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| 1 | Proton pump inhibitors and dysbiosis: Current knowledge and aspects to be clarified显示文摘Proton pump inhibitors (PPIs) are common medications within the practice of gastroenterology. These drugs, which act through the irreversible inhibition of the hydrogen/potassium pump (H+/K+-ATPase pump) in the gastric parietal cells, are used in the treatment of several acid-related disorders. PPIs are generally well tolerated but, through the long-term reduction of gastric acid secretion, can increase the risk of an imbalance in gut microbiota composition (i.e., dysbiosis). The gut microbiota is a complex ecosystem in which microbes coexist and interact with the human host. Indeed, the resident gut bacteria are needed for multiple vital functions, such as nutrient and drug metabolism, the production of energy, defense against pathogens, the modulation of the immune system and support of the integrity of the gut mucosal barrier. The bacteria are collected in communities that vary in density and composition within each segment of the gastrointestinal (GI) tract. Therefore, every change in the gut ecosystem has been connected to an increased susceptibility or exacerbation of various GI disorders. The aim of this review is to summarize the recently available data on PPI-related microbiota alterations in each segment of the GI tract and to analyze the possible involvement of PPIs in the pathogenesis of several specific GI diseases. | Giovanni Bruno Piera Zaccari Giulia Rocco Giulia Scalese Cristina Panetta Barbara Porowska Stefano Pontone Carola Severi | 2019 | World Journal of Gastroenterology2019，25，22： | 4 |
| 2 | Chronic pancreatitis as presentation of Crohn's disease in a child显示文摘It is reported that a pancreatic disease may precede the diagnosis of inflammatory bowel disease(IBD) both in children and in adults.Idiopathic chronic pancreatitis,however,occasionally co-exists with the IBD,mainly at pediatric age.We report a case of a patient who progressively developed the features of a chronic pancreatitis,before the diagnosis of Crohn's Disease(CD).Ten months after the onset of the first episode of pancreatitis the patient developed bloody diarrhea,mucus stools and biochemical findings of inflammation.The colonoscopy revealed a diffuse colitis without involvement of the last loop and the gastroscopy showed inflammation of the iuxta-papillary area.The histological findings confirmed the diagnosis of CD that involved the colon and the duodenum.In conclusion,in children the idiopathic chronic pancreatitis may be an unusual presentation of CD.Thus,if other known cause of chronic pancreatitis are not found,a not invasive work up to exclude the IBD should be warranted.An early coincidental diagnosis of the IBD may delay the progression of the pancreatic disease. | Daniela Knafelz Fabio Panetta Lidia Monti Fiammetta Bracci Bronislava Papadatou Giuliano Torre Luigi Dall'Oglio Antonella Diamanti | 2013 | World Journal of Gastroenterology2013，19，31： | 2 |
| 3 | Polyp detection rates using magnification with narrow band imaging and white light显示文摘AIM: To compare the yield of adenomas between narrow band imaging and white light when using high definition/magnification. METHODS: This prospective, non-randomized comparative study was performed at the endoscopy unit of veteran affairs medical center in Phoenix, Arizona. Consecutive patients undergoing first average risk colorectal cancer screening colonoscopy were selected. Two experienced gastroenterologists performed all the procedures that were blinded to each other's findings. Demographic details were recorded. Data are presented as mean ± SEM. Proportional data were compared using the χ2 test and means were compared using the Student's t test. Tandem colonoscopy was performed in a sequential and segmental fashion using one of 3 strategies: white light followed by narrow band imaging [Group A: white light(WL) → narrow band imaging(NBI)]; narrow band imaging followed by white light(Group B: NBI → WL) and, white light followed by white light(Group C: WL → WL). Detection rate of missed polyps and adenomas were evaluated in all three groups. RESULTS: Three hundred patients were studied(100 in each Group). Although the total time for the colonoscopy was