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| 1 | Nat Genet:单细胞分析解开结直肠癌细胞的神秘面纱显示文摘结合单细胞基因组学和计算机技术,一个研究团队(包括来自杰克逊实验室(JAx)单细胞生物学主任Paul Robson博士在内)鉴定出了11种结直肠癌肿瘤的癌细胞组成及邻近的非癌细胞。这对于更好的肿瘤靶向诊断和治疗很重要。”使用单细胞测序。”JAX科学家、这篇发表在Nature Genetics上的文章共同第一作者Elise Courtois说道。”我们可以根据肿瘤中的细胞组成将结直肠癌进一步分类。因为每种亚型的肿瘤病人生存率存在差别,我们的方法将为肿瘤医生提供更多的关于肿瘤预后和治疗的信息。” | Huipeng Li, Elise T Courtois, Debarka Sengupta, Yuliana Tan Shyam Prabhakar Elise T Courtois, Yuliana Tan Paul Robson Debarka Sengupta Kok Hao Chen, Jolene Jie Lin Goh Paul Jongjoon Choi Say Li Kong, Axel M Hillmer Iain Beehuat Tan Clarinda Chua Iain Beehuat Tan Lim Kiat Hon Wah Siew Tan Mark Wong Lawrence J K Wee Iain Beehuat Tan Paul Robson Paul Robson Paul Robson | 2017 | 现代生物医学进展2017，17，15： | 37 |
| 2 | 酒精滥用与成瘾中枢神经递质的研究进展显示文摘 | 陈锋 Andrew J Lawrence 梁建辉 | 2007 | 中国药物依赖性杂志2007，16，1： | 16 |
| 3 | Precore/basal core promoter mutants and hepatitis B viral DNA levels as predictors for liver deaths and hepatocellular carcinoma显示文摘AIM: To conduct a retrospective study in 400 chronic hepatitis B patients in order to identify hepatitis B viral factors associated with complications of liver disease or development of hepatocellular carcinoma.METHODS: The mean follow-up time was 83.6 ± 39.6 mo. Alpha-fetoprotein test and abdominal ultrasound were used for cancer surveillance. Hepatitis B basal core promoter mutants, precore mutants, genotypes, hepatitis B viral DNA (HBV DNA) level and hepatitis B e antigen (HBeAg) were measured. Univariate analysis and logistic regression were used to assess odds ratios for viral factors related to liver deaths and hepatocellular carcinoma development. RESULTS: During follow-up, 38 patients had liver deaths not related to hepatocellular carcinoma. On multivariate analysis, older age [odds ratio: 95.74 (12.13-891.31); P < 0.0001], male sex [odds ratio: 7.61 (2.20-47.95); P = 0.006], and higher log10 HBV DNA [odds ratio: 4.69 (1.16-20.43); P < 0.0001] were independently predictive for these liver related deaths. Also, 31 patients developed hepatocellular carcinoma. Multivariate analysis showed that older age [odds ratio: 26.51 (2.36-381.47); P = 0.007], presence of precore mutants [odds ratio: 4.23 (1.53-19.58); P = 0.02] and presence of basal core promoter mutants [odds ratio: 2.93 (1.24-7.57); P = 0.02] were independent predictors for progression to hepatocellular carcinoma.CONCLUSION: Our results show that high levels of baseline serum HBV DNA are associated with non- hepatocellular carcinoma-related deaths of liver failure, while genetic mutations in the basal core promoter and precore regions are predictive for development of hepatocellular carcinoma. | Myron J Tong Lawrence M Blatt Jia-Horng Kao Jason Tzuying Cheng William G Corey | 2006 | World Journal of Gastroenterology2006，12，41： | 11 |
| 4 | Involvement of eicosanoids in the pathogenesis of pancreatic cancer: the roles of cyclooxygenase-2 and 5-lipoxygenase显示文摘The interplay between inflammation and cancer progression is a growing area of research. A combination of clinical, epidemiological, and basic science investigations indicate that there is a relationship between inflammatory changes in the pancreas and neoplastic progression. Diets high in ω-6 polyunsaturated fatty acids provide increased substrate for arachidonic acid metabolism by cyclooxygenase-2(COX-2) and 5-lipoxygenase(5-LOX) to form eicosanoids. These eicosanoids directly contribute to pancreatic cancer cell proliferation. Both COX-2 and 5-LOX are upregulated in multiple cancer types, including pancreatic cancer. In vitro studies using pancreatic cancer cell lines have demonstrated upregulation of COX-2 and 5-LOX at both the mRNA and protein levels. When COX-2 and 5-LOX are blocked via a variety of mechanisms, cancer cell proliferation is abrogated both in vitro and in vivo.The mechanism of COX-2 has been shown to include effects on apoptosis as well as angiogenesis. 