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| 1 | 4-1BB signaling activates glucose and fatty acid metabolism to enhance CD8^(+) T cell proliferation显示文摘4-1BB(CD137)is a strong enhancer of the proliferation of CD8^(+)T cells.Since these cells require increased production of energy and biomass to support their proliferation,we hypothesized that 4-1BB signaling activated glucose and fatty acid metabolism.We found that treatment with agonistic anti-4-1BB mAb promoted the proliferation of CD8^(+)T cells in vitro,increasing their size and granularity.Studies with a glycolysis inhibitor and a fatty acid oxidation inhibitor revealed that CD8^(+)T cell proliferation required both glucose and fatty acid metabolism.Anti-4-1BB treatment increased glucose transporter 1 expression and activated the liver kinase B1(LKB1)-AMP-activated protein kinase(AMPK)-acetyl-CoA carboxylase(ACC)signaling pathway,which may be responsible for activating the metabolism of glucose and fatty acids.We also examined whether blocking glucose or fatty acid metabolism affected cell cycle progression and the anti-apoptotic effect of 4-1BB signaling.The increase of anti-apoptotic factors and cyclins in response to anti-4-1BB treatment was completely prevented by treating CD8^(+)T cells with the fatty acid oxidation inhibitor,etomoxir,but not with the glycolysis inhibitor,2-deoxy-D-glucose.We conclude that anti-4-1BB treatment activates glucose and fatty acid metabolism thus supporting the increased demand for energy and biomass,and that fatty acid metabolism plays a crucial role in enhancing the cell cycle progression of anti-CD3-activated CD8^(+)T cells in vitro and the anti-apoptotic effects of 4-1BB signaling on these cells. | Beom K Choi Do Y Lee Don G Lee Young H Kim Seon-Hee Kim Ho S Oh Chungyong Han Byoung S Kwon | 2017 | Cellular & Molecular Immunology2017，14，9： | 6 |
| 2 | Pseudo-second order model for sorption processes显示文摘 | Y.S Ho G McKay | 1999 | Process Biochemistry1999，，5： | 4 |
| 3 | Pseudo-second order model for sorption processes显示文摘 | Y.S Ho G McKay | 1999 | Process Biochemistry1999，，5： | 4 |
| 4 | Long-term effect of aspirin on cancer risk in carriers of hereditary colorectal cancer: an analysis from the CAPP2 randomised controlled trial显示文摘 | John Burn Anne-Marie Gerdes Finlay Macrae Jukka-Pekka Mecklin Gabriela Moeslein Sylviane Olschwang Diane Eccles D Gareth Evans Eamonn R Maher Lucio Bertario Marie-Luise Bisgaard Malcolm G Dunlop Judy WC Ho Shirley V Hodgson Annika Lindblom Jan Lubinski Pa | 2011 | The Lancet2011，，9809： | 3 |
| 5 | Influence of microstructure on the dielectric and piezoelectric properties of lead Zieconate titanate-polymer composites显示文摘 | LEE H G KIM Ho Gi | 1989 | J Am ceram soc1989，72，6： | 2 |
| 6 | Comparative effectiveness of axitinib versus sorafenib in advanced renal cell carcinoma (AXIS): a randomised phase 3 trial显示文摘 | Brian I Rini Bernard Escudier Piotr Tomczak Andrey Kaprin Cezary Szczylik Thomas E Hutson M Dror Michaelson Vera A Gorbunova Martin E Gore Igor G Rusakov Sylvie Negrier Yen-Chuan Ou Daniel Castellano Ho Yeong Lim Hirotsugu Uemura Jamal Tarazi David Cella | 2011 | The Lancet . 2011 (9807)2011，，9807： | 2 |
| 7 | Comparative effectiveness of axitinib versus sorafenib in advanced renal cell carcinoma (AXIS): a randomised phase 3 trial显示文摘 | Brian I Rini Bernard Escudier Piotr Tomczak Andrey Kaprin Cezary Szczylik Thomas E Hutson M Dror Michaelson Vera A Gorbunova Martin E Gore Igor G Rusakov Sylvie Negrier Yen-Chuan Ou Daniel Castellano Ho Yeong Lim Hirotsugu Uemura Jamal Tarazi David Cella | 2011 | The Lancet2011，，9807： | 2 |
| 8 | Ohioensins and pallidisetins:ovel cytotoxic agents from the moss polytrichum pallidisetum 显示文摘 | ZHENG G HO D K ELDER P L | 1994 | J Nat Prod1994，57，1： | 2 |
| 9 | The sorption of lead( Ⅱ ) ions on peat显示文摘 | Ho Y S Mekay G | 1999 | Water IRes1999，33，2： | 1 |
| 10 | The US national cholesterol education programe adult treatment panel Ⅲ(NCEPATP Ⅲ) prevalence of the meta bolic syndrome in a Chinese population显示文摘 | THOMAS G N HO S Y JANUS E D | 2005 | Diabetes Res Clin Pract2005，67，： | 1 |
| 11 | 显示文摘 | Gong H Wilk G D | 2002 | Appl Phys Lett2002，81，： | 1 |
| 12 | Kinetics of pollutant sorption by biosorbents : review 显示文摘 | Ho Y S Ng J C McKay G | 2000 | Sep Purif Methods2000，29，2： | 1 |
| 13 | Temperature effect on space charge dynamics in XLPE insulation显示文摘 | Chong Y L Chen G Ho Y F F | 2007 | IEEE Transactions on Dielectrics and Electrical Insulation2007，14，1： | 1 |
| 14 | A cluster of cases of severe acute respiratory syndrome in Hong Kong 显示文摘 | Tsang K W Ho P L Ooi G C | 2003 | N Engl J Med2003，31，： | 1 |
| 15 | Resveratrol analog,3,4,5,4'-tetrahydroxystilbene,differentially induces proapoptotic p53/Bax gene expression and inhibits the growth of transformed cells but not their normal counterparts显示文摘 | Lu J B Ho C T Ghai G | 2001 | Carcinogenesis2001，22，2： | 1 |
| 16 | Batch lead( Ⅱ ) removal from aqueous solution by peat: Equilibrium and kinetics显示文摘 | Ho Y S Mckay G | 1999 | Trans Ins Chem Eng1999，77，： | 1 |
| 17 | Pseudo-second order model for sorption processes显示文摘 | Ho Y S MeKay G | 1999 | Process Biochemistry1999，34，： | 1 |
| 18 | Co-localization of carbon monoxide and nitric oxide synthesizing enzymes in the human urethral sphincter显示文摘 | Ho KM Ny L MeMurray G et ol | 1999 | J Urol1999，161，6： | 1 |
| 19 | Impact of heavy metals on enzymatic activity of substrate and on composting worms Eiseniafetida 显示文摘 | Malley C Nair J Ho G | 2006 | Bioresurce Technology2006，97，13： | 1 |
| 20 | Electroporation of cell membranes:a review显示文摘 | Ho S Y Mittal G S | 1996 | Critical Reviews in Biotechnology1996，16，： | 1 |
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