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| 1 | Novel MSX1 variants identified in families with nonsyndromic oligodontia显示文摘The goal of this study was to identify MSX1 gene variants in multiple Chinese families with nonsyndromic oligodontia and analyse the functional influence of these variants.Whole-exome sequencing(WES)and Sanger sequencing were performed to identify the causal gene variants in five families with nonsyndromic oligodontia,and a series of bioinformatics databases were used for variant confirmation and functional prediction.Phenotypic characterization of the members of these families was described,and an in vitro analysis was performed for functional evaluation.Five novel MSX1 heterozygous variants were identified:three missense variants[c.662A>C(p.Q221P),c.670C>T(p.R224C),and c.809C>T(p.S270L)],one nonsense variant[c.364G>T(p.G122*)],and one frameshift variant[c.277delG(p.A93Rfs*67)].Preliminary in vitro studies demonstrated that the subcellular localization of MSX1 was abnormal with the p.Q221P,p.R224C,p.G122*,and p.A93Rfs*67 variants compared to the wild type.Three variants(p.Q221P,p.G122*,and p.A93Rfs*67)were classified as pathogenic or likely pathogenic,while p.S270L and p.R224C were of uncertain significance in the current data.Moreover,we summarized and analysed the MSX1-related tooth agenesis positions and found that the type and variant locus were not related to the severity of tooth loss.Our results expand the variant spectrum of nonsyndromic oligodontia and provide valuable information for genetic counselling. | Jinglei Zheng Miao Yu Haochen Liu Tao Cai Hailan Feng Yang Liu Dong Han | 2021 | International Journal of Oral Science2021，13，1： | 4 |
| 2 | Mode transition induced by back-breakdown of the gliding arc and its influence factors显示文摘Gliding arc is a mostly used non-equilibrium plasma generation method whose characteristic is affected by the backbreakdown phenomenon.Mode transition induced by back-breakdown of the gliding arc is studied in this work and effects of gas flow rate,applied voltage,electrode parameters on mode transition were studied.Experimental results show that there are two typical modes during the development of the gliding arc.Mode A comprises periodicitical development of the arc from the minimum gap breakdown to the longest extinguishment,while the arc in mode B continues to produce a back-breakdown at the ends of the electrodes.As the flow rate descends,the gliding arc gradually changes from mode A to B.It is the decrease of the arc velocity caused by lower flow rate leads to the occurrence of back-breakdown,which generates mode B.Smaller electrode opening angle,shorter length and wider minimum gap reduce the gliding speed,so that arc is more likely to enter mode B.As the applied voltage is increased,enhancing of the electric field strength on the breakdown path of the back-breakdown and thickening of the arc's diameter allow the gliding arc to enter mode B at a higher arc speed. | Ruobing Zhang Haochen Huang Tianshu Yang | 2020 | High Voltage2020，5，3： | 3 |
| 3 | A 10×10 deep ultraviolet light-emitting micro-LED array显示文摘In this work,we design and fabricate a deep ultraviolet(DUV)light-emitting array consisting of 10×10 micro-LEDs(μ-LEDs)with each device having 20μm in diameter.Strikingly,the array demonstrates a significant enhancement of total light output power by nearly 52%at the injection current of 100 mA,in comparison to a conventional large LED chip whose emitting area is the same as the array.A much higher(~22%)peak external quantum efficiency,as well as a smaller efficiency droop forμ-LED array,was also achieved.The numerical calculation reveals that the performance boost can be attributed to the higher light extraction efficiency at the edge of eachμ-LED.Additionally,the far-field pattern measurement shows that theμ-LED array possesses a better forward directionality of emission.These findings shed light on the enhancement of the DUV LEDs performance and provide new insights in controlling the light behavior of theμ-LEDs. | Huabin Yu Muhammad Hunain Memon Hongfeng Jia Haochen Zhang Meng Tian Shi Fang Danhao Wang Yang Kang Shudan Xiao Shibing Long Haiding Sun | 2022 | Journal of Semiconductors2022，43，6： | 3 |
