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| 1 | Implications of the immunoregulatory functions of mesenchymal stem cells in the treatment of human liver diseases显示文摘Transplantation of mesenchymal stem cells(MSCs)has been recently studied in animal models,and in clinical trials of patients with fulminant hepatic failure,end-stage liver diseases and inherited metabolic disorders.Modulatory cytokines produced by MSCs can inhibit immunocyte proliferation and migration to the liver,thereby attenuating inflammatory injury and reducing hepatocyte apoptosis.In addition,MSCs play an important role in regressing liver fibrosis and in supporting the function,proliferation and differentiation of endogenous hepatocytes under appropriate conditions.Although remarkable progress has been achieved in basic and clinical MSC studies,optimal therapeutic regimens for the clinical application of MSCs,such as optimal doses,transplantation routine and interval period for transplantation,need to be elucidated in detail.Furthermore,the long-term safety and therapeutic efficacy of MSC transplantation should be evaluated in future clinical trials.This review summarizes our current understanding of the immunomodulatory effects of MSC therapies on human liver diseases. | Hu Lin Ruonan Xu Zheng Zhang Liming Chen Ming Shi Fu-Sheng Wang | 2011 | Cellular & Molecular Immunology2011，8，1： | 26 |
| 2 | shRNA targeting HDGF suppressed cell growth and invasion of squamous cell lung cancer显示文摘导出 Hepatoma 的生长因素(HDGF ) ,有 mitogenic 的原子蛋白质和 angiogenic 活动,被报导了主要涉及 tumorigenesis 和非小的房间肺癌症的前进。在这研究, HDGF 表示被 specific-shRNA 与在肺指向 HDGF 的 lentivirus 表示向量击倒有鳞的房间癌 520 房间。shRNA 击倒的 HDGF 在 vitro 并且在由 MTT,板克隆和移植肿瘤模型试金显示了的 vivo 显著地压制了房间增长。另外, HDGF 的组合式的表达式也禁止了出现在 transwell 和 Boyden 实验的房间移植和侵略。因为参予有鳞的房间肺癌症的致病的 oncogene,和 HDGF 可以是为非小的房间肺癌症的一个关键治疗学的目标,我们断定 HDGF 行动。 | Jie Meng Wei Xie Liming Cao Chengping Hu Zhiyuan Zhen | 2010 | Acta Biochimica et Biophysica Sinica2010，42，1： | 19 |
| 3 | Biphasic insulin aspart 30 improved glycemic control in Chinese patients with type 2 diabetes poorly controlled on oral glucose-lowering drugs: a subgroup analysis of the A1chieve study显示文摘 | Chen Liming Xing Xiaoyan Lei Minxiang Liu Jie Shi Yongquan Li Pengqiu Qin Guijun Li Chengjiang Li Yukun Wang Qing Gao Tianshu Hu Ling Wang Yangwei Yang Wenying | 2014 | Chinese Medical Journal2014，，2： | 19 |
| 4 | Positive correlation between PPARγ/PGC-1α and γ-GCS in lungs of rats and patients with chronic obstructive pulmonary disease显示文摘氧化应力是长期的妨碍的肺的疾病(COPD ) 的主要致病之一。-Glutamylcysteine 合成酶(-GCS) 是在 COPD 的首要的抗氧化剂酶之一。Peroxisome 激活 proliferator 的 receptor-gamma (PPAR ) 是一个激活 ligand 的抄写因素,它被象 rosiglitazone (RGZ ) 那样的特定的 ligands 激活,施加多重生物效果。PPAR coactivator-1 (PGC-1 ) 是 PPAR 激活剂,它由 PPAR ligands 的正式就职绑在 PPAR,共同激活 PPAR 目标基因。成长证据建议了 PPAR/PGC-1 能调整多重抗氧化剂基因。然而, -GCS 上的 PPAR/PGC-1 的效果在 COPD 的发展期间仍然保持不清楚。这里,我们在 + lipopolysaccharide (LPS ) 和 CS +LPS + RGZ,以及病人的肺受不了的香烟烟(CS ) 对待的老鼠的肺测量了 PPAR, PGC-1 和 -GCS,-GCS 活动和反应的氧种类(ROS ) 内容的表示层次 COPD。与从 CS +对待 LPS 的老鼠的肺相比,对待 RGZ 的老鼠的肺表明了 -GCS 活动的显著地更低的 ROS 内容,和显著增加和 PPAR, PGC-1,和 -GCS 的表示层次的增加。与控制相比,而且, PPAR, PGC-1,和 -GCS 的表达式层次显著地在温和 COPD 病人的肺增加了,并且日益增多地与中等、严重的 COPD 在病人的肺减少了。-GCS 蛋白质断然与 FEV1% 被相关。PPAR 和 PGC-1 蛋白质断然与 -GCS 活动和 mRNA 水平被相关。在结论, -GCS 在 COPD 的早阶段显示出补偿 upregulation,它日益增多地与增加 COPD 严厉患心脏代偿失调。PPAR/PGC-1 小径的激活可以由 upregulating -GCS 免于 COPD 前进并且减轻氧化应力。 | Jie Li Aiguo Dai Ruicheng Hu Liming Zhu Shuangxiang Tan | 2010 | Acta Biochimica et Biophysica Sinica2010，42，9： | 13 |
