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| 1 | 帕博利珠单抗治疗伴脑转移NSCLC患者的一项非随机、开放Ⅱ期试验的长期随访结果和生物标志物分析显示文摘背景与目的我们开展了一项帕博利珠单抗用于伴未治疗脑转移的非小细胞肺癌(non-small cell lung cancer,NSCLC)或黑色素瘤患者的疗效和安全性的II期试验,旨在评估程序性死亡受体1(programmed cell death 1,PD-1)抑制剂在中枢神经系统(central nervous system,CNS)中的疗效。中期结果已发表,现报道对NSCLC队列的更新分析结果。方法这是一项开放性、单中心、II期试验。纳入标准:年龄≥18岁,诊断为晚期NSCLC并伴有≥1个5 mm-20 mm脑转移病灶,既往从未治疗或之前放疗后进展,无神经系统症状,不需要激素治疗且美国东部肿瘤协作组(Eastern Cooperative Oncology Group,ECOG)<2分。患者每2周接受一次帕博利珠单抗(10 mg/kg)治疗。队列1为程序性死亡配体1(programmed cell death ligand 1,PD-L1)≥1%的患者,队列2为PD-L1<1%或未评估的患者。主要终点是脑转移患者缓解比例。所有经治患者均纳入疗效与安全性终点的分析。该研究已结束入组,并于Clinicaltrials.gov登记注册,注册号为NCT02085070。结果2014年3月31日-2018年5月21日,共42例患者接受治疗。中位随访时间为8.3个月(IQR:4.5个月-26.2个月)。队列1的37例患者中11例有脑转移缓解[29.7%(95%CI:15.9%-47.0%)]。队列2未观察到缓解。治疗相关的3级-4级不良事件(adverse events,AEs)包括2例肺炎、1例全身症状、1例结肠炎、1例肾上腺皮质功能不全、1例高血糖症和1例低钾血症。6例(14%)患者发生了治疗相关的严重不良事件,包括肺炎、急性肾损伤、低钾血症和肾上腺皮质功能不全。没有观察到治疗相关死亡病例。结论帕博利珠单抗治疗PD-L1≥1%的NSCLC伴脑转移患者有效,且对所有纳入的未经治疗的脑转移患者安全。需要进一步探索免疫治疗用于NSCLC合并CNS转移。 | Sarah B GOLDBERG Kurt A SCHALPER Scott N GETTINGER Amit MAHAJAN Roy S HERBST Anne C CHANG Rogerio LILENBAUM Frederick H WILSON Sacit Bulent OMAY James B YU Lucia JILAVEANU Thuy TRAN Kira PAVLIK Elin ROWEN Heather GERRSH Annette KOMLO Richa GUPTA Hailey WYATT Matthew RIBEIRO Yuval KLUGER Geyu ZHOU Wei WEI Veronica L CHANG Harriet M KLUGER 董晓荣(翻译/校对) | 2021 | 中国肺癌杂志2021，24，9： | 34 |
| 2 | Blumgart's technique of pancreaticojejunostomy: Analysis of safety and outcomes显示文摘Background: Blumgart's pancreaticojejunostomy(PJ) has been described with low pancreatic leak rates. This study aimed to evaluate our experience with this technique regarding the pancreatic leak and other perioperative outcomes. Methods: We performed a single-center retrospective analysis of a cohort of 81 patients who underwent pancreaticoduodenectomy in our department from January 2011 to February 2018. The primary endpoint was the occurrence of a clinically relevant postoperative pancreatic fistula(CR-POPF) and analysis of its risk factors. Results: The CR-POPF rate was 12.3%. Fistula risk score(FRS) was the only significant risk factor for the occurrence of overall POPF in multivariate analysis. However, none of the other factors including FRS was found to be significantly associated with CR-POPF risk. A strong positive correlation was found between the CR-POPF and the incidence of delayed gastric emptying, post-pancreatectomy hemorrhage and increased length of hospital stay. Conclusion: Blumgart's technique is a safe technique of pancreatico-enteric anastomosis with low rates of CR-POPF. CR-POPF with this technique is independent of most of the preoperative and intraoperative factors. Therefore, this technique can be used for all types of the pancreas with consistently good results. | Vishal Gupta Saket Kumar Vivek Gupta Pradeep Joshi Rahul Rahul Rakesh Kumar Yadav Amit Dangi Abhijit Chandra | 2019 | Hepatobiliary & Pancreatic Diseases International2019，18，2： | 8 |
| 3 | Multicenter study on endoscopic ultrasound‐guided expandable biliary metal stent placement: Choice of access route, direction of stent insertion, and drainage route显示文摘 | Vinay Dhir Everson L. A. Artifon Kapil Gupta Juan J. Vila Roberta Maselli Mariana Frazao Amit Maydeo | 2014 | Digestive Endoscopy2014，，3： | 5 |