| 4 | Phylogenetic positions of some genera and species of the family Buccinidae (Gastropoda: Mollusca) from China based on ribosomal RNA and COI sequences显示文摘A phylogenetic analysis of members of the family Buccinidae was conducted using 18S rRNA gene, 28S rRNA gene and the mitochondrial cytochrome oxidase Ⅰ gene. We studied 18 species of Buccinidae that belong to eight different genera and inhabit the China coastal seas. We analyzed the patterns of divergence between an outgroup and basal ingroup taxa, the monophyly of the genus Neptunea, and the position of one unnamed species within the Buccinidae. A phylogenetic tree (neighbor-joining (NJ) method) was reconstructed based on the sequences of 18S rRNA, 28S rRNA and COI, with Rapana venosa as outgroup. The NJ tree indicated that the 18 species could be divided into five groups. The genus Buccinum was monophyletic, whereas Neptunea was shown to be paraphyletic since it included Siphonalia subdilatata and Neptunea sp., a new species. This novel species otherwise clustered consistently with Neptunea cumingi in three other phylogenetic trees, showing a low genetic distance and divergence percentage of sequences belonging to the genus Neptunea. A smaller genetic distance and a smaller difference of 18S rRNA, 28S rRNA and COI sequences between Neptunea cumingii and Neptunea arthritica cumingii confirmed them to be the same species. | HOU Lin DAHMS Hans-Uwe DONG ChangYong CHEN YiFei HOU HaoChen YANG WanXi ZOU XiangYang | 2013 | Chinese Science Bulletin2013，58，19： | 3 |
| 5 | Sodium tungsten bronze(Na_(x)WO_(3))-doped near-infrared-shielding bulk glasses for energy-saving applications显示文摘Tungsten bronze coatings and films have attracted global attention for their applications in near-infrared(NIR)-shielding windows.However,they are unstable in strong ultraviolet,humid heat,alkaline and/or oxidizing environments and are difficult to be coated on glass surfaces with complex shape.Here,we address these limitations by doping sodium tungsten bronze(Na_(x)WO_(3))into bulk glasses using a simple glass melting method.X-ray diffraction,Raman spectroscopy,X-ray photoelectron spectroscopy,TEM and SEM-EDS characterization confirmed the presence of sodium tungsten bronze(Na_(x)WO_(3))functional units inside the 34SiO_(2)-38B_(2)O_(3)-28NaF glass matrix.Because the functional units are well protected by the glass matrix,the fabricated glasses are stable under hot,humid,oxidizing conditions,as well as under ambient conditions,with no change after 360 days.The NIR-shielding performance of these glasses can be adjusted to as high as 100%by varying WO_(x)concentration(2-8 mol%)and quenching temperature(1000-1400℃).With a content of 6 mol%WO_(x)and a quenching temperature of 1000℃,the bulk glass shows 63%transmission of visible light and only 11%transmission of NIR light at 1100 nm.Thermal insulation experiments show that the NIR-shielding performance of the glasses are far superior to commercial soda lime window glass or indium-doped tin oxide(ITO)glass,and comparable to cesium tungsten bronze coated glass.The novel bulk glasses have higher stability,simpler processing,and can be easily made into complex shapes,making them excellent alternative materials for energy-saving glasses. | Guang Yang Yunhang Qi Daming Hu Haochen Wang Hongfei Chen Liangmiao Zhang Chuanxiang Cao Bin Liu Fang Xia Yanfeng Gao | 2021 | Journal of Materials Science & Technology2021，，30： | 3 |
| 6 | Efficacy of rigosertib, a small molecular RAS signaling disrupter for the treatment of KRAS-mutant colorectal cancer显示文摘Objective:Mutant KRAS,the principal isoform of RAS,plays a pivotal role in the oncogenesis of colorectal cancer by constitutively activating the RAF/MEK/ERK and PI3K/AKT pathways.Effective targeted therapies are urgently needed.We investigated whether rigosertib,a benzyl styryl sulfone RAS signaling disruptor,could selectively kill KRAS-mutant colorectal cancer cells.Methods:CCK-8 was used to determine the cell viability.Patient-derived tumor and cancer cell xenograft models were used to detect the inhibitory efficacy of rigosertib.Flow cytometry was used to evaluate the apoptosis and cell cycle progression.Apoptosis and cell cycle arrest markers were detected by Western blot.DCFH-DA was used to determine the reactive oxygen species.Immunohistochemistry staining and Western blot were performed to characterize RAS signaling markers in colorectal cancer tissues and cells.Results:Rigosertib(RGS)exhibited a cytotoxic effect against colorectal cancer cells,which was greater in KRAS-mutant cells.Furthermore,RGS induced mitotic arrest and oxidative stress-dependent apoptosis in KRAS-mutant DLD1 and HCT116 cells.Besides,RGS disrupted RAS signaling,and the inhibition of RAS/MEK/ERK was independent of