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| 1 | Cotton GhBAK1 Mediates Verticillium Wilt Resistance and Cell Death显示文摘导致病毒的基因 silencing (VIGS ) 由将他们的表示击倒为单个基因的功能的分析提供一条强大的途径。我们采用了这条途径把在对 Verticillium 抵抗的棉花的基因功能枯萎,世界范围的大多数破坏疾病之一。我们这里证明高度有效的 VIGS 在与部分抵抗引起线(CA4002 ) 到 Verticillium 的一朵棉花被获得枯萎,并且 GhMKK2 和 GhVe1 为它的抵抗被要求到 Verticillium 枯萎。Arabidopsis AtBAK1/SERK3,在工厂疾病抵抗的一个中央管理者,与五个成员,一起属于体的 embryogenesis 受体 kinases (SERK ) 的一个亚科 AtSERK1 到 AtSERK5。二 BAK1 orthologs 和一 SERK1 ortholog 在棉花染色体被识别。重要地, GhBAK1 为 CA4002 抵抗被要求到 Verticillium 枯萎。令人惊讶地, GhBAK1 的 silencing 是足够的触发在棉花伴有反应的氧种类的生产的房间死亡。这结果从 AtBAK1 和 AtSERK4 在房间死亡控制在玩冗余的函数的 Arabidopsis 是不同的。显然,而 AtSERK4/5 是在 Arabidopsis 的最新发展的基因,棉花仅仅发展了 SERK1 和 BAK1。我们的研究在 Verticillium 显示 BAK1 的功能的重要性枯萎抵抗并且在不同植物种类建议 SERK 家庭成员的动态进化。 | Xiquan Gao Fangjun Li Maoying Li Ali S.Kianinejad Jane K.Dever Terry A.Wheeler Zhaohu Li Ping He Libo Shan | 2013 | Journal of Integrative Plant Biology2013，55，7： | 13 |
| 2 | Genetic lineage tracing identifies in situ Kit-expressing cardiomyocytes显示文摘 | Qiaozhen Liu Rui Yang Xiuzhen Huang Hui Zhang Lingjuan He Libo Zhang Xueying Tian Yu Nie Shengshou Hu Yan Yan Li Zhang Zengyong Qiao Qing-Dong Wang Kathy O Lui Bin Zhou | 2016 | Cell Research2016，26，1： | 12 |
| 3 | Actively priming autophagic cell death with novel transferrin receptor-targeted nanomedicine for synergistic chemotherapy against breast cancer显示文摘Recently, considerable attention in the field of cancer therapy has been focused on the mammalian rapamycin target(m TOR), inhibition of which could result in autophagic cell death(ACD). Though novel combination chemotherapy of autophagy inducers with chemotherapeutic agents is extensively investigated, nanomedicine-based combination therapy for ACD remains in infancy. In attempt to actively trigger ACD for synergistic chemotherapy, here we incorporated autophagy inducer rapamycin(RAP) into 7 pep-modified PEG-DSPE polymer micelles(7 pep-M-RAP) to specifically target and efficiently priming ACD of MCF-7 human breast cancer cells with high expression of transferrin receptor(Tf R). Cytotoxic paclitaxel(PTX)-loaded micelle(7 pep-M-PTX) was regarded as chemotherapeutic drug model. We discovered that with superior intracellular uptake in vitro and more tumor accumulation of micelles in vivo, 7 pep-M-RAP exhibited excellent autophagy induction and synergistic antitumor efficacy with 7 pep-M-PTX. Mechanism study further revealed that 7 pep-M-RAP and 7 pep-MPTX used in combination provided enhanced efficacy through induction of both apoptosis-and mitochondria-associated autophagic cell death. Together, our findings suggested that the targeted excess autophagy may provide a rational strategy to improve therapeutic outcome of breast cancer, and simultaneous induction of ACD and apoptosis may be a promising anticancer modality. | Dong Mei Binlong Chen Bing He Haibin Liu Zhiqiang Lin Jialiang Lin Xiaoyan Zhang Ning Sun Libo Zhao Xiaoling Wang Qiang Zhang | 2019 | Acta Pharmaceutica Sinica B2019，9，5： | 8 |
| 4 | Fibroblasts in an endocardial fibroelastosis disease model mainly originate from mesenchymal derivatives of epicardium显示文摘 | Hui Zhang Xiuzhen Huang Kuo Liu Juan Tang Lingjuan He Wenjuan pu Qiaozhen Liu Yan Li Xueying Tian Yue Wang Libo Zhang Ying Yu Hongyan Wang Ronggui Hu Fengchao Wang Ting Chen Qing-Dong Wang Zengyong Qiao Li Zhang Kathy O Lui Bin Zhou | 2017 | Cell Research2017，27，9： | 6 |
| 5 | Big Roles of Small Kinases:The Complex Functions of Receptor-Like Cytoplasmic Kinases in Plant Immunity and Development显示文摘Plants have evolved a large number of receptor-like cytoplasmic kinases(RLCKs)that often functionally and physically associate with receptor-like kinases(RLKs)to modulate plant growth,development and immune responses.Without any apparent extracellular domain,RLCKs relay intracellular signaling often via RLK complex-mediated transphosphorylation events.Recent advances have suggested essential roles of diverse RLCKs in concert with RLKs in regulating various cellular and physiological responses.We summarize here the complex roles of RLCKs in mediating plant immune responses and growth regulation,and discuss specifc and overlapping functions of RLCKs in transducing diverse signaling pathways. | Wenwei Lin Xiyu Ma Libo Shan Ping He | 2013 | Journal of Integrative Plant Biology2013，55，12： | 6 |
