststroke depression: the sunnybrook stroke study显示文摘 | Singh A Black S E Herrmann N | 2000 | Stroke2000，31，3： | 1 |
| 12 | Proof of efficacy of the ginkgo biloba special extract( GbE761 ) in outpatients suffering from mild to moderate primary degenerative dementia of the Alaheimer type or multi - infarct dementia显示文摘 | Kanowski S Herrmann WM Stephan K | 1996 | Pharmacopsychiatry1996，29，2： | 1 |
| 13 | T7 phage display of Ep15 peptide for the detection of WNV IgG 显示文摘 | Herrmann S Leshem B Lobel L | 2007 | Virol Methods2007，141，2： | 1 |
| 14 | Development of a Micro-MiniatureNanoindentation Instrument with a Force Resolution of 1 nN 显示文摘 | Gao S Li Z Herrmann K | 2010 | Optoelectron Instrum Data Process2010，46，4： | 1 |
| 15 | Temporal profile of release of neuro biochemical markers of brain damage after traumatic brain injury is associated with intracranial pathology as demonstrated in cranialcomputerized tomography显示文摘 | Herrmann M Jest S Kutz S | | 0，，2： | 1 |
| 16 | Materials processing using an atmospheric pressure RF-generated plasma source显示文摘 | Selwyn G S Herrmann H W Park J | | 0，，6： | 1 |
| 17 | Regionalizarion of crustal coda Q in the continental United States显示文摘 | Singh S Herrmann R B | 1983 | J Geophys Res1983，88，： | 1 |
| 18 | Local cluster effect in different traffic flow models显示文摘 | Herrmann M Kerner B S | 1998 | Physica A1998，，255： | 1 |
| 19 | CEO personality, strategic flexibility, and firm performance:The case of the Indian busi- ness process outsourcing industry显示文摘 | Nadkarni S and Herrmann P O L | 2010 | Academy of Manage ment Journal2010，53，5： | 1 |
| 20 | Pathophysiology of HCN channels显示文摘 | Herrmann S Stieber J Ludwig A | | 0，，04： | 1 |
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