cellular oxidative stress.Using patient-derived xenograft models,the response and tumor inhibition of RGS were significantly higher in the KRAS-mutant subgroup,while p-MEK,p-ERK,and p-AKT levels of RGS-treated tumors were significantly decreased.Finally,in a KRAS-mutant,chemotherapy-resistant patient-derived xenograft model,RGS showed a stronger therapeutic effect than the combination standard therapy involving fluoropyrimidine+oxaliplatin/irinotecan+bevacizumab.Conclusions:These data showed that targeting RAS signaling using RGS could be a therapeutic treatment for KRAS-mutant colorectal cancer patients. | Xinyi Zhou Qian Xiao Dongliang Fu Haochen Zhang Yang Tang Jinjie He Yeting Hu Xiangxing Kong Fei Teng Xiangrui Liu Ying Yuan Kefeng Ding | 2022 | Cancer Biology & Medicine2022，19，2： | 2 |
| 7 | Improved peroxidase-mimic property: Sustainable, high- efficiency interfacial catalysis with H2O2 on the surface of vesicles of hexavanadate-organic hybrid surfactants显示文摘 | Kun Chen Aruuhan Bayaguud Hui Li Yang Chu Haochen Zhang Hongli Jia Baofang Zhang Zicheng Xiao Pingfan Wu Tianbo Liu Yongge wei | 2018 | Nano Research2018，11，3： | 2 |
| 8 | Multiple Impact Factor Based Accuracy Analysis for Power Quality Disturbance Detection显示文摘Nowadays,power quality problems are affecting people’s daily life and production activities.With an aim to improve disturbance detection accuracy,a novel analysis approach,based on multiple impact factors,is proposed in this paper.First,a multiple impact factors analysis is implemented in which two perspectives,i.e.,the wavelet analysis and disturbance features are simultaneously considered.Five key factors,including wavelet function,wavelet decomposition level,redundant algorithm,event type and disturbance intensity,and start and end moment of disturbance,have been considered.Next,an impact factor based accuracy analysis algorithm is proposed,through which each factor’s potential impact on disturbance location accuracy is investigated.Three transforms,i.e.,the classic wavelet,lifting wavelet and redundant lifting wavelet are employed,and their superiority on disturbance location accuracy is investigated.Finally,simulations are conducted for verification.Through the proposed method,the wavelet based parameters can be validly selected in order to accurately detect power quality disturbance. | Zijing Yang Haochen Hua Junwei Cao | 2023 | CSEE Journal of Power and Energy Systems2023，9，1： | 1 |
| 9 | Mechanically driven assembly of biomimetic 2D-material microtextures with bioinspired multifunctionality显示文摘Nature provides a wealth of bio-inspiration for advanced material research.Assembling various nanomaterials into biomimetic microtextures with bioinspired functionalities has spurred increasing research interests and facilitated technological advances in various applications.In recent years,two-dimensional materials(2DMs)have emerged as important building block units in the biomimicry field due to their distinct chemical,physical,electrical,electrochemical,and catalytic properties.In this review article,various mechanically driven assembly approaches are summarized to fabricate various genealogies of biomimetic 2DM microtextures with bio-inspired multifunctionality.First,sequential deformation strategies are discussed to programmably construct higher dimensional 2DM microtextures,ranging from wrinkles/crumples(one-time deformation)to multiscale hierarchies(multiple deformations).Next,the current progress using higher dimensional 2DM microtextures to imitate different biological structures and/or induce bio-inspired multifunctionality is systematically summarized.Four showcases of bio-inspiration and biomimicry using different 2DM nanosheets are highlighted:(1)wrinkle patterns of an earthworm that spur the design of strain sensors with programmable working ranges and sensitivities,(2)wrinkle appearance of a Shar-Pei dog that motivates the fabrication of stretchable energy storage devices,(3)hierarchical scale textures of a desert lizard that inspire cation-induced gelation platforms for 2DM aerogels,and(4)wrinkle skin of an elephant that influences the development of 2DM protective skin for soft robots.Finally,challenges and future opportunities of adopting 2DM nanosheets to assemble biomimetic microstructures with synergistic functionalities are discussed. | Yang Li Lin Jing Joshua M.Little Haochen Yang Tsai-Chun Chung Po-Yen Chen | 2024 | Nano Research2024，17，2： | 1 |
