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| 1 | Spin-decoupled metasurface for simultaneous detection of spin and orbital angular momenta via momentum transformation显示文摘With inherent orthogonality,both the spin angular momentum(SAM)and orbital angular momentum(OAM)of photons have been utilized to expand the dimensions of quantum information,optical communications,and information processing,wherein simultaneous detection of SAMs and OAMs with a single element and a single-shot measurement is highly anticipated.Here,a single azimuthal-quadratic phase metasurface-based photonic momentum transformation(PMT)is illustrated and utilized for vortex recognition.Since different vortices are converted into focusing patterns with distinct azimuthal coordinates on a transverse plane through PMT,OAMs within a large mode space can be determined through a single-shot measurement.Moreover,spin-controlled dual-functional PMTs are proposed for simultaneous SAM and OAM sorting,which is implemented by a single spin-decoupled metasurface that merges both the geometric phase and dynamic phase.Interestingly,our proposed method can detect vectorial vortices with both phase and polarization singularities,as well as superimposed vortices with a certain interval step.Experimental results obtained at several wavelengths in the visible band exhibit good agreement with the numerical modeling.With the merits of ultracompact device size,simple optical configuration,and prominent vortex recognition ability,our approach may underpin the development of integrated and high-dimensional optical and quantum systems. | Yinghui Guo Shicong Zhang Mingbo Pu Qiong He Jinjin Jin Mingfeng Xu Yaxin Zhang Ping Gao Xiangang Luo | 2021 | Light(Science & Applications)2021，10，4： | 14 |
| 2 | Crosstalk-free achromatic full Stokes imaging polarimetry metasurface enabled by polarization-dependent phase optimization显示文摘Imaging polarimetry is one of the most widely used analytical technologies for object detection and analysis.To date,most metasurface-based polarimetry techniques are severely limited by narrow operating bandwidths and inevitable crosstalk,leading to detrimental effects on imaging quality and measurement accuracy.Here,we propose a crosstalkfree broadband achromatic full Stokes imaging polarimeter consisting of polarization-sensitive dielectric metalenses,implemented by the principle of polarization-dependent phase optimization.Compared with the single-polarization optimization method,the average crosstalk has been reduced over three times under incident light with arbitrary polarization ranging from 9μm to 12μm,which guarantees the measurement of the polarization state more precisely.The experimental results indicate that the designed polarization-sensitive metalenses can effectively eliminate the chromatic aberration with polarization selectivity and negligible crosstalk.The measured average relative errors are 7.08%,8.62%,7.15%,and 7.59%at 9.3,9.6,10.3,and 10.6μm,respectively.Simultaneously,the broadband full polarization imaging capability of the device is also verified.This work is expected to have potential applications in wavefront detection,remote sensing,light-field imaging,and so forth. | Yaxin Zhang Mingbo Pu Jinjin Jin Xinjian Lu Yinghui Guo Jixiang Cai Fei Zhang Yingli Ha Qiong He Mingfeng Xu Xiong Li Xiaoliang Ma Xiangang Luo | 2022 | Opto-Electronic Advances2022，5，11： | 6 |
| 3 | Angle Dependence Analysis Method to Determine SNRArc Applied to GNSSMRSea Level Retrieval显示文摘The Global Navigation Satellite Systems(GNSS)broadcast radio signals are continuously at two or more frequencies in the L-band,and the multipath signals from sea surface recorded by off-the-shelf geodetic receivers have been demonstrated they can be used to estimate sea level,using a technology called GNSS multipath reflectometry(GNSS-MR).Before proceeding to estimate reflection parameters,the azimuth range and elevation angle range are needed to be defined,as only with suitable azimuths and elevation angles the sensing zones can be