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| 1 | 盐酸雷洛昔芬对绝经后骨质疏松妇女骨密度、骨代谢生化指标和血脂的影响显示文摘目的 确定盐酸雷洛昔芬 (raloxifeneHCl,RLX)对中国绝经后骨质疏松妇女骨密度、骨代谢生化指标及血脂的影响。方法 采用多中心、随机、双盲、安慰剂对照的临床研究 ,共入组 2 0 4例绝经后骨质疏松妇女 ,随机分为 :(1)RLX组 (10 2例 ) :每日服用RLX 6 0mg ;(2 )安慰剂组 (10 2例 ) :服用与RLX外观一样的安慰剂。两组对象均每日补充元素钙 5 0 0mg及维生素D 2 0 0U ,共治疗 12个月。观察指标为 :腰椎、髋部骨密度 ;骨代谢生化指标 [血清C端交联肽 (CTX)、骨钙素 (BGP) ];血脂。骨密度测定采用双能X线吸收法 ,骨代谢生化指标测定应用一步ELISA法 ,血脂测定应用酶法。结果 研究结束时 ,腰椎骨密度 :RLX组平均增加 3 3%± 4 8% ,安慰剂组增加 1 0 %± 4 9% (P <0 0 0 1)。髋部骨密度 :RLX组平均增加了 1 4 %± 4 8% ,安慰剂组平均降低了 0 9%± 5 0 % ,(P <0 0 0 1)。在RLX组 ,无一例发生新的椎体骨折 ,而安慰剂组有 5例发生新骨折 (P =0 0 5 9)。在RLX组 ,BGP及CTX分别降低 4 1 7%和 6 1 5 % ,而安慰剂组则分别降低 10 6 %和 35 6 % ,两组比较P均 <0 0 0 1。RLX组血总胆固醇 (TG)和低密度脂蛋白胆固醇 (LDL C)明显低于安慰剂组 (均P <0 0 0 1)。而两组的高密度脂蛋白胆固醇 (HDL C)和甘油三? | 刘建立 朱汉民 黄琪仁 张忠兰 李慧林 秦跃娟 张颖 魏道林 陆敬辉 刘慧 陈小平 刘玉娟 Abie Ekangaki 郑以漫 Adolfo Diez-Perez Kristine Harpe | 2004 | 中华医学杂志2004，84，4： | 8 |
| 2 | Bacteriophage M13 as a Scaffold for Preparing Conductive Polymeric Composite Fibers显示文摘Using biological templates to build one-dimensional functional materials holds great promise in developing nanosized electrical devices,sensors,catalysts,and energy storage units.In this communication,we report a versatile assembly process for the preparation of water-soluble conductive polyaniline(PANi)/M13 composite nanowires by employing the bacteriophage M13 as a template.The surface lysine residues of M13 can be derivatized with carboxylic groups to improve its binding ability to the aniline;the resulting modifi ed M13 is denoted as m-M13.Highly negatively-charged poly(sulfonated styrene)was used both as a dopant acid and a stabilizing agent to enhance the stability of the composite fi bers in aqueous solution.A transparent solution of the conductive PANi/m-M13 composite fi bers can be readily obtained without any further purifi cation step.The fi bers can be easily fabricated into thin conductive fi lms due to their high aspect ratio and good solubility in aqueous solution.This synthesis discloses a unique and versatile way of using bionanorods to produce composite fi brillar materials with narrow dispersity,high aspect ratio,and high processibility,which may have many potential applications in electronics,optics,sensing,and biomedical engineering. | Zhongwei Niu Michael ABruckman Brandon Harp Charlene MMello Qian Wang | 2008 | Nano Research2008，1，3： | 5 |
| 3 | Regional landslide-hazard assessment for Seattle, Washington, USA显示文摘 | Rex L. Baum Jeffery A. Coe Jonathan W. Godt Edwin L. Harp Mark E. Reid William Z. Savage William H. Schulz Dianne L. Brien Alan F. Chleborad Jonathan P. McKenna John A. Michael | 2005 | Landslides2005，，4： | 2 |
| 4 | A method for producing digital probabilistic seismic landslide hazard maps显示文摘 | Randall W Jibson Edwin L Harp John A Michael | 2000 | Engineering Geology2000，，3： | 2 |
| 5 | Analysis of mechanical seal behavior during transient operation显示文摘 | Harp S R Salant R F | 1998 | Journal oftribology1998，120，2： | 1 |
