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| 1 | First experimental constraints on WIMP couplings in the effective field theory framework from CDEX显示文摘We present weakly interacting massive particles(WIMPs) search results performed using two approaches of effective field theory from the China Dark Matter Experiment(CDEX), based on the data from both CDEX-1B and CDEX-10 stages. In the nonrelativistic effective field theory approach, both time-integrated and annual modulation analyses were used to set new limits for the coupling of WIMP-nucleon effective operators at 90% confidence level(C.L.) and improve over the current bounds in the low mχregion. In the chiral effective field theory approach, data from CDEX-10 were used to set an upper limit on WIMP-pion coupling at 90% C.L. We for the first time extended the limit to the m_(χ)<6 GeV/c^(2) region. | Yi Wang Zhi Zeng Qian Yue LiTao Yang KeJun Kang YuanJing Li Mehment Agartioglu HaiPeng An JianPing Chang JingHan Chen YunHua Chen JianPing Cheng Cheng Yi Chiang WenHan Dai Zhi Deng ChangHao Fang XinPing Geng Hui Gong QiuJu Guo XuYuan Guo HongJian He Li He ShengMing He JinWei Hu TuChen Huang HanXiong Huang HaiTao Jia LiPing Jia Xi Jiang HauBin Li JianMin Li Jin Li MingXuan Li RenMingJie Li Xia Li YuLan Li Bin Liao FongKay Lin ShinTed Lin ShuKui Liu YanDong Liu Yu Liu YuanYuan Liu ZhongZhi Liu Hao Ma YuCai Mao QiYuan Nie JinHua Ning Hui Pan NingChun Qi Jie Ren XiChao Ruan ChangSong Shang Vivek Sharma Ze She Lakhwinder Singh Monoj Kumar Singh TianXi Sun ChangJian Tang WeiYou Tang Yang Tian GuangFu Wang Li Wang Qing Wang Yu Chen Wang YunXiang Wang Zhen Wang Henry Tsz-King Wong ShiYong Wu YuCheng Wu HaoYang Xing Yin Xu Tao Xue YuLu Yan Nan Yi ChunXu Yu HaiJun Yu JianFeng Yue Ming Zeng BingTao Zhang Lei Zhang FengShou Zhang ZhenYu Zhang KangKang Zhao MingGang Zhao JiFang Zhou ZuYing Zhou JingJun Zhu | 2021 | Science China(Physics,Mechanics & Astronomy)2021，64，8： | 3 |
| 2 | Dispersion–tribological property relationship in mineral oils containing 2D layered α-zirconium phosphate nanoplatelets显示文摘Inorganic nanomaterials exhibit superior friction-reduction and anti-wear properties in oils. In this study, 2D layered α-zirconium phosphate (α-ZrP) nanosheets intercalated with different amines have been synthesized to study their dispersion stabilities in lubricating oil and tribological applications. The intercalated amines should be sufficiently long and lipophilic to provide stabilization to α-ZrP nanosheets in mineral oil. The results of tribological tests illustrate that with the addition of well-dispersed nanosheets, the coefficient of friction (COF) and pin volume loss reduce by ~47% and 75%, respectively. The excellent dispersion stability enables the nanosheets to flow into the contact area at the beginning, and thereby protect the rubbing surface. A reduction in the van der Waals forces between the adjacent layers induced by the intercalated amines transforms the friction between adjacent layers from pin disk to sliding, leading to a decrease in the COF under hydrodynamic lubrication. The study provides a new method to enhance the tribological properties via tuning the dispersion stabilities of nanomaterials in oils. | Feng JIANG Haoyang SUN Lei CHEN Fan LEI Dazhi SUN | 2020 | Friction2020，8，4： | 3 |
| 3 | A review on stress determination and control in metal-based additive manufacturing显示文摘Metal additive manufacturing(MAM)is an emerging and disruptive technology that builds three-dimensional(3D)components by adding layer-upon-layer of metallic materials.The complex cyclic thermal history and highly localized energy can produce large temperature gradients,which will,in turn,lead to compressive and tensile stress during the MAM process and eventually result in residual stress.Being an issue of great concern,residual stress,which can cause distortion,delamination,cracking,etc.,is considered a key mechanical quantity that affects the manufacturing quality and service performance of MAM parts.In this review paper,the ongoing work in the field of residual stress determination and control for MAM is described with a particular emphasis on the experimental measurement/control methods and numerical models.We also provide insight on what still requires to be achieved and the research opportunities and challenges. | Haoyang Luo Xing Sun Le Xu Wei He Xiaoyu Liang | 2023 | Theoretical & Applied Mechanics Letters2023，13，1： | 2 |
