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| 1 | Genetic and biological characteristics of the globally circulating H5N8 avian influenza viruses and the protective efficacy offered by the poultry vaccine currently used in China显示文摘The H5N8 avian influenza viruses have been widely circulating in wild birds and are responsible for the loss of over 33 million domestic poultry in Europe, Russia, Middle East, and Asia since January 2020. To monitor the invasion and spread of the H5N8 virus in China, we performed active surveillance by analyzing 317 wild bird samples and swab samples collected from 41,172 poultry all over the country. We isolated 22 H5N8 viruses from wild birds and 14 H5N8 viruses from waterfowls. Genetic analysis indicated that the 36 viruses formed two different genotypes: one genotype viruses were widely detected from different wild birds and domestic waterfowls;the other genotype was isolated from a whopper swan. We further revealed the origin and spatiotemporal spread of these two distinct H5N8 virus genotypes in 2020 and 2021. Animal studies indicated that the H5N8 isolates are highly pathogenic to chickens, mildly pathogenic in ducks, but have distinct pathotypes in mice. Moreover, we found that vaccinated poultry in China could be completely protected against H5N8 virus challenge. Given that the H5N8 viruses are likely to continue to spread in wild birds, vaccination of poultry is highly recommended in high-risk countries to prevent H5N8 avian influenza. | Pengfei Cui Xianying Zeng Xuyong Li Yanbing Li Jianzhong Shi Conghui Zhao Zhiyuan Qu Yanwen Wang Jing Guo Wenli Gu Qi Ma Yuancheng Zhang Weipeng Lin Minghui Li Jingman Tian Dongxue Wang Xin Xing Yanjing Liu Shuxin Pan Yaping Zhang Hongmei Bao Liling Liu Guobin Tian Chengjun Li Guohua Deng Hualan Chen | 2022 | Science China(Life Sciences)2022，65，4： | 12 |
| 2 | Bone marrow and the control of immunity显示文摘Bone marrow is thought to be a primary hematopoietic organ. However, accumulated evidences demonstrate that active function and trafficking of immune cells, including regulatory T cells, conventional T cells, B cells, dendritic cells, natural killer T (NKT) cells, neutrophils, myeloid-derived suppressor cells and mesenchymal stem cells, are observed in the bone marrow. Furthermore, bone marrow is a predetermined metastatic location for multiple human tumors. In this review, we discuss the immune network in the bone marrow. We suggest that bone marrow is an immune regulatory organ capable of fine tuning immunity and may be a potential therapeutic target for immunotherapy and immune vaccination. | Ende Zhao Huanbin Xu Lin Wang Ilona Kryczek Ke Wu Yu Hu Guobin Wang Weiping Zou | 2012 | Cellular & Molecular Immunology2012，9，1： | 3 |
| 3 | DEM SIMULATION OF LIQUEFACTION FOR GRANULAR MEDIA UNDER UNDRAINED AXISYMMETRIC COMPRESSION AND PLANE STRAIN CONDITIONS显示文摘Based on three dimensional (3D) Discrete Element Method (DEM), the paper presents simulation results of undrained tests on loose assemblies of polydisperse spheres under axisymmetric compression and plane strain conditions using a periodic cell. In the present work, undrained tests were modelled by deforming the samples under constant volume conditions. The undrained (effective) stress paths are shown to be qualitatively similar to experimental results in literature. A microscopic parameter in terms of redundancy factor (RF) is used to identify the onset of liquefaction (or temporary liquefaction), with the condition of RF equal to unity defining the transition from 'solid-like' to 'liquid-like' behaviour. It is found that the undrained behaviour is governed by the evolution of redundancy factor under both undrained axisymmetric compression and plane strain conditions, and a reversal of deviatoric stress in stress path for medium loose systems occurs due to the fact that the system becomes a structural mechanism (RF<1) transiently at the microscopic level during the evolution. | Guobin Gong Peng Lin Yawei Qin Jun Wei | 2012 | Acta Mechanica Solida Sinica2012，25，6： | 2 |