| 10 | Performance Modeling for Data Monitoring Services in Smart Grid: A Network Calculus Based Approach显示文摘This paper focuses on solving the modeling issues of monitoring system service performance based on the network calculus theory.First,we formulate the service model of the smart grid monitoring system.Then,we derive the flow arrival curve based on the incremental process related functions.Next,we develop flow arrival curves for the case of the incremental process being a fractional Gaussian process,and then we obtain the generalized Cauchy process.Three technical theorems related to network calculus are presented as our main results.Mathematically,the variance of arrival flow for the continuous time case is derived.Assuming that the incremental process of network flow is a Gaussian stationary process,and given the auto-correlation function of the incremental process with violation probability,the formula of the arrival curve is derived.In addition,the overall flow variance under the discrete time case is explicitly derived.The theoretical results are evaluated in smart grid applications.Simulations indicate that the generalized Cauchy process outperforms the fractional Gaussian process for our considered problem. | Junwei Cao Yuxin Wan Haochen Hua Gang Yang | 2020 | CSEE Journal of Power and Energy Systems2020，6，3： | 1 |
| 11 | In Situ Synthesis of Cu_(3)P/P-Doped g-C_(3)N_(4)Tight 2D/2D Heterojunction Boosting Photocatalytic H2 Evolution显示文摘Heterojunction design in a two-dimensional(2D)fashion has been deemed beneficial for improving the photocatalytic activity of g-C_(3)N_(4)because of the promoted interfacial charge transfer,yet still facing challenges.Herein,we construct a novel 2D/2D Cu_(3)P nanosheet/P-doped g-C_(3)N_(4)(PCN)nanosheet heterojunction photocatalyst(PCN/Cu_(3)P)through a simple in-situ phosphorization treatment of 2D/2D CuS/g-C_(3)N_(4)composite for photocatalytic H2 evolution.We demonstrate that the 2D lamellar structure of both CuS and g-C_(3)N_(4)could be well reserved in the phosphorization process,while CuS and g-C_(3)N_(4)in-situ transformed into Cu_(3)P and PCN,respectively,leading to the formation of PCN/Cu_(3)P tight 2D/2D heterojunction.Owing to the large contact area provided by intimate face-to-face 2D/2D structure,the PCN/Cu_(3)P photocatalyst exhibits significantly enhanced charge separation efficiency,thus achieving a boosted visible-light-driven photocatalytic behavior.The highest rate for H2 evolution reaches 5.12 umol·h^(-1),nearly 24 times and 368 times higher than that of pristine PCN and g-C_(3)N_(4),respectively.This work represents an excellent example in elaborately con-structing g-C_(3)N_(4)-based 2D/2D heterostructure and could be extended to other photocatalyst/co-catalyst system. | Fangyong Hou Feng Liu Haochen Wu Muhammad Qasim Yi Chen Yang Duan Zhibo Feng Maochang Liu | 2023 | Chinese Journal of Chemistry2023，41，2： | 1 |
| 12 | Evaluation of allergenic protein profiles in three Chinese high-oleic acid peanut cultivars using NanoLC-Orbitrap mass spectrometry显示文摘High oleic-acid peanuts are known for their pre-longed shelf-life and health benefit due to high content of oleic fatty acid.However,the allergenicity and allergenic protein profiles in Chinese high-oleic peanuts have yet to be studied.For this purpose,an Orbitrap Fusion mass spectrometry(MS)-based method that is feasible for identification of putative allergenic protein as well as semi-quantitation of five major allergen protein in three different Chinese high-oleic peanut cultivars(JH 13,JH 16 and JH 18)have been reported.Results show that three Chinese high-oleic acid peanut cultivars selected all contained highly allergenic proteins Ara h1,Ara h 2,Ara h 3 and Ara h 6.The allergenic protein profiles of Chinese high-oleic acid peanut cultivars were very similar to that of conventional peanuts,but the allergenic protein subunits varied greatly among higholeic peanuts.Additionally,a comprehensive peptide-filtering pipeline had been developed for identification of potential peptide markers in peanut allergen proteins.Through the peptide-filtering pipeline,three novel peptide markers,IVQIEAKPNTLVLPK,SSNPDIYNPQAGSLR and AQSENYEYLAFK surrogate to Ara h 1,Ara h 3 with high abundance,good MS response and highly reliability were identified,which can be used as candidate peptide markers for the detection of peanut allergens in different food matrices. | Xinke Yang Haochen Bai Lijun Yin Jin Wang Wentong Xue Xin Jia | 2023 | Food Science and Human Wellness2023，12，3： | 1 |