| 5 | Insight-HXMT observations of the first binary neutron star merger GW170817显示文摘Finding the electromagnetic(EM) counterpart of binary compact star merger, especially the binary neutron star(BNS) merger,is critically important for gravitational wave(GW) astronomy, cosmology and fundamental physics. On Aug. 17, 2017,Advanced LIGO and Fermi/GBM independently triggered the first BNS merger, GW170817, and its high energy EM counterpart,GRB 170817 A, respectively, resulting in a global observation campaign covering gamma-ray, X-ray, UV, optical, IR, radio as well as neutrinos. The High Energy X-ray telescope(HE) onboard Insight-HXMT(Hard X-ray Modulation Telescope) is the unique high-energy gamma-ray telescope that monitored the entire GW localization area and especially the optical counterpart(SSS17 a/AT2017 gfo) with very large collection area(~1000 cm^2) and microsecond time resolution in 0.2-5 MeV. In addition,Insight-HXMT quickly implemented a Target of Opportunity(ToO) observation to scan the GW localization area for potential X-ray emission from the GW source. Although Insight-HXMT did not detect any significant high energy(0.2-5 MeV) radiation from GW170817, its observation helped to confirm the unexpected weak and soft nature of GRB 170817 A. Meanwhile,Insight-HXMT/HE provides one of the most stringent constraints(~10^(-7) to 10^(-6) erg/cm^2/s) for both GRB170817 A and any other possible precursor or extended emissions in 0.2-5 MeV, which help us to better understand the properties of EM radiation from this BNS merger. Therefore the observation of Insight-HXMT constitutes an important chapter in the full context of multi-wavelength and multi-messenger observation of this historical GW event. | TiPei Li ShaoLin Xiong ShuangNan Zhang FangJun Lu LiMing Song XueLei Cao Zhi Chang Gang Chen Li Chen TianXiang Chen Yong Chen YiBao Chen YuPeng Chen Wei Cui WeiWei Cui JingKang Deng YongWei Dong YuanYuan Du MinXue Fu GuanHua Gao He Gao Min Gao MingYu Ge YuDong Gu Ju Guan ChengCheng Guo DaWei Han Wei Hu Yue Huang Jia Huo ShuMei Jia LuHua Jiang WeiChun Jiang Jing Jin YongJie Jin Bing Li ChengKui Li Gang Li MaoShun Li Wei Li Xian Li XiaoBo Li XuFang Li YanGuo Li ZiJian Li ZhengWei Li XiaoHua Liang JinYuan Liao CongZhan Liu GuoQing Liu HongWei Liu ShaoZhen Liu XiaoJing Liu Yuan Liu YiNong Liu Bo Lu XueFeng Lu Tao Luo Xiang Ma Bin Meng Yi Nang JianYin Nie Ge OU JinLu Qu Na Sai Liang Sun Yin Tan Lian Tao WenHui Tao YouLi Tuo GuoFeng Wang HuanYu Wang Juan Wang WenShuai Wang YuSa Wang XiangYang Wen BoBing WU Mei Wu GuangCheng Xiao He Xu YuPeng Xu LinLi Yan JiaWei Yang Sheng Yang YanJi Yang AiMei Zhang ChunLei Zhang ChengMo Zhang Fan Zhang HongMei Zhang Juan Zhang Qiang Zhang Shu Zhang Tong Zhang Wei Zhang WanChang Zhang WenZhao Zhang Yi Zhang Yue Zhang YiFei Zhang YongJie Zhang Zhao Zhang ZiLiang Zhang HaiSheng Zhao JianLing Zhao XiaoFan Zhao ShiJie Zheng Yue Zhu YuXuan Zhu ChangLin Zou | 2018 | Science China(Physics,Mechanics & Astronomy)2018，61，3： | 12 |
| 6 | The enhanced X-ray Timing and Polarimetry mission—eXTP显示文摘In this paper we present the enhanced X-ray Timing and Polarimetry mission—eXTP. eXTP is a space science mission designed to study fundamental physics under extreme conditions of density, gravity and magnetism. The mission aims at determining the equation of state of matter at supra-nuclear density, measuring effects of QED, and understanding the dynamics of matter in strong-field gravity. In addition to investigating fundamental physics, eXTP will be a very powerful observatory for astrophysics that will provide observations