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| 1 | HPLC-MS法同时测定5种抗癫痫药的血药浓度显示文摘癫痫是神经系统的一种常见病,不少患者需长期同时服用两种或两种以上抗癫痫药物.本研究采用高效液相色谱-电喷雾离子化质谱法同时测定5种常用抗癫痫药物卡马西平、氯硝西泮、阿普唑仑、艾司唑仑和苯妥英钠的血药浓度,色谱条件为以地西泮作为内标,Zorbax SB-C18(30mm×2.1mm,3.5μm)为色谱柱,甲醇-25mM的乙酸铵水溶液梯度洗脱,样品采用无水乙醚萃取.样品分析以离子阱质谱作为检测器,采用多重反应监测模式(MRM),选择MS2离子提高方法的专属性,5种抗癫痫药物在50~5000ng/mL浓度范围内均具有良好的线性关系,其日内、日间精密度均小于10%,方法回收率均大于90%.研究表明,本方法专属性强,灵敏度高,线性关系良好,适用于这5种抗癫痫药物的血药浓度监测、个体化给药方案的制定、药物滥用监测以及药代动力学研究. | 陈琴华 Stefanie Weiβig 罗尚文 陈子林 | 2010 | 中国科学:化学2010，40，6： | 6 |
| 2 | A global assessment of recent trends in gastrointestinal cancer and lifestyle-associated risk factors显示文摘Background:Gastrointestinal(GI)cancers were responsible for 26.3%of cancer cases and 35.4%of deaths worldwide in 2018.This study aimed to analyze the global incidence,mortality,prevalence,and contributing risk factors of the 6 major GI cancer entities[esophageal cancer(EC),gastric cancer(GC),liver cancer(LC),pancreatic cancer(PC),colon cancer,and rectal cancer].Methods:Using the Global Cancer Observatory and the Global Health Observatory databases,we reviewed the current GI cancer incidence,prevalence,and mortality,analyzed the association of GI cancer prevalence with national human development indices(HDIs),identified the contributing risk factors,and estimated developing age-and sex-specific trends in incidence and mortality.Results:In 2020,the trend in age-standardized rate of incidence of GI cancers closely mirrored that of mortality,with the highest rates of LC,EC,and GC in Asia and of colorectal cancer(CRC)and PC mainly in Europe.Incidence and mortality were positively,but the mortality-to-incidence ratio(MIR)was inversely correlated with the national HDI levels.High MIRs in developing countries likely reflected the lack of preventive strategies and effective treatments.GI cancer prevalence was highest in Europe and was also positively correlated with HDIs and lifestyle-associated risk factors,such as alcohol consumption,smoking,obesity,insufficient physical activity,and high blood cholesterol level,but negatively correlated with hypertension and diabetes.Incidences of EC were consistently and those of GC mostly decreasing,whereas incidences of CRC were increasing in most countries/regions,especially in the younger populations.Incidences of LC and PC were also increasing in all age-gender populations except for younger males.Mortalities were decreasing for EC,GC,and CRC in most countries/regions, and age-specific trends were observed in PC and LC with adecrease in the younger but an increase in the older population.Conclusions: On the global scale, higher GI cancer burden was accompanied,for the most part, by factors associated with the so-called Western