| 13 | Introduction to bioimaging-based spatial multi-omic novel methods显示文摘Background: Spatial multi-omics are demonstrated to be a powerful method to assist researchers on genetic studies. In this review, bioimaging-based spatial multi-omics techniques such as seqFISH+, merFISH, integrated DNA seqFISH+, DNA merFISH, and MINA are introduced along with each technique’s probe design, development, and imaging processes.Results: seqFISH employed 4–5 fluorophores to barcode and conducted multiple rounds of hybridization, in order that mRNA can be identified through color-coding. seqFISH+ added 60 pseudo-color and distributed them equally into three channels to enhance imaging power, in order that i.e., 24,000 genes can be imaged in total. merFISH utilized 4 out 16 Hamming distance to innovatively provide a robust error-detecting method. MINA, a methodology combining merFISH (multiplexed error-robust fluorescence in situ hybridization) and chromosomal tracing, enabled multiplexed genomic architecture imaged in mammalian single cells. Optical reconstruction of chromatin architecture (ORCA) a method that could conduct DNA path tracing in nanoscale manner with kilobase resolution, an FISH variation that improved genetic resolution, enable high-precision fiducial registration and sequential imaging, and utilized Oligopaint probe to hybridize the short genomic region ranging from 2 to 10 kilobase. ORCA then prescribes these short section primary probes with individual barcodes to attach fluorophore and to be imaged.Conclusion: This review concentrated on providing a comprehensive overview for these spatial-multi-omics techniques with the intention on helping researchers on selecting appropriate technique for their research. | Yan Yan Liheng Yang Leyuan Meng Haochen Su Cheng Zhou Le Yu Zhengtu Li Xu Zhang Huihua Cai Juntao Gao | 2023 | Quantitative Biology2023，11，3： | 0 |
| 14 | Reduction of mercury(Ⅱ)by electrons contained in carbon dots:An environmentally friendly cold vapor generation for mercury analysis显示文摘In this work,the reduction of mercury ions(Hg2+)to elemental mercury(Hg0)was easily achieved using highly reductive carbon dots(r-CDs),which synthesized from sucrose by a simple and cost-effective method.After a careful mechanistic study,the reduction was probably accomplished with the large numbers of electrons contained in r-CDs rather than the oxidation of its functional groups.Additionally,a3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT)assay showed that the r-CDs were nontoxic to wildlife and human beings.Consequently,the r-CDs were used as an alternative to toxic reductants(SnCl2 or NaBH4)for the sensitive and in situ determination of mercury by cold vapor gene ration(CVG)coupled to a miniature point discharge optical emission spectrometer(μPD-OES).Limit of detection of 0.05μg/L was obtained for Hg2+,with relative standard deviation(RSD)less than 5.4%at a concentration of 5μg/L.The accuracy of r-CDs induced CVG-μPD-OES was validated by the determination of mercury in a certified reference material(DOLT-5,dogfish liver)and five natural water samples collected from different rivers and lakes in Chengdu City,Since r-CDs are nontoxic and prepared from abundant and inexpensive sucrose,the r-CDs induced CVG-μPD-OES retains the great potential for the inexpensive and enviro nmentally friendly field analysis of mercury in natural water.The accuracy of the proposed method was validated by the analysis of a certified reference material and several water samples with satisfactory results. | Tao Chen Yao Lin Haochen Li Rui Yang Xiandeng Hou Baozhan Zheng Chengbin Zheng | 2020 | Chinese Chemical Letters2020，31，10： | 0 |
| 15 | Research on the Impacts of the Inertia and Droop Control Gains from a Variable-Speed Wind Turbine Generator on the Frequency Response显示文摘System frequency must be kept very close to its nominal range to ensure the stability of an electric power grid.Excessive system frequency variations are able to result in load shedding,frequency instability,and even generator damage.With increasing wind power penetration,there is rising concern about the reduction in inertia response and primary frequency control in the electric power grid.Converter-based wind generation is capable of providing inertia response and primary frequency response;nevertheless,the primary frequency and inertia responses of wind generation are different from those of conventional synchronous fleets;it is not completely understood how the primary frequency and inertia responses affect the given system under various disturbances and available kinetic energy levels.Simulations are used to investigate the influences of inertia and droop control strategies on the dynamic frequency responses,particularly the index of the second frequency drop under various disturbance and wind conditions.A quantitative analysis provides insight into setting of inertia and droop control coefficients for various wind and disturbance conditions to facilitate adequate dynamic frequency responses during frequency events. | Dejian Yang Yien Xu Tong Zhu Yang Wang Qiuhan Cao Yuang Ma Enshu Jin Xinsong Zhang Haochen Sun | 2022 | Energy Engineering2022，119，2： | 0 |