of unprecedented quality on a variety of galactic and extragalactic objects. In particular, its wide field monitoring capabilities will be highly instrumental to detect the electro-magnetic counterparts of gravitational wave sources.The paper provides a detailed description of:(1) the technological and technical aspects, and the expected performance of the instruments of the scientific payload;(2) the elements and functions of the mission, from the spacecraft to the ground segment. | ShuangNan Zhang Andrea Santangelo Marco Feroci YuPeng Xu FangJun Lu Yong Chen Hua Feng Shu Zhang Sφren Brandt Margarita Hernanz Luca Baldini Enrico Bozzo Riccardo Campana Alessandra De Rosa YongWei Dong Yuri Evangelista Vladimir Karas Norbert Meidinger Aline Meuris Kirpal Nandra Teng Pan Giovanni Pareschi Piotr Orleanski QiuShi Huang Stephane Schanne Giorgia Sironi Daniele Spiga Jiri Svoboda Gianpiero Tagliaferri Christoph Tenzer Andrea Vacchi Silvia Zane Dave Walton ZhanShan Wang Berend Winter Xin Wu Jean J.M.in't Zand Mahdi Ahangarianabhari Giovanni Ambrosi Filippo Ambrosino Marco Barbera Stefano Basso Jörg Bayer Ronaldo Bellazzini Pierluigi Bellutti Bruna Bertucci Giuseppe Bertuccio Giacomo Borghi XueLei Cao Franck Cadoux Francesco Ceraudo TianXiang Chen Yu Peng Chen Jerome Chevenez Marta Civitani Wei Cui WeiWei Cui Thomas Dauser Ettore Del Monte Sergio Di Cosimo Sebastian Diebold Victor Doroshenko Michal Dovciak YuanYuan Du Lorenzo Ducci QingMei Fan Yannick Favre Fabio Fuschino JoséLuis Ga'lvez Min Gao MingYu Ge Olivier Gevin Marco Grassi QuanYing Gu YuDong Gu DaWei Han Bin Hong Wei Hu Long Ji ShuMei Jia WeiChun Jiang Thomas Kennedy Ingo Kreykenbohm Irfan Kuvvetli Claudio Labanti Luca Latronico Gang Li MaoShun Li Xian Li Wei Li ZhengWei Li Olivier Limousin HongWei Liu XiaoJing Liu Bo Lu Tao Luo Daniele Macera Piero Malcovati Adrian Martindale Malgorzata Michalska Bin Meng Massimo Minuti Alfredo Morbidini Fabio Muleri Stephane Paltani Emanuele Perinati Antonino Picciotto Claudio Piemonte JinLu Qu Alexandre Rachevski Irina Rashevskaya Jerome Rodriguez Thomas Schanz ZhengXiang Shen LiZhi Sheng JiangBo Song LiMing Song Carmelo Sgro Liang Sun Ying Tan Phil Uttley Bo Wang DianLong Wang GuoFeng Wang Juan Wang LangPing Wang YuSa Wang Anna L.Watts XiangYang Wen Jörn Wilms ShaoLin Xiong JiaWei Yang Sheng Yang YanJi Yang Nian Yu WenDa Zhang Gianluigi Zampa Nicola Zampa Andrzej A.Zdziarski AiMei Zhang ChengMo Zhang Fan Zhang Long Zhang Tong Zhang Yi Zhang XiaoLi Zhang ZiLiang Zhang BaoSheng Zhao ShiJie Zheng Yu Peng Zhou Nicola Zorzi J.Frans Zwart | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，2： | 11 |
| 7 | Expression and role of factor inhibiting hypoxia-inducible factor-1 in pulmonary arteries of rat with hypoxia-induced hypertension显示文摘组织缺氧可诱导的 factor-1α 子单元(HIF-1α) 由它是的 transactivating 在导致组织缺氧的肺的高血压(HPH ) 的发展期间起一个枢轴的作用目标基因。作为一个氧敏感的衰减器,因素禁止 HIF-1 (FIH ) 氢氧根 ates 在在 normoxia 和中等组织缺氧下面的 HIF-1α 的 C 终端 transactivation 领域以内的保存天门冬素残余。FIH 蛋白质低在 HPH 遗体的开发期间响应组织缺氧,而是它的动态表达式和角色调整了不清楚。在这研究,一个 HPH 老鼠模型被建立。吝啬的肺的动脉的压力在组织缺氧的 7 d 以后显著地增加了。改变索引的肺的动脉在组织缺氧的 7 d 以后变得明显,当恰好室的肥大索引在组织缺氧的 14 d 以后变得重要时。送信人 RNA (mRNA ) 和 HIF-1α 和脉管的 endothelial 生长因素(VEGF ) 的蛋白质表示, HIF-1α 的描绘得好的目标基因,显著地起来在肺的动脉在暴露以后调整了到组织缺氧。在肺纸巾的 FIH 蛋白质在组织缺氧的 7 d 以后衰退了并且继续通过组织缺氧的持续时间衰退。FIH mRNA 在暴露以后有很少变化到组织缺氧与相比在到 normoxia 的暴露以后。在 hypoxic 老鼠, FIH 蛋白质与 VEGF mRNA 和 VEGF 蛋白质显示出重要否定关联。FIH 蛋白质否定地与吝啬的肺的动脉的压力,肺的动脉改变索引和恰好室的肥大索引被相关。总起来说,我们的结果建议在暴露节制组织缺氧的老鼠的肺的动脉,在 FIH 蛋白质的时间依赖者减少可以由提高象 VEGF 那样的 HIF-1α 目标基因的 transactivation 贡献老鼠 HPH 的发展。 | Daiyan Fu Aiguo Dai Ruicheng Hu Yunrong Chen Liming Zhu | 2008 | Acta Biochimica et Biophysica Sinica2008，40，10： | 9 |
