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| 1 | Early estrogen-induced gene 1, a novel RANK signaling component, is essential for osteoclastogenesis显示文摘NF-κ 的受体使活跃之物; B (等级) 和 immunoreceptor 包含适配器的基于酷氨酸的激活主题(ITAM ) 是涉及调整改变的骨破折形成和骨头的必要因素。这里,我们识别早导致雌激素的基因(EEIG1 ) 1 作为一篇小说评价身体上与等级并且进一步交往的可诱导的蛋白质与 Gab2 联系的 ligand (RANKL ) , PLCγ 2 并且在 RANKL 刺激之上的 Tec/Btk kinases。EEIG1 断然调整导致 RANKL 的骨破折形成,由于它便于刺激 RANKL 的 PLCγ 的能力可能; 2 phosphorylation 和 NFATc1 正式就职。另外,设计堵住 RANK-EEIG1 相互作用的禁止的肽由减少骨破折形成禁止了导致 RANKL 的骨头破坏。一起,我们的结果作为一篇小说识别 EEIG1 评价控制调停等级的骨破折形成的发信号的部件,并且建议那指向的 EEIG1 可能为病理学的骨头再吞的处理代表新治疗学的策略。 | Han Kyoung Choi Hye Ri Kang Eutteum Jung Tae Eon Kim Jing Jing Lin Soo Young Lee | 2013 | Cell Research2013，23，4： | 4 |
| 2 | Development of biomaterials for gene therapy显示文摘 | Han S Mahato RI Sung YK | 2000 | Mol Ther2000，2，4： | 1 |
| 3 | Neurologic signs in relation to cognitive function in subcortical ischemic vascular dementia: a CREDOS (Clinical Research Center for Dementia of South Korea) study显示文摘 | Seong Hye Choi SangYun Kim Seol-Heui Han Duk L. Na Doh-Kwan Kim Hae-Kwan Cheong Jae-Hong Lee Seong Yoon Kim Chang Hyung Hong So Young Moon Jay C. Kwon Jung Eun Kim Jee H. Jeong Hae Ri Na Kyung Ryeol Cha Sang Won Seo Yong S. Shim Jun-Young Lee Kyung Won Pa | 2012 | Neurological Sciences2012，，4： | 1 |
| 4 | Differential aortic and mitral valve interstitial cell mineralization and the induction of mineraliza- tion by lysophosphatidylcholine显示文摘 | Wiltz DC Han RI Wilson RL | 2014 | Cardiovas Eng Technol2014，5，4： | 1 |
| 5 | Biodegradable polymer-based interleukin-12 gene delivery:role of induced cytokines,tumor infiltrating cells and nitric oxide in anti-tumor activity 显示文摘 | Maheshwari A Han S Mahato RI | 2002 | Gene Ther2002，9，16： | 1 |
| 6 | Structural and functional characterization of HP0377, a thioredoxin‐fold protein from Helicobacter pylori显示文摘 | Ji Young Yoon Jieun Kim Doo Ri An Sang Jae Lee Hyoun Sook Kim Ha Na Im Hye‐Jin Yoon Jin Young Kim Soon‐Jong Kim Byung Woo Han Se Won Suh | 2013 | Acta Cryst D2013，，5： | 1 |
| 7 | Development of biomaterials for gene therapy显示文摘 | Han S Mahato RI Sung YK | 2000 | Mol Ther2000，2，4： | 1 |
| 8 | Effects of transcription factor activator protein-1 on interleukin-8 expression and enteritis in response to Clostridium difficile toxin A显示文摘 | Jin Young Lee Hye Ri Park Yu-Kyoung Oh Yeong-Jeon Kim Jeehee Youn Joong-Soo Han Jung Mogg Kim | 2007 | Journal of Molecular Medicine2007，，12： | 1 |
| 9 | Application of SYBRgreen PCR and 2DGE methods to authenticate edible bird’s nest food显示文摘 | Yajun Wu Ying Chen Bin Wang Liqun Bai Wu ri han Yiqiang Ge Fei Yuan | 2010 | Food Research International2010，，8： | 1 |
| 10 | Ap- plication of electron beam to treatment of wastewater from papermill 显示文摘 | SHN Hang Sik K M Yu Ri HAN Bum Soo | 2002 | Radiation Physics and Chemistry2002，65，： | 1 |
| 11 | Comparison between surgery and radiofrequency ablation for stage I non-small cell lung cancer显示文摘 | So Ri Kim Hyo Jin Han Seoung Ju Park Kyung Hoon Min Min Hee Lee Chi Ryang Chung Min Ho Kim Gong Yong Jin Yong Chul Lee | 2011 | European Journal of Radiology2011，，2： | 1 |
| 12 | Water-soluble lipopolymer for gene delivery 显示文摘 | Han S Mahato RI Kim SW | 2001 | Bioconjug Chem2001，12，3： | 1 |
