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| 1 | Biogenesis and regulation of the let-7 miRNAs and their functional implications显示文摘let-7 miRNA 是在线虫, Caenorhabditis elegans,和它的生物功能表演发现的第一 miRNAs 之一到人的从线虫的进化保存的高水平。在 C 不同。elegans,高级动物有 let-7 miRNAs 的多重 isoforms;一个一致序列把种子顺序和这些 isoforms 称为的这些 isoforms 份额被分成 let-7 miRNA 家庭。let-7 家庭的表示为发展预定和肿瘤 suppressor 功能被要求,但是必须为干细胞的自强被压制。因此, let-7 miRNA 生物的续生说必须小心地被控制。产生 let-7 miRNA,一个主要抄本被 RNA 聚合酶 II 生产然后随后由 Drosha/DGCR8, TUTase,和 Dicer 处理了。因为 let-7 处理的 dysregulation 是有害的, let-7 的生物的续生说被细胞的因素紧调整,例如 RNA 有约束力的蛋白质, LIN28A/B 和 DIS3L2。在这评论,我们讨论 let-7 miRNAs 的生物函数和生物的续生说,集中于在脊椎动物的 let-7 生物的续生说的规定的分子的机制,例如鼠标和人。 | Hosuk Lee Sungwook Han Chang Seob Kwon Daeyoup Lee | 2016 | Protein & Cell2016，7，2： | 24 |
| 2 | Chaga mushroom (Inonotus obliquus) induces G0/G1 arrest and apoptosis in human hepatoma HepG2 cells显示文摘AIM: To investigate the anti-proliferative and apoptotic effects of Chaga mushroom (Inonotus obliquus) water extract on human hepatoma cell lines,HepG2 and Hep3B cells. METHODS: The cytotoxicity of Chaga extract was screened by 3-4,5-dimethylthiazol-2-yl-2,5-diphenyltetrazolium bromide (MTT) assay. Morphological observation,flow cytometry analysis,Western blot were employed to elucidate the cytotoxic mechanism of Chaga extract. RESULTS: HepG2 cells were more sensitive to Chaga extract than Hep3B cells,as demonstrated by markedly reduced cell viability. Chaga extract inhibited the cell growth in a dose-dependent manner,which was accompanied with G0/G1-phase arrest and apoptotic cell death. In addition,G0/G1 arrest in the cell cycle was closely associated with down-regulation of p53,pRb,p27,cyclins D1,D2,E,cyclin-dependent kinase (Cdk) 2,Cdk4,and Cdk6 expression. CONCLUSION: Chaga mushroom may provide a new therapeutic option,as a potential anticancer agent,in the treatment of hepatoma. | Myung-Ja Youn Jin-Kyung Kim Seong-Yeol Park Yunha Kim Se-Jin Kim Jin Seok Lee Kyu Yun Chai Hye-Jung Kim Ming-Xun Cui Hong Seob So Ki-Young Kim Raekil Park | 2008 | World Journal of Gastroenterology2008，14，4： | 13 |
| 3 | Effect of electrical stimulation on neural regeneration via the p38-RhoA and ERK1/2-Bcl-2 pathways in spinal cord-injured rats显示文摘Although electrical stimulation is therapeutically applied for neural regeneration in patients, it remains unclear how electrical stimulation exerts its effects at the molecular level on spinal cord injury(SCI). To identify the signaling pathway involved in electrical stimulation improving the function of injured spinal cord, 21 female Sprague-Dawley rats were randomly assigned to three groups: control(no surgical intervention, n = 6), SCI(SCI only, n = 5), and electrical simulation(ES; SCI induction followed by ES treatment, n = 10). A complete spinal cord transection was performed at the 10^(th) thoracic level. Electrical stimulation of the injured spinal cord region was applied for 4 hours per day for 7 days. On days 2 and 7 post SCI, the Touch-Test Sensory Evaluators and the Basso-Beattie-Bresnahan locomotor scale were used to evaluate rat sensory and motor function. Somatosensory-evoked potentials of the tibial nerve of a hind paw of the rat were measured to evaluate the electrophysiological function of injured spinal cord. Western blot analysis was performed to measure p38-RhoA and ERK1/2-Bcl-2 pathways related protein levels in the injured spinal cord. Rat sensory and motor functions were similar between SCI and ES groups. Compared with the SCI group, in the ES group, the latencies of the somatosensory-evoked potential of the tibial nerve of rats were significantly shortened, the amplitudes were significantly increased, RhoA protein level was significantly decreased, protein gene product 9.5 expression, ERK1/2, p38, and Bcl-2 protein levels in the spinal cord were significantly increased. These data suggest that ES can promote the recovery of electrophysiological function of the injured spinal cord through regulating p38-RhoA and ERK1/2-Bcl-2 pathway-related protein levels in the injured spinal cord. | Min Cheol Joo Chul Hwan Jang Jong Tae Park Seung Won Choi Seungil Ro Min Seob Kim Moon Young Lee | 2018 | Neural Regeneration Research2018，13，2： | 6 |
