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| 1 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 2 | Efficacy of photodynamic therapy in circumscribed choroidal hemangioma显示文摘 | Gupta M Singh AD Rundle PA | 2004 | Eye2004，18，2： | 1 |
| 3 | Motion automated perimetry identifies early glaucomatous field defects显示文摘 | Bosworth CF Sample PA Gupta N | 1998 | Arch Ophthalmol1998，116，9： | 1 |
| 4 | Motion automated perimetry identifies early glaueomatous field defects 显示文摘 | Bosworth CF Sample PA Gupta N | 1998 | Arch Ophthalmol1998，116，9： | 1 |
| 5 | Association between al buminuria, kidney Iunetion, and inflammatory biomarker profile inCKDin CRIC 显示文摘 | Gupta J Mitra N Kanetsky PA | 2012 | Clin J Am Soe Nephrol2012，7，12： | 1 |
| 6 | Efficacy of photodynamic therapy in circumscribed choroidal haemangioma显示文摘 | Gupta M Singh AD Rundle PA | 2004 | Eye2004，18，2： | 1 |
| 7 | Motion automated perimetry identifies early glaucomatous field defects显示文摘 | Bosworth CF Sample PA Gupta N Bathija R Weinreb RN | 1998 | Arch Ophthalmol1998，116，9： | 1 |
| 8 | Association between albu- minuria, kidney function, and infiammatory biomarker profile in CKD in CRIC显示文摘 | Gupta J Mitra N Kanetsky PA | 2012 | Clin J Am Soc Nephrol2012，7，： | 1 |
| 9 | Bovine pericardium(Ocuguard)wrap for hydroxyapatite implants显示文摘 | Gupta M Singh AD Rundle PA Rennie IG | | 0，，06： | 1 |
| 10 | Bovine pericardium (Tutopatch) wrap for hydroxyapatite implants显示文摘 | Gupta M Lyon F Singh AD Rundle PA Rennie IG | | 0，，： | 1 |
| 11 | Association between albumi- nufia, kidney function, and inflammatory biomarker profile in CKD in CRIC 显示文摘 | Gupta J Mitra N Kanetsky PA | 2012 | Clin J Am Soc Nephro12012，7，12： | 1 |
| 12 | Association between albuminuria, kidney function, and inflammatory biomarker profile in CKD in CRIC显示文摘 | GUPTA J MITRA N KANETSKY PA | 2012 | Clin J Am Soc Nephrol2012，7，12： | 1 |
| 13 | Bovine pericardium(Ocuguard)wrap for hydroxyapatite implants显示文摘 | Gupta M Singh AD Rundle PA | 2004 | Br J Ophthalmol2004，88，6： | 1 |
| 14 | Ten novel FBN2 mutations in congenital contractural arachnodactyly: delineation of the molecular pathogenesis and clinical phenotype显示文摘 | Gupta PA Putnam EA Carmical SG | 2002 | Hum Mutat2002，19，1： | 1 |
| 15 | Immunoassay of tear lysozyme in acute adenovirus conjunctivitis显示文摘 | Gupta AK Sarin GS Lamba PA | 1986 | Br J Ophthalmol1986，70，： | 1 |
| 16 | Relationship between parapapiLlary atrophy and visual field abnormality in primary open-angle glaucoma显示文摘 | Kono Y Zangwill L Sample PA Jonas JB Emdadi A Gupta N | 1999 | Am J Ophthalmol1999，127，6： | 1 |
| 17 | Tp-e/Q T ratio as an index of arrhyt hmogenesis显示文摘 | Gupta P Pa Telc Pa Telh | 2008 | J Electrocardiol2008，41，6： | 1 |
| 18 | Efficacy of photodynamic therapy in circumscribed choroidal haemangioma显示文摘 | Gupta M Singh AD Rundle PA | 2004 | Eye (London England)2004，18，2： | 1 |
| 19 | Placenta Previa and previous cesarean section显示文摘 | Singh P Rodrigues C Gupta PA | 1981 | Acta Obstet Gynecol Scand1981，60，4： | 1 |
| 20 | An investigation of an outbreak of viral hepatitis B in modasa town, gujarat, India显示文摘 | Patel DA Gupta PA Kinariwala DM | 2012 | l Glob Infect Dis2012，4，1： | 1 |
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