| 4 | Ultrasensitive and stable all graphene field-effect transistor-based Hg^(2+)sensor constructed by using different covalently bonded RGO films assembled by different conjugate linking molecules显示文摘As'molecular bridge,'coupling agents can not only realize the covalent connection of composites,but also affect their properties,thus affecting the properties of devices based on them.Herein,leveraging differences in charge conduction properties of the(3-aminopropyl)trimethoxysilane and 5,10,15,20-tetrakis(4-aminophenyl)-21H,23H-porphine caused by conjugacy structural differences,two kinds of layerby-layer assembled smart carbon materials with different electrical properties are obtained at the same reduction temperature.The two graphene ultrathin films are then“planted”on Si/SiO2 substrates,respectively,as semiconductor layer and source/drain electrodes to fabricate an ultra-stable all-graphene field effect transistor(AG-FET).Enabled by the covalent functionalized configuration and the functionally diverse of coupling agents,the AG-FET obtained by this simple method won the high electrical characteristics,the hole,electron mobility,and the shelflife could reach 3.79 cm2/(V·s),3.78 cm2/(V·s),and 18months,respectively.In addition,good material stability and excellent device structure endow the device exceptional stability,electrical stability,and solvent resistance,improving its application prospect in solution phase sensing/detection.Such characteristics could be used to sense,transduce,and respond to external stimuli,especially in solution phase to monitor the important analytes,such as Hg^(2+)in a flowing sewage environment.We believe that such easy-to-manufacture AG-FETs with ultrahigh performance and ultrahigh stability could also show great application prospects in other significant fields. | Mingyuan Sun Congcong Zhang Duo Chen Jian Wang Yanchen Ji Na Liang Haoyang Gao Shanshan Cheng Hong Liu | 2021 | SmartMat2021，2，2： | 2 |
| 5 | A flexible BiFeO_(3)-based ferroelectric tunnel junction memristor for neuromorphic computing显示文摘Ferroelectric tunnel junctions(FTJs)as the artificial synaptic devices have been considered promising for constructing brain-inspired neuromorphic computing systems.However,the memristive synapses based on the flexible FTJs have been rarely studied.Here,we report a flexible FTJ memristor grown on a mica substrate,which consists of an ultrathin ferroelectric barrier of BiFeO_(3),a semiconducting layer of ZnO,and an electrode of SrRuO_(3).The obtained flexible FTJ memristor exhibits stable voltage-tuned multistates,and the resistive switchings are robust after 10^(3) bending cycles.The capability of the FTJ as a flexible synaptic device is demonstrated by the functionality of the spike-timing-dependent plasticity with bending,and the accurate conductance manipulation with small nonlinearity(-0.24)and low cycle-to-cycle variation(1.77%)is also realized.Especially,artificial neural network simulations based on experimental device behaviors reveal that the high recognition accuracies up to 92.8%and 86.2%are obtained for handwritten digits and images,respectively,which are close to the performances for ideal memristors.This work highlights the potential applications of FTJ as flexible electronics for data storage and processing. | Haoyang Sun Zhen Luo Chuanchuan Liu Chao Ma Zijian Wang Yuewei Yin Xiaoguang Li | 2022 | Journal of Materiomics2022，8，1： | 2 |
| 6 | Silk-based hydrogel incorporated with metal-organic framework nanozymes for enhanced osteochondral regeneration显示文摘Osteochondral defects(OCD)cannot be efficiently repaired due to the unique physical architecture and the pathological microenvironment including enhanced oxidative stress and inflammation.Conventional strategies,such as the control of implant microstructure or the introduction of growth factors,have limited functions failing to manage these complex environments.Here we developed a multifunctional silk-based hydrogel incorporated with metal-organic framework nanozymes(CuTA@SF)to provide a suitable microenvironment for enhanced OCD regeneration.The incorporation of CuTA nanozymes endowed the SF hydrogel with a uniform microstructure and elevated hydrophilicity.In vitro cultivation of mesenchymal stem cells(MSCs)and chondrocytes showed that CuTA@SF hydrogel accelerated cell proliferation and enhanced cell viability,as well as had antioxidant and antibacterial properties.Under the inflammatory environment with the stimulation of IL-1β,CuTA@SF