| 8 | DEVELOPMENT OF EXPERIMENTAL METHODS FOR IMPACT TESTING BY COMBINING HOPKINSON PRESSURE BAR WITH OTHER TECHNIQUES显示文摘The split Hopkinson pressure bar(SHPB) technique and the wave propagation inverse analysis(WPIA) technique are both extensively used to experimentally investigate the impact behavior of materials, although neither of them alone provides a fully satisfactory analysis. In the present paper, attention is given to new experimental techniques by incorporating a damagemodified constitutive model into the SHPB technique and combining the Hopkinson pressure bar(HPB) technique with WPIA. First, to distinguish the response due to dynamic constitutive behavior and the response due to dynamic damage evolution, the SHPB method incorporating a damage-modified constitutive model is developed, including an explicit damage-modified Zhu–Wang–Tang model and an implicit damage-modified constitutive model. Second, when the SHPB results become invalid, a method of combining new Lagrange inverse analyses with the HPB technique is developed, including cases of the HPB arranged in front of a long specimen and behind the specimen. As examples of these new methods, typical results are given for nonlinear viscoelastic polymers and concretes considering damage evolution, a super-elastic Ti–Ni alloy with phase transformation and an aluminum foam with shock waves propagating within it. | Lili Wang Shisheng Hu Liming Yang Zijian Sun Jue Zhu Huawei Lai Yuanyuan Ding | 2014 | Acta Mechanica Solida Sinica2014，27，4： | 9 |
| 9 | Lithium intercalation/de-intercalation behavior of a composite Sn/C thin film fabricated by magnetron sputtering显示文摘A tin film of 320 nm in thickness on Cu foil and its composite film with graphite of ~50 nm in thickness on it were fabricated by magnetron sputtering. The surface morphology, composition, surface distributions of alloy elements, and lithium intercalation/de-intercalation behaviors of the fabricated films were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), electron probe microanalyzer (EPMA), X-ray photoelectron spectroscopy (XPS), inductively coupled plasma atomic emission spectrometry (ICP), cyclic voltammetry (CV), and galvanostatic charge/discharge (GC) measurements. It is found that the lithium intercalation/de-intercalation behavior of the Sn film can be significantly improved by its composite with graphite. With cycling, the discharge capacity of the Sn film without composite changes from 570 mAh/g of the 2nd cycle to 270 mAh/g of the 20th cycle, and its efficiency for the discharge and charge is between 90% and 95%. Nevertheless, the discharge capacity of the composite Sn/C film changes from 575 mAh/g of the 2nd cycle to 515 mAh/g of the 20th cycle, and its efficiency for the discharge and charge is between 95% and 100%. The performance improvement of tin by its composite with graphite is ascribed to the retardation of the bulk tin cracking from volume change during lithium intercalation and de-intercalation, which leads to the pulverization of tin. | ZHAO Lingzhi HU Shejun LI Weishan LI Liming HOU Xianhua | 2008 | Rare Metals2008，27，5： | 8 |