5-LOX has been implicated in apoptosis. The use of COX-2 and 5-LOX inhibitors in clinical studies in patients with pancreatic cancer has been limited. Patient enrollment has been restricted to those with advanced disease which makes evaluation of these drugs as chemopreventive agents difficult. COX-2 and 5-LOX expression have been shown to be present during the early neoplastic changes of pancreatic cancer, well before progression to invasive disease. This indicates that the ideal role for these interventions is early in the disease process as preventive agents, perhaps in patients with chronic pancreatitis or hereditary pancreatitis. | Lawrence M Knab Paul J Grippo David J Bentrem | 2014 | World Journal of Gastroenterology2014，20，31： | 9 |
| 5 | Intravenous vitamin C as adjunctive therapy for enterovirus/rhinovirus induced acute respiratory distress syndrome显示文摘We report a case of virus-induced acute respiratory distress syndrome(ARDS) treated with parenteral vitamin C in a patient testing positive for enterovirus/rhinovirus on viral screening. This report outlines the first use of high dose intravenous vitamin C as an interventional therapy for ARDS, resulting from enterovirus/rhinovirus respiratory infection. From very significant preclinical research performed at Virginia Commonwealth Universitywith vitamin C and with the very positive results of a previously performed phase Ⅰ safety trial infusing high dose vitamin C intravenously into patients with severe sepsis, we reasoned that infusing identical dosing to a patient with ARDS from viral infection would be therapeutic. We report here the case of a 20-year-old, previously healthy, female who contracted respiratory enterovirus/rhinovirus infection that led to acute lung injury and rapidly to ARDS. She contracted the infection in central Italy while on an 8-d spring break from college. During a return flight to the United States, she developed increasing dyspnea and hypoxemia that rapidly developed into acute lung injury that led to ARDS. When support with mechanical ventilation failed, extracorporeal membrane oxygenation(ECMO) was initiated. Twelve hours following ECMO initiation, high dose intravenous vitamin C was begun. The patient's recovery was rapid. ECMO and mechanical ventilation were discontinued by day-7 and the patient recovered with no long-term ARDS sequelae. Infusing high dose intravenous vitamin C into this patient with virus-induced ARDS was associated with rapid resolution of lung injury with no evidence of post-ARDS fibroproliferative sequelae. Intravenous vitamin C as a treatment for ARDS may open a new era of therapy for ARDS from many causes. | Alpha A Fowler Ⅲ Christin Kim Lawrence Lepler Rajiv Malhotra Orlando Debesa Ramesh Natarajan Bernard J Fisher Aamer Syed Christine DeWilde Anna Priday Vigneshwar Kasirajan | 2017 | World Journal of Critical Care Medicine2017，6，1： | 9 |