| 6 | Two-dimensional vanadium carbide(V2CTx) MXene as supercapacitor electrode in seawater electrolyte显示文摘In this study,two-dimensional V2CTx MXene has been prepared by selectively etching Al layers from V2 AlC MAX phase by NaF+HCl etching at 90℃for 72 h and its performance as supercapacitor(SC)electrode were tested using simulating seawater as electrolyte.V2CTx MXene-based electrodes shows a good capacitance of 181.1 F/g,which is in accordance with the volumetric specific capacitance of 317.8 F/cm^3,and with 89.1%capacitance retention even after 5000 cycle.Compared with other MXenes,V2CTx have better electrochemical performance as SC electrode.This work provides an innovative strategy to apply V2CTx MXene as SC electrode in safety and effective seawater electrolyte. | Hongtian He Qixun Xia Bingxin Wang Libo Wang Qianku Hu Aiguo Zhou | 2020 | Chinese Chemical Letters2020，31，4： | 6 |
| 7 | Cartilage-targeting peptide-modified dual-drug delivery nanoplatform with NIR laser response for osteoarthritis therapy显示文摘Cartilage-targeting delivery of therapeutic agents is still an effective strategy for osteoarthritis(OA)therapy.Recently,scavenging for reactive oxygen species(ROS)and activating autophagy have been increasingly reported to treat OA effectively.In this study,we designed,for the first time,a dual-drug delivery system based on metal organic framework(MOF)-decorated mesoporous polydopamine(MPDA)which composed of rapamycin(Rap)loaded into the mesopores and bilirubin(Br)loaded onto the shell of MOF.The collagen II-targeting peptide(WYRGRL)was then conjugated on the surface of above nanocarrier to develop a cartilage-targeting dual-drug delivery nanoplatform(RB@MPMW).Our results indicated the sequential release of two agents from RB@MPMW could be achieved via near-infrared(NIR)laser irritation.Briefly,the rapid release of Br from the MOF shell exhibited excellent ROS scavenging ability and anti-apoptosis effects,however responsively reduced autophagy activity,to a certain extent.Meanwhile,following the NIR irradiation,Rap was rapidly released from MPDA core and further enhanced autophagy activation and chondrocyte protection.RB@MPMW continuously phosphorylated AMPK and further rescued mitochondrial energy metabolism of chondrocytes following IL-1βstimulation via activating SIRT1-PGC-1αsignaling pathway.Additionally,the cartilage-targeting property of peptide-modified nanocarrier could be monitored via Magnetic Resonance(MR)and IVIS imaging.More significantly,RB@MPMW effectively delayed cartilage degeneration in ACLT rat model.Overall,our findings indicated that the as-prepared dual-drug delivery nanoplatform exerted potent anti-inflammation and anti-apoptotic effects,rescued energy metabolism of chondrocytes in vitro and prevented cartilage degeneration in vivo,which thereby showed positive performance for OA therapy. | Song Xue Xiaojun Zhou Weilin Sang Cong Wang Haiming Lu Yiming Xu Yiming Zhong Libo Zhu Chuanglong He Jinzhong Ma | 2021 | Bioactive Materials2021，6，8： | 5 |