| 4 | Enhanced carbon solubility in solvent for SiC rapid solution growth:Thermodynamic evaluation of Cr-Ce-Si-C system显示文摘The carbon dissolution in solvent plays a key role in the process of solution growth route for SiC single crystal,which could determine the growth rate and quality of the products.However,the carbon dissolving ability of binary alloy solvent still needs to be improved.Here,we demonstrate the improved carbon dissolution and enlarged carbon supersaturation in Cr-Ce-Si ternary solvent,showing great potential for SiC solution growth.The phase relations of Cr-Ce-Si-C system were determined by using CALPHAD method based on thermodynamic parameters of CeCr_(2)Si_(2)C.It is indicated that the Cr-Ce-Si ternary solvent shows much larger carbon solubility in temperature range from 1700 to 2000℃compared to Cr-Si binary one,Furthermore,the carbon supersaturation in solvent is also significantly increased in low temperature range after the addition of Ce,leading to a rapid growth rate.Our work not only demonstrates the feasibility of adding Ce in the alloy solvent for rapid growth of SiC crystal,but also provides an example for investigating the C solubility in ternary solvent. | Lingling Guo Guobin Wang Jiawei Lin Zhongnan Guo Zesheng Zhang Hui Li Zhanmin Cao Wenxia Yuan | 2023 | Journal of Rare Earths2023，41，8： | 1 |
| 5 | TRIM28 protects CARM1 from proteasome-mediated degradation to prevent colorectal cancer metastasis显示文摘TRIM28 (Tripartite motif-containing protein 28), a member of TRIM family, is aberrantly expressed and reportedly has different functions in many types of human cancer. However, the biological roles of TRIM28 and related mechanism in colorectal cancer (CRC) remain unclear. Here, we showed that TRIM28 was downregulated in colorectal cancer compared with normal mucosa, especially at advanced stages, and acted as an independent prognostic factor of favorable outcome. Functional studies demonstrated that TRIM28 restrained CRC migration and invasion in vitro and in vivo. Mechanistically, we reported that CARM1 (co-activator-associated arginine methyltransferase1) was a critical player downstream of TRIM28. TRIM28 interacted with CARM1, and protected CARM1 from proteasome-mediated degradation through physical protein-protein interaction to suppress CRC metastasis. Further, TRIM28 suppressed the migration and invasion of CRC cells through inhibiting WNT/β-catenin signaling in a CARM1-dependent manner, but independent of CARM1′s methyltransferase activity. The protein expression of CARM1 was positively correlated with TRIM28 in CRC tissues. Patients with high levels of TRIM28 and CARM1 had improved prognosis, whereas patients with low TRIM28 and CARM1 expression had the poor outcomes. Thus, our study reveals an inhibitory role of TRIM28 in CRC metastasis, which was achieved through a TRIM28-CARM1-WNT/β-catenin axis. This work provides potential prognostic and therapeutic targets for CRC treatment. | Jinyuan Cui Jia Hu Zhilan Ye Yongli Fan Yuqin Li Guobin Wang Lin Wang Zheng Wang | 2019 | Science Bulletin2019，64，14： | 1 |
| 6 | Sericin microparticles enveloped with metal-organic networks as a pulmonary targeting delivery system for intra-tracheally treating metastatic lung cancer显示文摘Chemotherapy is one of the major approaches for the treatment of metastatic lung cancer.However,systemic chemotherapy is limited by poor therapeutic efficiency and severe toxic side effects,due to the extremely low delivery efficacy and non-specificity of anticancer drugs.Herein,we report a sericin microparticles enveloped with metal-organic networks as a pulmonary delivery system for treating lung metastasis of breast cancer in an animal model.The sericin microparticles(SMPs)were prepared using water in oil(w/o)emulsification method.After doxorubicin(DOX)loading,tannic acid(TA)/ferric irons(Fe3+)based metal organic networks(MON)were coated on the particles to obtain DOX-loaded microparticles(DOX@SMPs-MON).The SMPs-MON with good biocompatibility could effectively encapsulate DOX and sustainably unload cargos in a pH-dependent manner.The DOX-loaded microparticles could be uptaken