| 16 | Anti-Interference Low-Power Double-Edge Triggered Flip-Flop Based on C-Elements显示文摘When the input signal has been interfered and glitches occur,the power consumption of Double-Edge Triggered Flip-Flops(DETFFs)will significantly increase.To effectively reduce the power consumption,this paper presents an anti-interference low-power DETFF based on C-elements.The improved C-element is used in this DETFF,which effectively blocks the glitches in the input signal,prevents redundant transitions inside the DETFF,and reduces the charge and discharge frequencies of the transistor.The C-element has also added pull-up and pull-down paths,reducing its latency.Compared with other existing DETFFs,the DETFF proposed in this paper only flips once on the clock edge,which greatly reduces the redundant transitions caused by glitches and effectively reduces power consumption.This paper uses HSPICE to simulate the proposed DETFF and other 10 DETFFs.The findings show that compared with the other 10 types of DETFFs,the proposed DETFF has achieved large performance indexes in the total power consumption,total power consumption with glitches,delays,and power delay product.A detailed analysis of variance indicates that the proposed DETFF features less sensitivity to process,voltage,temperature,and Negative Bias Temperature Instability(NBTI)-induced aging variations. | Zhengfeng Huang Xiao Yang Tai Song Haochen Qi Yiming Ouyang Tianming Ni Qi Xu | 2022 | Tsinghua Science and Technology2022，27，1： | 0 |
| 17 | Dietary preferences and potential ecological impact on the zooplankton community of Nemopilema nomurai based on stable isotope and fatty acid analyses显示文摘Information on the dietary composition and food preferences of the giant jellyfish Nemopilema nomurai is important for understanding the trophic drivers of jellyfish outbreaks and their ecological consequences.We used fatty acid(FA)and stable isotope(SI)biomarkers to analyze the diet of N.nomurai from the Yellow Sea in August 2016.N.nomurai was found at all sampling stations,with abundances ranging from 59 inds./km^(2) to 1651 inds./km^(2).There were no significant differences between large(>80 cm in diameter)and small(20–30 cm in diameter)medusae,either in FA compositions or in SI values,which suggests that large and small jellyfi sh have the same food composition and similar trophic levels.Compared to other zooplanktons,the relatively high levels of C20꞉4n-6 in total FAs(~12%)indicates that organic detritus contributes considerably to the food composition of the jellyfish.The mixed model Stable Isotope Analysis in R(SIAR)revealed that N.nomurai tended to prey on smaller organisms(<1000μm in diameter)which comprised about 70%of its diet.This means the N.nomurai blooms will put high feeding pressure on the small plankton.The similar SI values and FA composition indicates that krill may share the same food resources with N.nomurai,which suggests that the jellyfi sh blooms may affect krill populations as a result of food competition. | Junjian WANG Chaolun LI Guang YANG Zhencheng TAO Yanqing WANG Haochen XIAN | 2022 | Journal of Oceanology and Limnology2022，40，3： | 0 |
| 18 | Spatio-temporal Variation of Distribution Patterns in Cunninghamia lanceolata Plantations显示文摘To aid in management of Cunninghamia lanceolata,the main timber species in Southern China,its variation of spatial distribution pattern was analyzed.Three permanent plots of C.lanceolata plantations with approximately the same site conditions,set by China continuous forest inventory in Shunchang,Fujian,were selected. C.lanceolata growth was divided into two stages: young trees(5 cm≤diameter at breast height (DBH)<10 cm) and mature trees(DBH≥10 cm). The DBH and coordinates of every tree(DBH≥5 cm) in the permanent plots were recorded in 2003 and 2008.The function L(r),improvement of Ripley’s K(r),the