| 4 | Surrogate-based modeling and dimension reduction techniques for multi-scale mechanics problems显示文摘Successful modeling and/or design of engineering systems often requires one to address the impact of multiple 'design variables' on the prescribed outcome.There are often multiple,competing objectives based on which we assess the outcome of optimization.Since accurate,high fidelity models are typically time consuming and computationally expensive,comprehensive evaluations can be conducted only if an efficient framework is available.Furthermore,informed decisions of the model/hardware's overall performance rely on an adequate understanding of the global,not local,sensitivity of the individual design variables on the objectives.The surrogate-based approach,which involves approximating the objectives as continuous functions of design variables from limited data,offers a rational framework to reduce the number of important input variables,i.e.,the dimension of a design or modeling space.In this paper,we review the fundamental issues that arise in surrogate-based analysis and optimization,highlighting concepts,methods,techniques,as well as modeling implications for mechanics problems.To aid the discussions of the issues involved,we summarize recent efforts in investigating cryogenic cavitating flows,active flow control based on dielectric barrier discharge concepts,and lithium(Li)-ion batteries.It is also stressed that many multi-scale mechanics problems can naturally benefit from the surrogate approach for 'scale bridging.' | Wei Shyy Young-Chang Cho Wenbo Du Amit Gupta Chien-Chou Tseng Ann Marie Sastry | 2011 | Acta Mechanica Sinica2011，27，6： | 4 |
| 5 | Traumatic cardiac injury: Experience from a level-1 trauma centre显示文摘 | Biplab Mishra Amit Gupta Sushma Sagar Maneesh Singhal Subodh Kumar | 2016 | Chinese Journal of Traumatology2016，19，6： | 4 |
| 6 | Gut microbiota and liver disease显示文摘 | Amit Goel Mahesh Gupta Rakesh Aggarwal | 2014 | J Gastroenterol Hepatol2014，，6： | 4 |
| 7 | 材料模型对高温Ti-6Al-4V合金理论成形极限图预测的影响(英文)显示文摘成形极限图是一种用来描述使板材不发生局部颈缩所需最大主应变的重要图形。它是一种预测板材变形过程中变形极限的方便、有效的工具。本研究中,在400°C和不同样品宽度的条件,通过Nakazima实验得到了Ti-6Al-4V合金的成形极限图。此外,为了使用成形极限图对材料参数进行理论预测,提出了不同的各向异性屈服准则(Barlat 1989,Barlat 1996,Hill 1993)和不同的硬化模型(Hollomon幂定律、Johnson-Cook(JC)模型、改进的Zerilli-Armstrong(m-ZA)和Arrhenius(m-Arr)模型)。结合所提出的屈服准则和本构模型,通过Marciniak和Kuczynski(M-K)理论确定了Ti-6Al-4V合金的成形极限图。结果表明:屈服模型对材料成形极限图的影响大于本构模型的影响。然而,材料的厚度缺陷系数(f_0)与其硬化模型密切相关。Hill(1993)屈服准则最适合于成形极限图右边区域的预测,而Barlat(1989)屈服准最适合于成形极限图左边区域的预测。由于所得到的混合理论成形极限图兼具Barlat(1989)和Hill(1993)屈服模型和m-Arr硬化模型的优点,因此,它与实验得到的成形极限图吻合很好。 | Nitin KOTKUNDE Sashank SRINIVASAN Geetha KRISHNA Amit Kumar GUPTA Swadesh Kumar SINGH | 2016 | Transactions of Nonferrous Metals Society of China2016，26，3： | 2 |
| 8 | Formability of galvanized interstitial-free steel sheets显示文摘 | Amit Kumar Gupta D. Ravi Kumar | 2005 | Journal of Materials Processing Tech2005，，2： | 2 |
| 9 | Adequacy of esophageal squamous mucosa specimens obtained during endoscopy: are standard biopsies sufficient for postablation surveillance in Barrett’s esophagus?显示文摘 | Neil Gupta Sharad C. Mathur John A. Dumot Vikas Singh Srinivas Gaddam Sachin B. Wani Ajay Bansal Amit Rastogi John R. Goldblum Prateek Sharma | 2012 | Gastrointestinal Endoscopy2012，，： | 2 |