by 4T1 cells,and effectively kill the cancer cells.In vivo,DOX@SMPs-MON was deposited in the lungs and remained for over 5 days after pulmonary administration.In contrast to conventional DOX treatment that did not show significantly inhibitory effects on lung metastatic tumor,DOX@SMPs-MON markedly decreased the number and size of metastatic nodules in lungs,and the lung weight and appearance were similar to those of healthy mice.In summary,the sericin microparticles with MON wrapping might be a promising pulmonary delivery system for treating lung metastatic cancer. | Jia Liu Yan Deng Daan Fu Ye Yuan Qilin Li Lin Shi Guobin Wang Zheng Wang Lin Wang | 2021 | Bioactive Materials2021，6，1： | 1 |
| 7 | Downregulation of the miR-30 family microRNAs contributes to endoplasmic reticulum stress in cardiac muscle and vascular smooth muscle cells显示文摘 | Ming Chen Guiling Ma Yin Yue Yu Wei Qiang Li Zichuan Tong Lin Zhang Guobin Miao Jianjun Zhang | 2014 | International Journal of Cardiology2014，，： | 1 |
| 8 | Exponential isothermal amplification coupled MALDI-TOF MS for microRNAs detection显示文摘Micro RNAs(mi RNAs) have attracted significant attention in biomedical research and clinical diagnosis.However, due to their inherent characteristics of low abundance and the high complexity of corresponding biological matrices, simultaneous detection of multiple mi RNAs at low abundance is still a challenge.In this work, a method coupling exponential amplification reaction(EXPAR) with matrix-assisted laser desorption/ionization time-of-flight mass spectrometry(MALDI-TOF MS) is developed for label-free and simultaneous detection of multiple mi RNAs. The assay can be performed under isothermal conditions in a single reaction tube, and finished in less than 30 min. It exhibits good quantification ability and with attomolar-level sensitivity for mi RNAs detection. It also shows high specificity to distinguish mi RNAs at single-nucleotide resolution. We used the method to detect the mi RNA-21, let-7a, mi RNA-100, and mi RNA-125b in samples of spiked human serum and breast cancer cells(i.e., MCF-7, MDA-MB-231 and SK-BR-3). The quantification results were well consistent with the standard real-time fluorescence EXPAR.Consequently, the label-free mass-spectrometric platform could be a potential tool for mi RNAs analysis in complex biological samples, and may be used for clinical diagnosis. | Guobin Han Dandan Li Qiuyuan Lin Jia Yi Qian Lyu Qingwei Ma Liang Qiao | 2023 | Chinese Chemical Letters2023，34，2： | 0 |
| 9 | On the Normality of Meromorphic Functions显示文摘In this paper,we deal with the problem of normal families concerning share-values.The results extend and improve some theorems put forward by Miranda,Pang,Chen,Hua and Fang.Moreover,we answer one question posed by Gu,Pang,Fang and so on. | Guobin LIN | 2014 | Journal of Mathematical Research with Applications2014，34，1： | 0 |
| 10 | Study on Superheavy Nuclide 271Ds显示文摘 | Zhang Zhiyuan Gan Zaiguo Ma Long Huang Minghui Huang Tianheng Wu Xiaolei Jia Guobin Li Guangshun Yu Lin Ren Zhongzhou Zhou Shangui Zhang Yuhu Zhou Xiaohong Xu Hushan Zhang Huanqiao Xiao Guoqing Zhan Wenlong | 2011 | IMP & HIRFL Annual Report2011，，1： | 0 |
| 11 | Injectable silk sericin scaffolds with programmable shape-memory property and neuro-differentiation-promoting activity for individualized brain repair of severe ischemic stroke显示文摘Severe ischemic stroke damages neuronal tissue,forming irregular-shaped stroke cavities devoid of supporting structure.Implanting biomaterials to provide structural and functional support is thought to favor ingrowth of regenerated neuronal networks.Injectable hydrogels capable of in situ gelation are often utilized for stroke repair,but challenged by incomplete gelation and imprecise control over end-macrostructure.Injectable shape-memory scaffolds might overcome these limitations,but are not explored for stroke repair.Here,we report an injectable,photoluminescent,carbon-nanotubes-doped sericin scaffold(CNTs-SS)with programmable shape-memory property.By adjusting CNTs’concentrations,CNTs-SS′recovery dynamics