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| 1 | Age,smoking and overweight contribute to the development of intestinal metaplasia of the cardia显示文摘AIM:To assess the role of Helicobacter pylori(H.pylori),gastroesophageal reflux disease(GERD),age,smoking and body weight on the development of intestinal metaplasia of the gastric cardia(IMC).METHODS:Two hundred and seventeen patients scheduled for esophagogastroduodenoscopy were enrolled in this study.Endoscopic biopsies from the esophagus,gastroesophageal junction and stomach were evaluated for inflammation,the presence of H.pylori and intestinal metaplasia.The correlation of these factors with the presence of IMC was assessed using logistic regression.RESULTS:IMC was observed in 42% of the patients.Patient age,smoking habit and body mass index(BMI) were found as potential contributors to IMC.The risk of developing IMC can be predicted in theory by combining these factors according to the following formula:Risk of IMC = a + s-2B where a = 2,…6 decade of age,s = 0 for non-smokers or ex-smokers,1 for < 10 cigarettes/d,2 for > 10 cigarettes/d and B = 0 for BMI < 25 kg/m2(BMI < 27 kg/m2 in females),1 for BMI > 25 kg/m2(BMI > 27 kg/m2 in females).Among potential factors associated with IMC,H.pylori had borderline signif icance(P = 0.07),while GERD showed no signif icance.CONCLUSION:Age,smoking and BMI are potential factors associated with IMC,while H.pylori and GERD show no significant association.IMC can be predicted in theory by logistic regression analysis. | Christian Felley Hanifa Bouzourene Marianne Bründler G VanMelle Antoine Hadengue Pierre Michetti Gian Dorta Laurent Spahr Emiliano Giostra Jean Louis Frossard | 2012 | World Journal of Gastroenterology2012，18，17： | 5 |
| 2 | Assessing the host genetic background effects on type 2 diabetes and obesity development in response to mixed–oral bacteria and high-fat diet using the collaborative cross mouse model显示文摘Background: Host genetic background and sex, play central roles in defining the pathogenesis of type 2 diabetes(T2 D), obesity and infectious diseases. Our previous studies demonstrated the utilization of genetically highly diverse inbred mouse lines, namely collaborative cross(CC), for dissecting host susceptibility for the development of T2 D and obesity, showing significant variations following high-fat(42% fat) diet(HFD). Here, we aimed to assessing the host genetic background and sex effects on T2 D and obesity development in response to oral-mixed bacterial infection and HFD using the CC lines.Materials and Methods: Study cohort consists of 97 mice from 2 CC lines(both sexes), maintained on either HFD or Standard diet(CHD) for 12 weeks. At week 5 a group of mice from each diet were infected with Porphyromonas gingivalis(Pg) and Fusobacterium nucleatum(Fn) bacteria(control groups without infection). Body weight(BW) and glucose tolerance ability were assessed at the end time point of the experiment.Results: The CC lines varied(P <.05) at their BW gain and glucose tolerance ability(with sex effect) in response to diets and/or infection, showing opposite responses despite sharing the same environmental conditions. The combination of diet and infection enhances BW accumulation for IL1912, while restraints it for IL72. As for glucose tolerance ability, only females(both lines) were deteriorated in response to infection.Conclusions: This study emphasizes the power of the CC mouse population for the characterization of host genetic makeup for defining the susceptibility of the individual to development of obesity and/or impaired glucose tolerance. | Luna Karkar Hanifa JAbu-Toamih Atamni Asal Milhem Yael Houri-Haddad Fuad A.Iraqi | 2020 | Animal Models and Experimental Medicine2020，3，2： | 5 |
| 3 | Studying host genetic background effects on multimorbidity of intestinal cancer development,type 2 diabetes and obesity in response to oral bacterial infection and high-fat diet using the collaborative cross(CC)lines显示文摘Background:Multimorbidity of intestinal cancer(IC),type 2 diabetes(T2D)and obesity is a complex set of diseases,affected by environmental and genetic risk factors.High-fat diet(HFD)and oral bacterial infection play important roles in the etiology of these diseases through inflammation and various biological mechanisms.Methods:To study the complexity of this multimorbidity,we used the collaborative cross(CC)mouse genetics reference population.We aimed to study the multimorbidity of IC,T2D,and