hydrogel still possessed the potential to promote MSC osteogenesis and deposition of cartilage-specific extracellular matrix(ECM).The proteomics analysis further confirmed that CuTA@SF hydrogel promoted cell proliferation and ECM synthesis.In the full-thickness OCD model of rabbit,CuTA@SF hydrogel displayed successfully in situ OCD regeneration,as evidenced by micro-CT,histology(HE,S/O,and toluidine blue staining)and immunohistochemistry(Col I and aggrecan immunostaining).Therefore,CuTA@SF hydrogel is a promising biomaterial targeted at the regeneration of OCD. | Zhicheng Cao Hongmei Wang Jialin Chen Yanan Zhang Qingyun Mo Po Zhang Mingyue Wang Haoyang Liu Xueyang Bao Yuzhi Sun Wei Zhang Qingqiang Yao | 2023 | Bioactive Materials2023，，2： | 2 |
| 7 | Revealing structural degradation in layered structure oxides cathode of lithium ion batteries via in-situ transmission electron microscopy显示文摘Transition metal oxides with layered structure have been widely used as cathode materials for lithium-ion batteries(LIBs)which have relatively high energy density,large capacity and long life.However,in the long-term electrochemical cycle,the inevitable degradation of performance of LIBs due to structural degradation in cathodes severely restricts their large-scale practical applications.Understanding the underlying mechanism of structural degradation is the most critical scientific problem.Recently,in situ transmission electron microscopy(TEM)has become a useful tool to study the structural and compositional evolutions at atomic scale in electrochemical reactions,which provided a unique and in-depth understanding of the structural degradation.In this review,we discuss the recent advances in the in situ TEM,focusing on its role in revealing the structural degradation mechanisms in the four key places:(1)the interface between the cathodes and electrolyte;(2)the cathode surface;(3)the particle interior and(4)those induced by thermal effect.The insight gained by the in-situ TEM which is still developing at its fast pace is unique and expected to provide guidance for designing better layered cathode materials. | Fanjie Xia Weihao Zeng Haoyang Peng Hong Wang Congli Sun Ji Zou Jinsong Wu | 2023 | Journal of Materials Science & Technology2023，，23： | 1 |
| 8 | Glucose supplementation improves intestinal amino acid transport and muscle amino acid pool in pigs during chronic cold exposure显示文摘Mammals in northern regions chronically suffer from low temperatures during autumn-winter seasons.The aim of this study was to investigate the response of intestinal amino acid transport and the amino acid pool in muscle to chronic cold exposure via Min pig models(cold adaptation)and Yorkshire pig models(non-cold adaptation).Furthermore,this study explored the beneficial effects of glucose supplementation on small intestinal amino acid transport and amino acid pool in muscle of cold-exposed Yorkshire pigs.Min pigs(Exp.1)and Yorkshire pigs(Exp.2)were divided into a control group(17℃,n=6)and chronic cold exposure group(7℃,n=6),respectively.Twelve Yorkshire pigs(Exp.3)were divided into a cold control group and cold glucose supplementation group(8℃).The results showed that chronic cold exposure inhibited peptide transporter protein 1(PepT1)and excitatory amino acid transporter 3(EAAT3)expression in ileal mucosa and cationic amino acid transporter-1(CAT-1)in the jejunal mucosa of Yorkshire pigs(P<0.05).In contrast,CAT-1,PepT1 and EAAT3 expression was enhanced in the duodenal mucosa of Min pigs(P<0.05).Branched amino acids(BCAA)in the muscle of Yorkshire pigs were consumed by chronic cold exposure,accompanied by increased muscle RING-finger protein-1(MuRF1)and muscle atrophy F-box(atrogin-1)expression(P<0.05).More importantly,reduced concentrations of dystrophin were detected in the muscle of Yorkshire pigs(P<0.05).However,glycine concentration in the muscle of Min pigs was raised(P<0.05).In the absence of interaction between chronic cold exposure and glucose supplementation,glucose supplementation improved CAT-1 expression in the jejunal mucosa and PepT1 expression in the ileal mucosa of cold-exposed Yorkshire pigs(P<0.05).It also improved BCAA and inhibited MuRF1 and atrogin-1 expression in muscle(P<0.05).Moreover,dystrophin concentration was improved by glucose supplementation(P<0.05).In summary,chronic cold exposure inhibits amino acid absorption in the small intestine,depletes BCAA and promotes protein degradation in muscle.Glucose supplementation ameliorates the negative effects of chronic cold exposure on amino acid transport and the amino acid pool in muscle. | Teng Teng Xin Song Guodong Sun Hongwei Ding Haoyang Sun Guangdong Bai Baoming Shi | 2023 | Animal Nutrition2023，，1： | 1 |
