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| 1 | Cyclin A2:At the crossroads of cell cycle and cell invasion显示文摘Cyclin A2 is an essential regulator of the cell division cycle through the activation of kinases that participate to the regulation of S phase as well as the mitotic entry. However,whereas its degradation by the proteasome in mid mitosis was thought to be essential for mitosis to proceed,recent observations show that a small fraction of cyclin A2 persists beyond metaphase and is degraded by autophagy. Its implication in the control of cytoskeletal dynamics and cell movement has unveiled its role in the modulation of Rho A activity. Since this GTPase is involved in both cell rounding early in mitosis and later,in the formation of the cleavage furrow,this suggests that cyclin A2 is a novel actor in cytokinesis. Taken together,these data point to this cyclin as a potential mediator of cell-niche interactions whose dysregulation could be taken as a hallmark of metastasis. | Abdelhalim Loukil Caroline T Cheung Nawal Bendris Bénédicte Lemmers Marion Peter Jean Marie Blanchard | 2015 | World Journal of Biological Chemistry2015，6，4： | 6 |
| 2 | COMPARISON OF POLYSACCHARIDES ISOLATED FROM THE MYCELIA OF A CULTIVATED STRAIN OF PORIA COCOS GROWN IN DIFFERENT LIQUID CULTURE MEDIA显示文摘Mycelium of a cultivated strain of Poria cocos was grown by submerged fermentation in a liquid medium containing com steep liquor with orbital shaking. Six polysaccharides coded as ac-PCM 1, ac-PCM2, ac-PCM3-I and II, acPCM4-I and II were isolated from the mycelium by extracting with 0.9% NaC1 aqueous solution, hot water, 0.5 mol/L NaOH aqueous solution and 88% formic acid. Exo-polysaccharide was obtained from the culture medium and coded as ac-PCM0.The monosaccharide composition and molecular weights of these polysaccharides were characterized by using infrared spectroscopy, gas chromatography, elemental analysis, 13C-NMR, viscometry and light scattering. The results indicated that ac-PCM0, ac-PCM1 and ac-PCM2 are heteropolysaccharides containing glucose, galactose, mannose and fucose, and acPCM3-I and ac-PCM3-II mainly consist of D-glucose. The content of the glucose in the polysaccharides increased with the isolation progress. Remarkably, a-glucan and β-glucan coexisted in the extract by NaOH aqueous solution (ac-PCM3), and could be separated by chemical methods. The protein in the ac-PCM polysaccharides cultured from the medium containing com steep liquor was higher than that in the ab-PCM from the medium with bran extract. Therefore, the polysaccharides from Poria cocos mycelia cultured in different media have different chemical composition, molecular weights and conformations. | Peter Chi Keung Cheung 张俐娜 | 2003 | Chinese Journal of Polymer Science2003，21，4： | 6 |
| 3 | Single-center study comparing computed tomography colonography with conventional colonoscopy显示文摘AIM:To compare the results from computed tomography (CT) colonography with conventional colonoscopy in symptomatic patients referred for colonoscopy. METHODS: The study included 227 adult outpatients, mean age 60 years, with appropriate indications for colonoscopy. CT colonography and colonoscopy were performed on the same day in a metropolitan teaching hospital. Colonoscopists were initially blinded to the results of CT colonography but there was segmental unblinding during the procedure. The primary outcome measures