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| 1 | An epigenomic approach to therapy for tamoxifen-resistant breast cancer显示文摘Tamoxifen 是为雌激素受体 alpha 的前线治疗(ERα) 在绝经前的女人的积极的胸肿瘤。然而,到 tamoxifen 的抵抗发生在许多病人。嗯仍然与获得的 tamoxifen 抵抗在乳癌房间的生长起一个关键作用,建议那 ERα为治疗仍然是一个有效目标 tamoxifen 抵抗(Tam-R ) 乳癌。以识别 ERα 的新奇管理者;发信号,通过对 histone 甲基修饰词的一幅小规模的 siRNA 屏幕,我们发现了 WHSC1, histone H3K36 methyltransferase, ERα 的一个积极管理者;在乳癌房间发信号。我们证明 WHSC1 被招募到 ERα由 BET 蛋白质 BRD3/4 的基因,并且便于 ERα基因表示。小分子的赌注蛋白质禁止者 JQ1 potently 压制了经典 ERα发信号的小径和在文化的 Tam-R 乳癌房间的生长。用一个 Tam-R 乳癌异种皮移植老鼠模型,我们与 JQ1 和 ER degrader fulvestrant 由 JQ1 和联合治疗的强壮的长持续的效果在 vivo 反胸癌症活动示威了。一起拿,我们提供 epigenomic 蛋白质 BRD3/4 和 WHSC1 是雌激素受体发信号的必要管理者并且是为 Tam-R 乳癌的治疗的新奇治疗学的目标的证据。 | Qin Feng Zheng Zhang Martin J Shea Chad J Creighton Cristian Coarfa Susan G Hilsenbeck Rainer Lanz Bin He Lei Wang Xiaoyong Fu Agostina Nardone Yongcheng Song James Bradner Nicholas Mitsiades Constantine S Mitsiades C Kent Osborne Rachel Schiff Bert W O'Malley | 2014 | Cell Research2014，24，7： | 10 |
| 2 | Anterior ankle arthrodesis显示文摘Ankle arthrodesis is a common procedure that resolves many conditions of the foot and ankle; however, complications following this procedure are often reported and vary depending on the fixation technique. Various techniques have been described in the attempt to achieve ankle arthrodesis and there is much debate as to the efficiency of each one. This study aims to evaluate the efficiency of anterior plating in ankle arthrodesis using customised and Synthes Tomo Fix plates. We present the outcomes of 28 ankle arthrodeses between 2005 and 2012, specifically examining rate of union, patient-reported outcomes scores, and complications. All 28 patients achieved radiographic union at an average of 36 wk; the majority of patients(92.86%) at or before 16 wk, the exceptions being two patients with Charcot joints who were noted to have bony union at a three year review. Patient-reported outcomes scores significantly increased(P < 0.05). Complications included two delayed unions as previously mentioned, infection, and extended postoperative pain. With multiple points for fixation and coaxial screw entry points, the contoured customised plate offers added compression and provides a rigid fixation for arthrodesis stabilization. | Gordon L Slater Stephanie C Sayres Martin J O'Malley | 2014 | World Journal of Orthopedics2014，5，1： | 5 |
| 3 | ASHP national survey of ambulatory care responsibilities of pharmacists in integrated health system显示文摘 | Reeder CE Kozma CM O'Malley C | 1998 | Am J Health Syst Pharm1998，55，： | 1 |
| 4 | Impact of heavy metals on enzymatic activity of substrate and on composting worms Eiseniafetida 显示文摘 | Malley C Nair J Ho G | 2006 | Bioresurce Technology2006，97，13： | 1 |
| 5 | The x-Kernel: A platform for accessing internet resourees 显示文摘 | L L Peterson N C Hutchinson S W O'Malley H C Rao | 1990 | IEEE Computer (S0018-9162)1990，23，5： | 1 |
| 6 | Compositional analysis of cattle manure during composting using a field-portable near-infrared spectrometer显示文摘 | Malley D F McClure C Martin P D | 2005 | Soil Science and Plant Analysis2005，36，4： | 1 |
| 7 | Vitrectomy with an alternative instrument system显示文摘 | O'Malley C Heintz RM Sr | | 0，，04： | 1 |
| 8 | Transient spine density increases in the mid-molecular layer of hippoeampal dentate gyrus accompany consolidation of a spatial learning task in the rodent显示文摘 | O'Malley A O'Connell C Murphy KJ | 2000 | Neuroseience2000，99，2： | 1 |
| 9 | Carcinogen mod ified dendritic cells induce immunosuppression by incomplete T-cell activation resulting from impaired antigen uptake and re duced CD86 expression显示文摘 | Woods G M Doherty K V Malley R C | 2000 | Immunology2000，99，1： | 1 |
| 10 | Assessment of bio- markers of protein anabolism in skeletal muscle during the life span of the rat : sarcopenia despite elevated protein synthesis 显示文摘 | Kimball S R O' Malley J P Anthony J C | 2004 | Am J Physiol Endocrinol Metab2004，287，4： | 1 |
| 11 | Agonistdriven development of CD4^+ CD25^+ Foxp3^+ regulatory T cells requires a second signal mediated by Stat6 显示文摘 | Sanchez-Guajardo V Tanchot C O' Malley JT | 2007 | J Immunol2007，178，12： | 1 |
| 12 | High-level JAG1 mRNA and protein predict poor outcome in breast cancer显示文摘 | Dickson B C Mulligan A M Zhang H Lockwood G O' Malley F P Egan S E | 2007 | Mod Pathol2007，20，： | 1 |
| 13 | Compuler-supported collaborative learning: problem solving and distance education显示文摘 | O'Malley C L Scanlon E | 1990 | Computers Education1990，15，： | 1 |
| 14 | Transient spine density increases in the mid-molecular layer of hippocampal dentate gyros accompany consolidation of a spatial learning task in the rodent显示文摘 | O'Malley A O'Connell C Murphy KJ | 2000 | Neuroseience2000，99，2： | 1 |
| 15 | The presence of a poly- morphism at the translation initiation site of the vitamin D recep- tor gene is associated with low bone mineral density in post- menopausal Mexican American women 显示文摘 | Gross C Eccleshall TR Malley PJ | 1996 | Bone Miner Res1996，11，12： | 1 |
| 16 | Providing ' Better' Data: Not as simple as it might seem 显示文摘 | O'Malley R O Cavender-Bares K Clark W C | 2003 | Environment2003，45，4： | 1 |
| 17 | As sessment of biomarkers of protein anabolism in skeletal muscle during the life span of the rat: sarcopenia despite elevated pro rein synthesis显示文摘 | KIMBALL S R O'MALLEY J P ANTHONY J C | 2004 | Am J Physiol Endocrinol Metab2004，287，4： | 1 |
| 18 | Chronic toxicity/oncogenicity of dimethylformamide in rats and mice following inhalation exposure显示文摘 | Malley LA Slone TW Jr Van Pelt C | 1994 | Fundam Appl Toxicol1994，23，： | 1 |
| 19 | Improved breastfeeding success through the baby-friendly hospital initiative 显示文摘 | Meyers D Mallei C T | 2008 | Am Faro Physician2008，78，2： | 1 |
| 20 | Are the DSM Ⅳ Personality Disorders Related to Mindfulness? An Italian Study on Clinical Participants显示文摘 | Fossati A Porro F V Mallei C | 2012 | Journal of Clinical Psychology2012，68，6： | 1 |
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