| 9 | Geochronology of the giant Beiya gold-polymetallic deposit in Yunnan Province, Southwest China and its relationship with the petrogenesis of alkaline porphyry显示文摘 | Yu Fu Xiaoming Sun Hai Lin Haoyang Zhou Xin Li Xianqing Ouyang Liyi Jiang Guiyong Shi Yeheng Liang | 2015 | Ore Geology Reviews2015，，： | 1 |
| 10 | Performance of Methanol-to-Olefins Catalytic Reactions by the Addition of PEG in the Synthesis of SAPO-34显示文摘SAPO-34, a silicoaluminophosphate zeolite, has been synthesized by the hydrothermal method with the addition of different molecular weights of polyethylene glycol(PEG), and has been characterized with XRD, SEM,N_2 adsorption–desorption, FT-IR, and NH_3 temperatureprogrammed desorption(NH_3-TPD). We studied SAPO-34 as a catalyst in the methanol-to-olefins(MTO) reaction, in a fixed-bed reactor. The results show that the chain length of PEG has a great influence on the particle size and morphology of SAPO-34. PEG acts as inhibitor in the crystallization process. With the increase of the chain length of PEG used in the synthesis, from a relative molecular weight of 400-6000, the morphology of SAPO-34 changes gradually from cubic to nanoplate-like and then changes to cubic again. The particle size decreases markedly at first and then increases to some extent. The catalytic stability in the MTO reaction also increases first and then decreases, with all the catalysts having almost the same selectivity to olefins. When the sample is synthesized with PEG800, the particles become nanoplate-like with a thickness of 46 nm on average, and the catalytic stability is appreciably prolonged, which is attributed to the shorter diffusion paths of the reactants in the zeolite. | Yaquan Wang Zhao Wang Chao Sun Hengbao Chen Hongyao Li Haoyang Li | 2017 | Transactions of Tianjin University2017，23，6： | 1 |
| 11 | Dynamic modelling and engineering simulation of fluid mechanics in water injectors显示文摘To study the fluid dynamic response mechanism under the working condition of water injection well borehole,based on the microelement analysis of fluid mechanics and the classical theory of hydrodynamics,a fluid microelement pressure-flow rate relationship model is built to derive and solve the dynamic distribution of fluid pressure and flow rate in the space of well borehole.Combined with the production data of a typical deviated well in China,numerical simulations and analyses are carried out to analyze the dynamic distribution of wellbore pressure at different injection pressures and injection volumes,the delayed and attenuated characteristics of fluid transmission in tube,and the dynamic distribution of wellbore pressure amplitude under the fluctuation of wellhead pressure.The pressure loss along the wellbore has nothing to do with the absolute pressure,and the design of the coding and decoding scheme for wave code communication doesn’t need to consider the absolute pressure during injecting.When the injection pressure is constant,the higher the injection flow rate at the wellhead,the larger the pressure loss along the wellbore.The fluid wave signal delay amplitude mainly depends on the length of the wellbore.The smaller the tubing diameter,the larger the fluid wave signal attenuation amplitude.The higher the target wave code amplitude(differential pressure identification root mean square)generated at the same well depth,the greater the wellhead pressure wave amplitude required to overcome the wellbore pressure loss. | JIA Deli WEN Haoyang SUN Fuchao WANG Quanbin YANG Qinghai FU Tao | 2023 | Petroleum Exploration and Development2023，50，5： | 0 |
| 12 | Improved energy storage performance of nanocomposites with Bi_(4.2)K_(0.8)Fe_(2)O_(9+δ) nanobelts显示文摘Modern electronics and electric power grids require high performance polymer-based dielectric nanocomposites.To realize large-scale applications,the energy density of nanocomposites needs to be further increased.Here,we demonstrate a remarkable improvement in energy density of poly(vinylidene fluoride)(PVDF)matrix upon the incorporation of high-k Bi_(4.2)K_(0.8)Fe_(2)O_(9+δ)(BKFO)nanobelts.High aspect ratio BKFO nanobelts can enhance the Young's moduli of the nanocomposites and increase the path tortuosity of electrical trees,which are favorable for increasing the breakdown strength of the system.Thus,the dielectric constant and breakdown strength increase simultaneously at a low volume fraction(0.35 vol%)of BKFO nanobelts,and an ultrahigh recoverable energy density of 25.4 J/cm^(3) is achieved.These results provide a strategy to develop high performance flexible high-energy-density devices. | Chuangming Hou Zhiwei Bao Haoyang Sun Yuewei Yin Xiaoguang Li | 2020 | Journal of Materiomics2020，6，2： | 0 |