| 8 | Simultaneous extraction of DNA and RNA from Escherichia coli BL 21 based on silica-coated magnetic nanoparticles显示文摘The extraction of nucleic acid is recognized as one of the most essential steps in molecular biology for initiating other downstream applications such as sequencing, amplification, hybridization, and cloning. Many commercial kits and methods are currently available that allow the extraction of only one type of nucleic acids-DNA or RNA. However, in parallel clinical detection of several diseases, a method for simultaneous extraction of both DNA and RNA from the same source is needed in such cases. In this study, a method for simultaneous extraction of DNA and RNA from bacteria based on magnetic nanoparticles(MNPs) was described. Lysis buffers were prepared to help the nucleic acid released and adsorbed to MNPs. Then, two washing buffers were used to remove the contamination of proteins and carbohydrates. The nucleic acids were finally eluted by Deoxyribonuclease(DNase) and Ribonucleases(RNase) free water. Different factors which might affect the purification of the nucleic acid were investigated, and the quantity and quality parameters of the nucleic acid were also recorded. The DNA and RNA extracted from bacteria were then respectively subjected to polymerase chain reaction(PCR) and reverse transcription PCR(RT-PCR) to further confirm its quality. The results indicated that our method can be successfully used to simultaneously extract DNA and RNA from bacteria. | Jiuhai Wang Zeeshan Ali Nianyue Wang Wenbiao Liang Hongna Liu Fu Li Haowen Yang Lei He Libo Nie Nongyue He Zhiyang Li | 2015 | Science China Chemistry2015，58，11： | 5 |
| 9 | New discoveries from the classic Quaternary mammalian fossil area of Yanjinggou,Chongqing,and their chronological explanations显示文摘Yanjinggou in Wanzhou District of Chongqing is one of the earliest reported and most famous Quaternary mammalian fossil areas in China.The fauna from this area used to be taken as a benchmark for the biochronological comparison of Quaternary paleontology of South China,but the chronology of this fauna has many controversies for the lack of exact locational and stratigraphical records.The present article,on the basis of recent investigations and discoveries,discusses and explains the distribution and biochronology of the mammalian faunas in the Yanjinggou area.The newly discovered Dayakou fissure fauna,including Rhizomys troglodytes,Homotherium sp.,Panthera pardus,Stegodon orientalis,Dicerorhinus sumatrensis,Hesperotherium sinense,Sus sp.,Cervavitus fenqii,Cervus sp.and Muntiacus sp.,is correlated to the middle Early Pleistocene.The presence of Early Pleistocene mammalian fauna in the Yanjinggou area is therefore confirmed.The'Wanhsien fauna'or'Yenchingkou(=Yanjinggou)fauna'as a Mid-Late Pleistocene biostratigraphical datum should be abandoned.The Dayakou fauna and the Upper Cave fauna of Pingba,both in the Yanjinggou area,are correlated to the middle Early Pleistocene and the early Middle Pleistocene in age,respectively. | CHEN ShaoKun PANG LiBo HE CunDing WEI GuangBiao HUANG WanBo YUE ZongYing ZHANG XiaoHu ZHANG Hua QIN Li | 2013 | Chinese Science Bulletin2013，58，31： | 4 |
| 10 | Size-tunable synthesis of gold nanorods using pyrogallol as a reducing agent显示文摘A novel and facile seed-mediated method for the preparation of monodispersed gold nanorods(GNRs) is presented by introducing pyrogallol as a reductant. Fast Fourier transformation of high-resolution transmission electron microscopy reveals that the synthesized GNRs are single crystalline. The longitudinal surface plasmon resonance of GNRs can be finely tuned by varying silver ion concentrations or seed amounts. Also, both thick(diameter >30 nm) and thin(diameter <10 nm) GNRs with exceptional monodispersity can be well prepared by this method. These findings indicate that this method has a greater performance in controlling the morphology of GNRs than that of traditional approach with ascorbic acid as a reductant. | Yuanfu Huang Kai Xia Nongyue He Zhuoxuan Lu Liming Zhang Yan Deng Libo Nie | 2015 | Science China Chemistry2015，58，11： | 3 |