lifestylereflected by high and very high national HDI levels. In countries/regionswith very high HDI levels, patients survived longer, and increasing GI cancercases were observed with increasing national HDI levels. Optimizing GI cancer prevention and improving therapies, especially for patients with comorbidmetabolic diseases, are thus urgently recommended. | Lili Lu Christina S.Mullins Clemens Schafmayer Sebastian Zeißig Michael Linnebacher | 2021 | Cancer Communications2021，41，11： | 6 |
| 3 | Au–Pd单原子合金(SAA)催化剂的催化机理和成键分析:CO氧化反应显示文摘单原子催化剂(SACs)在催化科学领域引起了人们的广泛关注,包括被称为单原子合金(SAAs)的包含金属-金属键合的双金属催化剂.本文通过量子化学计算方法研究了Au–Pd单原子合金模型Au37Pd1上CO氧化反应的催化机理和成键分析,确定了CO@Au–Pd,O2@Au–Pd和CO/O2@Au–Pd等吸附构型的几何结构以及吸附物与底物间的结合能.Pd原子位于核芯位置的核-壳结构被证实为Au–Pd单原子合金的最稳定构型,该结构的稳定性来源于Pd原子向Au原子的电荷转移.根据结合能和化学成键分析,CO和O2分子均优先吸附在配位数低且位于顶点位置的Pd原子上.本文报道了一种新的CO和O2共吸附结构,其中CO和O2分别在两个相邻Au–Pd键上以垂直和平行桥联方式吸附,该Au–Pd单原子合金的CO氧化反应具有低能垒且遵循Langmuir-Hinshewood(L-H)机理.本文探讨了单原子合金催化剂中单原子在催化反应中的重要作用,可以为设计具有优异催化活性的新型单原子合金催化剂提供依据. | Sambath Baskaran 许聪俏 王阳刚 Ig nacio LGarzon 李隽 | 2020 | Science China Materials2020，63，6： | 5 |
| 4 | 蛋白磷酸酯酶在Alzheimer氏病tau蛋白异常磷酸化中的作用显示文摘用蛋白磷酸酯酸PP-2A、-2B和-1型分别处理的Alzheimer病(AD)异常磷酸化tau蛋白可不同程度恢复其促微管聚集和组装功能。PP-2A的恢复作用比PP-2B和PP-1更强.PP-2A,PP-2B和PP-1使异常tau蛋白水解释放磷酸的量分别为其总量的57%,36%和30%。tau蛋白Ser-235位的磷酸化不是决定其功能的关键位点,而Thr-231的磷酸化可能与微管组装早期的成核聚集作用有关。该研究证明:体内蛋白磷酸酯酶PP-2A,PP-2B和PP-1可能参与tau蛋白异常磷酸化过程,保持这些磷酸酯酶的活性有可能抑制AD神经原纤维退化. | 王建枝 Iqba.,IG | 1999 | 基础医学与临床1999，19，4： | 4 |
| 5 | 女性健康倡议单用雌激素试验中冠状动脉钙化与试验后心血管事件及死亡率的关系显示文摘参与女性健康倡议(women’s health initiative,WHI)单用雌激素(estrogen—alone,E—Alone)试验的年龄50~59岁的女性中,与安慰剂组相比,基线时随机使用合成雌激素的女性心肌梗死的风险和死亡率更低。 | 黄洁 叶鹏 Poornima IG Mackey RH Allison MA Manson JE Carr JJ LaMonte MJ Chang Y Kuller LH | 2017 | 中华高血压杂志2017，25，11： | 3 |
| 6 | The methionine synthase polymorphism D919G alters susceptibility to primary central nervous system lymphoma(英文)显示文摘Primary central nervous system lymphomas (PCNSL) frequently reveal genomic instability. We analysed different functional genetic variants affecting the folate and homocysteine metabolism important for DNA integrity in 31 PCNSL patients and 142 controls. We found significantly less carriers of the methionine synthase c. 2756A> G (D919G) missense polymorphism among the patients (0.16 vs 0.42; odds ratio 0.26, CI(95%): 0.09-0.74; P=0.005), suggesting a protective function of the G allele. These data stimulate further epidemiological and functional studies focusing on the role of homoeysteine and folate metabolism in lymphoma tumorigenesis. | Linnebank M Schmidt S Kolsch H Linnebank A Heun R Schmidt-Wolf IG Glasmacher A Fliessbach K Klockgether T Schlegel U Pels H | 2004 | 中国神经肿瘤杂志2004，2，2： | 3 |