| 10 | Deep Learning Based Automated Detection of Diseases from Apple Leaf Images显示文摘In Agriculture Sciences, detection of diseases is one of the mostchallenging tasks. The mis-interpretations of plant diseases often lead towrong pesticide selection, resulting in damage of crops. Hence, the automaticrecognition of the diseases at earlier stages is important as well as economicalfor better quality and quantity of fruits. Computer aided detection (CAD)has proven as a supportive tool for disease detection and classification, thusallowing the identification of diseases and reducing the rate of degradationof fruit quality. In this research work, a model based on convolutional neuralnetwork with 19 convolutional layers has been proposed for effective andaccurate classification of Marsonina Coronaria and Apple Scab diseases fromapple leaves. For this, a database of 50,000 images has been acquired bycollecting images of leaves from apple farms of Himachal Pradesh (H.P)and Uttarakhand (India). An augmentation technique has been performedon the dataset to increase the number of images for increasing the accuracy.The performance analysis of the proposed model has been compared with thenew two Convolutional Neural Network (CNN) models having 8 and 9 layersrespectively. The proposed model has also been compared with the standardmachine learning classifiers like support vector machine, k-Nearest Neighbour, Random Forest and Logistic Regression models. From experimentalresults, it has been observed that the proposed model has outperformed theother CNN based models and machine learning models with an accuracy of99.2%. | Swati Singh Isha Gupta Sheifali Gupta Deepika Koundal Sultan Aljahdali Shubham Mahajan Amit Kant Pandit | 2022 | Computers, Materials & Continua2022，，4： | 2 |
| 11 | Lattice Boltzmann simulation to study multiple bubble dynamics显示文摘 | Amit Gupta Ranganathan Kumar | 2008 | International Journal of Heat and Mass Transfer2008，，21： | 2 |
| 12 | Blunt traumatic superior gluteal artery pseudoaneurysm presenting as gluteal hematoma without bony injury: A rare case report显示文摘 | Annu Babu Amit Gupta Pawan Sharma Piyush Ranjan Atin Kumar | 2016 | Chinese Journal of Traumatology2016，19，4： | 2 |
| 13 | Metallurgical Studies of Austenitic Stainless Steel 304 under Warm Deep Drawing显示文摘Austenitic stainless steel 304 was deep drawn with different blank diameters under warm conditions using20 thydraulic press.A number of deep drawing experiments both at room temperature and at 150℃ were conducted to study the metallography.Also,tensile test experiments were conducted on a universal testing machine up to 700 ℃and the broken specimens were used to study the fractography of the material using scanning electron microscopy in various regions.The microstructure changes were observed at limiting draw ratio(LDR)when the cup is drawn at different temperatures.In austenitic stainless steel,martensite formation takes place that is not only affected by temperature,but also influenced by the rate at which the material is deformed.In austenitic stainless steel 304,dynamic strain regime appears above 300℃ and it decreases the formability of material due to brittle fracture as studied in its fractography.From the metallographic studies,the maximum LDR of the material is observed at 150 ℃ before dynamic strain regime.It is also observed that at 150 ℃,grains are coarse in the drawn cups at LDR. | Jayahari Lade Balu Naik Banoth Amit Kumar Gupta Swadesh Kumar Singh | 2014 | Journal of Iron and Steel Research(International)2014，21，12： | 2 |