guaranteed on water.So,this study presents an angle dependence analysis method to jointly select the azimuth range and elevation angle range based on wavelet analysis which can describe the nonstationary power of different sinusoidal oscillations changed with elevation angle.The key of this method is to use one grid model to screen the spectrum power of multipath oscillation on different elevation angles and azimuths in this work.Then the elevation angles and the azimuths can be determined by searching grids with greater power.The GPS and GLONASS data of two MultiGNSS Experiment(MGEX)stations named BRST and MAYG was analyzed and used to retrieve.Firstly,the angle dependence analysis was carried out to determine the elevation range and azimuth range.Secondly,the sea levels were retrieved from individual signals.Finally,the retrievals of individual signals are combined to form a 10-min sea level retrieval series.The RMSEs of the combined retrievals are both less than 15 cm.The results show the effectiveness of the selection of angle range based on the angle dependence analysis method. | Xiaolei WANG Xiufeng HE Qin ZHANG Mingfeng SONG Zijin NIU | 2021 | Journal of Geodesy and Geoinformation Science2021，4，2： | 6 |
| 4 | Discrimination of False Negative Results in RT-PCR Detection of SARS-CoV-2 RNAs in Clinical Specimens by Using an Internal Reference显示文摘Reverse transcription-polymerase chain reaction(RT-PCR)is an essential method for specific diagnosis of SARS-CoV-2 infection.Unfortunately,false negative test results are often reported.In this study,we attempted to determine the principal causes leading to false negative results of RT-PCR detection of SARS-CoV-2 RNAs in respiratory tract specimens.Multiple sputum and throat swab specimens from 161 confirmed COVID-19 patients were tested with a commercialfluorescent RT-PCR kit targeting the ORF1 ab and N regions of SARS-CoV-2 genome.The RNA level of a cellular housekeeping gene ribonuclease P/MRP subunit p30(RPP30)in these specimens was also assessed by RT-PCR.Data for a total of 1052 samples were retrospectively re-analyzed and a strong association between positive results in SARS-CoV-2 RNA tests and high level of RPP30 RNA in respiratory tract specimens was revealed.By using the ROC-AUC analysis,we identified Ct cutoff values for RPP30 RT-PCR which predicted false negative results for SARS-CoV-2 RT-PCR with high sensitivity(95.03%–95.26%)and specificity(83.72%–98.55%)for respective combination of specimen type and ampli-fication reaction.Using these Ct cutoff values,false negative results could be reliably identified.Therefore,the presence of cellular materials,likely infected host cells,are essential for correct SARS-CoV-2 RNA detection by RT-PCR in patient specimens.RPP30 could serve as an indicator for cellular content,or a surrogate indicator for specimen quality.In addition,our results demonstrated that false negativity accounted for a vast majority of contradicting results in SARS-CoV-2 RNA test by RT-PCR. | Yafei Zhang Changtai Wang Mingfeng Han Jun Ye Yong Gao Zhongping Liu Tengfei He Tuantuan Li Mengyuan Xu Luping Zhou Guizhou Zou Mengji Lu Zhenhua Zhang | 2020 | Virologica Sinica2020，35，6： | 5 |
| 5 | 2022 Chinese expert consensus and guidelines on clinical management of toxicity in anti-CD19 chimeric antigen receptor T-cell therapy for B-cell non-Hodgkin lymphoma显示文摘Adoptive cellular immunotherapy with chimeric antigen receptor(CAR)T cells has emerged as a novel modality for treating relapsed and/or refractory B-cell non-Hodgkin lymphoma(B-NHL).With increasing approval of CAR T-cell products and advances in CAR T cell therapy,CAR T cells are expected to be used in a growing number of cases.However,CAR T-cell-associated toxicities can be severe or even fatal,thus compromising the survival benefit from this therapy.Standardizing and studying the clinical management of these toxicities are imperative.In contrast to other hematological malignancies,such as acute lymphoblastic leukemia and multiple myeloma,anti-CD19 CAR T-cell-associated