| 13 | Deep Learning-Based Program-Wide Binary Code Similarity for Smart Contracts显示文摘Recently,security issues of smart contracts are arising great attention due to the enormous financial loss caused by vulnerability attacks.There is an increasing need to detect similar codes for hunting vulnerability with the increase of critical security issues in smart contracts.Binary similarity detection that quantitatively measures the given code diffing has been widely adopted to facilitate critical security analysis.However,due to the difference between common programs and smart contract,such as diversity of bytecode generation and highly code homogeneity,directly adopting existing graph matching and machine learning based techniques to smart contracts suffers from low accuracy,poor scalability and the limitation of binary similarity on function level.Therefore,this paper investigates graph neural network to detect smart contract binary code similarity at the program level,where we conduct instruction-level normalization to reduce the noise code for smart contract pre-processing and construct contract control flow graphs to represent smart contracts.In particular,two improved Graph Convolutional Network(GCN)and Message Passing Neural Network(MPNN)models are explored to encode the contract graphs into quantitatively vectors,which can capture the semantic information and the program-wide control flow information with temporal orders.Then we can efficiently accomplish the similarity detection by measuring the distance between two targeted contract embeddings.To evaluate the effectiveness and efficient of our proposed method,extensive experiments are performed on two real-world datasets,i.e.,smart contracts from Ethereum and Enterprise Operation System(EOS)blockchain-based platforms.The results show that our proposed approach outperforms three state-of-the-art methods by a large margin,achieving a great improvement up to 6.1%and 17.06%in accuracy. | Yuan Zhuang Baobao Wang Jianguo Sun Haoyang Liu Shuqi Yang Qingan Da | 2023 | Computers, Materials & Continua2023，，1： | 0 |
| 14 | A Dynamic Multi-ary Query Tree Protocol for Passive RFID Anti-collision显示文摘In this paper,a dynamic multi-ary query tree(DMQT)anti-collision protocol for Radio Frequency Identification(RFID)systems is proposed for large scale passive RFID tag identification.The proposed DMQT protocol is based on an iterative process between the reader and tags which identifies the position of collision bits through map commands and dynamically encodes them to optimize slots allocation through query commands.In this way,the DMQT completely eliminates empty slots and greatly reduces collision slots,which in turn reduces the identification time and energy costs.In addition and differently to other known protocols,the DMQT does not need to estimate the number of tags,reducing the protocol implementation complexity and eliminating the uncertainty caused by the estimation algorithm.A numerical analysis shows that DMQT has better performance than other algorithms for a number of tags larger than 300.Meanwhile,when the number of tags is 2000 and the tag identity(ID)length is 128 bits,the total identification time is 2.58 s and the average energy cost for a tag identification is 1.2 mJ,which are 16.9%and 10.4%less than those of state-of-the-art algorithms,respectively.In addition,a DMQT extension based on ACK command has also been presented to deal with capture effect and avoid missing identification. | Gang Li Haoyang Sun Zhenbing Li Peiqi Wu Daniele Inserra Jian Su Xiaochuan Fang Guangjun Wen | 2022 | Computers, Materials & Continua2022，，9： | 0 |