| 10 | Allele-defined genome reveals biallelic differentiation during cassava evolution显示文摘Dear Editor,Generation of heterozygous genomes by hybridization between or within species can help maintain plant diversity and serve as a potential source of new species(Baek et al.,2018).Moreover,genomic heterozygosity is associated with genomic coadaptation,developmental stability,and heterosis.Accurate definition of alleles in haplotypes is necessary to precisely characterize allelic variation controlling agriculturally important traits(Shi et al.,2019).Currently,most released genomes have mosaic assembly of haplotypes due to random selection or collapse of alleles during genome assembly(Shi et al.,2019),which masked allelic variation and functional differentiation of divergent alleles in heterozygous species. | Wei Hu Changmian Ji Haitao shi Zhe Liang Zehong Ding Jianqiu Ye Wenjun Ou Gang Zhou Weiwei Tie Yan Yan Jinghao Yang Xiaoying Yang Yunxie Wei Zhiqiang Jin Jianghui Xie Ming Peng Wenquan Wang Anping Guo Biyu Xu Jianchun Guo Songbi Chen Liming Ma Mingcheng Wang Yang Zhou Xiaolong Li Ruoxi Li Siyi Guo Xinhui Xiao Zhongqing Wan Feifei An Jie Zhang Qingyun Leng Yin Li Ray Ming Kaimian Li | 2021 | Molecular Plant2021，14，6： | 8 |
| 11 | Ten years of carbon-based metal-free electrocatalysts显示文摘Since the discovery of the first carbon-based metal-free electrocatalysts(C-MFECs,i.e.,N-doped carbon nanotubes)for the oxygen reduction reaction in 2009,the field of C-MFECs has grown enormously over the last 10 years.C-MFECs,as alternatives to nonprecious transition metals and/or precious noble metal-based electrocatalysts,have been consistently demonstrated as efficient catalysts for oxygen reduction,oxygen evolution,hydrogen evolution,carbon dioxide reduction,nitrogen reduction,and many other(electro-)chemical reactions.Recent research and development of C-MFECs have indicated their potential applications in fuel cells,metal-air batteries,and hydrogen generation through water oxidation as well as electrochemical production of various commodity chemicals,such as ammonia,alcohols,hydrogen peroxide,and other useful hydrocarbons.Further research and development of C-MFECs would surely revolutionize traditional energy conversion and storage technologies with minimal environmental impact.In this short review article,we summarize the journey of C-MFECs over the past 10 years with an emphasis on materials development and their structure-property characterization for applications in fuel cells and metal-air batteries.Current challenges and future prospects of this emerging field are also discussed. | Rajib Paul Quanbin Dai Chuangang Hu Liming Dai | 2019 | Carbon Energy2019，1，1： | 7 |
| 12 | Influence of alloying elements on hot tearing susceptibility of Mg-Zn alloys based on thermodynamic calculation and experimental显示文摘Based on the hot tearing index|△T/△(fs)^(0.5)|recently proposed by Kou and the thermodynamic calculations of Pandat software,Al,Cu,and Mn elements were picked up and their influence on hot tearing susceptibility of Mg-x Zn(x=6,8,10,wt%)alloys was studied by experiments.The results indicate that Al addition can significantly reduce the hot tearing susceptibility of Mg-Zn alloys.Either 0.5Cu or 0.3Mn addition individually can reduce the HTS of the Mg-6Zn-(1,4)Al alloys,while adding together increases the susceptibility.The addition of 0.5Cu and 0.3Mn both individually and together increases the HTS of Mg-8/10Zn-1Al alloys.Based on the experimental and calculation results,the index can be modified to|△T/△(fs)^(0.5)|(d)^(2)for more accurate prediction on the hot tearing resistance of Mg-Zn based alloys.Grain refinement significantly improves the hot tearing resistance of Mg-Zn based alloys. | Zhenzhen Yang Ke Wang Penghuai Fu Liming Peng Bin Hu Ming Liu Anil K.Sachdev | 2018 | Journal of Magnesium and Alloys2018，6，1： | 6 |