were the sensitivity and specificity of CT colonography for the identification of polyps seen at colonoscopy (i.e. analysis by polyp). Secondary outcome measures included an analysis by patient, extracolonic findings at CT colonography, adverse events with both procedures and patient acceptance and preference. RESULTS: Twenty-five patients (11%) were excluded from the analysis because of incomplete colonoscopy or poor bowel preparation that affected either CT colonography, colonoscopy or both procedures. Polyps and masses (usually cancers) were detected at colonoscopy and CT colonography in 35% and 42% of patients, respectively. Of nine patients with a finaldiagnosis of cancer, eight (89%) were identified by CT colonography as masses (5) or polyps (3). For polyps analyzed according to polyp, the overall sensitivity of CT colonography was 50% (95% CI, 39%-61%) but this increased to 71% (95% CI, 52%-85%) for polyps ≥ 6 mm in size. Similarly, specificity for all polyps was 48% (95% CI, 39%-58%) increasing to 67% (95% CI, 56%-76%) for polyps ≥ 6 mm. Adverse events were uncommon but included one colonic perforation at colonoscopy. Patient acceptance was high for both procedures but preference favoured CT colonography. CONCLUSION: Although CT colonography was more sensitive in this study than in some previous studies, the procedure is not yet sensitive enough for widespread application in symptomatic patients. | Ian C Roberts-Thomson Graeme R Tucker Peter J Hewett Peter Cheung Ruben A Sebben EE Win Khoo Julie D Marker Wayne K Clapton | 2008 | World Journal of Gastroenterology2008，14，3： | 4 |
| 4 | Risk factors and natural history of breast cancer in younger Chinese women显示文摘AIM: To investigate the age differences in the risk factors, clinicopathological characteristics and patterns of treatment of female breast cancer patients. METHODS: Seven thousand one hundred and fiftytwo women with primary breast cancer from the Hong Kong Breast Cancer Registry were recruited after receiving patients' consent, they were asked to complete standardized questionnaires which captured their sociodemographic characteristics and risk factors associated with breast cancer development. Among them, clinicopathological data and patterns of treatment were further collected from medical records of 5523 patients with invasive breast cancers. Patients were divided into two groups according to the age at diagnosis: younger(< 40 years old) vs older patients(≥ 40 years old) for subsequent analyses.RESULTS: Analysis on the sociodemographic characteristics and exposure to risk factors were performed on 7152 women with primary breast cancer and the results revealed that younger patients were more likely to have unhealthy lifestyles; these include a lack of exercise(85.4% vs 73.2%, P < 0.001), having high stress in life(46.1% vs 35.5%, P < 0.001), having dairy/meat-rich diets(20.2% vs 12.9%, P < 0.001),having alcohol drinking habit(7.7% vs 5.2%, P = 0.002). Younger patients were also more likely to have hormone-related risk factors including nulliparity(43.3% vs 17.8%, P < 0.001) and an early age at menarche(20.7% vs 13.2%, P < 0.001). Analyses on clinicopathological characteristics and patterns of treatment were performed on 5523 women diagnosed with invasive breast cancer. The invasive tumours in younger patients showed more aggressive pathological features such as having a higher percentage of grade 