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| 1 | Hydroxycut hepatotoxicity:A case series and review of liver toxicity from herbal weight loss supplements显示文摘Dietary supplements represent an increasingly common source of drug-induced liver injury. Hydroxycut is a popular weight loss supplement which has previously been linked to hepatotoxicity, although the individual chemical components underlying liver injury remain poorly understood. We report two cases of acute hepatitis in the setting of Hydroxycut exposure and describe possible mechanisms of liver injury. We also comprehensively review and summarize the existing literature on commonly used weight loss supplements, and their individual components which have demon-strated potential for liver toxicity. An increased effort to screen for and educate patients and physicians about supplement-associated hepatotoxicity is warranted. | Lily Dara Jennifer Hewett Joseph Kartaik Lim | 2008 | World Journal of Gastroenterology2008，14，45： | 10 |
| 2 | Validation of a Simple Classification System for Endoscopic Diagnosis of Small Colorectal Polyps Using Narrow-Band Imaging显示文摘 | David G. Hewett Tonya Kaltenbach Yasushi Sano Shinji Tanaka Brian P. Saunders Thierry Ponchon Roy Soetikno Douglas K. Rex | 2012 | Gastroenterology2012，，3： | 4 |
| 3 | Single-center study comparing computed tomography colonography with conventional colonoscopy显示文摘AIM:To compare the results from computed tomography (CT) colonography with conventional colonoscopy in symptomatic patients referred for colonoscopy. METHODS: The study included 227 adult outpatients, mean age 60 years, with appropriate indications for colonoscopy. CT colonography and colonoscopy were performed on the same day in a metropolitan teaching hospital. Colonoscopists were initially blinded to the results of CT colonography but there was segmental unblinding during the procedure. The primary outcome measures were the sensitivity and specificity of CT colonography for the identification of polyps seen at colonoscopy (i.e. analysis by polyp). Secondary outcome measures included an analysis by patient, extracolonic findings at CT colonography, adverse events with both procedures and patient acceptance and preference. RESULTS: Twenty-five patients (11%) were excluded from the analysis because of incomplete colonoscopy or poor bowel preparation that affected either CT colonography, colonoscopy or both procedures. Polyps and masses (usually cancers) were detected at colonoscopy and CT colonography in 35% and 42% of patients, respectively. Of nine patients with a finaldiagnosis of cancer, eight (89%) were identified by CT colonography as masses (5) or polyps (3). For polyps analyzed according to polyp, the overall sensitivity of CT colonography was 50% (95% CI, 39%-61%) but this increased to 71% (95% CI, 52%-85%) for polyps ≥ 6 mm in size. Similarly, specificity for all polyps was 48% (95% CI, 39%-58%) increasing to 67% (95% CI, 56%-76%) for polyps ≥ 6 mm. Adverse events were uncommon but included one colonic perforation at colonoscopy. Patient acceptance was high for both procedures but preference favoured CT colonography. CONCLUSION: Although CT colonography was more sensitive in this study than in some previous studies, the procedure is not yet sensitive enough for widespread application in symptomatic patients. | Ian C Roberts-Thomson Graeme R Tucker Peter J Hewett Peter Cheung Ruben A Sebben EE Win Khoo Julie D Marker Wayne K Clapton | 2008 | World Journal of Gastroenterology2008，14，3： | 4 |
| 4 | High Prevalence of Sessile Serrated Adenomas With BRAF Mutations: A Prospective Study of Patients Undergoing Colonoscopy显示文摘 | Kevin J. Spring Zhen Zhen Zhao Rozemary Karamatic Michael D. Walsh Vicki L.J. Whitehall Tanya Pike Lisa A. Simms Joanne Young Michael James Grant W. Montgomery Mark Appleyard David Hewett Kazutomo Togashi Jeremy R. Jass Barbara A. Leggett | 2006 | Gastroenterology2006，，5： | 3 |