| 7 | Vanadium compounds: biological actions and potential as pharmacological agents显示文摘 | Tsiani E Fantus IG | 1997 | Ttends Endocrinol Metab1997，8，： | 2 |
| 8 | Destabilization of acrosome and elastase influence mediate the release of secretory phospholipase A2 from human spermatozoa显示文摘 | Jacqueline Leβig Uta Reibetanz Jiirgen Arnhold Hans-Jtirgen Glander | 2008 | Asian Journal of Andrology2008，10，6： | 2 |
| 9 | 弯月面处浇铸条件的改善显示文摘 | Sauc.,IG 徐长青 | 1990 | 钢铁译文集1990，，3： | 2 |
| 10 | 新生大鼠腰交感神经节凋亡细胞的电镜观察显示文摘目的 :观察出生后早期大鼠腰交感神经节细胞凋亡超微结构变化特点。方法 :大鼠按出生后 1d、1w、2w和3w分组 ,取L3、L4交感神经节常规超薄切片 ,铅轴染色 ,透射电镜观察。结果 :1d 2w组腰交感神经节内可见到明显的神经节神经细胞胞体凋亡和突起的退变 ,同时可观察到包绕上述突起的雪旺细胞也发生凋亡。早期凋亡细胞的超微结构特点为核染色质在核膜下的凝集。结论 :出生后早期部分腰交感神经节神经细胞因未能与其靶区建立联系而凋亡 ,随后包绕凋亡神经细胞突起的雪旺细胞也发生凋亡。 | 王鹤鸣 Charyeva IG 韩群颖 Andrusova NG Pylaev AS 苏殿三 | 2002 | 解剖学杂志2002，25，4： | 2 |
| 11 | Epi-LASIK: comparative histological evaluation of mechanical and alcohol-assisted epithelial separation 显示文摘 | Pallikaris IG Naoumidi Ⅱ Kalyvianaki MI | 2003 | J Cataract Refract Surg2003，29，8： | 1 |
| 12 | Corneal ectasia inducedby laser in situ keratomileusis 显示文摘 | Pallikaris IG Kymionis GD Astyrakakis NI | 2001 | J Cataract Refract Surg2001，27，： | 1 |
| 13 | Individual cerebellar Purkinje cells express different cGMP phosphodiesterases (PDEs) : in vivo phosphorylation of cGMP-specific PDE (PDE5) as an indicator of eGMP-dependent protein kinase (PKG) activation 显示文摘 | Shimizu-Albergine M Rybalkin SD Rybalkina IG | 2003 | J Neurosei2003，23，16： | 1 |
| 14 | Early oxidative stress in the diabetic kidneyz effect of DL-alpha-lipoic acid显示文摘 | Obrosova IG Fathallth L Liu E etal | 2003 | Free Radic Biol Med2003，34，2： | 1 |
| 15 | Treatment of moderate mitral regurgitation and coronary disease by coronary bypass alone:late results显示文摘 | Duarte IG Shen Y Macdonald MJ | 1999 | Ann Thorac Surg1999，68，： | 1 |
| 16 | Role of nitrosative stress and peroxynitrite in the pathogenesis of diabetic complications,emerging new therapeutical strategies显示文摘 | Pacher P Obrosova IG Mabley JG | 2005 | Curr Med Chem2005，12，3： | 1 |
| 17 | Advances in subepthelial excimer refractive syrgery techniques:Epi-LASIK显示文摘 | Pallikaris IG Katsanevaki VJ Kalyvianaki MI | 2003 | Curr Opin Oph-thalmol2003，14，4： | 1 |
| 18 | Randomized placebo-controlled trial of long-term treatment with sibutramine in mild to moderate obesity显示文摘 | Goulder MA | 2001 | J Fam Pract2001，，50： | 1 |
| 19 | Excimer laser in situ keratom ileusis and photorefractive keratectomy for correction of high myopia显示文摘 | Siganos DS | 1994 | J Refract Corneal Surg1994，10，5： | 1 |
| 20 | A comparison of two adjunctive treatments for Intrauterine adhesions following lysis显示文摘 | Orhue AA Aziken ME Ig beeoh JO | 2003 | Int IGynecol Obstet2003，82，1： | 1 |
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