3 histology(45.7% vs 36.5%, P < 0.001), having a higher proportion of tumours with lymphovascular invasion(39.6% vs 33.2%, P = 0.003), and having multifocal disease(15.7% vs 10.3%, P < 0.001); they received different patterns of treatment than their older counterparts.CONCLUSION: Younger patients in Hong Kong are more likely to encounter risk factors associated with breast cancer development and have more aggressive tumours than their older counterparts. | Winnie Yeo Hang-Mei Lee Amy Chan Emily YY Chan Miranda CM Chan Keeng-Wai Chan Sharon WW Chan Foon-Yiu Cheung Polly SY Cheung Peter HK Choi Josette SY Chor William WL Foo Wing-Hong Kwan Stephen CK Law Lawrence PK Li Janice WH Tsang Yuk Tung Lorna LS Wong Ting-Ting Wong Chun-Chung Yau Tsz-Kok Yau Benny CY Zee | 2014 | World Journal of Clinical Oncology2014，5，5： | 4 |
| 5 | 虎奶菇菌丝体细胞壁成分分析及多糖结构表征显示文摘该文以液态发酵的虎奶菇(Pleurotus tuber-regium,PTR)菌丝体为原料,对PTR菌丝体细胞壁(PTR-MCW)的组分进行分析,并阐明细胞壁骨架结构。采用不同提取强度的溶剂分离MCW的可溶性成分,对各组分进行含量测定、化学成分分析及基本结构表征。结果表明,PTR-MCW主要由4部分组成:热水提多糖和蛋白质复合物的外层,常温碱提的杂多糖部分,热碱提的高度支化杂多糖部分和碱不溶性多糖-几丁质复合物部分,这4种组分在PTR-MCW中的比例为2.06∶22.06∶46.97∶18.95。占主要组分的热碱提多糖经纯化后得到纯多糖MHA-I,单糖组成和甲基化分析表明其糖苷键类型包括T-木糖、T-鼠李糖、T-葡萄糖、1,3-葡萄糖、1,6-葡萄糖、1,4-葡萄糖、1,3,6-葡萄糖、1,4,6-葡萄糖、1,3,6-甘露糖,摩尔比为2.01∶1.00∶27.64∶8.19∶38.22∶20.88∶14.38∶6.98∶3.22,该多糖的分支度(degree of branching,DB)为0.45,FT-IR分析鉴定MHA-I中主要为β-糖苷键。SEC-MALLS分析表明,超支化杂多糖MHA-I的分子量为4.502×10^4 g/mol,回转半径为33.2 nm。电镜结果显示,MHA-I为具有超支化结构的多糖,在干燥的粉末状态下呈现准球形结构。该研究成果为虎奶菇多糖的开发及活性研究提供一定的理论依据。 | 葛梦蝶 代安然 杨崇婧 刘京京 CHEUNG Chi Keung Peter 陈磊 | 2020 | 食品与发酵工业2020，46，6： | 3 |
| 6 | Randomized Controlled Trial of the Effects of Remote Ischemic Preconditioning on Children Undergoing Cardiac Surgery显示文摘 | Michael M.H. Cheung Rajesh K. Kharbanda Igor E. Konstantinov Mikiko Shimizu Helena Frndova Jia Li Helen M. Holtby Peter N. Cox Jeffrey F. Smallhorn Glen S. Van Arsdell Andrew N. Redington | 2006 | Journal of the American College of Cardiology2006，，11： | 2 |
| 7 | Fast numerical generation and hybrid encryption of a computer-generated Fresnel holographic video sequence显示文摘Research demonstrates that a Fresnel hologram can be generated and simultaneously encrypted numerically based on a secret symmetric key formed by the maximal length sequence (M-sequence). The method can be directly extended to encrypt a video holographic clip in a frame-by-frame manner. However, given the limited combination of signals in the family of M-sequence, hacking the secret key through trial and error can be time consuming but not difficult. In this letter, we propose a method that is difficult to crack with brute force for encrypting a holographic video sequence. An M-sequence is first randomly assigned to encrypt each frame of the holographic video signal. Subsequently, the index of the selected M-sequence, which is necessary to decrypt the hologram, is encrypted with the RSA algorithm before transmitting to the receiving end. At the receiving end, the decoder is provided with a private key to recover the index for each frame, and the corresponding M-sequence is used to decrypt the encoded hologram. | Peter Tsang K.W.-K. Cheung T.-C. Poon | 2013 | Chinese Optics Letters2013，11，2： | 2 |
| 8 | Advances in lentinan: Isolation, structure, chain conformation and bioactivities显示文摘 | Yangyang Zhang Sheng Li Xiaohua Wang Lina Zhang Peter C.K. Cheung | 2010 | Food Hydrocolloids2010，，2： | 1 |
