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| 1 | Anticancer immunotherapy by CTLA-4 blockade: obligatory contribution of IL-2 receptors and negative prognostic impact of soluble CD25显示文摘堵住抗体 ipilimumab 的细胞毒素的 T 淋巴细胞 antigen-4 (CTLA-4 ) 在很少的病人导致变形黑瘤的调停免疫者的长期的控制。尽管 ipilimumab 无疑经由 immunostimulation 施加它的治疗学的效果,这样远的临床上有用的、 immunologically 相关的 biomarkers 预言治疗效率是逃犯的。这里,我们显示出 IL-2 的那中立化或堵住 α并且 βIL-2 受体的子单元(CD25 和 CD122,分别地) 否则在现出症状之前的潜的老鼠模型由 CTLA-4 封锁导致了,废除了 antitumor 效果和 intratumoral T 受动器对规章的房间(Tregs ) 的比率的伴随的改进,它是。CTLA-4 封锁导致了在失去了 FoxP3 表示并且在 regressing 肿瘤积累了的 IL-2-producing 受动器房间与伴随物上升表示 Lag3, ICOS, IL-10 和 Egr2 的一个镇压 CD4 + T 房间子集的减小。当 recombinant IL-2 改进了 CTLA-4 封锁的治疗学的功效时,圈套 IL-2 受体 α(IL-2Rα, sCD25 ) 禁止了 CTLA-4 的 anticancer 效果封锁。在收到 ipilimumab 的 262 个变形黑瘤病人, sCD25 的基线浆液集中代表了全面幸存的独立指示物,与预言到治疗的抵抗的高水平。总的来说,这些结果解开为在 CTLA-4 的 anticancer 活动的 IL-2 和 IL-2 受体的一个角色封锁。重要地,我们的学习提供第一 immunologically 相关的 biomarker,也就是提高的浆液 sCD25,那与黑瘤在病人预言抵抗到 CTLA-4 封锁。 | Dalil Hannani Marie Vetizou David Enot Sylvie Rusakiewicz Nathalie Chaput David Klatzmann Melanie Desbois Nicolas Jacquelot Nadege Vimond Salem Chouaib Christine Mateus James P Allison Antoni Ribas Jedd D Wolchok Jianda Yuan Philip Wong Michael Postow Andrzej Mackiewicz Jacek Mackiewicz Dirk Schadendorff Dirk Jaeger Alan J Korman Keith Bahjat Michele Maio Luana Calabro Michele WL Teng Mark J Smyth Alexander Eggennont Caroline Robert Guido Kroemer Laurence Zitvogel | 2015 | Cell Research2015，25，2： | 14 |
| 2 | Shear-flexural strength mechanical model for the design and assessment of reinforced concrete beams subjected to point or distributed loads显示文摘最近为苗条增强的水泥的 shear 力量开发的一个机械模型微笑有或没有砍加强与一致地分布式的负担被介绍并且延长给元素,特殊在这份报纸集中于实际设计和评价。如果他们存在, shear 强度被认为是具体压缩弦转移的 shear 的和,沿着裂缝,由于张力的剩余和摩擦压力,由马镫并且,,由纵的加强。把简单表情基于结构的力学的原则为各个独立被导出砍转移行动并且为他们以最终的限制状态的相互作用。模型的预言与使用 EC2, MC2010 和 ACI 318-08 食物获得的那些相比,他们从最近出版的 ACI-DAfStb 数据库适合可得到的试验性的结果很好砍有或没有马镫的苗条增强的具体横梁上的测试。最后,一个详细应用程序例子被举了,获得到批评裂缝的 shear 力量和假定形状和位置的每个作出贡献的部件。 | Antonio MAIRI Antoni CLADERA Jesus BAIRAN Eva OLLER Carlos RIBAS | 2014 | Frontiers of Structural and Civil Engineering2014，8，4： | 5 |
| 3 | Effect of silymarin on biochemical indicators in patients with liver disease: systematic review with meta-analysis显示文摘AIM To evaluate the effect of silymarin on the serum levels of alanine aminotransferase(ALT),aspartate aminotransferase(AST) and gamma glutamyl transpeptidase(γGT) in patients with liver diseases. METHODS A systematic review with meta-analysis of ramdomized and controlled clinical trials was performed,evaluating the effects of sylimarin in patients with hepatic diseases,published by January 31,2016. Clinical trials were sought on the basis of The Cochrane Central Register of Controlled Trials in the Cochrane Library,Pub Med/Medline,Scopus,Web of Science,Lilacs and Clinical Trials. The trials with adult and elderly patients of both sexes,with Liver Diseases who took oral