| 4 | Cinnamon extract suppresses experimental colitis through modulation of antigen-presenting cells显示文摘AIM:To investigate the anti-inflammatory effects of cinnamon extract and elucidate its mechanisms for targeting the function of antigen presenting cells.METHODS:Cinnamon extract was used to treat murine macrophage cell line(Raw 264.7),mouse primary antigen-presenting cells(APCs,MHCII+) and CD11c+dendritic cells to analyze the effects of cinnamon extract on APC function.The mechanisms of action of cinnamon extract on APCs were investigated by analyzing cytokine production,and expression of MHC antigens and co-stimulatory molecules by quantitative real-time PCR and flow cytometry.In addition,the effect of cinnamon extract on antigen presentation capacity and APC-dependent T-cell differentiation were analyzed by [H3]-thymidine incorporation and cytokine analysis,respectively.To confirm the anti-inflammatory effects of cinnamon extract in vivo,cinnamon or PBS was orally administered to mice for 20 d followed by induction of experimental colitis with 2,4,6 trinitrobenzenesulfonic acid.The protective effects of cinnamon extract against experimental colitis were measured by checking clinical symptoms,histological analysis and cytokine expression prof iles in inflamed tissue.RESULTS:Treatment with cinnamon extract inhibited maturation of MHCII+ APCs or CD11c+ dendritic cells(DCs) by suppressing expression of co-stimulatory molecules(B7.1,B7.2,ICOS-L),MHCII and cyclooxygenase(COX)-2.Cinnamon extract induced regulatory DCs(rDCs) that produce low levels of pro-inflammatory cytokines [interleukin(IL)-1β,IL-6,IL-12,interferon(IFN)-γ and tumor necrosis factor(TNF)-α] while expressing high levels of immunoregulatory cytokines(IL-10 and transforming growth factor-β).In addition,rDCs generated by cinnamon extract inhibited APC-dependent T-cell proliferation,and converted CD4+ T cells into IL-10high CD4+ T cells.Furthermore,oral administration of cinnamon extract inhibited development and progression of intestinal colitis by inhibiting expression of COX-2 and pro-inflammatory cytokines(IL-1β,IFN-γ and TNF-α),while enhancing IL-10 levels.CONCLUSION:Our study suggests the potential of cinnamon extract as an anti-inflammatory agent by targeting the generation of regulatory APCs and IL-10+ regulatory T cells. | Ho-Keun Kwon Ji-Sun Hwang Choong-Gu Lee Jae-Seon So Anupama Sahoo Chang-Rok Im Won Kyung Jeon Byoung Seob Ko Sung Haeng Lee Zee Yong Park Sin-Hyeog Im | 2011 | World Journal of Gastroenterology2011，17，8： | 6 |
| 5 | 覆盆子对酒精戒断大鼠海马中去甲肾上腺素的作用显示文摘目的:研究覆盆子对酒精戒断焦虑症的治疗作用,并探讨起对脑内海马组织中去甲肾上腺素的机制。方法:选取健康SD大鼠36只,体重220~250 g,随机分为6组,空白组、模型组、高剂量药物组、中剂量药物组、低剂量药物组、阳性药物组。除空白组外,其余5组每天腹腔内注射20%(w/v)酒精1.5 ml/100 g,共28天,制备酒精成瘾模型,然后灌胃不同剂量药物,每天一次,共给3天,最后一次给药1 h后,用高架十字迷宫测其焦虑行为,断头取脑,分离海马,用HPLC测海马中去甲肾上腺素的含量。结果:在高架十字迷宫中,与空白对照组相比,酒精戒断大鼠在开放臂的逗留次数、时间明显减少(P<0.01);与模型组相比,高剂量覆盆子提取物显著地增加其次数、时间(P<0.05),而中、低剂量覆盆子提取物作用效果不明显(P>0.05);HPLC检测显示与空白组相比,酒精成瘾大鼠海马中去甲肾上腺素的含量显著升高(P<0.01),与模型组相比,高剂量覆盆子可降低海马中去甲肾上腺素含量(P<0.05),中、低剂量覆盆子降低去甲肾上腺素含量的趋势不明显(P>0.05)。结论:覆盆子提取物能减轻酒精戒断时大鼠所表现出的焦虑样行为,其抗焦虑症的作用机制可能与降低大鼠脑内海马组织中去甲肾上腺素含量有关。 | 邢宇双 吴宜艳 梁启超 杨志 赵容杰 Young Seob Gwak | 2018 | 中医药学报2018，46，1： | 5 |
| 6 | 喷墨印刷/软光刻技术结合气相聚合法制备聚3,4-乙撑二氧噻吩图像显示文摘采用气相聚合,以咪唑衍生物为辅助料可以成功制备高导电透明的聚3,4-乙撑二氧噻吩(PEDOT)薄膜。带有1~2个烷基官能团的咪唑衍生物的加入可以显著提高PEDOT的电导率。为了研制一种易于实现的PEDOT成像法,本文采用了喷墨印刷或软光刻技术结合气相聚合法,并以带取代基的对甲苯磺酸铁为氧化剂,3,4-乙撑二氧噻吩为聚合单体来制备PEDOT图像。这种新型方法的实现将为制得本征导电高分子材料图像提供一个高效便捷的方法。 | Jong Seob Choi Kuk Young Cho Jin-Heong Yim 孟维华(编译) | 2010 | 中国印刷与包装研究2010，2，4： | 3 |