| 6 | Juvenile hominoid cranium from the terminal Miocene of Yunnan,China显示文摘Fossil apes are known from several late Miocene localities in Yunnan Province,southwestern China,principally from Shihuiba(Lufeng)and the Yuanmou Basin,and represent three species of Lufengpithecus.They mostly comprise large samples of isolated teeth,but there are also several partial or complete adult crania from Shihuiba and a single juvenile cranium from Yuanmou.Here we describe a new,relatively complete and largely undistorted juvenile cranium from the terminal Miocene locality of Shuitangba,also in Yunnan.It is only the second ape juvenile cranium recovered from the Miocene of Eurasia and it is provisionally assigned to the species present at Shihuiba,Lufengpithecus lufengensis.Lufengpithecus has most often been linked to the extant orangutan,Pongo pygmaeus,but recent studies of the crania from Shihuiba and Yuanmou have demonstrated that this is unlikely.The new cranium reinforces the view that Lufengpithecus represents a distinct,late surviving lineage of large apes in the late Miocene of East Asia that does not appear to be closely affiliated with any extant ape lineage.It substantially increases knowledge of cranial morphology in Lufengpithecus and demonstrates that species of this genus represent a morphologically diverse radiation of apes,which is consistent with the dynamic tectonic and biotic milieu of southwestern China in the late Miocene. | JI XuePing JABLONSKI Nina G SU Denise F DENG ChengLong FLYNN Lawrence J YOU YouShan KELLEY Jay | 2013 | Chinese Science Bulletin2013，58，31： | 8 |
| 7 | 先天性嗜酒大鼠的饮酒行为特性显示文摘目的系统考察先天性嗜酒(FH/Wjd)大鼠嗜酒的行为特性。方法采用双瓶(5%或10%乙醇和自来水)自由选择的方法,观察FH/Wjd大鼠的饮酒量、饮水量和乙醇偏爱率,并进一步探讨FH/Wjd大鼠饮酒的昼夜差异性;在乙醇剥夺实验中,研究乙醇剥夺24h对FH/Wjd大鼠饮酒量和乙醇偏爱率的影响;选用固定比率(FR1)实验程序,探讨FH/Wjd大鼠操作性自身饮酒的行为特点。结果在双瓶自由选择饮酒实验中,给予5%乙醇,大鼠的饮酒量为(4.3±0.2)g·kg-1·d-1,饮水量为(20.1±2.3)g·kg-1·d-1,乙醇偏爱率为(82.9±2.0)%;给予10%乙醇,大鼠的饮酒量为(6.4±0.2)g·kg-1·d-1,饮水量为(37.2±2.7)g·kg-1·d-1,乙醇偏爱率为(69.2±2.0)%,与5%乙醇相比较,饮酒量和饮水量显著增大,但乙醇偏爱率明显降低。FH/Wjd大鼠的饮酒行为呈明显的昼夜节律,夜间饮酒量和乙醇偏爱率均显著高于白天,夜间饮水量虽呈增加趋势,但差异无显著性。FH/Wjd大鼠乙醇剥夺24h,再次给酒后1h的饮酒量增加37.7%,乙醇偏爱率增加22.1%;再次给酒后24h的饮酒量增加15.6%,乙醇偏爱率存在增高趋势,但差异无显著性。FH/Wjd大鼠操作性自身饮酒行为训练13d后,连续测试3d,操作性饮酒行为的偏爱率为49%~64%。结论FH/Wjd大鼠具有饮酒量大和乙醇偏爱率高的特点,存在明显的乙醇剥夺效应,并可在短期内建立操作性自身饮酒行为,是一种理想的先天嗜酒动物模型。 | 景丽 张振华 王卫平 张敏 罗娟 陈锋 Andrew J LAWRENCE 梁建辉 | 2009 | 中国药理学与毒理学杂志2009，23，1： | 6 |
| 8 | Erucine suppresses ethanol intake and preference in alcohol-preferring Fawn-Hooded rats显示文摘 | Yu-ling LI Qing LIU Qi GONG Jun-xu LI Shou-peng WEI Yan-ting WANG Hui LIANG Min ZHANG Li JING ZhengYONG Andrew J LAWRENCE Jian-hui LIANG | 2014 | Acta Pharmacologica Sinica2014，35，7： | 3 |
| 9 | Co-author Weighting in Bibliometric Methodology and Subfields of a Scientific Discipline显示文摘Purpose: To give a theoretical framework to measure the relative impact of bibliometric methodology on the subfields of a scientific discipline, and how that impact depends on the method of evaluation used to credit individual scientists with citations and publications. The authors include a study of the discipline of physics to illustrate the method. Indicators are introduced to measure the proportion of a credit space awarded to a subfield or a set of authors.Design/methodology/approach: The theoretical methodology introduces the notion of credit spaces for a discipline. These quantify the total citation or publication credit accumulated by the scientists in the discipline. One can then examine how the credit is divided among the subfields. The design of the physics study uses the American Physical Society print journals to assign subdiscipline classifications to articles and gather