silymarin supplementation,as extract or isolated,as well as Silymarin combined with other nutrients,were included. The trials should provide information about the intervention,such as dosages and detailing of the product used,besides the mean and standard deviation of serum levels of ALT,AST and γGT of the baseline and at the end of the intervention.RESULTS An amount of 10904 publications were identified. From those,only 17 were included in the systematic review and 6 in the meta-analysis,according to the used selection criteria. In this meta-analysis,the results indicated a reduction of 0.26 IU/m L(95%CI:-0.46-0.07,P = 0.007) at the level of ALT and 0.53 IU/m L(95%CI:-0.74-0.32,P = 0.000) at the serum levels of AST after using the silymarin,both,statistically significant,but with no clinical relevance. There was no significant change in the γGT levels. Subgroup analyzes were also performed for the biochemical markers in relation to the type of intervention,whether silymarin isolated or associated with other nutrients and the time of intervention(whether ≥ 6 mo or < 6 mo). Significant differences were not found. The evaluated studies presented a high degree of heterogeneity and low methodological quality in the carried out analysis. CONCLUSION Silymarin minimally reduced,but without clinical relevance,the serum levels of ALT and AST. It is necessary to carry out studies with more appropriate methodological designs. | Camila Ribeiro de Avelar Emile Miranda Pereira Priscila Ribas de Farias Costa Rosangela Passos de Jesus Lucivalda Pereira Magalhaes de Oliveira | 2017 | World Journal of Gastroenterology2017，23，27： | 5 |
| 4 | 铌元素在锂离子电池中的应用显示文摘锂离子电池因其能量密度高、环境污染小等优点得到了广泛应用,但其仍然存在不容忽视的问题,电极材料结构劣化导致的电化学性能下降及热稳定性差等问题仍然比较严重,因此电极材料改性仍然是目前锂离子电池的研究重点。基于铌具有其自身独特的优势,将铌引入锂离子电池作为正极掺杂材料,可以提高电子导电性、提高稳定性、扩展Li+嵌入/脱出通道及降低阳离子混排程度;将铌引入锂离子电池作为负极活性材料,铌氧化物和铌基复合氧化物也表现出优异的电化学性能;在固态电解质中,铌既可以作为Li7La3Zr2O12的主要掺杂元素,也是Li5La3Nb2O12中的主要组成元素。本文通过对近期相关文献的梳理,对铌在锂离子电池领域中的应用进行了总结与分析,重点阐述了其掺杂作用机理及其在锂离子电池正极材料、负极材料和固态电解质中的应用。在锂离子电池正极材料中,介绍了Nb在一元材料、二元材料、三元材料以及聚阴离子材料中的研究与应用情况;在锂离子电池负极材料中,介绍了铌氧化物和铌基复合氧化物作为新型负极材料的研究与应用情况;在锂离子电池固态电解质中,介绍了铌的掺杂和应用情况。最后对Nb修饰电极材料的产业应用前景和可行性做了适当的分析。综合分析表明,铌在锂系列电池中的研究范围越来越广阔,应用不断深入,相信未来铌会在锂电池领域发挥更加重要的作用。 | 高鹏 张珊 贲留斌 赵文武 刘中柱 RIBAS Rogerio 朱永明 黄学杰 | 2020 | 储能科学与技术2020，9，5： | 3 |
| 5 | The primate median eminence显示文摘 | Prof. D. E. Scott Gerda Krobisch-Dudley W. K. Paull G. P. Kozlowski J. Ribas | 1975 | Cell and Tissue Research1975，，1： | 2 |
| 6 | Serum proinflammatory cytokines and nutritional status in pediatric chronic liver disease显示文摘AIM: To evaluate the nutritional status and its association with proinflammatory cytokines in children with chronic liver disease.METHODS: We performed a cross-sectional study with 43 children and adolescents, aged 0 to 17 years, diagnosed with chronic liver disease. All patients regularly attended the Pediatric Hepatology Unit and were under nutritional