| 7 | Porous Microspheres Comprising CoSe2 Nanorods Coated with N-Doped Graphitic C and Polydopamine-Derived C as Anodes for Long-Lived Na-Ion Batteries显示文摘Metal–organic framework-templated nitrogen-doped graphitic carbon(NGC)and polydopaminederived carbon(PDA-derived C)-double coated one-dimensional CoSe_(2) nanorods supported highly porous threedimensional microspheres are introduced as anodes for excellent Na-ion batteries,particularly with long-lived cycle under carbonate-based electrolyte system.The microspheres uniformly composed of ZIF-67 polyhedrons and polystyrene nanobeads(φ=40 nm)are synthesized using the facile spray pyrolysis technique,followed by the selenization process(P-CoSe_(2)@NGC NR).Further,the PDA-derived C-coated microspheres are obtained using a solution-based coating approach and the subsequent carbonization process(P-CoSe_(2)@PDA-C NR).The rational synthesis approach benefited from the synergistic effects of dual carbon coating,resulting in a highly conductive and porous nanostructure that could facilitate rapid diffusion of charge species along with efficient electrolyte infiltration and effectively channelize the volume stress.Consequently,the prepared nanostructure exhibits extraordinary electrochemical performance,particularly the ultra-long cycle life stability.For instance,the advanced anode has a discharge capacity of 291(1000th cycle,average capacity decay of 0.017%)and 142 mAh g^(-1)(5000th cycle,average capacity decay of 0.011%)at a current density of 0.5 and 2.0 A g^(-1),respectively. | Jae Seob Lee Rakesh Saroha Jung Sang Cho | 2022 | Nano-Micro Letters2022，14，7： | 3 |
| 8 | Length of negative resection margin does not affect local recurrence and survival in the patients with gastric cancer显示文摘AIM:To investigate the influence of the resection margin on local recurrence and survival in gastric cancer patients.METHODS:We reviewed the medical records of 1788patients who had undergone gastrectomy for gastric cancer at the Seoul National University Bundang Hospital,South Korea,between May 2003 and July 2009.The patients were divided into early and advanced gastric cancer groups.In each group,we analyzed the relationship between clinicopathologic factors and survival outcomes,and compared the hazard rates of event occurrence between patients with resection margins above and below the cut-off value,using a Cox proportional hazard model.RESULTS:The early and advanced gastric cancer groups included 1001 and 787 patients,respectively.The hazard rates of event occurrence did not significantly differ between the patients with resection margins above the cut-off value and those with resection margins below the cut-off value(P>0.05,in all comparisons).Based on the multivariable analyses,the proximal and distal resection margins were not significantly associated with survival outcomes and local recurrence(P>0.05,in all analyses).CONCLUSION:The proximal or distal resection margins did not affect the prognosis of patients with gastric cancer if the margins were pathologically negative. | Chang Min Lee Ye Seob Jee Ju-Hee Lee Sang-Yong Son Sang-Hoon Ahn Do Joong Park Hyung-Ho Kim | 2014 | World Journal of Gastroenterology2014，20，30： | 2 |
| 9 | Risk Factors for Operative Complications in Elderly Patients During Laparoscopy-Assisted Gastrectomy显示文摘 | Sun-Hwi Hwang Do Joong Park Ye Seob Jee Hyung-Ho Kim Hyuk-Joon Lee Han-Kwang Yang Kuhn Uk Lee | 2009 | Journal of the American College of Surgeons2009，，2： | 2 |
| 10 | Laparoscopic Gastrectomy in Patients With Previous Gastrectomy for Gastric Cancer: A Report of 17 Cases显示文摘 | Hee Sung Kim Beom Su Kim In Seob Lee Sol Lee Jeoung Hwan Yook Byung Sik Kim | 2014 | Surgical Laparoscopy, Endoscopy & Percutaneous Techniques2014，，2： | 2 |
| 11 | Partial Eigenstructure Assignment Algorithm in Flight Control System Design显示文摘 | Hee Seob Kim Youdan Kim | 1999 | IEEE Transactions on Aerospace and Electronic System1999，35，4： | 2 |