toxicities in B-NHL have several distinctive features,most notably local cytokine-release syndrome(CRS).However,previously published guidelines have provided few specific recommendations for the grading and management of toxicities associated with CAR T-cell treatment for B-NHL.Consequently,we developed this consensus for the prevention,recognition,and management of these toxicities,on the basis of published literature regarding the management of anti-CD19 CAR T-cell-associated toxicities and the clinical experience of multiple Chinese institutions.This consensus refines a grading system and classification of CRS in B-NHL and corresponding measures for CRS management,and delineates comprehensive principles and exploratory recommendations for managing anti-CD19 CAR T-cell-associated toxicities in addition to CRS. | Ping Li Yang Liu Yun Liang Jian Bo Sujun Gao Yongxian Hu Yu Hu He Huang Xiaojun Huang Hongmei Jing Xiaoyan Ke Jianyong Li Yuhua Li Qifa Liu Peihua Lu Heng Mei Ting Niu Yongping Song Yuqin Song Liping Su Sanfang Tu Jianxiang Wang Depei Wu Zhao Wang Kailin Xu Zhitao Ying Qingming Yang Yajing Zhang Fengxia Shi Bin Zhang Huilai Zhang Xi Zhang Mingfeng Zhao Weili Zhao Xiangyu Zhao Liang Huang Jun Zhu Wenbin Qian Weidong Han Aibin Liang | 2023 | Cancer Biology & Medicine2023，20，2： | 3 |
| 6 | An Overview and Experimental Study of Learning-Based Optimization Algorithms for the Vehicle Routing Problem显示文摘The vehicle routing problem(VRP)is a typical discrete combinatorial optimization problem,and many models and algorithms have been proposed to solve the VRP and its variants.Although existing approaches have contributed significantly to the development of this field,these approaches either are limited in problem size or need manual intervention in choosing parameters.To solve these difficulties,many studies have considered learning-based optimization(LBO)algorithms to solve the VRP.This paper reviews recent advances in this field and divides relevant approaches into end-to-end approaches and step-by-step approaches.We performed a statistical analysis of the reviewed articles from various aspects and designed three experiments to evaluate the performance of four representative LBO algorithms.Finally,we conclude the applicable types of problems for different LBO algorithms and suggest directions in which researchers can improve LBO algorithms. | Bingjie Li Guohua Wu Yongming He Mingfeng Fan Witold Pedrycz | 2022 | IEEE/CAA Journal of Automatica Sinica2022，9，7： | 2 |
| 7 | Experimental and simulation studies on concentration polarization in tt2 enrichment by highly permeable and selective Pd membranes显示文摘 | Zhang Jian Liu Dongyu He Mingfeng | 2006 | Journal of Membrane Science2006，274，： | 1 |
| 8 | Experimental study of melt electrospinning in parallel electrical field显示文摘 | HAO Mingfeng LIU Yong HE Xuetao | 2011 | Advanced Materials Research2011，，211： | 1 |
| 9 | Density functional theory study of mercury adsorption on V2 O: (001) surface with implications for oxidation 显示文摘 | LIU Jing HE Mingfeng ZHENG Chuguang | 2011 | Proceedings of the Combustion Institute2011，33，2： | 1 |
| 10 | Experimental studyof melt electrospinning in parallel electrical field显示文摘 | Hao Mingfeng Liu Yong He Xuetao | 2011 | AdvancedMaterials Research2011，221，： | 1 |
| 11 | Factors influencing diameter of polypropylene fiber in melt electrospinning显示文摘 | HAO Mingfeng LIU Yong HE Xuetao | 2011 | Advanced Polymer Science and Engineering2011，，221： | 1 |