follow up. The exclusion criteria were fever from any etiology at the time of enrollment, inborn errors of the metabolism and any chronic illness. The severity of liver disease was assessed by Child-Pugh, Model for End-stage Liver Disease(MELD) and Pediatric End Stage Liver Disease(PELD) scores. Anthropometric parameters were height/age, body mass index/age and triceps skinfold/age according to World Health Organization standards. The cutoff points for nutritional status were risk of malnutrition(Z-score <-1.00) and malnutrition(Z-score <-2.00). Interleukin-1β(IL-1β), IL-6 and tumor necrosis factor-α levels were assessed by commercial ELISA kits. For multivariate analysis, linear regression was applied to assess the association between cytokine levels, disease severity and nutritional status. RESULTS: The median(25th-75 th centile) age of the study population was 60(17-116)-mo-old, and 53.5% were female. Biliary atresia was the main cause of chronic liver disease(72%). With respect to Child-Pugh score, cirrhotic patients were distributed as follows: 57.1% Child-Pugh A, a mild presentation of the disease, 34.3% Child-Pugh B, a moderate stage of cirrhosis and 8.6% Child-Pugh C, were considered severe cases. PELD and MELD scores were only above the cutoff point in 5 cases. IL-6 values were increased in patients at nutritional risk(34.9%) compared with those who were well-nourished [7.12(0.58-34.23) pg/m L vs 1.63(0.53-3.43) pg/m L; P = 0.02], correlating inversely with triceps skinfold-for-age z-score(rs =-0.61; P < 0.001). IL-6 levels were associated with liver disease severity assessed by Child-Pugh score(P = 0.001). This association remained significant after adjusting for nutritional status in a linear regression model. CONCLUSION: High IL-6 levels were found in children with chronic liver disease at nutritional risk. Inflammatory activity may be related to nutritional status deterioration in these patients. | Daniele Santetti Maria Inês de Albuquerque Wilasco Cristina Toscani Leal Dornelles Isabel Cristina Ribas Werlang Fernanda Urruth Fontella Carlos Oscar Kieling Jorge Luiz dos Santos Sandra Maria Goncalves Vieira Helena Ayako Sueno Goldani | 2015 | World Journal of Gastroenterology2015，21，29： | 2 |
| 7 | The Society of Thoracic Surgeons Expert Consensus for the Surgical Treatment of Hyperhidrosis显示文摘 | Robert J. Cerfolio Jose Ribas Milanez De Campos Ayesha S. Bryant Cliff P. Connery Daniel L. Miller Malcolm M. DeCamp Robert J. McKenna Mark J. Krasna | 2011 | The Annals of Thoracic Surgery2011，，5： | 2 |
| 8 | Molecular analysis of hypervirulent somatic hybrids of the entomopathogenic fungi Beauveria bassiana and Beauveria sulfurescens 显示文摘 | VIAUD M COULEAUDIER Y RIBA G | 1998 | Appl Environ Microbiol1998，64，1： | 1 |
| 9 | Immunotherapy for hepatocellular carcinoma显示文摘 | Butterfield LH Ribas A | 2002 | Exper Opin Biol Ther2002，2，2： | 1 |