| 12 | Effects of bamboo charcoal and bamboo vinegar as antibiotic alternatives on growth performance, immune responses and fecal microflora population in fattening pigs显示文摘 | Gyo Moon CHU Cheol Kyu JUNG Hoi Yun KIM Ji Hee HA Jong Hyun KIM Min Seob JUNG Shin Ja LEE Yuno SONG Rashid Ismael Hag IBRAHIM Jae Hyeon CHO Sung Sill LEE Young Min SONG | 2012 | Animal Science Journal2012，，2： | 2 |
| 13 | Clinical Application of Human Adipose Tissue–Derived Mesenchymal Stem Cells in Progressive Hemifacial Atrophy (Parry-Romberg Disease) With Microfat Grafting Techniques Using 3-Dimensional Computed Tomography and 3-Dimensional Camera显示文摘 | Kyung Suk Koh Tae Suk Oh Hoon Kim In Wook Chung Kang Woo Lee Hyo Bo Lee Eun Jung Park Jae Seob Jung Il Seob Shin Jeong Chan Ra Jong Woo Choi | 2012 | Annals of Plastic Surgery2012，，3： | 2 |
| 14 | Effects of humic acid on phytodegradation of petroleum hydrocarbons in soil simultaneously contaminated with heavy metals显示文摘The use of humic acid (HA) to enhance the efficiency of phytodegradation of petroleum hydrocarbons in soil contaminated with diesel fuel was evaluated in this study. A sample of soil was artificially contaminated with commercially available diesel fuel to an initial total petroleum hydrocarbons (TPH) concentration of 2300 mg/kg and four heavy metals with concentrations of 400 mg/kg for Pb, 200 mg/kg for Cu, 12 mg/kg for Cd, and 160 mg/kg for Ni. Three plant species, Brassica campestris, Festuca arundinacea, and Helianthus annuus, were selected for the phytodegradation experiment. Percentage degradation of TPH in the soil in a control pot supplemented with HA increased to 45% from 30% without HA. The addition of HA resulted in an increases in the removal of TPH from the soil in pots planted with B. campestris, F. arundinacea, and H. annuus, enhancing percentage degradation to 86%, 64%, and 85% from 45%, 54%, and 66%, respectively. The effect of HA was also observed in the degradation of n-alkanes within 30 days. The rates of removal of n-alkanes in soil planted with B. campestris and H. annuus were high for n-alkanes in the range of C11-C28. A dynamic increase in dehydrogenase activity was observed during the last 15 days of a 30-day experimental period in all the pots amended with HA. The enhanced biodegradation performance for TPHs observed might be due to an increase in microbial activities and bioavailable TPH in soils caused by combined effects of plants and HA. The results suggested that HA could act as an enhancing agent for phytodegradation of petroleum hydrocarbons in soil contaminated with diesel fuel and heavy metals. | Soyoung Park Ki Seob Kim Jeong-Tae Kim Daeseok Kang Kijune Sung | 2011 | Journal of Environmental Sciences2011，23，12： | 2 |
| 15 | New solid superacid catalyst prepared by doping ZrO2 with Ce and modifying with sulfate and its catalytic activity for acid catalysis显示文摘 | Jong Rack Sohn Si Hoon Lee Jun Seob Lim | 2006 | Catalysis Today2006，116，14： | 1 |
| 16 | Model development and control methodology of a new electric power steering system显示文摘 | Jeonghoon Song Kwangsuck Boo Heung Seob Kim | 2004 | Proceedings of the Institution of Mechanical Engineers2004，2004，： | 1 |
| 17 | A general correlation for pressure drop in a Kenics static mixer 显示文摘 | Hyun Seob Song Sang Phil Hart | 2005 | Chem Eng Sci2005，，60： | 1 |
| 18 | Condensation Heat Transfer of R22 and R410A in Horizontal Smooth and Micro-fin Tubes显示文摘 | Man-Hoe Kim Joeng Seob | 2005 | Refrigeration2005，28，： | 1 |
| 19 | Model development and control methodology of a new electric power steering system显示文摘 | Song Jeonghoon Boo Kwangsuck Kim Heung Seob | 2004 | Journal of Automobile Engineering2004，218，9： | 1 |
| 20 | Enhanced magnetic abrasive polishing of non - ferrous metals utilizing a permanent magnet 显示文摘 | Jae - Seob Kwak | 2009 | International Journal of Ma- chine Tools & Manufacture2009，49，： | 1 |
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