| 12 | Solar term peak of onset and death in 1 597 patients with acute ischemic stroke Circular statistical analysis显示文摘BACKGROUND: Previously, time data were analyzed by using constituent ratio or relative ratio; however, circular statistical analysis could exactly provide average peak phase of diseases. OBJECTIVE: To investigate the correlation of solar term peak with onset and death of acute ischemic stroke. DESIGN: Retrospective case analysis. SETTINGS: Emergency Department of Foshan Municipal Hospital of Traditional Chinese Medicine; Department of Science and Education, the Second People's Hospital of Foshan. PARTICIPANTS: A total of 1 597 patients with acute ischemic stroke were selected from Emergency Room, Department of Neurology, Foshan Municipal Hospital of Traditional Chinese Medicine from 1994 to 2002. There were 875 males and 722 females, and their ages ranged from 33 to 97 years. All cases met the diagnostic criteria of acute cerebral infarction modified by the Second National Cerebrovascular Disease Academic Meeting; meanwhile, they were diagnosed with CT/MRI test. Patients and their relatives provided the confirmed consent. METHODS: Solar term of onset was retrospectively analyzed in 1 597 patients with acute ischemic stroke; among them, solar term of death in 90 cases were analyzed by using circular statistical analysis to calculate peak phase of onset and death of acute ischemic stroke and investigate the correlation of solar term with onset and death of acute ischemic stroke. MAIN OUTCOME MEASURES: Onset and death time of patients with acute ischemic stroke. RESULTS: Solar term of onset in 1 597 patients, especially solar term of death in 90 patients, was not concentrated (P > 0.05), and specific peak phase was not found out. Acute ischemic stroke low attacked from vernal equinox to summer begins, but death caused by acute ischemic stroke high attacked from grain buds to autumn begins. CONCLUSION: Patients with acute ischemic stroke do not have specific solar term peak of onset and death. | Mingfeng He Zhangrong Liang Jiping Zhang Zhenhe Gao Shaoyong Mo Yingjian Zhang Fang Shen Zixing Chen Liyun Cai Weihong Xiang | 2007 | Neural Regeneration Research2007，2，9： | 1 |
| 13 | Rational Design of Ratiometric Fe^(3+) Fluorescent Probes Based on FRET Mechanism显示文摘As the most abundant transition metal element in mammals, iron(Fe) plays a vital role in life activities. It is of great significance to study the variation of Fe3+ level in living organisms. In virtue of the advantages of high sensitivity, good selectivity and low damage to living systems, the fluorescence detection of Fe3+ has attracted much attention. Compared with the intensity-based fluorescent probe, the ratiometric fluorescent probe has less interference of environmental and can realize quantitative detection. In this study, four ratiometric Fe3+ fluorescent probes, R1, R2, R3 and R4, were designed and synthesized using fluorescence resonance energy transfer(FRET) mechanism to achieve quantitative detection of Fe3+. In the FRET systems, 1,8-naphthalimide fluorophore derivatives were adopted as donors while rhodamine B derivatives were selected as receptors. The connection sites of the donor and acceptor in R3 and R4 are different from those in R1 and R2. All the four probes showed good response and selectivity to Fe3+. The energy transfer efficiencies of R3 and R4 were obviously higher than those of R1 and R2. This work provided a promising strategy for the development of fluorescent ratiometic Fe3+sensors. | LI Mingfeng FANG Hongbao JI Yifan CHEN Yuncong HE Weijiang GUO Zijian | 2022 | Chemical Research in Chinese Universities2022，38，1： | 1 |
| 14 | Density functional theory study of mercury adsorption on V 2 O 5 (001) surface with implications for oxidation显示文摘 | Jing Liu Mingfeng He Chuguang Zheng Ming Chang | 2010 | Proceedings of the Combustion Institute2010，，： | 1 |
| 15 | Putative functions of EpsK in teichuronic acid synthesis and phosphate starvation in Bacillus licheniformis显示文摘Extracellular polymeric substances(EPSs)are extracellular macromolecules in bacteria,which function in cell growth and show potential for mechanism study and biosynthesis application.However,the biosynthesis mechanism of EPS is still not clear.We herein chose Bacillus licheniformis CGMCC 2876 as a target strain to investigate the EPS biosynthesis.epsK,a member of eps cluster,the predicted polysaccharide synthesis cluster,was overexpressed and showed that the overexpression of epsK led to a 26.54%decrease in the production of EPS and resulted in slenderer cell shape.Transcriptome analysis combined