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| 1 | Pharmacomicrobiomics: a novel route towards personalized medicine?显示文摘在药反应的内部个人的异质是影响病人幸福并且在社会水平上提出庞大的临床、金融的负担的一个严重问题。Pharmacogenomics 在关于药反应可变性或药毒性的对单个基因背景的影响的研究的最前线,并且最近,内脏 microbiome,也被称为第二个染色体,在这个方面作为一个重要播放器被认出了。而且, microbiome 是为由于机会改进药功效和安全操作它的作文的一个很吸引人的目标。Pharmacomicrobiomics 是调查 microbiome 变化和药反应和布置(吸收,分发,新陈代谢和排泄) 的相互影响的一个新兴的领域。在这评论,我们提供历史的概述并且在在内脏 microbiome,主人和药之间的复杂相互作用上检验当前的最先进的知识。我们主张那联合 pharmacogenomics 和 pharmacomicrobiomics 将为在个性化的药做主要进展提供一个重要基础。 | Marwah Doestzada Arnau Vich Vila Alexandra Zhernakova Debby P.Y. Koonen Rinse K. Weersma Daan J. TOUW Folkert Kuipers Cisca Wijmenga Jingyuan Fu | 2018 | Protein & Cell2018，9，5： | 7 |
| 2 | Sericin microparticles enveloped with metal-organic networks as a pulmonary targeting delivery system for intra-tracheally treating metastatic lung cancer显示文摘Chemotherapy is one of the major approaches for the treatment of metastatic lung cancer.However,systemic chemotherapy is limited by poor therapeutic efficiency and severe toxic side effects,due to the extremely low delivery efficacy and non-specificity of anticancer drugs.Herein,we report a sericin microparticles enveloped with metal-organic networks as a pulmonary delivery system for treating lung metastasis of breast cancer in an animal model.The sericin microparticles(SMPs)were prepared using water in oil(w/o)emulsification method.After doxorubicin(DOX)loading,tannic acid(TA)/ferric irons(Fe3+)based metal organic networks(MON)were coated on the particles to obtain DOX-loaded microparticles(DOX@SMPs-MON).The SMPs-MON with good biocompatibility could effectively encapsulate DOX and sustainably unload cargos in a pH-dependent manner.The DOX-loaded microparticles could be uptaken by 4T1 cells,and effectively kill the cancer cells.In vivo,DOX@SMPs-MON was deposited in the lungs and remained for over 5 days after pulmonary administration.In contrast to conventional DOX treatment that did not show significantly inhibitory effects on lung metastatic tumor,DOX@SMPs-MON markedly decreased the number and size of metastatic nodules in lungs,and the lung weight and appearance were similar to those of healthy mice.In summary,the sericin microparticles with MON wrapping might be a promising pulmonary delivery system for treating lung metastatic cancer. | Jia Liu Yan Deng Daan Fu Ye Yuan Qilin Li Lin Shi Guobin Wang Zheng Wang Lin Wang | 2021 | Bioactive Materials2021，6，1： | 1 |
| 3 | An infection-microenvironment-targeted and responsive peptide-drug nanosystem for sepsis emergency by suppressing infection and inflammation显示文摘Sepsis is a life-threatening emergency that causes millions of deaths every year due to severe infection and inflammation.Nevertheless,current therapeutic regimens are inadequate to promptly address the vast diversity of potential pathogens.Omiganan,an antimicrobial peptide,has shown promise for neutralizing endotoxins and eliminating diverse pathogens.However,its clinical application is hindered by safety and stability concerns.Herein,we present a nanoscale drug delivery system(Omi-hyd-Dex@HA NPs)that selectively targets infectious microenvironments(IMEs)and responds to specific stimuli for efficient intervention in sepsis.The system consists of omiganan-dexamethasone conjugates linked by hydrazone bonds which self-assemble into nanoparticles coated with a hyaluronic acid(HA).The HA coating not only facilitates IMEs-targeting through interaction with intercellular-adhesion-molecule-1 on inflamed endotheliocytes,but also improves the biosafety of the nanosystem and enhances drug accumulation in primary infection sites triggered by hyaluronidase.The nanoparticles release dual drugs in IMEs through pH-sensitive cleavage of hydrazone bonds to eradicate pathogens and suppress inflammation.In multiple tissue infection and sepsis animal models,Omi-hyd-Dex@HA NPs exhibited rapid source control and comprehensive inflammation reduction,thereby preventing subsequent fatal complications and significantly improving survival outcomes.The bio-responsive and self-delivering nanosystem offers a promising strategy for systemic sepsis treatment in emergencies. | Wei He Daan Fu Yongkang Gai Xingxin Liu Chang Yang Zhilan Ye Xu Chen Jia Liu Bingcheng Chang | 2023 | Asian Journal of Pharmaceutical Sciences2023，18，6： | 0 |
| 4 | Gold nanoparticles-embedded ceria with enhanced antioxidant activities for treating inflammatory bowel disease显示文摘The excessive reactive oxygen species(ROS)is a hallmark associated with the initiation and progression of inflammatory bowel disease(IBD),which execrably form a vicious cycle of ROS and inflammation to continually promote disease progression.Here,the gold nanoparticles-embedded ceria nanoparticles(Au/CeO_(2))with enhanced antioxidant activities are designed to block this cycle reaction for treating IBD by scavenging overproduced ROS.The Au/CeO_(2) with core-shell and porous structure exhibits significantly higher enzymatic catalytic activities compared with commercial ceria nanoparticles,likely due to the effective exposure of catalytic sites,higher content of Ce(III)and oxygen vacancy,and accelerated reduction from Ce(IV)to Ce(III).Being coated with negatively-charged hyaluronic acid,the Au/CeO_(2)@HA facilitates accumulation in inflamed colon tissues via oral administration,reduces pro-inflammatory cytokines,and effectively alleviates colon injury in colitis mice.Overall,the Au/CeO_(2)@HA with good biocompatibility is a promising nano-therapeutic for treating IBD. | Mingyi Li Jia Liu Lin Shi Cheng Zhou Meizhen Zou Daan Fu Ye Yuan Chundong Yao Lifang Zhang Sumei Qin Miaodeng Liu Qian Cheng Zheng Wang Lin Wang | 2023 | Bioactive Materials2023，，7： | 0 |
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