| 11 | Plant plasma membrane-resident receptors:Surveillance for infections and coordination for growth and development显示文摘As sessile organisms, plants are exposed to pathogen invasions and environmental fluctuations. To overcome the challenges of their surroundings, plants acquire the potential to sense endogenous and exogenous cues, resulting in their adaptability. Hence, plants have evolved a large collection of plasma membrane-resident receptors, including RECEPTOR-LIKE KINASEs(RLKs) and RECEPTOR-LIKE PROTEINs(RLPs) to perceive those signals and regulate plant growth,development, and immunity. The ability of RLKs and RLPs to recognize distinct ligands relies on diverse categories of extracellular domains evolved. Co-regulatory receptors are often required to associate with RLKs and RLPs to facilitate cellular signal transduction. RECEPTOR-LIKE CYTOPLASMIC KINASEs(RLCKs) also associate with the complex, bifurcating the signal to key signaling hubs, such as MITOGEN-ACTIVATED PROTEIN KINASE(MAPK) cascades, to regulate diverse biological processes. Here, we discuss recent knowledge advances in understanding the roles of RLKs and RLPs in plant growth, development, and immunity, and their connection with co-regulatory receptors, leading to activation of diverse intracellular signaling pathways. | Ana Marcia Escocard de Azevedo Manhaes Fausto Andres Ortiz-Morea Ping He Libo Shan | 2021 | Journal of Integrative Plant Biology2021，63，1： | 3 |
| 12 | Cotton Gh BAK 1 Mediates Verticillium Wilt Resistance and Cell Death显示文摘 | Xiquan Gao Fangjun Li Maoying Li Ali S. Kianinejad Jane K. Dever Terry A. Wheeler Zhaohu Li Ping He Libo Shan | 2013 | J Integr Plant Biol2013，，7： | 2 |
| 13 | Image Inpainting Based on Improved Deep Convolutional Auto-encoder Network显示文摘This paper proposes an effective image inpainting method using an improved deep convolutional auto-encoder network.By analogy with exiting methods of image inpainting based on auto-decoders,inpainting methods using the deep convolutional auto-encoder networks are significantly more effective in capturing high-level features than classical methods based on exemplar.However,the inpainted regions would appear blurry and global inconsistency.To alleviate the fuzzy problem,we improved the network model by adding skip connections between mirrored layers in encoder and decoder stacks,so that the generative process of the inpainting area can directly use the low-level features information of the processing image.For making the inpainted result look both more plausible and consistent with its surrounding contexts,the model is trained with a combination of standard pixel-wise reconstruction loss and two adversarial losses which ensures pixel-accurate and local-global contents consistency.With extensive experimental on the ImageNet and Paris Streetview datasets,we demonstrate qualitatively and quantitatively that our approach performs better than state of the art. | QIANG Zhenping HE Libo DAI Fei ZHANG Qinghui LI Junqiu | 2020 | Chinese Journal of Electronics2020，29，6： | 2 |
| 14 | In situ atomic-scale observation of dislocation behaviors in twin-structured Pt nanocrystals显示文摘The deformation mechanisms of twin-structured metallic materials have attracted great interest.Though previous theoretical predictions have suggested that the repulsive force of the twin boundary(TB)can significantly affect the deformation of twinstructured metals,it remains unclear whether this prediction applies to experimental conditions.In this paper,the atomic-scaled deformation process of twin-structured Pt nanocrystals was in situ observed using our home-made device in a high-resolution transmission electron microscope.We have shown that the plastic deformation of the twin-structured Pt nanocrystals was governed by full dislocation generation as well as Lomer dislocation(LD)lock formation and destruction.After LD locks were destructed,these full dislocations tended to move towards the surface of the nanocrystals.The findings revealed that due to the ultra-high repulsive force of TB on dislocation,there was no dislocation-TB reaction during the deformation.These findings can enrich our understanding of the dislocation behaviors of twin-structured nanocrystals. | GUO YiZhong SUN Tao FU LiBo HAO LongHu HUANG Ming WEI RuJian LUO JunFeng HE Xin WANG XingQuan XIONG XiaoDong WANG LiHua HAN XiaoDong | 2021 | Science China(Technological Sciences)2021，64，3： | 2 |