citation, publication, and author information. Credit spaces for the collection of Physical Review Journal articles are computed as a proxy for physics.Findings: There is a substantial difference in the value or impact of a specific subfield depending on the credit system employed to credit individual authors.Research limitations: Subfield classification information is difficult to obtain. In the illustrative physics study, subfields are treated in groups designated by the Physical Review journals. While this collection of articles represents a broad part of the physics literature, it is not all the literature nor a random sample.Practical implications: The method of crediting individual scientists has consequences beyond the individual and affects the perceived impact of whole subfields and institutions. Originality/value: The article reveals the consequences of bibliometric methodology on subfields of a disciple by introducing a systematic theoretical framework for measuring the consequences. | Lawrence Smolinsky Aaron J Lercher | 2020 | Journal of Data and Information Science2020，5，3： | 3 |
| 10 | A concise, practical guide to diagnostic assessment for mast cell activation disease显示文摘As recognition of mast cell(MC) involvement in a range of chronic inflammatory disorders has increased, diagnosticians' suspicions of MC activation disease(MCAD) in their chronically mysteriously inflamed patients have similarly increased. It is now understood that the various forms of systemic mastocytosis- diseases of inappropriate activation and proliferation of MCs seemingly driven by a small set of rare, usually constitutively activating mutations in assorted MC regulatory elements-comprise merely the tip of the MCAD iceberg, whereas the far larger and far more clinically heterogeneous(and thus more difficult to recognize) bulk of the iceberg consists of assorted forms of MC activation syndrome(MCAS) which manifest little to no abnormal MC proliferation and may originate from a far more heterogeneous set of MC mutations. It is reasonable to suspect MCAD when symptoms and signs of MC activation are present and no other diagnosis better accounting for the full range of findings is present. Initial laboratory assessment should include not only routine blood counts and serum chemistries but also a serum total tryptase level, which helps direct further evaluation for mastocytosis vs MCAS. Appropriate tissue examinations are needed to diagnose mastocytosis, while elevated levels of relatively specific mast cell mediators are sought to support diagnosis of MCAS. Whether assessing for mastocytosis or MCAS, testing is fraught with potential pitfalls which can easily yield false negatives leading to erroneous rejection of diagnostic consideration of MCAD in spite of a clinical history highly consistent with MCAD. Efforts at accurate diagnosis of MCAD are worthwhile, as many patients then respond well to appropriately directed therapeutic efforts. | Lawrence B Afrin Gerhard J Molderings | 2014 | World Journal of Hematology2014，3，1： | 3 |
| 11 | Management of the Open Abdomen: From Initial Operation to Definitive Closure显示文摘 | Vargo Daniel Richardson J David Campbell Andre Chang Michael Fabian Timothy Franz Michael Kaplan Mark Moore Frederick Reed R Lawrence Scott Bradford Silverman Ronald | 2009 | The American Surgeon2009，，11： | 2 |