paircorrelation function g(r),and the uniform angle index(W_i) were used to analyze the spatio-temporal variation of spatial distribution patterns.The three permanent plots had mean uniform angle index(W) between 0.494-0.578 at low altitudes,0.465-0.477 at medium altitudes,and 0.426-0.601 at high altitudes.Results showed that altitude did not affect the spatial distribution pattern. The L(r ) and g(r) function curves of mature trees were generally lower than young trees’,i.e.tend to be more random or uniform distribution.So regardless of the initial distribution of young or mature trees,with the passage of time,there was a tendency for the aggregated distribution to change to a random distribution,and a random distribution to change to a uniform distribution. | Yang Ziqing Chen Pingliu Liu Jian Yu Kunyong Liao Xiaoli You Haochen Gong Conghong | 2012 | Chinese Forestry Science and Technology2012，11，3： | 0 |
| 19 | Blockade of integrin signaling reduces chemotherapy-induced premature senescence in collagen cultured bladder cancer cells显示文摘Background:Diminished sensitivity towards chemotherapy remains the major impediment to the clinical treatment of bladder cancer.However,the critical elements in control of chemotherapy resistance remain obscure.Methods:We adopted improved collagen gels and performed cytotoxicity analysis of doxorubicin(DOX)and mitomycin C(MMC)of bladder cancer cells in a 3D culture system.We then detected the expression of multidrug resistant gene ABCB1,dormancy-associated functional protein chicken ovalbumin upstream-transcription factor 1(COUPTF1),cell proliferation marker Ki-67,and cellular senescence marker senescence-associatedβ-galactosidase(SA-β-Gal)in these cells.We further tested the effects of integrin blockade or protein kinase B(AKT)inhibitor on the senescent state of bladder cancer.Also,we examined the tumor growth and survival time of bladder cancer mouse models given the combination treatment of chemotherapeutic agents and integrinα2β1 ligand peptide TFA(TFA).Results:Collagen gels played a repressive role in bladder cancer cell apoptosis induced by DOX and MMC.In mechanism,collagen activated the integrinβ1/AKT cascade to drive bladder cancer cells into a premature senescence state via the p21/p53 pathway,thus attenuating chemotherapy-induced apoptosis.In addition,TFA had the ability to mediate the switch from senescence to apoptosis of bladder cancer cells in xenograft mice.Meanwhile,TFA combined with chemotherapeutic drugs produced a substantial suppression of tumor growth as well as an extension of survival time in vivo.Conclusions:Based on our finding that integrinβ1/AKT acted primarily to impart premature senescence to bladder cancer cells cultured in collagen gel,we suggest that integrinβ1 might be a feasible target for bladder cancer eradication. | Linghui Deng Kun Jin Xianghong Zhou Zilong Zhang Liming Ge Xingyu Xiong Xingyang Su Di Jin Qiming Yuan Chichen Zhang Yifan Li Haochen Zhao Qiang Wei Lu Yang Shi Qiu | 2022 | Precision Clinical Medicine2022，5，2： | 0 |
| 20 | Boosted high-temperature electrical characteristics of AlGaN/GaN HEMTs with rationally designed compositionally graded AlGaN back barriers显示文摘Wide bandgap GaN-based HEMTs have shown great potential as key components in various power electronic systems but still face challenges in the pursuit of devices with stable operation capability especially in harsh environments.Here,we report a high-performance double heterojunction(DH)based AlGaN/GaN HEMT by incorporating a decreasing-Al-composition(DAC)graded AlGaN back barrier(BB)beneath the GaN channel.Thanks to the improved electron confinement enabled by graded BB,the DHHEMT exhibits significantly improved on-state drain current density and off-state breakdown voltage compared with a single heterojunction(SH)based HEMT.More intriguingly,with an additional Si Nx passivation layer,the surface states of the DH-HEMTs can be effectively suppressed,leading to an almost constant offstate leakage current and negligible gate contact degradation across the temperature range from 25℃to 150℃.These results highlight the superiority and reliability of the proposed graded AlGaN BB to boost device characteristics for applications under high temperatures and harsh conditions. | Haochen ZHANG Yue SUN Kunpeng HU Lei YANG Kun LIANG Zhanyong XING Hu WANG Mingshuo ZHANG Huabin YU Shi FANG Yang KANG Haiding SUN | 2023 | Science China(Information Sciences)2023，66，8： | 0 |
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