| 9 | Trust in construction partnering:views from parties of the partnering dance 显示文摘 | Peter Shek - Pui Wong Sai - On Cheung | 2004 | International Journal of Project Management2004，，22： | 1 |
| 10 | Structural equation model of trust and partnering success显示文摘 | Peter Shek Pui Wong Sai On Cheung | 2005 | Journal of Man- agement in Engineering2005，21，2： | 1 |
| 11 | Radiochromic film for medical radiation dosimetry显示文摘 | Buston M J Peter K N Yu Tsang Cheung | 2003 | Mat Sci Eng2003，41，： | 1 |
| 12 | 双肺通气时混合吸入空气可延迟单肺通气时的肺萎陷显示文摘背景一侧肺萎陷有助于显露胸外科手术的手术野。双肺通气时吸入不同的混合气体可通过加速或延迟肺萎陷过程,从而改善或影响单肺通气时的手术条件。我们观察了双肺通气时吸入3种不同的混合气体对单肺通气时肺萎陷和氧合的影响:空气/氧气(FiO2=0.4)、氧化亚氮(N2O)/氧气(FiO2=0.4)、氧气(FiO2=1.0)。方法将受试者随机分为3组:空气/氧气组(n=33)、N2O组(n=34)和O2组(n=33),麻醉诱导时吸入不同的混合气体直至开始单肺通气。在单肺通气过程中所有受试者的FiO2均为1.0。手术者不参与分组,并在单肺通气开始后10和20分钟的时间点用口头量表评价肺萎陷的程度。在麻醉诱导前、双肺通气时以及单肺通气后的30分钟内每5分钟查一次动脉血气。结果双肺通气时混合吸入空气可延迟单肺通气时的肺萎陷,而混合吸入氧化亚氮则可加速肺萎陷。O2组的动脉氧合仅在单肺通气开始10分钟内显著改善,之后各组间的平均PaO2差异无显著性。结论双肺通气时去除肺内的氮气是改善单肺通气时手术条件的一项重要策略。双肺通气时使用FiO2=1.0或N2O/O2(FiO2=0.4)时,对单肺通气的氧合并没有明显的不利影响。 | Raynauld Ko, MD Karen McRae, MDCM Gail Darling, MD Thomas K. Waddell MD, PhD Desmond McGlade, MBBS, FANZCA Ken Cheung, MD Joel Katz, PhD Peter Slinger, MD 刘晓(译) | 2011 | 麻醉与镇痛2011，7，3： | 1 |
| 13 | Relationship of Smoking and Cardiovascular Risk Factors with Polypoidal Choroidal Vasculopathy and Age-related Macular Degeneration in Chinese Persons显示文摘 | Peter Cackett Ian Yeo Chui Ming Gemmy Cheung Eranga N. Vithana Doric Wong Wan Ting Tay E. Shyong Tai Tin Aung Tien Y. Wong | 2011 | Ophthalmology2011，，5： | 1 |
| 14 | Antecedents and sex/gender differences in youth suicidal behavior显示文摘Suicide is the second leading cause of death in youth globally; however, there is uncertainty about how best to intervene. Suicide rates are typically higher in males than females, while the converse is true for suicide attempts. We review this 'gender paradox' in youth, and in particular, the age-dependency of these sex/gender differences and the developmental mechanisms that may explain them. Epidemiologic, genetic,neurodevelopmental and psychopathological research have identified suicidal behaviour risks arising from genetic vulnerabilities and sex/gender differences in early adverse environments, neurodevelopment, mental disorder and their complex interconnections. Further, evolving sex-/gender-defined social expectations and norms have been thought to influence suicide risk. In particular, how youth perceive and cope with threats and losses(including conforming to others' or one's own expectations of sex/gender identity) and adapt to pain(through substance use and helpseeking behaviours). Taken together, considering brain plasticity over the lifespan, these proposed antecedents to youth suicide highlight the importance of interventions that alter early environment(s)(e.g., childhood maltreatment) and/or one's ability to adapt to them. Further, such interventions may have more enduring protective effects, for the individual and for future generations, if implemented in youth. | Anne E Rhodes Michael H Boyle Jeffrey A Bridge Mark Sinyor Paul S Links Lil Tonmyr Robin Skinner Jennifer M Bethell Corine Carlisle Sarah Goodday Travis Salway Hottes Amanda Newton Kathryn Bennett Purnima Sundar Amy H Cheung Peter Szatmari | 2014 | World Journal of Psychiatry2014，4，4： | 1 |
| 15 | A mechanistic study of the enhancing effect of Tween 80 on the mycelial growth and exopolysaccharide production by Pleurotus tuber-regium显示文摘 | Bo-Bo Zhang Peter C.K. Cheung | 2011 | Bioresource Technology2011，，17： | 1 |