with protein-protein interactions analysis and protein modeling revealed that epsK was likely responsible for the synthesis of teichuronic acid,a substitute cell wall component of teichoic acid when the strain was suffering phosphate limitation.Further cell cultivation showed that either phosphate limitation or the overexpression of teichuronic acid synthesis genes,tuaB and tuaE could similarly lead to EPS reduction.The enhanced production of teichuronic acid induced by epsK overexpression triggered the endogenous phosphate starvation,resulting in the decreased EPS synthesis and biomass,and the enhanced bacterial chemotaxis.This study presents an insight into the mechanism of EPS synthesis and offers the potential in controllable synthesis of target products. | Yiyuan Xu Lijie Yang Haiyan Wang Xiaoyu Wei Yanyan Shi Dafeng Liang Mingfeng Cao Ning He | 2022 | Synthetic and Systems Biotechnology2022，7，2： | 1 |
| 16 | Physics-data-driven intelligent optimization for large-aperture metalenses显示文摘Metalenses have gained significant attention and have been widely utilized in optical systems for focusing and imaging,owing to their lightweight,high-integration,and exceptional-flexibility capabilities.Traditional design methods neglect the coupling effect between adjacent meta-atoms,thus harming the practical performance of meta-devices.The existing physical/data-driven optimization algorithms can solve the above problems,but bring significant time costs or require a large number of data-sets.Here,we propose a physics-data-driven method employing an“intelligent optimizer”that enables us to adaptively modify the sizes of the meta-atom according to the sizes of its surrounding ones.The implementation of such a scheme effectively mitigates the undesired impact of local lattice coupling,and the proposed network model works well on thousands of data-sets with a validation loss of 3×10^(−3).Based on the“intelligent optimizer”,a 1-cm-diameter metalens is designed within 3 hours,and the experimental results show that the 1-mm-diameter metalens has a relative focusing efficiency of 93.4%(compared to the ideal focusing efficiency)and a Strehl ratio of 0.94.Compared to previous inverse design method,our method significantly boosts designing efficiency with five orders of magnitude reduction in time.More generally,it may set a new paradigm for devising large-aperture meta-devices. | Yingli Ha Yu Luo Mingbo Pu Fei Zhang Qiong He Jinjin Jin Mingfeng Xu Yinghui Guo Xiaogang Li Xiong Li Xiaoliang Ma Xiangang Luo | 2023 | Opto-Electronic Advances2023，6，11： | 1 |
| 17 | Effect of remimazolam vs. propofol on hemodynamics during general anesthesia induction in elderly patients: Single-center, randomized controlled trial显示文摘The current study aimed to compare the effects between remimazolam and propofol on hemodynamic stability during the induction of general anesthesia in elderly patients.We used propofol at a rate of 60 mg/(kg·h)in the propofol group(group P)or remimazolam at a rate of 6 mg/(kg·h)in the remimazolam group(group R)for the induction.A processed electroencephalogram was used to determine whether the induction was successful and when to stop the infusion of the study drug.We measured when patients entered the operating room(T_(0)),when the induction was successful(T_(1)),and when before(T_(2))and 5 min after successful endotracheal intubation(T_(3)).We found that mean arterial pressure(MAP)was lower at T_(1–3),compared with T_(0) in both groups,but higher at T_(2) in the group R,whileΔMAP_(T0–T2) andΔMAP_(max) were smaller in the group R(ΔMAP_(T0–T2):the difference between MAP at time point T_(0) and T_(2),ΔMAP_(max):the difference between MAP at time point T_(0) and the lowest value from T_(0) to T_(3)).Cardiac index and stroke volume index did not differ between groups,whereas systemic vascular resistance index was higher at T_(1–3) in the group R.These findings show that remimazolam,compared with propofol,better maintains hemodynamic stability during the induction,which may be attributed to its ability to better maintain systemic vascular resistance levels. | Mingfeng He Chanjuan Gong Yinan Chen Rongting Chen Yanning Qian | 2024 | The Journal of Biomedical Research2024，38，1： | 0 |