| 5 | Prevalence and Variable Detection of Proximal Colon Serrated Polyps During Screening Colonoscopy显示文摘 | Charles J. Kahi David G. Hewett Dustin Lee Norton George J. Eckert Douglas K. Rex | 2011 | Clinical Gastroenterology and Hepatology2011，，1： | 3 |
| 6 | GDF15/MIC-1 Functions As a Protective and Antihypertrophic Factor Released From the Myocardium in Association With SMAD Protein Activation显示文摘 | Jian Xu Thomas R. Kimball John N. Lorenz David A. Brown Asne R. Bauskin Raisa Klevitsky Timothy E. Hewett Samuel N. Breit Jeffery D. Molkentin | 2006 | Circulation Research2006，，3： | 3 |
| 7 | Short-Term Outcomes of the Australasian Randomized Clinical Study Comparing Laparoscopic and Conventional Open Surgical Treatments for Colon Cancer: The ALCCaS Trial显示文摘 | Peter J. Hewett Randall A. Allardyce Philip F. Bagshaw Christopher M. Frampton Francis A. Frizelle Nicholas A. Rieger J Shona Smith Michael J. Solomon Jacqueline H. Stephens Andrew R. L. Stevenson | 2008 | Annals of Surgery2008，，5： | 3 |
| 8 | Vascular endothelial growth factor-D expression is an independent prognostic maker for survival in cotorectal carcinoma显示文摘 | White J D Hewett P W Kosuge D | | 0，，： | 2 |
| 9 | Cyclooxygenase-2 contributes to N-methyl-D-aspartate-mediated neuronal cell death in primary cortical cell culture显示文摘 | Hewett SJ Uliasz TF Vidwans AS | 2000 | J Pharmacol Exp Ther2000，293，2： | 2 |
| 10 | Customer response capability in a sense-and-respond era: The role of customer knowledge process显示文摘 | Satish Jayachandran Kelly Hewett Peter Kaufman | 2004 | Journal of the Academy of Marketing Science2004，，3： | 2 |
| 11 | 端粒酶逆转录酶在结肠癌组织中表达的临床意义显示文摘背景与目的:尽管能够在70%~90%的恶性肿瘤细胞中可检测到端粒酶活性,但其活性与恶性肿瘤患者预后的关系仍存在争议。本研究旨在探讨端粒酶逆转录酶(humantelomerasereversetranscriptase,hTERT)在结肠癌组织中表达的临床意义。方法:用定量实时RT-PCR检测59例大肠癌标本的癌组织和癌旁非癌组织hTERT表达。结果:癌组织和癌旁非癌组织hTERT表达与临床病理学特征无相关性。32例DukesA和B期患者中,18例(56%)癌组织hTERT表达低于0.6,14例(44%)表达高于0.6,前者的预后较后者好。20例(62%)癌组织/癌旁非癌组织hTERT表达差异低于0.5,12例(38%)表达差异高于0.5,前者的预后较后者好。27例DukesC和D期患者中,癌组织hTERT表达和癌组织/癌旁非癌组织hTERT表达差异对预测患者的预后无意义。结论:结肠癌组织hTERT表达和癌组织/癌旁非癌组织hTERT表达差异可作为DukesA和B期结肠癌患者预后的指标之一。 | 李力人 万德森 潘志忠 Jenny Hardingham Nick Rieger Peter Hewett 周志伟 陈功 | 2004 | 癌症2004，23，z1： | 2 |
| 12 | Serrated polyps of the large intestine: current understanding of diagnosis, pathogenesis, and clinical management显示文摘 | Christophe Rosty David G. Hewett Ian S. Brown Barbara A. Leggett Vicki L. J. Whitehall | 2013 | Journal of Gastroenterology2013，，3： | 2 |
| 13 | Differentiating adenomas from hyperplastic colorectal polyps: narrow-band imaging can be learned in 20 minutes显示文摘 | Meghana Raghavendra David G. Hewett Douglas K. Rex | 2010 | Gastrointestinal Endoscopy2010，，： | 2 |
| 14 | Electromagnetic Direct Implicit Plasma Simulation显示文摘 | Hewett D W Langdon A B | 1987 | Journal of Computational Physics1987，72，： | 1 |
| 15 | Upscaling, gridding, and simulating using streamtuhes 显示文摘 | Portella R C M Hewett T A | 2000 | SPE656842000，，： | 1 |
| 16 | Peering through the OH forest:a new technique to remove residual sky features from Sloan digital sky survey spectra显示文摘 | Wild V Hewett P C | 2005 | MNRAS2005，358，3： | 1 |
| 17 | Reducing knee and anterior cruciate ligament injuries among female athletes:a systematic review of neuromuscular training interventions显示文摘 | Hewett TE Myer GD Ford KR | | 0，，01： | 1 |
| 18 | Short-term outcomes of the Australasian randomized clinical study comparing laparoscopic and conventional open surgical treatments for colon cancer:the ALCCa S trial显示文摘 | Hewett PJ Allardyce RA Bagshaw PF | 2008 | Ann Surg2008，248，5： | 1 |
| 19 | A ' plane' explanation of anterior cruciate ligament injury echanisms: A systematic review 显示文摘 | Quatman CE Quatman-Yates CC Hewett TE | 2010 | Sports Med2010，40，9： | 1 |
| 20 | Vascular endothelial growth factor-D expression independent prognostic marker for survival in colorectal carcinoma显示文摘 | White JD Hewett PW Kosuge D | 2002 | Cancer Res2002，62，6： | 1 |
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