| 13 | Numerical analysis and centrifugal modeling of LNAPLs transport in subsurface system显示文摘在不饱和的土壤和地下水的非水的阶段液体(NAPL ) 的运输是在 geo 环境的工程的一个重要研究话题。在这篇论文,在表面下的系统的轻 NAPL (LNAPL ) 运输的机制简短被介绍,并且集体运输方程,液体流动方程,和相对渗透的组成的模型 - 浸透 - 毛状的压力被讨论。然后,数字方法被介绍在多孔的媒介模仿多相的流动问题,并且 LNAPL 的速度空间的分发被获得。而且,不同边界条件在数字模拟被采用在运输行为上调查它的效果。验证数字数据,离心的测试被进行为 LNAPL 建模,在不饱和的土壤和地下水的移植。计算结果与离心的建模的试验性的调查结果是令人喜悦的的,它显示从漏的 LNAPL 由于严肃力量向下削尖行动,并且在毛状的穗上面形成一个高集中地区,然后沿着地下水表格旁边地展开。一些 LNAPL 进入地下水系统进一步移居。当模特儿的数字模拟和离心机的联合能是一个有用工具在表面下的系统学习 LNAPL 的运输行为。 | HU Liming LOI. M. C. MEEGODA J. N. | 2006 | Progress in Natural Science:Materials International2006，16，4： | 6 |
| 14 | Postoperative chemotherapy with S-1 plus oxaliplatin versus S-1alone in locally advanced gastric cancer(RESCUE-GC study): a protocol for a phase Ⅲ randomized controlled trial显示文摘Background:The ACTS-GC study had shown postoperative adjuvant therapy with S-1 improved survival of patients with locally advanced gastric cancer.Addition of oxaliplatin to S-1 is considered to be acceptable as one of the treatment options for gastric cancer patients after radical gastrectomy with D2 lymph node excision.Methods:We have commenced a randomized phase III trial in December 2016 to evaluate S-1 plus oxaliplatin compared with S-1 alone in the adjuvant setting for locally advanced gastric cancer.A total of 564 patients will be accrued from 13 Chinese institutions in two years.The primary endpoint is 3-year relapse-free survival.The secondary endpoints are 5-year overall survival,proportion of patients who complete the postoperative chemotherapy and incidence of adverse events.Ethic and dissemination:The trial has been approved by the institutional review board of each participating institution and it was activated on December,2016.The enrollment will be finished in December,2018.Patient’s follow-up will be ended until December,2023.Trial registration:Clinical Trials.gov,identifier:NCT02867839.Registered on August 4,2016. | Xiang Hu Lin Chen Yian Du Biao Fan Zhaode Bu Xin Wang Yingjiang Ye Zhongtao Zhang Gang Xiao Fei Li Qingsi He Guoli Li Xian Shen Bin Xiong Liming Zhu Jiwei Liui Lian Liu Tao Wu Jing Zhou Jun Zhang Gang Zhao Xulin Wang Pin Liang Xinxin Wang Yan Zhang Xiaojiang Wu Ji Zhang Xin Ji Xianglong Zong Tao Fu Ziyu Jia Jiafu Ji | 2017 | Chinese Journal of Cancer Research2017，29，2： | 5 |
| 15 | Myofiber necroptosis promotes muscle stem cell proliferation via releasing Tenascin-C during regeneration显示文摘Necroptosis,a form of programmed cell death,is characterized by the loss of membrane integrity and release of intracellular contents,the execution of which depends on the membrane-disrupting activity of the Mixed Lineage Kinase Domain-Like protein(MLKL)upon its phosphorylation.Here we found myofibers committed MLKL-dependent necroptosis after muscle injury.Either pharmacological inhibition of the necroptosis upstream kinase Receptor Interacting Protein Kinases 1(RIPK1)or genetic ablation of MLKL expression in myofibers led to significant muscle regeneration defects.By releasing factors into the muscle stem cell(MuSC)microenvironment,necroptotic myofibers facilitated muscle regeneration.Tenascin-C(TNC),released by necroptotic myofibers,was found to be critical for MuSC proliferation.The temporary expression of TNC in myofibers is tightly controlled by necroptosis;the extracellular release of TNC depends on necroptotic membrane rupture.TNC directly activated EGF receptor(EGFR)signaling pathway in MuSCs through its N-terminus assembly domain together with the EGF-like domain.These findings indicate that necroptosis plays a key role in promoting MuSC proliferation to facilitate muscle regeneration. | Shen'ao Zhou Wei Zhang Gaihong Cai Yingzhe Ding Caixia Wei Sheng Li Yu Yang Jie Qin Dan Liu Hao Zhang Xiexiang Shao Jianhua Wang Hongye Wang Wenjun Yang Huating Wang She Chen Ping Hu Liming Sun | 2020 | Cell Research2020，30，12： | 4 |
