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| 1 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 2 | The consequences of anxious temperament for disease detection, self-management behavior, and quality of life in type 2 diabetes mellitus 显示文摘 | Hall PA Rodin GM Vallis TM | 2009 | Psyehosomat Res2009，67，4： | 1 |
| 3 | Engineering splicing factors with designed specificities显示文摘 | Wang Y Cheong CG Hall TM | 2009 | Nat Methods2009，6，11： | 1 |
| 4 | An in jnctable calcium sulfate-based bone graft putty using hydroxypropylmethylcellulose as the plasticizer显示文摘 | Urban RM Turner TM Hall DJ | 2004 | Orthopedics2004，27，1： | 1 |
| 5 | Osseous healing using injectable calcium sulfatebased putty for the derivery of demineralized bone matrix and cancellous hone chips显示文摘 | Turner TM Urban RM Hall DJ | 2003 | Orthopedics2003，26，5： | 1 |
| 6 | Rasteratian of large hone defects using a hard-setting,injectable putty containing demineralized bone particles compared to cancellous autograft hone显示文摘 | Turner TM Urban RM Hall DJ | 2003 | Orthopedics2003，26，5： | 1 |
| 7 | Fat embolism precipitated by rea ming of the femoral canal during revision of a total knee arthroplasty: A case r eport显示文摘 | Calahan JJ | 1994 | J Bone Joint Surg(Am)1994，76，： | 1 |
| 8 | Atlantoaxial stabilization : clinicalcomparison of posterior cervical wiring techniquewith transarticu-lar screw fixation 显示文摘 | Reilly TM Sasso KC Hall PV | 2003 | J Spinal Disord Tech2003，16，3： | 1 |
| 9 | Quantification of myelin loss in frontal lobe white matter in vascular dementia, Alzheimer's disease, and dementia with Lewy bodies 显示文摘 | Ihara M Polvikoski TM Hall R | 2010 | Acta Neuropathol2010，119，5： | 1 |
| 10 | Peak flow monitoring in pediatric asthma manage-ment: a clinical practice column submission显示文摘 | Callahan KA Panter TM Hall TM | 2009 | J Pediatr Nurs2009，25，1： | 1 |
| 11 | Late preterm Infants:birth outcomes and health care utilization in the first year显示文摘 | Bird TM Bronstein JM Hall RW | | 0，，02： | 1 |
| 12 | Healing of large defects treated with calcium sulfate pellets containing demineralized bone matrix particles 显示文摘 | Urban RM Turner TM Hall D J | 2003 | J Orthopedics2003，26，5： | 1 |
| 13 | Optimization of a real-time RT-PCR assay reveals an increase of genogroup I norovirus in the clinical setting显示文摘 | Van Stelten A Kreman TM Hall N | | 0，，01： | 1 |
| 14 | Atlantoaxial stabilization:clinical comparison of posterior cervical wiring technique with transarticular screw fixation显示文摘 | Reilly TM Sasso RC Hall PV | 2003 | Journal of Spinal Disorders & Techniques2003，16，3： | 1 |
| 15 | Comparison of normal or heparinised saline flushing on function of arterial lines显示文摘 | Whitta RK Hall KF Bennetts TM | | 0，，03： | 1 |
| 16 | Local and systemic levels of tobramycin delivered from calcium sulfate bone graft substitute pellets显示文摘 | Turner TM Urban RM Hall DJ | 2005 | Clin Orthop Relat Res2005，，437： | 1 |
| 17 | Comparison of normal or heparinised saline flushing on function of arterial lines显示文摘 | Whitta RK Hall KF Bennetts TM | | 0，，03： | 1 |
| 18 | Reliability of thermal quantitative sensory testing of the hand in a cohort of young, healthy adults显示文摘 | Moloney NA Hall TM O'Sullivan TC | 2011 | Muscle Nerve2011，44，4： | 1 |
| 19 | Peak flow monitoring in pediatric asthma management: a clinical practice column submission 显示文摘 | Callahan KA Panter TM Hall TM et at | 2010 | J Pediatr Nurs2010，25，1： | 1 |
| 20 | Schistosoma mansoni: molecular cloning and sequencing Of the 200-kDa chemotherapeutic target antigen显示文摘 | Hall TM Joseph GT Strand M | 1995 | Exp Parasitol1995，80，2： | 1 |
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