| 18 | Oceanic vertical mixing of the lower halocline water in the Chukchi Borderland and Mendeleyev Ridge显示文摘Oceanic vertical mixing of the lower halocline water(LHW)in the Chukchi Borderland and Mendeleyev Ridge was studied based on in situ hydrographic and turbulent observations.The depth-averaged turbulent dissipation rate of LHW demonstrates a clear topographic dependence,with a mean value of 1.2×10^(-9) W/kg in the southwest of Canada Basin,1.5×10^(-9) W/kg in the Mendeleyev Abyssal Plain,2.4×10^(-9) W/kg on the Mendeleyev Ridge,and2.7×10^(-9) W/kg on the Chukchi Cap.Correspondingly,the mean depth-averaged vertical heat flux of the LHW is0.21 W/m^(2) in the southwest Canada Basin,0.30 W/m^(2) in the Mendeleyev Abyssal Plain,0.39 W/m^(2) on the Mendeleyev Ridge,and 0.46 W/m^(2) on the Chukchi Cap.However,in the presence of Pacific Winter Water,the upward heat released from Atlantic Water through the lower halocline can hardly contribute to the surface ocean.Further,the underlying mechanisms of diapycnal mixing in LHW—double diffusion and shear instability—was investigated.The mixing in LHW where double diffusion were observed is always relatively weaker,with corresponding dissipation rate ranging from 1.01×10^(-9) W/kg to 1.57×10^(-9) W/kg.The results also show a strong correlation between the depth-average dissipation rate and strain variance in the LHW,which indicates a close physical linkage between the turbulent mixing and internal wave activities.In addition,both surface wind forcing and semidiurnal tides significantly contribute to the turbulent mixing in the LHW. | Long Lin Hailun He Yong Cao Tao Li Yilin Liu Mingfeng Wang | 2021 | Acta Oceanologica Sinica2021，40，11： | 0 |
| 19 | CORRECTION:Correction to:Discrimination of False Negative Results in RT-PCR Detection of SARS-CoV-2 RNAs in Clinical Specimens by Using an Internal Reference显示文摘In the original version of Fig.41 and 4J,the cutoff lines were accidently shifted during figure layout.Figures 41 and 4J are re-drawn and provided below. | Yafei Zhang Changtai Wang Mingfeng Han Jun Ye Yong Gao Zhongping Liu Tengfei He Tuantuan Li Mengyuan Xu Luping Zhou Guizhou Zou Mengji Lu Zhenhua Zhang | 2020 | Virologica Sinica2020，35，6： | 0 |
| 20 | Genomic and metabolomic analysis of Bacillus licheniformis with enhanced poly-γ-glutamic acid production through atmospheric and room temperature plasma mutagenesis显示文摘Poly-γ-glutamic acid is an extracellular polymeric substance with various applications owing to its valuable properties of biodegradability,flocculating activity,water solubility,and nontoxicity.However,the ability of natural strains to produce poly-γ-glutamic acid is low.Atmospheric and room temperature plasma was applied in this study to conduct mutation breeding of Bacillus licheniformis CGMCC 2876,and a mutant strain M32 with an 11%increase in poly-γ-glutamic acid was obtained.Genome resequencing analysis identified 7 nonsynonymous mutations of ppsC encoding lipopeptide synthetase associated with poly-γ-glutamic acid metabolic pathways.From molecular docking,more binding sites and higher binding energy were speculated between the mutated plipastatin synthase subunit C and glutamate,which might contribute to the higher poly-γ-glutamic acid production.Moreover,the metabolic mechanism analysis revealed that the upregulated amino acids of M32 provided substrates for glutamate and promoted the conversion between L-and D-glutamate acids.In addition,the glycolytic pathway is enhanced,leading to a better capacity for using glucose.The maximum poly-γ-glutamic acid yield of 14.08 g·L^(–1)was finally reached with 30 g·L^(–1)glutamate. | Xiaoyu Wei Lijie Yang Haiyan Wang Zhen Chen Yiyuan Xu Yue Weng Mingfeng Cao Qingbiao Li Ning He | 2022 | Frontiers of Chemical Science and Engineering2022，16，12： | 0 |
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