| 13 | Generation of chlorsulfuron-resistant transgenic garlic plants (Allium sativum L.) by particle bombardment显示文摘 | Mee Yeon Park Na Ri Yi Han Yong Lee Sung Tae Kim Minkyun Kim Ju-Hyun Park Ju-Kon Kim Jong Seob Lee Jong-Joo Cheong Yang Do Choi | 2002 | Molecular Breeding2002，，3： | 1 |
| 14 | Application of electron beam to treatment of wastewater from paper mill显示文摘 | Hang Sik Shin Yu Ri Kim Bum Soo Han | 2002 | Radiation Physics and Chemistry2002，65，45： | 1 |
| 15 | Parathyroid carcinoma: a difficult histological diagnosis 显示文摘 | Rodriguez C Nadéri S Hans C | 2012 | Eur Ann Otorhinolaryngol Head Neck Dis2012，129，3： | 1 |
| 16 | HOXB8 contributed to oxaliplatin chemo-resistance in colon cancercells by activating STAT3显示文摘Background:Homeobox B8(HOXB8),a member of HOX family,plays a key role in the development of colorectal cancer(CRC).However,the function of HOXB8 in oxaliplatin(OXA)resistance in CRC is still unclear.This study investigated the role and precise molecular mechanism of HOXB8 in OXA-resistant CRC cells.Methods:The cell viability was measured by the 3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide(MTT)assay,and the colony forming ability was determined by colony formation assay.The silencing RNA(siRNA)approach was used to knockdown HOXB8 in CRC cells while the lentiviral transfection system was used to establish stable HOXB8 overexpressing CRC cells.The protein and mRNA levels were evaluated by western blot and real-time reverse transcription-polymerase chain reaction.Results:HOXB8 expression was upregulated in OXA-resistant HCT116 cells(HCT116/OXA)compared to its level in the parent HCT116 cells.Knockdown of HOXB8 significantly inhibited CRC cell growth by suppressing the signal transducer and activator of transcription 3(STAT3)pathway.HOXB8 knockdown also potentiated cytotoxicity of OXA in CRC cells.Inversely,HOXB8 overexpression attenuated OXAinduced growth inhibition of HCT116 cells and RKO cells by activating STAT3 signaling.HOXB8 knockdown effectively inhibited HCT116/OXA cell viability regardless of OXA treatment by suppressing STAT3 signaling.Conclusions:These results shed light on the important functions of HOXB8 in OXA-resistant CRC and suggested that targeting HOXB8 might be an effective therapeutic strategy for select OXA-resistant CRC patients. | LIANLI NI YUN YU HAN LIN WEISHAN ZHUGE LU TAO YIWEI SHEN RI CUI SHAOTANG LI | 2023 | BIOCELL2023，47，10： | 0 |
| 17 | Lichen Planus Pigmentosus Inversus:Two Case Reports显示文摘Introduction:Lichen planus pigmentosus inversus(LPPI)is a rare a rare variant of lichen planus characterized by hyperpigmented patches with predominating localization in intertriginous areas.Due to its rarity,only a few LPPI cases are reported.We herein describe two rare cases of LPPI.Case presentation:The two patients were all with a brownish macular lesion on the intertriginous area.A diagnosis of LPPI was made based on their clinical manifestations,dermoscopic features,and histopathologic features,which revealed an interface change,lichenoid infiltration,and pigmentary incontinence.Discussion:LPPI is pruritic or asymptomatic,hyperpigmented macules and patches on the flexural folds.The axillae and flanks were the most commonly affected areas,followed by the groin and genitalia.About half of the female patients had inframammary fold lesions.LPPI shows higher female predominance than Lichen planus pigmentosus.There were fewer cases that lasted more than 3 years compared to LPP.Conclusion:LPPI is a rare variant of lichen planus,with a locational characteristic and female predominance.Therefore,in the case of a pigmented disease occurring in the flexural folds,it should be placed in the differential diagnosis. | Se Hoon Lee Minah Cho Yu Jin Han Yu Ri Woo Sang Hyun Cho Jeong Deuk Lee Hei Sung Kim | 2022 | International Journal of Dermatology and Venereology2022，5，2： | 0 |