similar in the 3 groups(23.8 ± 0.7, 22.2 ± 0.5 and 24.1 ± 0.7 min for Groups A, B and C, respectively), it reached statistical significance between Groups B and C(P < 0.05). The cecal intubation time in Groups B and C was longer than for Group A(6.5 ± 0.4 min and 6.5 ± 0.4 min vs 4.9 ± 0.3 min; P < 0.05). The withdrawal time for Groups A and C was longer than Group B(18.9 ± 0.7 min and 17.6 ± 0.6min vs 15.7 ± 0.4 min; P < 0.05). Overall miss rate for polyps and adenomas detected in three groups during the second look was 18% and 17%, respectively(P = NS). Detection rate for polyps and adenomas after first look with white light was similar irrespective of the light used during the second look(WL → WL: 13.7% for polyps, 12.6% for adenomas; WL → NBI: 14.2% for polyps, 11.3% for adenomas). Miss rate of polyps and adenomas however was significantly higher when NBI was used first(29.3% and 30.3%, respectively; P < 0.05). Most missed adenomas were ≤ 5 mm in size. There was only one advanced neoplasia(defined by size only) missed during the first look. CONCLUSION: Our data suggest that the tandem nature of the procedure rather than the optical techniques was associated with the detection of additional polyps' and adenomas. | Nooman Gilani Sally Stipho James D Panetta Sorin Petre Michele A Young Francisco C Ramirez | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，5： | 2 |
| 4 | Transform coefficient histogram-based image enhancement algorithms using contrast entropy 显示文摘 | Agaian S Silver B and Panetta K A | 2007 | IEEE Transactions on Image Processing2007，16，3： | 1 |
| 5 | Telomere length maintenance in aging and carcinogenesis显示文摘 | Maisano R Panetta S | 2000 | Int J Oncol2000，17，5： | 1 |
| 6 | Incidence,correlates,management,and clinical outcome of coronary perforation:analysis of 16298 procedures显示文摘 | Fasseas P Orford JL Panetta CJ | 2004 | Am Heart J2004，147，1： | 1 |
| 7 | Feeder-free deriva- tion of induced pluripotent stem cells from adult human adipose stem cells显示文摘 | Sun N Panetta N J Gupta DM | 2009 | Proc Natl Acad Sci U S A2009，106，15： | 1 |
| 8 | UGT1A1 promoter genotype correlates with SN-38 pharmacokinetics,but not severe toxicity in patients receiving low-dose irinotecan显示文摘 | Stewart CF Panetta JC O’Shaughnessy MA | 2007 | J Clin Oncol2007，25，18： | 1 |
| 9 | Methotrexate intracellular disposition in acute lymphoblastic leukemia:A mathematical model of γ-glutamyl hydrolase activity显示文摘 | Panetta J C Wall A Pui C H | 2002 | Clin Cancer Res2002，8，7： | 1 |
| 10 | Telomere length maintenance in aging and carcimgenesis显示文摘 | ARAGONA M MAISANO R PANETTA S | 2000 | Int J Oncol2000，17，5： | 1 |
| 11 | Lipoprotein (a) binds and inactivates tissue factor pathway inhibitor: a novel link between lipoproteins and thrombosis显示文摘 | Caplice NM Panetta C Peter son TE | 2001 | Blood2001，98，10： | 1 |
| 12 | Arterial embolectomy: a 34 year experience with 400 cases显示文摘 | Panetta T Thompson J Talkington C | 1986 | Surg Clin North Am1986，66，： | 1 |
| 13 | Smooth muscle progenitor cello is human blood显示文摘 | Simper D Stalboerger PG Panetta C J | 2002 | Circulation2002，106，10： | 1 |
| 14 | Why do companies go public显示文摘 | Pagano M Panetta F Zingales L | | 0，，01： | 1 |
| 15 | Population pharmacoki- netic studies in pediatrics: issues in design and analysis 显示文摘 | Meibohm B Laer S Panetta JC | 2005 | AAPS J2005，7，2： | 1 |
| 16 | Transluminally placed endovascular stented graft repair for arterial trauma显示文摘 | Marin ML Veith FJ Panetta TF | 1994 | Journal of Vascular Surgery1994，20，3： | 1 |
| 17 | Behaviour of Buried and Surface-sown Seeds ofParthenium hysterophoms显示文摘 | NAVIES C PANETTA F D MCFADYEN R E | 1998 | Weed Res1998，38，33： | 1 |
| 18 | Percutaneous transfemoral insertion of a stented graft to repair a traumatic femoral ar- teriovenous fistula显示文摘 | Matin ML Veith FJ Panetta TF | 1993 | Journal of Vascular Surgery1993，18，2： | 1 |
| 19 | Hay fever and asthma in relation to markers of infection in the United States显示文摘 | Matricardi PM Rosmini F Panetta V | 2002 | J Allergy Clin Immunol2002，110，3： | 1 |
| 20 | Repair of type IV thoracoabdominal aneurysm with a combined endovascular and surgical approach显示文摘 | Quinones-Baldrich WJ Panetta TF Vescera CL | 1999 | J Vasc Surg1999，30，3： | 1 |
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