| 10 | VEGFR1 - positive haematopoictic bone marrow progenitors initiate the pre - metastatic niche 显示文摘 | Kaplan RN Riba RD Zacharoulis S | 2005 | Nature2005，438，7069： | 1 |
| 11 | Prostate-targeted radiosensiti zation via aptamer-shRNA chimeras in human tumor xeno grafts显示文摘 | Ni X Zhang Y Ribas J | 2011 | J Clin Invest2011，121，6： | 1 |
| 12 | Characterization of the surface tension of vegetable oils to be used as fuel in diesel engines 显示文摘 | Esteban B Riba J R Baquero G | 2012 | Fuel2012，102，2： | 1 |
| 13 | Mechanisms of regulation of the expression and function of G protein-coupled recep- tor kinases 显示文摘 | Penela P Ribas C Mayor F Jr | 2003 | Cell Signal2003，15，11： | 1 |
| 14 | Video-nystagmography findings in healthy elderly subjects显示文摘 | Amor Dorado J C Rubio Rodríguez J P Costa Ribas C | 2003 | Acta Otorrinolaringol Esp2003，54，3： | 1 |
| 15 | Ferromagnetic Nickel ( Ⅱ ) polynuelear complexes with end-on azido as bridging ligand: The first Nickel ( Ⅱ)-azido one- dimensional ferromagnetic systems 显示文摘 | Ribas J Monfort M Diaz C | 1994 | Inorg Chem1994，33，： | 1 |
| 16 | Study of the effects of two-step aging heat treatment on fatigue crack growth on AA7050 aluminum alloy显示文摘 | RIBAS L JACUMASSO S C FIGUEIREDO T R | 2014 | Advanced Materials Research2014，，： | 1 |
| 17 | A late Neolithic expansion of Y chromosomal haplogroup O2a1-M95 from east to west显示文摘Y-Chromosomal haplogroup O2a1-M95 的起源和疏开,越过 Austro 分布式东方和南亚的亚洲说带,充分还有待于被理解。各种各样的研究也建议了一个东方印第安人或 O2a1-M95 的东南亚洲起源。我们从印度,老挝,和中国由采样 8748 人处理了古代的问题和 O2a1-M95 的疏开并且从从文学拿的另外的干涉区域把他们比作 3307 件样品。一个总数上的 haplogroup 频率和 Y-STR 数据的分析 2413 个 O2a1-M95 染色体表明老挝样品拥有了 O2a1-M95 的最高的频率(74%与> 0.5 )并且它的祖先的 haplogroups ( O2 *-P31, O *象有 14STR-median haplotype 的样品的一个更高的比例一样的-M175)( 17 取样在里面 14 张人口),深结合时间( 5.7 ± 0.3 Kya )和 consorted O2a1-M95 扩大从 STR 证实了进化。所有这些建议老挝将在学习区域之中带 O2a1-M95 的深古代。在西方的从东方的扩大时间的连续减少:在老挝,在东北印度的 5.2 ± 0.6,和在东方印度的 4.3 ± 0.2 的 5.7 ± 0.3 Kya,建议到西方的晚过时的东方从老挝系 O2a1-M95 传播了。 | GaneshPrasad Arunkumar Lan-Hai Wei Valampuri John Kavitha Adhikarla Syama Varatharajan Santhakumari Arun Surendra Sathua Raghunath Sahoo R. Balakrishnan Tomo Riba Jharna Chakravarthy Bapukan Chaudhury Premanada Panda Pradipta K. Das Prasanna K. Nayak Hui Li Ramasamy Pitchappan 无 | 2015 | Journal of Systematics and Evolution2015，53，6： | 1 |
| 18 | Rate control in DCT video coding for low delay communications显示文摘 | Ribas Corbera Jordi Lei Shawmin | 1999 | IEEE Transactions on Circutts and Systems for Video Technology1999，9，1： | 1 |
| 19 | Anthropometric values and cardiovascular risk factors in Canary Islands (1997-1998)显示文摘 | Navarro RMC Lainez SP Ribas BL | 2000 | Arch Latinoam Nutr2000，50，1： | 1 |
| 20 | An experimental study of the hydrodynamic characteristics of external loop airlift contactors显示文摘 | Bentifraouine C Xuereb C Riba J P | 1997 | Journal of Chemical Technology and Biotech- nology1997，69，3： | 1 |
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