| 16 | Characterization of particle number size distribution and new particle formation in Southern China显示文摘Knowledge of particle number size distribution(PND) and new particle formation(NPF)events in Southern China is essential for mitigation strategies related to submicron particles and their effects on regional air quality,haze,and human health.In this study,seven field measurement campaigns were conducted from December 2013 to May 2015 using a scanning mobility particle sizer(SMPS) at four sites in Southern China,including three urban sites and one background site.Particles were measured in the size range of15-515 nm,and the median particle number concentrations(PNCs) were found to vary in the range of 0.3× 10~4-2.2 × 10~4 cn^(-3) at the urban sites and were approximately 0.2 × 10~4 cm^(-3) at the background site.The peak diameters at the different sites varied largely from 22 to 102 nm.The PNCs in the Aitken mode(25-100 nm) at the urban sites were up to 10 times higher than they were at the background site,indicating large primary emissions from traffic at the urban sites.The diurnal variations of PNCs were significantly influenced by both rush hour traffic at the urban sites and NPF events.The frequencies of NPF events at the different sites were0%-30%,with the highest frequency occurring at an urban site during autumn.With higher SO_2 concentrations and higher ambient temperatures being necessary,NPF at the urban site was found to be more influenced by atmospheric oxidizing capability,while NPF at the background site was limited by the condensation sink.This study provides a unique dataset of particle number and size information in various environments in Southern China,which can help understand the sources,formation,and the climate forcing of aerosols in this quickly developing region,as well as help constrain and validate NPF modeling. | Xiaofeng Huang Chuan Wang Jianfei Peng Lingyan He Liming Cao Qiao Zhu Jie Cui Zhijun Wu Min Hu | 2017 | Journal of Environmental Sciences2017，29，1： | 4 |
| 17 | Temporal and spatial cellular and molecular pathological alterations with single-cell resolution in the adult spinal cord after injury显示文摘Spinal cord injury(SCI)involves diverse injury responses in different cell types in a temporally and spatially specific manner.Here,using single-cell transcriptomic analyses combined with classic anatomical,behavioral,electrophysiological analyses,we report,with single-cell resolution,temporal molecular and cellular changes in crush-injured adult mouse spinal cord.Data revealed pathological changes of 12 different major cell types,three of which infiltrated into the spinal cord at distinct times post-injury.We discovered novel microglia and astrocyte subtypes in the uninjured spinal cord,and their dynamic conversions into additional stage-specific subtypes/states.Most dynamic changes occur at 3-days post-injury and by day-14 the second wave of microglial activation emerged,accompanied with changes in various cell types including neurons,indicative of the second round of attacks.By day-38,major cell types are still substantially deviated from