obesity using CC lines,measuring their responses to HFD and oral bacterial infection.The study used 63 mice of both sexes generated from two CC lines(IL557 and IL711).For 12 weeks,experimental mice were maintained on specific dietary regimes combined with co-infection with oral bacteria Porphyromonas gingivalis and Fusobacterium nucleatum,while control groups were not infected.Body weight(BW)and results of a intraperitoneal glucose tolerance test(IPGTT)were recorded at the end of 12 weeks,after which length and size of the intestines were assessed for polyp counts.Results:Polyp counts ranged between 2 and 10 per CC line.The combination of HFD and infection significantly reduced(P<.01)the colon polyp size of IL557 females to 2.5 cm 2,compared to the other groups.Comparing BW gain,IL557 males on HFD gained 18 g,while the females gained 10 g under the same conditions and showed the highest area under curve(AUC)values of 40000-45000(min mg/dL)in the IPGTT.Conclusion:The results show that mice from different genetic backgrounds respond differently to a high fat diet and oral infection in terms of polyp development and glucose tolerance,and this effect is gender related. | Asal Milhem Hanifa J.Abu Toamih-Atamni Luna Karkar Yael Houri-Haddad Fuad A.Iraqi | 2021 | Animal Models and Experimental Medicine2021，4，1： | 4 |
| 4 | Mapping novel genetic loci associated with female liver weight variations using Collaborative Cross mice显示文摘Background: Liver weight is a complex trait, controlled by polygenic factors and differs within populations. Dissecting the genetic architecture underlying these variations will facilitate the search for key role candidate genes involved directly in the hepatomegaly process and indirectly involved in related diseases etiology.Methods: Liver weight of 506 mice generated from 39 different Collaborative Cross(CC) lines with both sexes at age 20 weeks old was determined using an electronic balance. Genomic DNA of the CC lines was genotyped with high-density single nucleotide polymorphic markers.Results: Statistical analysis revealed a significant(P < 0.05) variation of liver weight between the CC lines, with broad sense heritability(H^2) of 0.32 and genetic coefficient of variation(CV_G) of 0.28. Subsequently, quantitative trait locus(QTL) mapping was performed, and results showed a significant QTL only for females on chromosome 8 at genomic interval 88.61-93.38 Mb(4.77 Mb). Three suggestive QTL were mapped at chromosomes 4, 12 and 13. The four QTL were designated as LWL1-LWL4 referring to liver weight loci 1-4 on chromosomes 8, 4, 12 and 13,respectively.Conclusion: To our knowledge, this report presents, for the first time, the utilization of the CC for mapping QTL associated with baseline liver weight in mice. Our findings demonstrate that liver weight is a complex trait controlled by multiple genetic factors that differ significantly between sexes. | Hanifa J.Abu-Toamih Atamni Maya Botzman Richard Mott Irit Gat-Viks Fuad A.Iraqi | 2018 | Animal Models and Experimental Medicine2018，1，3： | 3 |
| 5 | Plantar Pressures in Diabetes with No Known Neuropathy显示文摘 | Syed N Maiya A G Hanifa N | 2012 | J Diabetes2012，28，10： | 1 |
| 6 | Tuberculosis among adults starting antiretroviral therapy in South Africa:the need for routine case finding显示文摘 | Hanifa Y Fielding KL Charalambous S | 2012 | Int J Tuberc Lung Dis2012，16，9： | 1 |
| 7 | United Arab Emirates Female Entrepreneurs:Motivations and Frustrations显示文摘 | Hanifa Itani | | 0，，： | 1 |
| 8 | PAR2 Promotes Vaccine-Induced Protection Against Helicobacter Infection in Mice显示文摘 | Dominique Velin Sharmal Narayan Eric Bernasconi Nathalie Busso Giancarlo Ramelli Michel H. Maillard Daniel Bachmann Catherine Pythoud Hanifa Bouzourene Pierre Michetti Alexander So | 2011 | Gastroenterology2011，，4： | 1 |
| 9 | Vitamin D accelerates resolution of inflammatory responses during tuberculosis treatment显示文摘 | Coussens AK Wilkinson RJ Hanifa Y | | 0，，： | 1 |
| 10 | Dukes B colorectal cancer: Distinct genetic categories and clinical outcome based on proximal or distal tumor location显示文摘 | Pascal Gervaz Hanifa Bouzourene Jean-Philippe Cerottini Pascal Chaubert Jean Benhattar Michelle Secic Steven Wexner Jean-Claude Givel Bruce Belin | 2001 | Diseases of the Colon & Rectum2001，，： | 1 |
| 11 | Th e infl uence of breast density on the sensitivity and specifi city of ultrasound and mammography in breast cancer diagnosis显示文摘 | Svjetlana Mujagi Mensura Burina Hanifa Fejzi | 2013 | Acta Medica Acadernica2013，40，2： | 1 |