| 14 | Gallbladder perforation:A single-center experience in north India and a step-up approach for management显示文摘Background: Spontaneous gallbladder perforation(GBP) is an uncommon diagnosis. This study presented the experience of managing spontaneous GBP over nine years at a large, tertiary care university hospital in north India and investigated the outcomes and treatment strategies. Methods: A retrospective review of prospectively maintained digital database of consecutive patients was performed. All patients received medical and/or surgical treatment for spontaneous GBP in our department between January 2010 and June 2018. Results: We identifed 151 patients(81 females and 70 males) with mean age of 53 years. Most common presenting features were pain(96.7%), fever(54.3%) and jaundice(31.1%). Most common cause was gallbladder stones(84.8%) followed by common bile duct stones(30.5%), xanthogranulomatous cholecystitis(17.9%) and malignancy(11.9%). As per Niemeier classifcation, 8.6% had type 1 GBP(free perforation in peritoneal cavity), 76.2% had type 2 GBP(localized perforation) and 13.2% had type 3 GBP(cholecystoenteric fstula). About 60% of the perforations were diagnosed preoperatively. Type 1 was more common in patients with diabetes and also had the worst prognosis. Surgery was performed in 109 patients(72.2%). Seven patients(4.6%) had a postoperative morbidity of Clavien-Dindo Ⅲ or higher. There were three mortalities in patients who underwent surgery. Conclusions: High index of suspicion is required for preoperative diagnosis of GBP, especially in types 2 and 3. Laparoscopic cholecystectomy can be difficult in these patients and patients may require open or partial cholecystectomy. Early diagnosis and step-up approach for the treatment of GBP is critical. | Vivek Gupta Abhijit Chandra Vishal Gupta Ravi Patel Amit Dangi Ajay Pai | 2022 | Hepatobiliary & Pancreatic Diseases International2022，21，2： | 2 |
| 15 | A prospective, single-blind, randomized, controlled trial of EUS-guided FNA with and without a stylet显示文摘 | Amit Rastogi Sachin Wani Neil Gupta Vikas Singh Srinivas Gaddam Savio Reddymasu Ozlem Ulusarac Fang Fan Maria Romanas Katie L. Dennis Prateek Sharma Ajay Bansal Melissa Oropeza-Vail Mojtaba Olyaee | 2011 | Gastrointestinal Endoscopy2011，，1： | 1 |
| 16 | An experimental study of the effects of water mist characteristics on pool fire suppression显示文摘 | Meenakshi Gupta Amit Pasi Anjan Ray S.R. Kale | 2013 | Experimental Thermal and Fluid Science2013，，： | 1 |
| 17 | A simple space vector PWM scheme to operate a three-level NPC inverter at high modulation index including overmodulation region, with neutral point balancing显示文摘 | Amit Kumar Gupta Ashwin M Khambadkone | 2007 | IEEE Transactions on Industry Applications2007，43，3： | 1 |
| 18 | Study of the adjuvantici-ty of lysine lipopeptides;carbamate analogs elicit strong Th1and Th2response to ovalbumin in mice显示文摘 | Ismail Tabasum Shafi Syed Gupta Amit | 2011 | International Immunopharmacology2011，11，11： | 1 |
| 19 | Hybrid Mode Switched Control of DC-DC Boost Converter Circuits显示文摘 | Pawan Gupta Amit Pattra | 2005 | IEEE transactions on Circuit and Systems II2005，52，11： | 1 |
| 20 | Gallic acid based steroidal phenstatin analogues for selective targeting of breast cancer cells through inhibiting tubulin polymerization显示文摘 | Swati Parihar Atul Gupta Amit K | 2012 | Sterodis2012，77，89： | 1 |
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