uninjured states,demonstrating prolonged alterations.This study provides a comprehensive mapping of cellular/molecular pathological changes along the temporal axis after SCI,which may facilitate the development of novel therapeutic strategies,including those targeting microglia. | Chen Li Zhourui Wu Liqiang Zhou Jingliang Shao Xiao Hu Wei Xu Yilong Ren Xingfei Zhu Weihong Ge Kunshan Zhang Jiping Liu Runzhi Huang Jing Yu Dandan Luo Xuejiao Yang Wenmin Zhu Rongrong Zhu Changhong Zheng Yi Eve Sun Liming Cheng | 2022 | Signal Transduction and Targeted Therapy2022，7，4： | 4 |
| 18 | Efficient and photostable CsPbI_(2) Br solar cells realized by adding PMMA显示文摘Organic–inorganic hybrid perovskite materials demonstrate promising applications in high-efficiency perovskite solar cells (PSCs) with a certified power conversion efficiency(PCE) of 25.5%(http://gffzz8798726073dc471cspwn9vv99ckoq6vx9.ffgz.tsg.suse.edu.cn/pv/cell-efficiency.html). | Yanbo Shang Zhimin Fang Wanpei Hu Chuantian Zuo Bairu Li Xingcheng Li Mingtai Wang Liming Ding Shangfeng Yang | 2021 | Journal of Semiconductors2021，42，5： | 4 |
| 19 | Elastic Scattering of 7Be on Pb Target显示文摘 | Yang Yanyun Wang Jiansong Wang Qi Huang Meirong Ma Junbing Ma Peng Cao Xiguang Han Jianlong Bai Zhen Jin Shilong Hu Qiang Jin Lei Chen Jiangbo Zhang Xueying Chen Ruofu Hu Zhengguo Xu Shiwei Zhen Chuan Xu Zhiguo Xu Hushan Duan Liming Sun Zhiyu Chen Zhiqiang He Jianjun Li Songlin Lei Xiangguo Fu Fen Zhang Xueheng Yuan Xiaohua Du Chengming Yan Xinshuang Hu Jun Tang Shuwen Ye Ruiping Yang Kun Shi Fudong Zhang Wei Chen Ze Li Long Xu Xing Liu Longxiang Zhang Liyong Lin Qingyun Gou Boxing Xu Ge Zhou Xionghong Zhang Yuhu Xiao Guoqing | 2011 | IMP & HIRFL Annual Report2011，，1： | 4 |
| 20 | Mid-Cretaceous Hothouse Climate and the Expansion of Early Angiosperms显示文摘The remarkable transition of early angiosperms from a small to a dominant group characterized the terrestrial ecosystem of the Cretaceous. This transition was instigated and promoted by environmental changes. Mid-Cretaceous is characterized by major geological events that affected the global environment. δ^(18)O, palaeothermometer TEX86, and other climatic indices from marine sediments suggest rapid temperature increase during mid-Cretaceous despite occasional short cooling events. Simultaneously, terrestrial deposits in East Asia changed from coal-bearing to shale, then to red beds and evaporites. Plant assemblages and other paleoclimate indicators point to rapid aridification for midCretaceous terrestrial environments. In addition, the wildfires were frequently spread all over the earth by the numerous charcoal evidence during the Mid-Cretaceous. Thus, we speculate that the seasonally dry and hot conditions of mid-Cretaceous created a fiery hothouse world. Early angiosperms increased in abundance and diversity and evolved from a few aquatic species to terrestrial herbaceous and then to the diversified flora of today. Angiosperms showed rapid physiological evolution in vein density and leaf area that improved photosynthesis and water absorption. These ecophysiological changes made early angiosperms well adapted to the hot and dry environment in mid-Cretaceous. Moreover, these physiological changes facilitated the fire–angiosperm cycles in mid-Cretaceous that likely further stimulated the early angiosperm evolution. | ZHANG Mingzhen DAI Shuang DU Baoxia JI Liming HU Shusheng | 2018 | Acta Geologica Sinica(English Edition)2018，92，5： | 4 |
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