can be mathematically calculated at the scale of seconds,and its shapes can be pre-designed to precisely match any irregular-shaped cavities.Using a preclinical stroke model,we show that CNTs-SS with the customized shape is successfully injected into the cavity and recovers its pre-designed shape to well fit the cavity.Notably,CNTs-SS’near-infrared photoluminescence enables non-invasive,real-time tracking after in vivo implantation.Moreover,as a cell carrier,CNTs-SS not only deliver bone marrow mesenchymal stem cells(BMSCs)into brain tissues,but also functionally promote their neuronal differentiation.Together,we for the first time demonstrate the feasibility of applying injectable shape-memory scaffolds for stroke repair,paving the way for personalized stroke repair. | Jian Wang Xiaolin Li Yu Song Qiangfei Su Xiakeerzhati Xiaohalati Wen Yang Luming Xu Bo Cai Guobin Wang Zheng Wang Lin Wang | 2021 | Bioactive Materials2021，6，7： | 0 |
| 12 | Effects of surface nanostructure on boundary lubrication using molecular dynamics显示文摘Molecular dynamics simulations are used to study the boundary lubrication behaviors of squalane lubricant between two iron wall structures during shearing at different pressures and temperatures.Boundary lubrication models with a smooth iron wall and a nanostructured iron wall,respectively,are constructed,and the density distribution of the lubricating film and the velocity distribution in the shearing process are analyzed.The mechanical response of the solid wall is output,and the friction coefficient is calculated.A tribological test is performed with a UMT-2 tribometer under sliding conditions to evaluate the reliability of the simulation method.The results show that the surface nanostructure has a significant effect on the film thickness and delamination of the lubricating film but little effect on the velocity distribution of the lubricating film.The nano strip groove helps to reduce the friction coefficient of the boundary lubrication system. | Ling Pan Hui Yu Shiping Lu Guobin Lin | 2021 | Nanotechnology and Precision Engineering2021，4，3： | 0 |
| 13 | Studying bona fide SARS-CoV-2 biology in a BSL-2 biosafety environment using a split-virus-genome system显示文摘Dear Editor,Severe acute respiratory syndrome coronavirus 2(SARSCoV-2)was identified as the pathogen causing the coronavirus disease(COVID-19),which sometimes resulted in fatal pneumonia(Hu et al.,2021).SARS-CoV-2 is a biosafety level 3(BSL-3)pathogen,and the requirement for high containment conditions is a bottleneck for basic research on viral biology.To help general researchers who wish to study SARS-CoV-2 but do not have access to a BSL-3 facility,a system that(1)can mimic the real life cycle of the virus;(2)allows easy genetic manipulation;and(3)shows high biosafety in BSL-2 laboratory is required. | Yingxin Ma Guobin Mao Weishan Yang Guoqiang Wu Guoqiang Li Xiaoying Li Xin Lin Junnan Lu Shijun Zhao Wei Zhao Junbiao Dai Xian-En Zhang | 2022 | Science China(Life Sciences)2022，65，9： | 0 |
| 14 | Reduction of G_0 phase cells of colon cancer caco-2 cells may enhance 5-fluorouracil efficacy显示文摘Objective:A major problem in the chemotherapy of colon caner may be due to those cells that are in residence in the G 0 phase where they are less vulnerable to conventional therapy.To overcome this phenomenon, we attempted to recruit the reentry of these cells into the cell cycle via a signaling pathway that manipulates tumor growth.Methods:Epidermal growth factor(EGF)was used to stimulate colon cancer caco-2 cells.FACS analysis and proliferating cell nuclear antigen(PCNA)staining were used to estimate the cell cycle transition and cell proliferation activated by EGF,and a MTT assay was used to evaluate the synergistic effect of EGF and chemotherapy.Results:The percentage of caco-2 cells in the G 0 /G 1 phase was significantly reduced by nearly 20%and the percentages in the S and G 2 /M phases were increased by EGF.The combined use of EGF and 5-fluorouracil(5-FU)enhanced the caco-2 cell chemosensitivity to 5-FU,reaching a maximum of an approximately threefold greater sensitivity than to 5-FU alone as judged by the 50%inhibiting concentration(IC 50 ). Conclusion:Our study demonstrated that stimulation by EGF enhanced the chemosensitivity of caco-2 cells to 5-FU,which may be a novel therapeutic protocol in colon cancer. | Lin Ye Kaixiong Tao Yang Yu Guobin Wang | 2010 | The Journal of Biomedical Research2010，24，1： | 0 |