| 15 | Performances of a prototype point-contact germanium detector immersed in liquid nitrogen for light dark matter search显示文摘The CDEX-10 experiment searches for light weakly interacting massive particles, a form of dark matter, at the China Jinping Underground Laboratory, where approximately 10 kg of germanium detectors are arranged in an array and immersed in liquid nitrogen. Herein, we report on the experimental apparatus, detector characterization, and spectrum analysis of one prototype detector. Owing to the higher rise-time resolution of the CDEX-10 prototype detector as compared with CDEX-1 B, we identified the origin of an observed category of extremely fast events. For data analysis of the CDEX-10 prototype detector, we introduced and applied an improved bulk/surface event discrimination method. The results of the new method were compared to those of the CDEX-1 B spectrum. Both sets of results showed good consistency in the 0-12 ke Vee energy range, except for the 8.0 keV K-shell X-ray peak from the external copper. | Hao Jiang LiTao Yang Qian Yue KeJun Kang JianPing Cheng YuanJing Li Henry Tsz-King Wong M.A?artio?lu HaiPeng An JianPing Chang JingHan Chen YunHua Chen Zhi Deng Qiang Du Hui Gong Li He Jin Wei Hu QingDong Hu HanXiong Huang LiPing Jia HauBin Li Hong Li Jian Min Li Jin Li Xia Li XueQian Li YuLan Li Bin Liao FongKay Lin ShinTed Lin ShuKui Liu YanDong Liu YuanYuan Liu ZhongZhi Liu Hao Ma JingLu Ma Hui Pan Jie Ren XiChao Ruan B.Sevda Vivek Sharma ManBin Shen Lakhwinder Singh Monoj Kumar Singh TianXi Sun ChangJian Tang WeiYou Tang Yang Tian GuangFu Wang JiMin Wang Li Wang Qing Wang Yi Wang ShiYong Wu YuCheng Wu HaoYang Xing Yin Xu Tao Xue SongWei Yang Nan Yi ChunXu Yu HaiJun Yu JianFeng Yue XiongHui Zeng Ming Zeng Zhi Zeng FengShou Zhang YunHua Zhang MingGang Zhao JiFang Zhou ZuYing Zhou JingJun Zhu ZhongHua Zhu | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，3： | 0 |
| 16 | Continuous and fast magneto-ionic control of magnetism in Ta/Co/ BiFeO_(3)/SrRuO_(3) multiferroic heterostructure显示文摘Room temperature electric field controlled magnetism is extremely promising for the next-generation high-performance spintronic devices.Here,based on the ferroelectric switching driven oxygen ion migration in the Ta/Co/BiFeO_(3)/SrRuO_(3) heterostructures,the magnetic moment,magnetic coercive field,exchange bias field,and junction resistance are reversibly manipulated by tuning the ferroelectric polarization of the BiFeO_(3) layer.All these phenomena are consistently explained by the oxygen ion migration induced CoOx/Co redox effect,which is evidenced by the synchrotron X-ray absorption spectroscopy measurements.Interestingly,owing to the controllable ferroelectric switching dynamics of the BiFeO_(3) thin film,the magnetic coercive field of the Co thin film can be continuously and precisely tuned by controlling the ferroelectric polarization of the BiFeO_(3) thin film,and the manipulating speed of the voltage control of magnetism can be fast to 100 ns.This nonvolatile,stable,reversible,fast,and reproducible voltage control of magnetism shows great potential for designing low-power and high-speed spintronics. | Zhiwei Chen Haoyang Sun Xiang Zhou Hengli Duan Wensheng Yan Yuewei Yin Xiaoguang Li | 2022 | Journal of Materiomics2022，8，6： | 0 |
| 17 | Probing region-resolved heterogeneity of phosphoproteome in human lens by hybrid metal organic frameworks显示文摘Phosphorylation plays crucial parts in lenticular biological function.Getting knowledge of region-resolved phosphoproteome contributes to better comprehending the pathogenesis.Here,we prepared the hybrid metal organic frameworks(HMOFs)for probing the region-resolved heterogeneity of phosphoproteome in human lens.1334 phosphosites corresponding to 564 phosphoproteins,1160 phosphosites corresponding to 316 phosphoproteins and 517 phosphosites corresponding to 205 phosphoproteins were identified in capsule,cortex and nucleus,respectively,providing the relatively extensive distribution mapping of phosphorylation in human lens for the first time.The label-free quantification experiments and principal component analysis presented differential expression of phopshoproteins in three subregions.For instance,α-crystallin,β-crystallin and fibrillin-1 closely associated with cataract and Marfan syndrome showed disparate spatial distribution.The preferential phosphoproteins in capsule,cortex and nucleus were involved in cytoskeleton organization,metabolic process and lens development in camera-type eye,respectively.This work first provided a general overview of region-resolved phosphoproteome of human lens. | Huimin Chu Haoyang Zheng Aizhu Miao Chunhui Deng Nianrong Sun | 2023 | Chinese Chemical Letters2023，34，1： | 0 |
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