| 6 | Simplified enzymatic assay of angiotensin converting enzyme in serum 显示文摘 | James L Gruff Joyce B Harp Mario Digirolamo | 1993 | Clin Chem1993，39，3： | 1 |
| 7 | Effect of calciumantag onist-nimodipine on cerebral blood flow and metabolism in the primate显示文摘 | Harpe AM Crraigen L Kazda S | 1981 | J Cereb Blood Flow Metabol1981，22，1： | 1 |
| 8 | Analysis of mechanical seal behavior during transient operation显示文摘 | Harp S R Salant R F | 1998 | Journal of Tribology1998，120，： | 1 |
| 9 | Simplified enzymatic assay of angiotensin- converting enzyme in serum 显示文摘 | Groff JL Harp JB DiGirolamo M | 1993 | Clinical Chemistry1993，39，： | 1 |
| 10 | Inter-asperity cavitation and global cavitation in seals:an average flow analysis显示文摘 | Harp S R Salant R F | 2002 | Tribology International2002，35，： | 1 |
| 11 | The effect of nitrate and sulfate on mediator-less microbial fuel ceils with high internal re- sistance 显示文摘 | Yi T Harpe W F | 2009 | Water Environ Res2009，81，11： | 1 |
| 12 | Low-molecular-weight polyethylenimine as a non-viral vector for DNA delivery : compari- son of physicochemical properties, transfection efficiency and in vivo distribution with high-molecular-weight polyethylenimine 显示文摘 | Kunath K yon Harpe A Fischer D | 2003 | J Control Relece2003，89，1： | 1 |
| 13 | Recombinant adenovirus encoding the HA gene from swine H3N2 influenza virus partially protects mice from challenge with heterologous virus:A/HK/1/68 (H3N2)显示文摘 | Harp J A Wesley R D | 2004 | Archives of Virology2004，147，11： | 1 |
| 14 | Computer modeling of greenhouse energy conservation strategies 显示文摘 | Epperly - DR Harp - SL Huhnke - RL | 1991 | American Society of Agricultural Engineers1991，91，： | 1 |
| 15 | Microwave synthesis of core-shell gold/palladium bimetallic nanoparticles显示文摘 | Harpeness R Gedanken A | 2004 | Langmuir2004，20，： | 1 |
| 16 | The relative lymphocyte count on hospital admission is a risk factor for long-term mortality in patients with acute heart failure显示文摘 | Rudiger A Burckhardt OA Harpes P | | 0，，： | 1 |
| 17 | Clinical sings in the Wer nicke Korsakoff: a retrospective analysis of 131 cases dignosed at necropsy 显示文摘 | Harpe CG Giles M Finlay-Jones R | 1986 | J Neurol Neurosurg Psychiatry1986，49，4： | 1 |
| 18 | A method for producing digital probabilistic seismic landslide haz-ard maps显示文摘 | Jibson R W Harp E L Michael J A | 2000 | Engineering Geology2000，58，： | 1 |
| 19 | Activities of DL-alpha- difluoromethylarginine and polyamine analogues against Cryptosporidium parvum infection in a T-cell receptor alpha-deficient mouse model显示文摘 | Yarlett N Waters WR Harp JA | 2007 | Antimicrob Agents Chemother2007，51，4： | 1 |
| 20 | An assessment of the efficacy and safety of orlistat forthe long-term management of obesity 显示文摘 | HARP JB | 1998 | Nutr Biochem1998，9，9： | 1 |
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