| 12 | Prognostically relevant gene signatures of high-grade serous ovarian carcinoma显示文摘 | Verhaak Roel G W Tamayo Pablo Yang Ji-Yeon Hubbard Diana Zhang Hailei Creighton Chad J Fereday Sian Lawrence Michael Carter Scott L Mermel Craig H Kostic Aleksandar D Etemadmoghadam Dariush Saksena Gordon Cibulskis Kristian Duraisamy Sekhar | 2013 | Journal of Clinical Investigation2013，，1： | 2 |
| 13 | 2009年南极冰穹A的双色天光背景统计和分析显示文摘天光背景是天文台址的一个重要指标。利用2009年位于南极冰穹A的CSTAR望远镜两个波段的观测数据,对南极冰穹A的天光背景进行了统计和分析。结果表明约74%的g波段天光背景的ADU值小于每像素100/s;90.5%的r波段的天光背景的ADU值小于每像素100/s。在不考虑大气消光的情况下,定标后的结果为2009年冰穹A的观测数据中天光背景亮度的中值:g波段为19.9 mag/arcsec2,r波段为20.1 mag/arcsec2。 | 宗伟凯 付建宁 牛家树 Ashley Michael C B 宫雪非 Lawrence J S 刘强 Luong-Van Daniel Pennypacker C R Storey John W V 王灵芝 王力帆 杨惠根 袁祥岩 York Donald G 朱镇熹 | 2014 | 天文研究与技术2014，11，1： | 2 |
| 14 | Risk of colonoscopic polypectomy bleeding with anticoagulants and antiplatelet agents: analysis of 1657 cases显示文摘 | Aric J Hui Ronald M.Y Wong Jessica Y.L Ching Lawrence C.T Hung S.C Sydney Chung Joseph J.Y Sung | 2004 | Gastrointestinal Endoscopy2004，，1： | 2 |
| 15 | Yttrium-90 microsphere selective internal radiation therapy for liver metastases following systemic chemotherapy and surgical resection for metastatic adrenocortical carcinoma显示文摘Adrenocortical carcinoma(ACC)is a rare malignancy with generally poor outcomes and limited treatment options.While surgical resection can be curative for early local disease,most patients present with advanced ACC owing to nonspecific symptoms.For those patients,treatment options include systemic chemotherapy and locoregional therapies including radiofrequency ablation and transarterial chemoembolization.We present the first reported case of utilizing yttrium-90 microsphere selective internal radiation therapy(SIRT)in combination with first line EDP-M(Etoposide,Doxorubicin,Cisplatin,Mitotane)chemotherapy and debulking surgical primary tumor resection for treatment of metastatic ACC.Stable complete radiologic response has been maintained after twelve months with resolution of clinical symptoms.These findings prompt the need for further consideration and studies to elucidate the role of SIRT in combination with systemic and surgical treatment for metastatic ACC. | Mina S Makary Lawrence S Krishner Evan J Wuthrick Mark P Bloomston Joshua D Dowell | 2018 | World Journal of Clinical Oncology2018，9，1： | 2 |
| 16 | Treatment and prognostic factors for long-term outcome in patients with anti-NMDA receptor encephalitis: an observational cohort study显示文摘 | Maarten J Titulaer Lindsey McCracken I?igo Gabilondo Thaís Armangué Carol Glaser Takahiro Iizuka Lawrence S Honig Susanne M Benseler Izumi Kawachi Eugenia Martinez-Hernandez Esther Aguilar Núria Gresa-Arribas Nicole Ryan-Florance Abiguei Torrents Albert S | 2013 | Lancet Neurology2013，，2： | 2 |
| 17 | The reactions between Ca-based solids and gases representative of those found in a fluidized-bed incinerator显示文摘 | LAWRENCE A D BU J | 2000 | Chemical Engineering Science2000，55，24： | 2 |
| 18 | The effect of salinity on growth and survival of Penaeus vannamei, with observations on the interaction of IHHN virus and salinity 显示文摘 | Bray W A Lawrence A L Leung-Trujillo J R | 1994 | Aquaculture1994，122，23： | 1 |
| 19 | Dough and baking quality of wheat line deficient in glutenin subunits controlled by the Glu-A1,Glu-b1,Glu-D1 Loci显示文摘 | | 1988 | Cereal Sci1988，7，： | 1 |
| 20 | State anxiety modulation of the amygdala response to unattended threat-related stimuli显示文摘 | Bishop S Duncan J Lawrence AD | 2004 | J Neurosci2004，24，10： | 1 |
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