| 15 | Adaptive fault-tolerant control of high-speed maglev train suspension system with partial actuator failure: design and experiments显示文摘High-speed maglev trains will play an important role in the high-speed transportation system in the near future.However,under the conditions of strong magnetic fields and continuous operation,the actuators of the high-speed maglev train suspension system are prone to lose partial effectiveness,which makes the suspension control problem challenging.In addition,most existing fault-tolerant control(FTC)methods for suspension systems require linearization around the equilibrium points during the controller design or stability analysis.Therefore,from a practical perspective,this study presents a novel nonlinear FTC strategy with adaptive compensation for high-speed maglev train suspension systems.First,a nonlinear dynamic model of the suspension system based on join-structure is established and the actuator failures are described.Then,a nonlinear fault-tolerant suspension control law with an adaptive update law is designed to achieve stable suspension against partial actuator failure.The Lyapunov theory and extended Barbalat lemma are utilized to rigorously prove the closed-loop asymptotic stability even if there is partial actuator failure,without any approximation to the original nonlinear dynamics.Finally,hardware experimental results are included to demonstrate the effectiveness of the proposed approach. | Yougang SUN Fengxing LI Guobin LIN Junqi XU Zhenyu HE | 2023 | Journal of Zhejiang University-Science A(Applied Physics & Engineering)2023，24，3： | 0 |
| 16 | Self-erasable dynamic surface patterns via controllable elastic modulus boosting multi-encoded and tamper-proof information storage显示文摘Dynamic surface patterns(DSPs)have attracted significant interest in anti-counterfeiting,enabling information to be stored,encrypted and decrypted in response to external stimuli.However,creating dynamic surface patterns,capable of controlling wrinkling time and independently modulating different information in both wrinkled and fluorescent states,remains a tremendous challenge.These limit DSPs to further enhance tamper-proofing capacity and extend the information storage density.Here,a rationally designed patterning strategy based on controllable elastic modulus was demonstrated to fabricate self-erasable dynamic surface patterns(S-DSPs)that increase information storage density.These novel S-DSPs strategically integrated amino co-oligomers(ACOs)with the 9-anthracenemethanol(9-AM)as skin layers,designing a bilayer multi-encoding system which could carry several different types of information with wrinkled and fluorescent patterns.The ACOs with relatively low molecular weight can endow the elastic modulus of skin layers with a wide range of regulation.As a result,the difference between the compressive strain and the critical wrinkle strain in the bilayer system would be precisely modulated by photo-dimerization to form quick-response(minimum<1 min)and self-erasable(3 min–8 days)wrinkled patterns for S-DSPs.Meanwhile,the fluorescence pattern could be independently erased and reprogrammed without affecting the change in the wrinkle pattern under modulus-controlled conditions.Moreover,controllable self-erasure in S-DSPs significantly develops tamper-proof capabilities in a supply chain.This original strategy could provide a new approach to the tamper-proof,high-density,and multi-encoded information storage in the product security or inkless printing. | Ziquan Fang Xiaofeng Lin Yihui Lin Jiamin Gao Li Gong Ruijun Lin Guoyi Pan Jianyu Wu Wenjing Lin Xudong Chen Guobin Yi | 2023 | Nano Research2023，16，1： | 0 |
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