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| 1 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 2 | SRY-negative 46, XX male with normal genitals, complete masculinization and infertility显示文摘 | Rajender S Rajani V Gupta NJ | 2006 | Mol Hum Reprod2006，12，5： | 1 |
| 3 | Bone tissue engineering scaffolds of today and tomorrow 显示文摘 | Panetta NJ Gupta DM Longaker MT | 2009 | J Craniofac Surg2009，20，5： | 1 |
| 4 | Cardiac troponin Ⅰ predicts myocardial dysfunction and adverse outcome in septic shock显示文摘 | Mehta NJ Khan IA Gupta V | 2004 | Intern J Cardiol2004，95，1： | 1 |
| 5 | Feeder-free derivation of induced pluripotent stem cells from adult human adipose stem cells显示文摘 | Sun N Panetta NJ Gupta DM | | 0，，： | 1 |
| 6 | SRY-negative 46, XX male with normal genitals, complete mas- culinization and infertility显示文摘 | Rajender S Rajani V Gupta NJ | 2006 | Mol Hum Reprod2006，12，5： | 1 |
| 7 | A novel missense mutation C11994T in the mitochondrial ND4 gene as a cause of low sperm motility in the Indian subcontinent 显示文摘 | Selvi RD Vanniarajan A Gupta NJ | 2006 | Fertil Steril2006，86，6： | 1 |
| 8 | Cardiac troponin I predicts myocardial dysfunction and adverse outcome in septic shock显示文摘 | Mehta NJ Khan IA Gupta V | 2004 | Int J Cardiol2004，95，1： | 1 |
| 9 | Evaluation of a mixture of zinc oxide,calcium hydroxide,and sodium fluoride as a new root canal filling material for primary teeth显示文摘 | Chawla HS Setia S Gupta NJ | 2008 | Indian Soc Pedod Prey Dent2008，26，2： | 1 |
| 10 | Cardiac troponin I pre- dicts myocardial dysfunction and adverse outcome in septic shock显示文摘 | Mehta NJ Khan IA Gupta V | 2004 | Int J Cardiol2004，95，1： | 1 |
| 11 | SRY negative 46,XX male with normal genitals, complete masculinization and infertility显示文摘 | Rajender S Rajani V Gupta NJ | 2006 | Mol Hum Reprod2006，12，5： | 1 |
| 12 | SRY-negative 46, XX male with normal genitals, complete masculinization and infertility显示文摘 | Rajender S Rajani V Gupta Nj | 2006 | Mol Hum Rerod2006，12，5： | 1 |
| 13 | Cardiac troponin Ⅰ predicts myocardial dysfunction and adverse outcome in septic shock 显示文摘 | Mehta NJ Khana IA Gupta V | 2004 | Int J Cardiol2004，95，1： | 1 |
| 14 | Radical external beam radiotherapy for 333 squamous carcinomas of the oral cavityevaluation of late morbidity and a watch policy for the clinically negative neck显示文摘 | Turner SL Slevin NJ Gupta NK | 1996 | Radiother Oncol1996，41，1： | 1 |
| 15 | Mesenchymal cells for skeletal tissue engineering显示文摘 | Panetta NJ Gupta DM Quarto N | 2009 | Panminerva Med2009，51，1： | 1 |
| 16 | Radical external beam radiotherapy for 333 squamous carcinomas of the oral cavityevaluation of late morbidity and a watch policy for the clinically negative neck显示文摘 | Turner SL Slevin NJ Gupta NK | 1996 | Radiother Oncol1996，41，1： | 1 |
| 17 | Cardiac troponin I predicts myocardial dysfunction and adverse outcome in septic shock显示文摘 | Mehta NJ Khan IA Gupta V | 2004 | Int J Cardiol2004，95，1： | 1 |
| 18 | Cardiac troponin I predicts myocardial dysfunction and adverse outcome in septic shock显示文摘 | Mehta NJ Khan IA Gupta V et ai | 2004 | Int J Cardiol2004，95，1： | 1 |
| 19 | Feeder-free derivation of in- duced pluripotent stem cells from adult human adipose stem cells 显示文摘 | Sun N Panetta NJ Gupta DM | 2009 | Proc Natl Acad Sci USA2009，106，15： | 1 |
| 20 | Feeder-free derivation of induced pluripotent stem cells from adult human adipose stem cells 显示文摘 | Sun N Panetta NJ Gupta DM | 2009 | Proc Natl Acad Sci USA2009，106，15： | 1 |
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