| 18 | Unveil the Redox Evolution of Ore-forming Fluids using Sulfur Isotope:A Case Study of the Zhengguang Intermediate Sulfidation Epithermal Au-Zn Deposit,NE China显示文摘Oxygen fugacity(fO_(2))is a key intensity variable during the entire magmatic-hydrothermal mineralization courses.The redox state and its variations between different stages of the ore-forming fluids of intermediate sulfidation epithermal deposits are rarely deciphered due to the lack of appropriate approaches to determine fO_(2)of the fluids.Here,we reported theδ^(34)S of the sulfides from three different stages(stageⅠ,Ⅱ,Ⅲ)of Zhengguang,an Early Ordovician Au-rich intermediate sulfidation(IS)epithermal deposit,to decipher the redox evolution of the ore-forming fluids.The increasingδ^(34)S values from stageⅠpyrite(pyl,average-2.6‰)through py2(average-1.9‰)to py3(average-0.2‰)indicates a decrease of the oxygen fugacity of the ore-forming fluids.A compilation ofδ^(34)S values of sulfides from two subtypes of IS deposits(Au-rich and Ag-rich)from NE China shows that theδ^(34)S values of sulfides from Au-rich IS deposits are systematically lighter than those of Ag-rich IS Ag-Pb-Zn deposit,indicating the ore-forming fluids of the former are more oxidized than the latter.We highlight that sulfur isotopic composition of hypogene sulfides is an efficacious proxy to fingerprint the oxygen fugacity fluctuations of epithermal deposits and could potentially be used to distinguish the subtypes of IS deposits. | WANG Le GAO Shen QIN Kezhang SONG Guoxue HAN Ri SU Shiqiang GUO Jihai PANG Xuyong LI Guangming | 2023 | Acta Geologica Sinica(English Edition)2023，97，5： | 0 |
| 19 | Discussion of reasonable drilling parameters in impregnated diamond bit drilling显示文摘The impregnated diamond(ID)bit drilling is one of the main rotary drilling methods in hard rock drilling and it is widely used in mineral exploration,oil and gas exploration,mining,and construction industries.In this study,the quadratic polynomial model in ID bit drilling process was proposed as a function of controllable mechanical operating parameters,such as weight on bit(WOB)and revolutions per minute(RPM).Also,artificial neural networks(ANN)model for predicting the rate of penetration(ROP)was developed using datasets acquired during the drilling operation.The relationships among mechanical operating parameters(WOB and RPM)and ROP in ID bit drilling were analyzed using estimated quadratic polynomial model and trained ANN model.The results show that ROP has an exponential relationship with WOB,whereas ROP has linear relationship with RPM.Finally,the optimal regime of mechanical drilling parameters to achieve high ROP was confirmed using proposed model in combination with rock breaking principal. | PAK Kumdol HO Yinchol PENG Jianming RI Jaemyong HAN Changson | 2023 | Global Geology2023，26，2： | 0 |
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