| 12 | Prevalence and risk factors of low back pain among nurses in a typical Nigerian hospital 显示文摘 | Sikiru L Hanifa S | 2010 | Afr Health Sci2010，10，1： | 1 |
| 13 | Interleukin-17 Is a Critical Mediator of Vaccine-Induced Reduction of Helicobacter Infection in the Mouse Model显示文摘 | Dominique Velin Laurent Favre Eric Bernasconi Daniel Bachmann Catherine Pythoud Essia Saiji Hanifa Bouzourene Pierre Michetti | 2009 | Gastroenterology2009，，7： | 1 |
| 14 | Plantar Pressures in Di- abetes with No Known Neuropathy 显示文摘 | Syed N Maiya AG Hanifa N et a/ | 2012 | J Diabetes2012，28，10： | 1 |
| 15 | Vitamin D and Acute Respirato- ry Tract Infection显示文摘 | Yasmeen Hanifa Robert Walton | 2011 | Current Respiratory Medicine Reviews2011，76，： | 1 |
| 16 | Prevalence and risk factors of low back pain a- mong nurses in a typical nigerian hospital显示文摘 | Sikiru L Hanifa S | 2010 | African Health Sciences2010，10，1： | 1 |
| 17 | Association of leaf roller resistance with certain plant characters in rice显示文摘 | Hanifa A M Subramaniam T R | | 0，，： | 1 |
| 18 | The Collaborative Cross mouse genetic reference population designed for dissecting complex traits显示文摘Complex traits are multifactorial traits controlled by polygenic host factors.These trait-related phenotypic characteristics and performance including body weight,blood chemistry,immune cell profiles,as well host susceptibility to infectious and chronic diseases.In recent years,tremendous efforts were invested aiming to map the host genetic factors attribute to these traits and subsequently clone the gene/s underlying these loci.In parallel to human studies,a number of mouse models and approaches were developed aimed to enhance the mapping process and the gene cloning.These include of using resources such as F2,backcross,advanced intercross lines,outbred populations,consomic,congenic and recombinant inbred lines(RIL).The constraints of these approaches were the limited resolution mapping of genomic regions of the quantitative trait loci(QTL)associated with the trait of interests,and the limited genetic diversity observed in the parental founders.To overcome these limitations,a new genetically highly diverse recombinant inbred lines of mouse population was established,namely the Collaborative Cross(CC),created from full reciprocal mating of 8 divergent strains of mice:A/J,C57BL/6J,129S1/SvI mJ,NOD/LtJ,NZO/HiL tJ,CAST/Ei,PWK/PhJ,and WSB/EiJ.By intercrossing these eight founders to generate the different CC lines,the genetic makeup of the newly developed resource is completely different from the eight parental lines,and will show heterosis,which subsequently will response differently comparing with their original founders.Finally,our results suggest that it is not essential to defining the phenotypic response of the eight parental lines,prior of assessing the CC lines,because it is believed that genetic interaction of the new genetic makeup of the new lines will reveal new phenotypic response,which completely different from the parental lines.In this report,we present to the community the power of the CC for dissecting variety of complex traits including host susceptibility to infectious and chronic diseases as well body performance traits.Based on our results from a variety of studies,we recommend to the community,that the best strategy of using this population is to aim of phenotyping about 50 and more of CC lines,with limited number of biological replicates(3-4 mice per line),and subsequently using the publicly available high dense genotype information of the CC lines as well the sequence database of the eight founders,it will be possible performing QTL mapping to a unprecedented precision genomic regions less than 1 MB,subsequently lead to identify potential strong candidate genes.These achievements are believed cannot be obtained with any other currently available mouse resource populations. | Hanifa Abu Toamih Atamni Mahmoud Egbaria Yaser Salaymeh Aysar Nashif Fuad A.Iraqi | 2016 | 中国比较医学杂志2016，26，8： | 1 |
| 19 | Biosorption of Cu (Ⅱ) ions from aqueous efflu- ents by black gram bran (BGB)显示文摘 | Raziya Nadeema Muhammad Asif Hanifa Abid Mahmoo- da | 2009 | Journal of Hazardous Materials2009，，168： | 1 |
| 20 | Naturally acquired MAGE-A10 end SSX-2-Specific CDS+T cell responses in patients with hepatocellular carcinoma显示文摘 | Gabriel B Hanifa B Olivier M | 2005 | The Journal of Immunology2005，174，： | 1 |
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