| 16 | Tranexamic acid for intracerebral haemorrhage within 2 hours of onset: protocol of a phase Ⅱ randomised placebo-controlled double-blind multicentre trial显示文摘Rationale Haematoma growth is common early after intracerebral haemorrhage(ICH),and is a key determinant of outcome.Tranexamic acid,a widely available antifibrinolytic agent with an excellent safety profile,may reduce haematoma growth.Methods and design Stopping intracerebral haemorrhage with tranexamic acid for hyperacute onset presentation including mobile stroke units(STOP-MSU)is a phase Ⅱ double-blind,randomised,placebo-controlled,multicentre,international investigator-led clinical trial,conducted within the estimand statistical framework.Hypothesis In patients with spontaneous ICH,treatment with tranexamic acid within 2 hours of onset will reduce haematoma expansion compared with placebo.Sample size estimates A sample size of 180 patients(90 in each arm)would be required to detect an absolute difference in the primary outcome of 20%(placebo 39%vs treatment 19%)under a two-tailed significance level of 0.05.An adaptive sample size re-estimation based on the outcomes of 144 patients will allow a possible increase to a prespecified maximum of 326 patients.Intervention Participants will receive 1 g intravenous tranexamic acid over 10 min,followed by 1 g intravenous tranexamic acid over 8 hours;or matching placebo.Primary efficacy measure The primary efficacy measure is the proportion of patients with haematoma growth by 24±6 hours,defined as either≥33%relative increase or≥6 mL absolute increase in haematoma volume between baseline and follow-up CT scan.Discussion We describe the rationale and protocol of STOP-MSU,a phase Ⅱ trial of tranexamic acid in patients with ICH within 2 hours from onset,based in participating mobile stroke units and emergency departments. | Nawaf Yassi Henry Zhao Leonid Churilov Bruce C V Campbell Teddy Wu Henry Ma Andrew Cheung Timothy Kleinig Helen Brown Philip Choi Jiann-Shing Jeng Annemarei Ranta Hao-Kuang Wang Geoffrey C Cloud Rohan Grimley Darshan Shah Neil Spratt Der-Yang Cho Karim Mahawish Lauren Sanders John Worthington Ben Clissold Atte Meretoja Vignan Yogendrakumar Mai Duy Ton Duc Phuc Dang Nguyen Thai My Phuong Huy-Thang Nguyen Chung Y Hsu Gagan Sharma Peter J Mitchell Bernard Yan Mark W Parsons Christopher Levi Geoffrey A Donnan Stephen M Davis | 2022 | Stroke & Vascular Neurology2022，7，2： | 1 |
| 17 | Radiochromic film for medical radiation dosimetry显示文摘 | Martin J Butson Peter K N Yu Tsang Cheung | 2003 | Mat Sci Eng2003，41，： | 1 |
| 18 | The hypocholesterolemic effect of two edible mushrooms : A uricularia auricular ( tree - ear ) and Tremella fuciformis ( white jelly-leaf) in hypercholesterolemic rats显示文摘 | Cheung Chi Keung Peter | 1996 | Nutrition Research1996，16，10： | 1 |
| 19 | Stroke Survivor Depressive Symptoms Are Associated With Family Caregiver Depression During the First 2 Years Poststroke显示文摘 | Jill I. Cameron Angela M. Cheung David L. Streiner Peter C. Coyte Donna E. Stewart | 2011 | Stroke2011，，2： | 1 |
| 20 | Evaluation of sulfated fungal b-glucans from the sclerotium of Pleurotus tuber-regium as a potential water-soluble anti-viral agent显示文摘 | Mei Zhang Peter C K Cheung Vincent E C Ooia | 2004 | Carbohydrate Research2004，339，： | 1 |
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