| 15 | Endless Hide-and-Seek: Dynamic Co-evolution in Plant-Bacterium Warfare显示文摘植物拥有天生的免疫系统阻止很潜在的感染。古老、保存的天生的免疫反应被联系微生物的分子的模式(MAMP ) 触发并且在用途广泛的防卫起重要作用。然而,成功的细菌的病原体发展了类型 III 毒力受动器压制调停 MAMP 的免疫。幸存,植物进一步开发了高度特定的抵抗(R) 基因触发 gene-for-gene-mediatedimmunity 并且把剧毒的病原体变成无毒害的。我们这里在植物细菌相互作用的这动态 coevolution 总结最近的进展。 | Libo Shan Ping He Jen Sheen | 2007 | Journal of Integrative Plant Biology2007，49，1： | 2 |
| 16 | Synthesis and electrochemical properties of V_(2)C MXene by etching in opened/closed environments显示文摘The effect of etching environment(opened or closed)on the synthesis and electrochemical properties of V_(2)C MXene was studied.V_(2)C MXene samples were synthesized by selectively etching of V2AlC at 90℃in two different environments:opened environment(OE)in oil bath pans under atmosphere pressure and closed environment(CE)in hydrothermal reaction kettles under higher pressures.In OE,only NaF(sodium fluoride)+HCl(hydrochloric acid)etching solution can be used to synthesize highly pure V_(2)C MXene.However,in CE,both LiF(lithium fluoride)+HCl and NaF+HCl etchant can be used to prepare V_(2)C MXene.Moreover,the V_(2)C MXene samples made in CE had higher purity and better-layered structure than those made in OE.Although the purity of V_(2)C obtained by LiF+HCl is lower than that of V_(2)C obtained using NaF+HCl,it shows better electrochemical performance as anodes of lithium-ion batteries(LIBs).Therefore,etching in CE is a better method for preparing highly pure V_(2)C MXene,which provides a reference for expanding the synthesis methods of V_(2)C with better electrochemical properties. | Meng WU Yan HE Libo WANG Qixun XIA Aiguo ZHOU | 2020 | Journal of Advanced Ceramics2020，9，6： | 2 |
| 17 | Two Physics-Based Schwarz Preconditioners for Three-Temperature Radiation Diffusion Equations in High Dimensions显示文摘We concentrate on the parallel,fully coupled and fully implicit solution of the sequence of 3-by-3 block-structured linear systems arising from the symmetrypreserving finite volume element discretization of the unsteady three-temperature radiation diffusion equations in high dimensions.In this article,motivated by[M.J.Gander,S.Loisel,D.B.Szyld,SIAM J.Matrix Anal.Appl.33(2012)653–680]and[S.Nardean,M.Ferronato,A.S.Abushaikha,J.Comput.Phys.442(2021)110513],we aim to develop the additive and multiplicative Schwarz preconditioners subdividing the physical quantities rather than the underlying domain,and consider their sequential and parallel implementations using a simplified explicit decoupling factor approximation and algebraic multigrid subsolves to address such linear systems.Robustness,computational efficiencies and parallel scalabilities of the proposed approaches are numerically tested in a number of representative real-world capsule implosion benchmarks. | Xiaoqiang Yue Jianmeng He Xiaowen Xu Shi Shu Libo Wang | 2022 | Communications in Computational Physics2022，32，8： | 1 |
| 18 | Isolation and expres- sion of grass carp toll-like receptor 5a (CiTLRSa) and 5h (CiTLR5b) gene involved in the response to flagellin stimula- tion and grass carp reovirus infection 显示文摘 | Jiang Yao He Libo Ju Changsong | 2015 | Fish Shellfish Im- munol2015，44，： | 1 |
| 19 | Polymer Nanofiber‐Embedded Microchips for Detection, Isolation, and Molecular Analysis of Single Circulating Melanoma Cells显示文摘 | Shuang Hou Libo Zhao Qinglin Shen Juehua Yu Charles Ng Xiangju Kong Dongxia Wu Min Song Xiaohong Shi Xiaochun Xu Wei‐Han OuYang Rongxian He Xing‐Zhong Zhao Tom Lee F. Charles Brunicardi Mitch André Garcia Antoni Ribas Roger S. Lo Hsian‐Rong Tseng | 2013 | Angew Chem Int Ed2013，，12： | 1 |
| 20 | One for all: the receptor-associated kinase BAK1 显示文摘 | Chinchilla D Shan Libo He Ping | 2009 | Trends in Plant Science2009，14，10： | 1 |
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